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Entry version 117 (31 Jul 2019)
Sequence version 3 (28 Nov 2002)
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Protein

Alpha-galactosidase

Gene

aga

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. EC:3.2.1.22

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei472NucleophileBy similarity1
Active sitei541Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandMagnesium, NAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SMUT210007:G1FZX-842-MONOMER

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH36 Glycoside Hydrolase Family 36

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-galactosidase (EC:3.2.1.22)
Alternative name(s):
Melibiase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aga
Synonyms:agaL
Ordered Locus Names:SMU_877
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri210007 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002512 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001348761 – 720Alpha-galactosidaseAdd BLAST720

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P27756

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
210007.SMU_877

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P27756

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 36 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DME Bacteria
COG3345 LUCA

KEGG Orthology (KO)

More...
KOi
K07407

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHDIDYI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27756

Family and domain databases

Conserved Domains Database

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CDDi
cd14791 GH36, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1180, 1 hit
2.70.98.60, 1 hit
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR038417 Alpga-gal_N_sf
IPR000111 Glyco_hydro_27/36_CS
IPR002252 Glyco_hydro_36
IPR031705 Glyco_hydro_36_C
IPR031704 Glyco_hydro_36_N
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16874 Glyco_hydro_36C, 1 hit
PF16875 Glyco_hydro_36N, 1 hit
PF02065 Melibiase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005536 Agal, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00743 GLHYDRLASE36

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445 SSF51445, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00512 ALPHA_GALACTOSIDASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P27756-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGIVIKDNLF YIHTKDSSLI IEERDGDLLL KHLGKKIEAY HFSNTVFEKD
60 70 80 90 100
HAFSANPVAD NRNYSYDTQR QIFGVHGFGD FRVPSLILQH DNNDLTRFKF
110 120 130 140 150
KKAKIIKGGI KARGLPNPHS SESAQSLALI LEDDLAKLRM TLYYTAYDDN
160 170 180 190 200
ATISTFVKFE NLSDKPVILH RALSTMFDLP ASHYDVITFQ GAYAREKTLR
210 220 230 240 250
RHQIEQGLFK IGSNRGASGH AQTPSLILTE HDSNEFYGEA LALQLIYSGN
260 270 280 290 300
FQAFVQKNQL NEVRLGIGIN DDNFSWDLQA NQSFETPVAL ITYTDKGLTD
310 320 330 340 350
LTQESHNFIK RHIIPKNFAN KERPILINNW EATYFDFNRS QLLGLADEAR
360 370 380 390 400
KLGIELFVLD DGWFGHRFDD NSSLGDWFVN EEKLGGSLDS FIKEIHDRGL
410 420 430 440 450
QFGLWFEPEM VSVDSKLYRA HPDWVIQADQ REHTYSRNQL VLNLANPDVV
460 470 480 490 500
AYIKTVLDKL LTENTIDYVK WDYNRNITNI GNGRTYLETQ MQSHAYILGL
510 520 530 540 550
YNIVSYLTTK HDKVLFESCS GGGGRNDLGM MCYFPQVWSS DNTDAIARLP
560 570 580 590 600
IQYGSSYLYP TISMGAHVSA VPNHQMNRHT PLTTRGHVAM MGNLGYELDL
610 620 630 640 650
AILTKNEKKA VANQIKHYKK IRSVVQFGKL YRLINPEVGI NEVAVQYTYD
660 670 680 690 700
NQVLVTYVRI QSTIEMMETT VKLRGLDADA IYVLIETGQI FSGAELMYAG
710 720
LTIDMPQGDY LSKQYYFIKK
Length:720
Mass (Da):82,141
Last modified:November 28, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED2ABF54ACFC5247
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138 – 143LRMTLY → SRIVSD in AAA26933 (PubMed:1649890).Curated6
Sequence conflicti198T → S in AAA26933 (PubMed:1649890).Curated1
Sequence conflicti262E → V in AAA26933 (PubMed:1649890).Curated1
Sequence conflicti277D → E in AAA26933 (PubMed:1649890).Curated1
Sequence conflicti447P → L in AAA26933 (PubMed:1649890).Curated1
Sequence conflicti502 – 504NIV → DMF in AAA26933 (PubMed:1649890).Curated3
Sequence conflicti586G → A in AAA26933 (PubMed:1649890).Curated1
Sequence conflicti602I → V in AAA26933 (PubMed:1649890).Curated1
Sequence conflicti690I → A in AAA26933 (PubMed:1649890).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M77351 Genomic DNA Translation: AAA26933.1
AE014133 Genomic DNA Translation: AAN58592.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A44819

NCBI Reference Sequences

More...
RefSeqi
NP_721286.1, NC_004350.2
WP_002262871.1, NC_004350.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAN58592; AAN58592; SMU_877

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1028243

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
smu:SMU_877

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|210007.7.peg.783

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77351 Genomic DNA Translation: AAA26933.1
AE014133 Genomic DNA Translation: AAN58592.1
PIRiA44819
RefSeqiNP_721286.1, NC_004350.2
WP_002262871.1, NC_004350.2

3D structure databases

SMRiP27756
ModBaseiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_877

Protein family/group databases

CAZyiGH36 Glycoside Hydrolase Family 36

Proteomic databases

PRIDEiP27756

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58592; AAN58592; SMU_877
GeneIDi1028243
KEGGismu:SMU_877
PATRICifig|210007.7.peg.783

Phylogenomic databases

eggNOGiENOG4105DME Bacteria
COG3345 LUCA
KOiK07407
OMAiYHDIDYI
PhylomeDBiP27756

Enzyme and pathway databases

BioCyciSMUT210007:G1FZX-842-MONOMER

Family and domain databases

CDDicd14791 GH36, 1 hit
Gene3Di2.60.40.1180, 1 hit
2.70.98.60, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR038417 Alpga-gal_N_sf
IPR000111 Glyco_hydro_27/36_CS
IPR002252 Glyco_hydro_36
IPR031705 Glyco_hydro_36_C
IPR031704 Glyco_hydro_36_N
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF16874 Glyco_hydro_36C, 1 hit
PF16875 Glyco_hydro_36N, 1 hit
PF02065 Melibiase, 1 hit
PIRSFiPIRSF005536 Agal, 1 hit
PRINTSiPR00743 GLHYDRLASE36
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00512 ALPHA_GALACTOSIDASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGAL_STRMU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27756
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 28, 2002
Last modified: July 31, 2019
This is version 117 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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