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Protein

Protein lyl-1

Gene

Lyl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lyl-1
Alternative name(s):
Lymphoblastic leukemia-derived sequence 1
Gene namesi
Name:Lyl1
Synonyms:Lyl-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96891 Lyl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272631 – 278Protein lyl-1Add BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP27792
PeptideAtlasiP27792
PRIDEiP27792

PTM databases

iPTMnetiP27792
PhosphoSitePlusiP27792

Expressioni

Gene expression databases

BgeeiENSMUSG00000034041 Expressed in 179 organ(s), highest expression level in spleen
CleanExiMM_LYL1
GenevisibleiP27792 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046010

Structurei

3D structure databases

ProteinModelPortaliP27792
SMRiP27792
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 201bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000113414
HOVERGENiHBG094957
InParanoidiP27792
KOiK15604
OMAiIKMEQTA
OrthoDBiEOG091G0ESI
PhylomeDBiP27792
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P27792-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCPPQARAEV GSAMTEKTEM VCASSPAPAP PSKPASPGPL STEEVDHRNT
60 70 80 90 100
CTPWLPPGVP VINLGHTRPI GAAMPTTELS AFRPSLLQLT ALGRAPPTLA
110 120 130 140 150
VHYHPHPFLN SVYIGPAGPF SIFPNSRLKR RPSHSELDLA DGHQPQKVAR
160 170 180 190 200
RVFTNSRERW RQQHVNGAFA ELRKLLPTHP PDRKLSKNEV LRLAMKYIGF
210 220 230 240 250
LVRLLRDQTA VLTSGPSAPG SRKPPARRGV EGSARFGAGH RVEAARSQPV
260 270
LPGDCDGDPN GSVRPIKLEQ TSLSPEVR
Length:278
Mass (Da):30,142
Last modified:April 14, 2009 - v2
Checksum:i83582AAF03C1C832
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7R → G in CAA40870 (PubMed:2000219).Curated1
Sequence conflicti7R → G in CAJ18375 (Ref. 3) Curated1
Sequence conflicti7R → G in EDL10953 (Ref. 6) Curated1
Sequence conflicti7R → G in AAH05736 (PubMed:15489334).Curated1
Sequence conflicti34P → L in CAA40870 (PubMed:2000219).Curated1
Sequence conflicti34P → L in EDL10953 (Ref. 6) Curated1
Sequence conflicti34P → L in AAH05736 (PubMed:15489334).Curated1
Sequence conflicti111S → R in CAA38896 (PubMed:2067848).Curated1
Sequence conflicti239G → E in CAA40870 (PubMed:2000219).Curated1
Sequence conflicti239G → E in EDL10953 (Ref. 6) Curated1
Sequence conflicti239G → E in AAH05736 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57687 mRNA Translation: CAA40870.1
X55055 Genomic DNA Translation: CAA38896.1
CT010167 mRNA Translation: CAJ18375.1
AK076114 mRNA Translation: BAC36194.1
AC145556 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL10953.1
BC005736 mRNA Translation: AAH05736.1
CCDSiCCDS22476.1
PIRiS16678
RefSeqiNP_032561.2, NM_008535.2
XP_006530807.1, XM_006530744.2
UniGeneiMm.4925

Genome annotation databases

EnsembliENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041
GeneIDi17095
KEGGimmu:17095
UCSCiuc009mnb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57687 mRNA Translation: CAA40870.1
X55055 Genomic DNA Translation: CAA38896.1
CT010167 mRNA Translation: CAJ18375.1
AK076114 mRNA Translation: BAC36194.1
AC145556 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL10953.1
BC005736 mRNA Translation: AAH05736.1
CCDSiCCDS22476.1
PIRiS16678
RefSeqiNP_032561.2, NM_008535.2
XP_006530807.1, XM_006530744.2
UniGeneiMm.4925

3D structure databases

ProteinModelPortaliP27792
SMRiP27792
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046010

PTM databases

iPTMnetiP27792
PhosphoSitePlusiP27792

Proteomic databases

PaxDbiP27792
PeptideAtlasiP27792
PRIDEiP27792

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041
GeneIDi17095
KEGGimmu:17095
UCSCiuc009mnb.1 mouse

Organism-specific databases

CTDi4066
MGIiMGI:96891 Lyl1

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000113414
HOVERGENiHBG094957
InParanoidiP27792
KOiK15604
OMAiIKMEQTA
OrthoDBiEOG091G0ESI
PhylomeDBiP27792
TreeFamiTF315153

Miscellaneous databases

PROiPR:P27792
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034041 Expressed in 179 organ(s), highest expression level in spleen
CleanExiMM_LYL1
GenevisibleiP27792 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLYL1_MOUSE
AccessioniPrimary (citable) accession number: P27792
Secondary accession number(s): Q4FK84, Q8BPE2, Q923F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 14, 2009
Last modified: September 12, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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