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Protein

C-C motif chemokine 6

Gene

Ccl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CCL6(22-95) and CCL6(23-95) are potent chemoattractants.1 Publication

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 6
Alternative name(s):
Protein C10
Small-inducible cytokine A6
Cleaved into the following 2 chains:
Gene namesi
Name:Ccl6
Synonyms:C10, Scya6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98263 Ccl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000518222 – 116C-C motif chemokine 6Add BLAST95
ChainiPRO_000004184443 – 116CCL6(22-95)Add BLAST74
ChainiPRO_000004184544 – 116CCL6(23-95)Add BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 73By similarity
Disulfide bondi51 ↔ 89By similarity
Disulfide bondi60 ↔ 100By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP27784
PaxDbiP27784
PeptideAtlasiP27784
PRIDEiP27784

PTM databases

iPTMnetiP27784
PhosphoSitePlusiP27784

Expressioni

Tissue specificityi

Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.

Inductioni

Associated with stimuli that promote myeloid differentiation.

Gene expression databases

BgeeiENSMUSG00000018927 Expressed in 175 organ(s), highest expression level in blood
CleanExiMM_CCL6
GenevisibleiP27784 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019071

Structurei

3D structure databases

ProteinModelPortaliP27784
SMRiP27784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4DG Eukaryota
ENOG4111C2C LUCA
GeneTreeiENSGT00910000144306
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP27784
KOiK05510
OMAiCCISYIS
OrthoDBiEOG091G14Y2
PhylomeDBiP27784
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27784-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRNSKTAISF FILVAVLGSQ AGLIQEMEKE DRRYNPPIIH QGFQDTSSDC
60 70 80 90 100
CFSYATQIPC KRFIYYFPTS GGCIKPGIIF ISRRGTQVCA DPSDRRVQRC
110
LSTLKQGPRS GNKVIA
Length:116
Mass (Da):12,984
Last modified:August 1, 1992 - v1
Checksum:i2B483B5DE8417082
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43F → V in AAH02073 (PubMed:15489334).Curated1
Sequence conflicti93S → R in BAB25734 (PubMed:16141072).Curated1
Sequence conflicti111G → R in AAH02073 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58004 mRNA Translation: AAA37329.1
AF128188 mRNA Translation: AAF22529.1
AF128189 mRNA Translation: AAF22530.1
AF128190 mRNA Translation: AAF22531.1
AF128191 mRNA Translation: AAF22532.1
AF128192 mRNA Translation: AAF22533.1
AB051897 Genomic DNA Translation: BAB18729.1
AK002697 mRNA Translation: BAB22291.1
AK008547 mRNA Translation: BAB25734.1
AK150336 mRNA Translation: BAE29478.1
AK154553 mRNA Translation: BAE32672.1
AL596122 Genomic DNA Translation: CAI25134.1
BC002073 mRNA Translation: AAH02073.1
CCDSiCCDS25171.1
PIRiI49555
RefSeqiNP_033165.1, NM_009139.3
UniGeneiMm.137

Genome annotation databases

EnsembliENSMUST00000019071; ENSMUSP00000019071; ENSMUSG00000018927
GeneIDi20305
KEGGimmu:20305
UCSCiuc007kpm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58004 mRNA Translation: AAA37329.1
AF128188 mRNA Translation: AAF22529.1
AF128189 mRNA Translation: AAF22530.1
AF128190 mRNA Translation: AAF22531.1
AF128191 mRNA Translation: AAF22532.1
AF128192 mRNA Translation: AAF22533.1
AB051897 Genomic DNA Translation: BAB18729.1
AK002697 mRNA Translation: BAB22291.1
AK008547 mRNA Translation: BAB25734.1
AK150336 mRNA Translation: BAE29478.1
AK154553 mRNA Translation: BAE32672.1
AL596122 Genomic DNA Translation: CAI25134.1
BC002073 mRNA Translation: AAH02073.1
CCDSiCCDS25171.1
PIRiI49555
RefSeqiNP_033165.1, NM_009139.3
UniGeneiMm.137

3D structure databases

ProteinModelPortaliP27784
SMRiP27784
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019071

PTM databases

iPTMnetiP27784
PhosphoSitePlusiP27784

Proteomic databases

MaxQBiP27784
PaxDbiP27784
PeptideAtlasiP27784
PRIDEiP27784

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019071; ENSMUSP00000019071; ENSMUSG00000018927
GeneIDi20305
KEGGimmu:20305
UCSCiuc007kpm.1 mouse

Organism-specific databases

CTDi20305
MGIiMGI:98263 Ccl6

Phylogenomic databases

eggNOGiENOG410J4DG Eukaryota
ENOG4111C2C LUCA
GeneTreeiENSGT00910000144306
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP27784
KOiK05510
OMAiCCISYIS
OrthoDBiEOG091G14Y2
PhylomeDBiP27784
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands

Miscellaneous databases

ChiTaRSiCcl6 mouse
PROiPR:P27784
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018927 Expressed in 175 organ(s), highest expression level in blood
CleanExiMM_CCL6
GenevisibleiP27784 MM

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL6_MOUSE
AccessioniPrimary (citable) accession number: P27784
Secondary accession number(s): Q3U3W3
, Q5QNW1, Q99M24, Q9D830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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