UniProtKB - P27792 (LYL1_MOUSE)
Protein
Protein lyl-1
Gene
Lyl1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- B cell differentiation Source: UniProtKB
- blood vessel maturation Source: UniProtKB
- definitive hemopoiesis Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein lyl-1Alternative name(s): Lymphoblastic leukemia-derived sequence 1 |
Gene namesi | Name:Lyl1 Synonyms:Lyl-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96891, Lyl1 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127263 | 1 – 278 | Protein lyl-1Add BLAST | 278 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 274 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P27792 |
PeptideAtlasi | P27792 |
PRIDEi | P27792 |
PTM databases
iPTMneti | P27792 |
PhosphoSitePlusi | P27792 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034041, Expressed in spleen and 200 other tissues |
Genevisiblei | P27792, MM |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000046010 |
Miscellaneous databases
RNActi | P27792, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 149 – 201 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162404 |
HOGENOMi | CLU_047980_1_0_1 |
InParanoidi | P27792 |
OMAi | HRVPDDG |
OrthoDBi | 1453623at2759 |
PhylomeDBi | P27792 |
TreeFami | TF315153 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P27792-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCPPQARAEV GSAMTEKTEM VCASSPAPAP PSKPASPGPL STEEVDHRNT
60 70 80 90 100
CTPWLPPGVP VINLGHTRPI GAAMPTTELS AFRPSLLQLT ALGRAPPTLA
110 120 130 140 150
VHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHSELDLA DGHQPQKVAR
160 170 180 190 200
RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF
210 220 230 240 250
LVRLLRDQTA VLTSGPSAPG SRKPPARRGV EGSARFGAGH RVEAARSQPV
260 270
LPGDCDGDPN GSVRPIKLEQ TSLSPEVR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A571BE88 | A0A571BE88_MOUSE | Protein lyl-1 | Lyl1 | 205 | Annotation score: | ||
A0A571BFA2 | A0A571BFA2_MOUSE | Protein lyl-1 | Lyl1 | 20 | Annotation score: | ||
A0A571BG04 | A0A571BG04_MOUSE | Protein lyl-1 | Lyl1 | 34 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 7 | R → G in CAA40870 (PubMed:2000219).Curated | 1 | |
Sequence conflicti | 7 | R → G in CAJ18375 (Ref. 3) Curated | 1 | |
Sequence conflicti | 7 | R → G in EDL10953 (Ref. 6) Curated | 1 | |
Sequence conflicti | 7 | R → G in AAH05736 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 34 | P → L in CAA40870 (PubMed:2000219).Curated | 1 | |
Sequence conflicti | 34 | P → L in EDL10953 (Ref. 6) Curated | 1 | |
Sequence conflicti | 34 | P → L in AAH05736 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 111 | S → R in CAA38896 (PubMed:2067848).Curated | 1 | |
Sequence conflicti | 239 | G → E in CAA40870 (PubMed:2000219).Curated | 1 | |
Sequence conflicti | 239 | G → E in EDL10953 (Ref. 6) Curated | 1 | |
Sequence conflicti | 239 | G → E in AAH05736 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57687 mRNA Translation: CAA40870.1 X55055 Genomic DNA Translation: CAA38896.1 CT010167 mRNA Translation: CAJ18375.1 AK076114 mRNA Translation: BAC36194.1 AC145556 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL10953.1 BC005736 mRNA Translation: AAH05736.1 |
CCDSi | CCDS22476.1 |
PIRi | S16678 |
RefSeqi | NP_032561.2, NM_008535.2 XP_006530807.1, XM_006530744.2 |
Genome annotation databases
Ensembli | ENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041 |
GeneIDi | 17095 |
KEGGi | mmu:17095 |
UCSCi | uc009mnb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57687 mRNA Translation: CAA40870.1 X55055 Genomic DNA Translation: CAA38896.1 CT010167 mRNA Translation: CAJ18375.1 AK076114 mRNA Translation: BAC36194.1 AC145556 Genomic DNA No translation available. CH466525 Genomic DNA Translation: EDL10953.1 BC005736 mRNA Translation: AAH05736.1 |
CCDSi | CCDS22476.1 |
PIRi | S16678 |
RefSeqi | NP_032561.2, NM_008535.2 XP_006530807.1, XM_006530744.2 |
3D structure databases
SMRi | P27792 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000046010 |
PTM databases
iPTMneti | P27792 |
PhosphoSitePlusi | P27792 |
Proteomic databases
PaxDbi | P27792 |
PeptideAtlasi | P27792 |
PRIDEi | P27792 |
Protocols and materials databases
ABCDi | P27792, 1 sequenced antibody |
Antibodypediai | 26353, 158 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041 |
GeneIDi | 17095 |
KEGGi | mmu:17095 |
UCSCi | uc009mnb.1, mouse |
Organism-specific databases
CTDi | 4066 |
MGIi | MGI:96891, Lyl1 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162404 |
HOGENOMi | CLU_047980_1_0_1 |
InParanoidi | P27792 |
OMAi | HRVPDDG |
OrthoDBi | 1453623at2759 |
PhylomeDBi | P27792 |
TreeFami | TF315153 |
Miscellaneous databases
BioGRID-ORCSi | 17095, 3 hits in 17 CRISPR screens |
PROi | PR:P27792 |
RNActi | P27792, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034041, Expressed in spleen and 200 other tissues |
Genevisiblei | P27792, MM |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LYL1_MOUSE | |
Accessioni | P27792Primary (citable) accession number: P27792 Secondary accession number(s): Q4FK84, Q8BPE2, Q923F0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | April 14, 2009 | |
Last modified: | December 2, 2020 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot