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UniProtKB - P27810 (KTR1_YEAST)
Protein
Alpha-1,2 mannosyltransferase KTR1
Gene
KTR1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Mannosyltransferase that transfers a mannose residue from GDP-mannose to a range of acceptors in vitro, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.
Miscellaneous
Present with 5480 molecules/cell in log phase SD medium.1 Publication
Cofactori
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 280 | NucleophileSequence analysis | 1 |
GO - Molecular functioni
- alpha-1,2-mannosyltransferase activity Source: SGD
GO - Biological processi
- cell wall mannoprotein biosynthetic process Source: GO_Central
- mannosylation Source: GO_Central
- protein N-linked glycosylation Source: SGD
- protein O-linked glycosylation Source: SGD
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Ligand | Manganese |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT15, Glycosyltransferase Family 15 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:KTR1 Ordered Locus Names:YOR099W ORF Names:YOR3189W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005625, KTR1 |
VEuPathDBi | FungiDB:YOR099W |
Subcellular locationi
Golgi apparatus
Golgi apparatus
- Golgi apparatus Source: SGD
- Golgi membrane Source: UniProtKB-SubCell
Vacuole
- fungal-type vacuole Source: SGD
- fungal-type vacuole membrane Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 16 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 17 – 34 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 18 | |
Topological domaini | 35 – 393 | LumenalSequence analysisAdd BLAST | 359 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208242 | 1 – 393 | Alpha-1,2 mannosyltransferase KTR1Add BLAST | 393 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 120 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | P27810 |
PaxDbi | P27810 |
PRIDEi | P27810 |
PTM databases
iPTMneti | P27810 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 34497, 122 interactors |
DIPi | DIP-7181N |
IntActi | P27810, 1 interactor |
MINTi | P27810 |
STRINGi | 4932.YOR099W |
Miscellaneous databases
RNActi | P27810, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 68 | Stem regionBy similarityAdd BLAST | 34 | |
Regioni | 69 – 393 | CatalyticBy similarityAdd BLAST | 325 |
Sequence similaritiesi
Belongs to the glycosyltransferase 15 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4472, Eukaryota |
GeneTreei | ENSGT00940000176287 |
HOGENOMi | CLU_024327_4_1_1 |
InParanoidi | P27810 |
OMAi | LTDAPIH |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR002685, Glyco_trans_15 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR31121, PTHR31121, 1 hit |
Pfami | View protein in Pfam PF01793, Glyco_transf_15, 1 hit |
PIRSFi | PIRSF018153, Glyco_trans_15, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
P27810-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKIMIPASK QPVYKKLGLL LVAVFTVYVF FHGAQYARGS APSPKYSTVL
60 70 80 90 100
SSGSGYKYSK VELPKYTGPR EKATFVTLVR NRDLYSLAES IKSVEDRFNS
110 120 130 140 150
KFNYDWVFLN DEEFTDEFKN VTSALVSGTT KYGVIPKEHW SFPEWIDEEK
160 170 180 190 200
AAQVRKEMGE KRIIYGDSIS YRHMCRFESG FFYRHPLMDD YDWYWRVEPD
210 220 230 240 250
IKLHCDIDYD VFKFMKDNKK KYAFAISIKE YEATIPTLWE TTRKFMEAHP
260 270 280 290 300
ELIHENNMLD FVSDDQGLSY NLCHFWSNFE IAALDLWRSP AYSAYFDYLD
310 320 330 340 350
REGGFFYERW GDAPVHSIGA ALFLDRSEIH HFGDIGYYHV PFHSCPIDTS
360 370 380 390
IRLANKCDCD PSKDFTWHSY SCTTKFYNIN KLPKPAGWQN HIG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62941 Genomic DNA Translation: CAA44713.1 X94335 Genomic DNA Translation: CAA64021.1 Z75007 Genomic DNA Translation: CAA99296.1 BK006948 Genomic DNA Translation: DAA10876.1 |
PIRi | S61659 |
RefSeqi | NP_014742.1, NM_001183518.1 |
Genome annotation databases
EnsemblFungii | YOR099W_mRNA; YOR099W; YOR099W |
GeneIDi | 854266 |
KEGGi | sce:YOR099W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62941 Genomic DNA Translation: CAA44713.1 X94335 Genomic DNA Translation: CAA64021.1 Z75007 Genomic DNA Translation: CAA99296.1 BK006948 Genomic DNA Translation: DAA10876.1 |
PIRi | S61659 |
RefSeqi | NP_014742.1, NM_001183518.1 |
3D structure databases
SMRi | P27810 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 34497, 122 interactors |
DIPi | DIP-7181N |
IntActi | P27810, 1 interactor |
MINTi | P27810 |
STRINGi | 4932.YOR099W |
Protein family/group databases
CAZyi | GT15, Glycosyltransferase Family 15 |
PTM databases
iPTMneti | P27810 |
Proteomic databases
MaxQBi | P27810 |
PaxDbi | P27810 |
PRIDEi | P27810 |
Genome annotation databases
EnsemblFungii | YOR099W_mRNA; YOR099W; YOR099W |
GeneIDi | 854266 |
KEGGi | sce:YOR099W |
Organism-specific databases
SGDi | S000005625, KTR1 |
VEuPathDBi | FungiDB:YOR099W |
Phylogenomic databases
eggNOGi | KOG4472, Eukaryota |
GeneTreei | ENSGT00940000176287 |
HOGENOMi | CLU_024327_4_1_1 |
InParanoidi | P27810 |
OMAi | LTDAPIH |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
Miscellaneous databases
PROi | PR:P27810 |
RNActi | P27810, protein |
Family and domain databases
Gene3Di | 3.90.550.10, 1 hit |
InterProi | View protein in InterPro IPR002685, Glyco_trans_15 IPR029044, Nucleotide-diphossugar_trans |
PANTHERi | PTHR31121, PTHR31121, 1 hit |
Pfami | View protein in Pfam PF01793, Glyco_transf_15, 1 hit |
PIRSFi | PIRSF018153, Glyco_trans_15, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KTR1_YEAST | |
Accessioni | P27810Primary (citable) accession number: P27810 Secondary accession number(s): D6W2G0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families