Lyl1

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB
protein dimerization activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16514064
blood vessel maturation Source: UniProtKB
definitive hemopoiesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16514064
positive regulation of transcription, DNA-templated Source: UniProtKB
regulation of transcription, DNA-templated Source: UniProtKB
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein lyl-1 Alternative name(s): Lymphoblastic leukemia-derived sequence 1
Gene namesⁱ	Name:Lyl1 Synonyms:Lyl-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:96891 Lyl1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127263	1 – 278	Protein lyl-1Add BLAST		278

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	274	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P27792
PeptideAtlas More...PeptideAtlasⁱ	P27792
PRIDEⁱ	P27792

PTM databases

iPTMnetⁱ	P27792
PhosphoSitePlusⁱ	P27792

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000034041 Expressed in 179 organ(s), highest expression level in spleen
CleanExⁱ	MM_LYL1
Genevisibleⁱ	P27792 MM

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000046010

STRINGⁱ

10090.ENSMUSP00000046010

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P27792
SMRⁱ	P27792
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	149 – 201	bHLHPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119097
HOGENOMⁱ	HOG000113414
HOVERGENⁱ	HBG094957
InParanoidⁱ	P27792
KEGG Orthology (KO) More...KOⁱ	K15604
OMAⁱ	IKMEQTA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ESI
PhylomeDBⁱ	P27792
TreeFamⁱ	TF315153

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P27792-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCPPQARAEV GSAMTEKTEM VCASSPAPAP PSKPASPGPL STEEVDHRNT 
        60         70         80         90        100
CTPWLPPGVP VINLGHTRPI GAAMPTTELS AFRPSLLQLT ALGRAPPTLA 
       110        120        130        140        150
VHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHSELDLA DGHQPQKVAR 
       160        170        180        190        200
RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF 
       210        220        230        240        250
LVRLLRDQTA VLTSGPSAPG SRKPPARRGV EGSARFGAGH RVEAARSQPV 
       260        270 
LPGDCDGDPN GSVRPIKLEQ TSLSPEVR

Length:278

Mass (Da):30,142

Last modified:April 14, 2009 - v2

Checksum:ⁱ83582AAF03C1C832

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	7	R → G in CAA40870 (PubMed:2000219).Curated	1
Sequence conflictⁱ	7	R → G in CAJ18375 (Ref. 3) Curated	1
Sequence conflictⁱ	7	R → G in EDL10953 (Ref. 6) Curated	1
Sequence conflictⁱ	7	R → G in AAH05736 (PubMed:15489334).Curated	1
Sequence conflictⁱ	34	P → L in CAA40870 (PubMed:2000219).Curated	1
Sequence conflictⁱ	34	P → L in EDL10953 (Ref. 6) Curated	1
Sequence conflictⁱ	34	P → L in AAH05736 (PubMed:15489334).Curated	1
Sequence conflictⁱ	111	S → R in CAA38896 (PubMed:2067848).Curated	1
Sequence conflictⁱ	239	G → E in CAA40870 (PubMed:2000219).Curated	1
Sequence conflictⁱ	239	G → E in EDL10953 (Ref. 6) Curated	1
Sequence conflictⁱ	239	G → E in AAH05736 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X57687 mRNA Translation: CAA40870.1 X55055 Genomic DNA Translation: CAA38896.1 CT010167 mRNA Translation: CAJ18375.1 AK076114 mRNA Translation: BAC36194.1 AC145556 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL10953.1 BC005736 mRNA Translation: AAH05736.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22476.1
PIRⁱ	S16678
NCBI Reference Sequences More...RefSeqⁱ	NP_032561.2, NM_008535.2 XP_006530807.1, XM_006530744.2
UniGeneⁱ	Mm.4925

Genome annotation databases

Ensemblⁱ	ENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041
GeneIDⁱ	17095
KEGGⁱ	mmu:17095
UCSC genome browser More...UCSCⁱ	uc009mnb.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P27792	Protein lyl-1		RAT		278	UniRef90_P27792
UPI00001F664F		MOUSE		205
UPI000A30D613		MUSPA		278
UPI000A314B9F		MUSCR		278

Protein	Similar proteins		Species	Score	Length	Source
P27792	Protein lyl-1		RAT		278	UniRef50_P27792
Uncharacterized protein		OTOGA		276
Protein lyl-1		TUPCH		267
Uncharacterized protein		MUSPF		279
protein lyl-1		Enhydra lutris kenyoni		279
+77

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X57687 mRNA Translation: CAA40870.1 X55055 Genomic DNA Translation: CAA38896.1 CT010167 mRNA Translation: CAJ18375.1 AK076114 mRNA Translation: BAC36194.1 AC145556 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL10953.1 BC005736 mRNA Translation: AAH05736.1
CCDSⁱ	CCDS22476.1
PIRⁱ	S16678
RefSeqⁱ	NP_032561.2, NM_008535.2 XP_006530807.1, XM_006530744.2
UniGeneⁱ	Mm.4925

3D structure databases

ProteinModelPortalⁱ	P27792
SMRⁱ	P27792
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000046010

STRINGⁱ

10090.ENSMUSP00000046010

PTM databases

iPTMnetⁱ	P27792
PhosphoSitePlusⁱ	P27792

Proteomic databases

PaxDbⁱ	P27792
PeptideAtlasⁱ	P27792
PRIDEⁱ	P27792

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041
GeneIDⁱ	17095
KEGGⁱ	mmu:17095
UCSCⁱ	uc009mnb.1 mouse

Organism-specific databases

CTDⁱ	4066
MGIⁱ	MGI:96891 Lyl1

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00760000119097
HOGENOMⁱ	HOG000113414
HOVERGENⁱ	HBG094957
InParanoidⁱ	P27792
KOⁱ	K15604
OMAⁱ	IKMEQTA
OrthoDBⁱ	EOG091G0ESI
PhylomeDBⁱ	P27792
TreeFamⁱ	TF315153

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P27792
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034041 Expressed in 179 organ(s), highest expression level in spleen
CleanExⁱ	MM_LYL1
Genevisibleⁱ	P27792 MM

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LYL1_MOUSE
Accessionⁱ	P27792Primary (citable) accession number: P27792 Secondary accession number(s): Q4FK84, Q8BPE2, Q923F0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	April 14, 2009
	Last modified:	September 12, 2018
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P27792 (LYL1_MOUSE)

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Protein lyl-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ