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Protein

Killer cell lectin-like receptor subfamily B member 1A

Gene

Klrb1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a stimulatory role on natural killer (NK) cell cytotoxicity.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionReceptor
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell lectin-like receptor subfamily B member 1A
Short name:
NKR-P1A
Alternative name(s):
CD161 antigen-like family member A
Lymphocyte antigen 55A
Short name:
Ly-55A
NKR-P1.7
Natural killer cell surface protein P1-2
Short name:
NKR-P1 2
CD_antigen: CD161a
Gene namesi
Name:Klrb1a
Synonyms:Ly55, Ly55a, Nkrp1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107540 Klrb1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45CytoplasmicSequence analysisAdd BLAST45
Transmembranei46 – 66Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini67 – 227ExtracellularSequence analysisAdd BLAST161

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466751 – 227Killer cell lectin-like receptor subfamily B member 1AAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 105PROSITE-ProRule annotation1 Publication
Disulfide bondi122 ↔ 210PROSITE-ProRule annotation1 Publication
Disulfide bondi189 ↔ 202PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP27811
PRIDEiP27811

Expressioni

Tissue specificityi

Expressed in natural killer cells.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with tyrosine kinase LCK (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032512

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP27811
SMRiP27811
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27811

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 212C-type lectinPROSITE-ProRule annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi31 – 34LCK-binding motifBy similarity4

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOVERGENiHBG052267
InParanoidiP27811
KOiK06543
PhylomeDBiP27811

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P27811-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTARVYFGL KPPRTPGAWH ESPPSLPPDA CRCPRSHRLA LKLSCAGLIL
60 70 80 90 100
LVVTLIGMSV LVRVLIQKPS IEKCYVLIQE NLNKTTDCSA KLECPQDWLS
110 120 130 140 150
HRDKCFHVSH VSNTWEEGLV DCDGKGATLM LIQDQEELRF LLDSIKEKYN
160 170 180 190 200
SFWIGLRYTL PDMNWKWING STLNSDVLKI TDDTENDSCA AISGDKVTFE
210 220
SCNSDNRWIC QKELYHETLS NYVGYGH
Length:227
Mass (Da):25,782
Last modified:January 9, 2007 - v2
Checksum:iB8283253E076C673
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E882G5E882_MOUSE
Killer cell lectin-like receptor su...
Klrb1a
233Annotation score:
A0A0N4SVG1A0A0N4SVG1_MOUSE
Killer cell lectin-like receptor su...
Klrb1a
216Annotation score:
A0A0N4SWH4A0A0N4SWH4_MOUSE
Killer cell lectin-like receptor su...
Klrb1a
225Annotation score:
E9Q0W1E9Q0W1_MOUSE
Killer cell lectin-like receptor su...
Klrb1a
200Annotation score:
A0A0N4SUJ4A0A0N4SUJ4_MOUSE
Killer cell lectin-like receptor su...
Klrb1a
83Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39L → S in AAA39822 (PubMed:1880421).Curated1
Sequence conflicti39L → S in CAA45971 (PubMed:1517565).Curated1
Sequence conflicti56I → T in CAA45976 (PubMed:1517565).Curated1
Sequence conflicti110H → Q in AAA39822 (PubMed:1880421).Curated1
Sequence conflicti110H → Q in AAA39366 (PubMed:1680927).Curated1
Sequence conflicti110H → Q in AAK39102 (PubMed:10229823).Curated1
Sequence conflicti110H → Q in AAK83003 (PubMed:11685472).Curated1
Sequence conflicti110H → Q in AAI20708 (PubMed:15489334).Curated1
Sequence conflicti117E → K in AAK39101 (PubMed:10229823).Curated1
Sequence conflicti168I → L in CAA45976 (PubMed:1517565).Curated1
Sequence conflicti182D → G in AAA39822 (PubMed:1880421).Curated1
Sequence conflicti182D → G in AAA39366 (PubMed:1680927).Curated1
Sequence conflicti182D → G in AAK39102 (PubMed:10229823).Curated1
Sequence conflicti182D → G in AAK83003 (PubMed:11685472).Curated1
Sequence conflicti182D → G in AAI20708 (PubMed:15489334).Curated1
Sequence conflicti217E → D in AAK39101 (PubMed:10229823).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77676 mRNA Translation: AAA39822.1
M77753 mRNA Translation: AAA39366.1
X64716
, X64717, X64718, X64724 Genomic DNA Translation: CAA45971.1
X64723 mRNA Translation: CAA45976.1
AF354261 mRNA Translation: AAK39101.1
AF354262 mRNA Translation: AAK39102.1
AF285840, AF285839 Genomic DNA Translation: AAK83003.1
DQ143102 Genomic DNA Translation: ABA43353.1
DQ237927 mRNA Translation: ABB72025.1
BC120707 mRNA Translation: AAI20708.1
PIRiA46467
RefSeqiNP_001153374.1, NM_001159902.1
NP_034867.3, NM_010737.3
UniGeneiMm.16729

Genome annotation databases

GeneIDi17057
KEGGimmu:17057

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77676 mRNA Translation: AAA39822.1
M77753 mRNA Translation: AAA39366.1
X64716
, X64717, X64718, X64724 Genomic DNA Translation: CAA45971.1
X64723 mRNA Translation: CAA45976.1
AF354261 mRNA Translation: AAK39101.1
AF354262 mRNA Translation: AAK39102.1
AF285840, AF285839 Genomic DNA Translation: AAK83003.1
DQ143102 Genomic DNA Translation: ABA43353.1
DQ237927 mRNA Translation: ABB72025.1
BC120707 mRNA Translation: AAI20708.1
PIRiA46467
RefSeqiNP_001153374.1, NM_001159902.1
NP_034867.3, NM_010737.3
UniGeneiMm.16729

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M94NMR-A89-227[»]
3M9ZX-ray1.70A89-227[»]
3T3AX-ray2.30A/B89-227[»]
ProteinModelPortaliP27811
SMRiP27811
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032512

Proteomic databases

PaxDbiP27811
PRIDEiP27811

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17057
KEGGimmu:17057

Organism-specific databases

CTDi17057
MGIiMGI:107540 Klrb1a

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOVERGENiHBG052267
InParanoidiP27811
KOiK06543
PhylomeDBiP27811

Miscellaneous databases

EvolutionaryTraceiP27811
PROiPR:P27811
SOURCEiSearch...

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLRBA_MOUSE
AccessioniPrimary (citable) accession number: P27811
Secondary accession number(s): Q1AG01
, Q1WJB8, Q61972, Q61973, Q91V25, Q925G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 9, 2007
Last modified: November 22, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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