UniProtKB - P27784 (CCL6_MOUSE)
Protein
C-C motif chemokine 6
Gene
Ccl6
Organism
Mus musculus (Mouse)
Status
Functioni
CCL6(22-95) and CCL6(23-95) are potent chemoattractants.1 Publication
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: MGI
GO - Biological processi
- cell chemotaxis Source: MGI
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- lymphocyte chemotaxis Source: GO_Central
- monocyte chemotaxis Source: GO_Central
- neutrophil chemotaxis Source: GO_Central
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis |
Enzyme and pathway databases
Reactomei | R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events R-MMU-444473, Formyl peptide receptors bind formyl peptides and many other ligands |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokine 6Alternative name(s): Protein C10 Small-inducible cytokine A6 Cleaved into the following 2 chains: |
Gene namesi | Name:Ccl6 Synonyms:C10, Scya6 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98263, Ccl6 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000005182 | 22 – 116 | C-C motif chemokine 6Add BLAST | 95 | |
ChainiPRO_0000041844 | 43 – 116 | CCL6(22-95)Add BLAST | 74 | |
ChainiPRO_0000041845 | 44 – 116 | CCL6(23-95)Add BLAST | 73 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 50 ↔ 73 | By similarity | ||
Disulfide bondi | 51 ↔ 89 | By similarity | ||
Disulfide bondi | 60 ↔ 100 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MaxQBi | P27784 |
PaxDbi | P27784 |
PeptideAtlasi | P27784 |
PRIDEi | P27784 |
PTM databases
iPTMneti | P27784 |
PhosphoSitePlusi | P27784 |
Expressioni
Tissue specificityi
Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.
Inductioni
Associated with stimuli that promote myeloid differentiation.
Gene expression databases
Bgeei | ENSMUSG00000018927, Expressed in granulocyte and 195 other tissues |
Genevisiblei | P27784, MM |
Interactioni
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019071 |
Miscellaneous databases
RNActi | P27784, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine beta (chemokine CC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TJX7, Eukaryota |
GeneTreei | ENSGT01000000214365 |
HOGENOMi | CLU_141716_4_1_1 |
InParanoidi | P27784 |
OMAi | AQFTNDA |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P27784 |
TreeFami | TF334888 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P27784-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRNSKTAISF FILVAVLGSQ AGLIQEMEKE DRRYNPPIIH QGFQDTSSDC
60 70 80 90 100
CFSYATQIPC KRFIYYFPTS GGCIKPGIIF ISRRGTQVCA DPSDRRVQRC
110
LSTLKQGPRS GNKVIA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 43 | F → V in AAH02073 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 93 | S → R in BAB25734 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 111 | G → R in AAH02073 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58004 mRNA Translation: AAA37329.1 AF128188 mRNA Translation: AAF22529.1 AF128189 mRNA Translation: AAF22530.1 AF128190 mRNA Translation: AAF22531.1 AF128191 mRNA Translation: AAF22532.1 AF128192 mRNA Translation: AAF22533.1 AB051897 Genomic DNA Translation: BAB18729.1 AK002697 mRNA Translation: BAB22291.1 AK008547 mRNA Translation: BAB25734.1 AK150336 mRNA Translation: BAE29478.1 AK154553 mRNA Translation: BAE32672.1 AL596122 Genomic DNA No translation available. BC002073 mRNA Translation: AAH02073.1 |
CCDSi | CCDS25171.1 |
PIRi | I49555 |
RefSeqi | NP_033165.1, NM_009139.3 |
Genome annotation databases
Ensembli | ENSMUST00000019071; ENSMUSP00000019071; ENSMUSG00000018927 |
GeneIDi | 20305 |
KEGGi | mmu:20305 |
UCSCi | uc007kpm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58004 mRNA Translation: AAA37329.1 AF128188 mRNA Translation: AAF22529.1 AF128189 mRNA Translation: AAF22530.1 AF128190 mRNA Translation: AAF22531.1 AF128191 mRNA Translation: AAF22532.1 AF128192 mRNA Translation: AAF22533.1 AB051897 Genomic DNA Translation: BAB18729.1 AK002697 mRNA Translation: BAB22291.1 AK008547 mRNA Translation: BAB25734.1 AK150336 mRNA Translation: BAE29478.1 AK154553 mRNA Translation: BAE32672.1 AL596122 Genomic DNA No translation available. BC002073 mRNA Translation: AAH02073.1 |
CCDSi | CCDS25171.1 |
PIRi | I49555 |
RefSeqi | NP_033165.1, NM_009139.3 |
3D structure databases
SMRi | P27784 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019071 |
PTM databases
iPTMneti | P27784 |
PhosphoSitePlusi | P27784 |
Proteomic databases
MaxQBi | P27784 |
PaxDbi | P27784 |
PeptideAtlasi | P27784 |
PRIDEi | P27784 |
Genome annotation databases
Ensembli | ENSMUST00000019071; ENSMUSP00000019071; ENSMUSG00000018927 |
GeneIDi | 20305 |
KEGGi | mmu:20305 |
UCSCi | uc007kpm.1, mouse |
Organism-specific databases
CTDi | 20305 |
MGIi | MGI:98263, Ccl6 |
Phylogenomic databases
eggNOGi | ENOG502TJX7, Eukaryota |
GeneTreei | ENSGT01000000214365 |
HOGENOMi | CLU_141716_4_1_1 |
InParanoidi | P27784 |
OMAi | AQFTNDA |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P27784 |
TreeFami | TF334888 |
Enzyme and pathway databases
Reactomei | R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events R-MMU-444473, Formyl peptide receptors bind formyl peptides and many other ligands |
Miscellaneous databases
BioGRID-ORCSi | 20305, 0 hits in 17 CRISPR screens |
PROi | PR:P27784 |
RNActi | P27784, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018927, Expressed in granulocyte and 195 other tissues |
Genevisiblei | P27784, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL6_MOUSE | |
Accessioni | P27784Primary (citable) accession number: P27784 Secondary accession number(s): Q3U3W3 Q9D830 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families