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Protein

Troponin I, fast skeletal muscle

Gene

Tnni2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi105 – 116By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • cardiac muscle contraction Source: GO_Central
  • muscle contraction Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: Ensembl
  • regulation of muscle contraction Source: RGD
  • skeletal muscle contraction Source: GO_Central

Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

ReactomeiR-RNO-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene namesi
Name:Tnni2
Synonyms:Trp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi62050 Tnni2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861462 – 182Troponin I, fast skeletal muscleAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei118PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP27768
PRIDEiP27768

PTM databases

CarbonylDBiP27768
iPTMnetiP27768
PhosphoSitePlusiP27768

Expressioni

Gene expression databases

BgeeiENSRNOG00000020276 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiP27768 baseline and differential
GenevisibleiP27768 RN

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027487

Structurei

3D structure databases

ProteinModelPortaliP27768
SMRiP27768
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Involved in binding TNCAdd BLAST47
Regioni97 – 117Involved in binding TNC and actinAdd BLAST21

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
GeneTreeiENSGT00390000002746
HOGENOMiHOG000293300
HOVERGENiHBG052737
InParanoidiP27768
KOiK12043
OMAiPDWSKKN
PhylomeDBiP27768

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P27768-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KQNYLSEHCP
60 70 80 90 100
PLHIPGSMSE VQELCKQLHA KIDAAEEEKY DMEVKVQKSS KELEDMNQKL
110 120 130 140 150
FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE
160 170 180
KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES
Length:182
Mass (Da):21,328
Last modified:January 23, 2007 - v2
Checksum:i6640081F44AA0EDA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WG17F8WG17_RAT
Troponin I, fast skeletal muscle
Tnni2
182Annotation score:
A0A0G2K3X1A0A0G2K3X1_RAT
Troponin I type 2 (Skeletal, fast),...
Tnni2 rCG_47348
161Annotation score:
A0A0G2K0N9A0A0G2K0N9_RAT
Troponin I, fast skeletal muscle
Tnni2
182Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73701 mRNA Translation: AAA42149.1
RefSeqiNP_058881.1, NM_017185.1
UniGeneiRn.9924

Genome annotation databases

EnsembliENSRNOT00000076140; ENSRNOP00000068152; ENSRNOG00000020276
ENSRNOT00000076187; ENSRNOP00000068190; ENSRNOG00000020276
GeneIDi29389
KEGGirno:29389
UCSCiRGD:62050 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73701 mRNA Translation: AAA42149.1
RefSeqiNP_058881.1, NM_017185.1
UniGeneiRn.9924

3D structure databases

ProteinModelPortaliP27768
SMRiP27768
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027487

PTM databases

CarbonylDBiP27768
iPTMnetiP27768
PhosphoSitePlusiP27768

Proteomic databases

PaxDbiP27768
PRIDEiP27768

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000076140; ENSRNOP00000068152; ENSRNOG00000020276
ENSRNOT00000076187; ENSRNOP00000068190; ENSRNOG00000020276
GeneIDi29389
KEGGirno:29389
UCSCiRGD:62050 rat

Organism-specific databases

CTDi7136
RGDi62050 Tnni2

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
GeneTreeiENSGT00390000002746
HOGENOMiHOG000293300
HOVERGENiHBG052737
InParanoidiP27768
KOiK12043
OMAiPDWSKKN
PhylomeDBiP27768

Enzyme and pathway databases

ReactomeiR-RNO-390522 Striated Muscle Contraction

Miscellaneous databases

PROiPR:P27768

Gene expression databases

BgeeiENSRNOG00000020276 Expressed in 8 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiP27768 baseline and differential
GenevisibleiP27768 RN

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI2_RAT
AccessioniPrimary (citable) accession number: P27768
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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