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Entry version 139 (02 Dec 2020)
Sequence version 2 (26 May 2009)
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Protein

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

Gene

acvA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Each of the constituent amino acids of the tripeptide acv are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 3 phosphopantetheines covalently.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: penicillin G biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase (acvA)
  2. Isopenicillin N synthase (ipnA)
  3. Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form (penDE)
This subpathway is part of the pathway penicillin G biosynthesis, which is itself part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes penicillin G from L-alpha-aminoadipate and L-cysteine and L-valine, the pathway penicillin G biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3623For thioesterase activityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processAntibiotic biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00149;UER00239

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
emeni-acvs, Thioesterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase (EC:6.3.2.26)
Alternative name(s):
Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase
Short name:
ACV synthetase
Short name:
ACVS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:acvA
ORF Names:AN2621
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VI
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930571 – 3770N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthaseAdd BLAST3770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi638N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi639N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi655N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi787N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei882O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Glycosylationi1256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1735N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1965O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Glycosylationi2410N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei3050O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Glycosylationi3130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3332N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.
Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P27742

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00010505

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27742

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini845 – 922Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini1928 – 2005Carrier 2PROSITE-ProRule annotationAdd BLAST78
Domaini3015 – 3090Carrier 3PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni321 – 910Domain 1 (adipate-activating)Add BLAST590
Regioni1413 – 1993Domain 2 (cysteine-activating)Add BLAST581
Regioni2494 – 3078Domain 3 (valine-activating)Add BLAST585

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1176, Eukaryota
KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27742

Identification of Orthologs from Complete Genome Data

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OMAi
NRQHWNQ

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 3 hits
3.30.559.10, 3 hits
3.40.50.12780, 3 hits
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR001031, Thioesterase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 3 hits
PF00550, PP-binding, 3 hits
PF00975, Thioesterase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 3 hits
SSF53474, SSF53474, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P27742-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPPGLLSED GPGYSGGYAD PTVPKVNWKQ SNGKSAGGNG DVDAGNGNID
60 70 80 90 100
PSKSGVGVQV CFAGGLEGWK AGISKITERC DLSSIATNST KYQLAVTGFS
110 120 130 140 150
DGPDDYNEYS VPFPSEVLVA MEEMCLARDI SMRSVIQFAV HYVLKGFGGG
160 170 180 190 200
SHTVAASIDV GDDPNNIATS YTITPSIVCH ESRQGQTVMQ EIQSMEKLNQ
210 220 230 240 250
LRKQEMHPGE AGLSLIRMGL FDILVIFADA NKCEGLIAGL PLAVMVCEGG
260 270 280 290 300
GRLQVRIHFS GSLFRQKTLV DIAEALNVLF AKAASGGATP VRDLELLSAE
310 320 330 340 350
QKQQLEEWNK TDGEYPECKR LNHLIEEATQ LHEDKVAIVY KRRQLTYGEL
360 370 380 390 400
NAQANCFAHY LRSIGILPEQ LVALFLEKSE NLIVTILGIW KSGAAYVPID
410 420 430 440 450
PTYPDERVRF VLEDTQAKVI IASNHLAERL QSEVISDREL SIIRLEHCLS
460 470 480 490 500
AIDQQPSTFP RANLRDPSLT SKQLAYVTYT SGTTGFPKGI LKQHTNVVNS
510 520 530 540 550
ITDLSARYGV TGDHHEAILL FSAYVFEPFV RQMLMALVNG HLLAMVDDAE
560 570 580 590 600
KYDAEKLIPF IREHKITYLN GTASVLQEYD FSSCPSLKRL ILVGENLTES
610 620 630 640 650
RYLALRRHFK NCILNEYGFT ESAFVTALNV FEPGSARNNT SLGRPVRNVK
660 670 680 690 700
CYILNKSLKR VPIGATGELH IGGLGISKGY LNRPDLTPQR FIPNPFQTDH
710 720 730 740 750
EKELGLNQLM YKTGDLARWL PNGEIEYLGR ADFQIKLRGI RIEPGEIEST
760 770 780 790 800
LAGYPGVRTS LVVSKRLRHG EKETTNEHLV GYYVGDNTSV SETALLQFLE
810 820 830 840 850
LKLPRYMIPT RLVRVSQIPV TVNGKADLRA LPSVDLIQPK VSSCELTDEV
860 870 880 890 900
EIALGKIWAD VLGAHHLSIS RKDNFFRLGG HSITCIQLIA RIRQQLGVII
910 920 930 940 950
SIEDVFSSRT LERMAELLRS KESNGTPDER ARPQLKTVAG EVANANVYLA
960 970 980 990 1000
NSLQQGFVYQ FLKNMGRSEA YVMQSVLRYD VNINPDLFKK AWKQVQHMLP
1010 1020 1030 1040 1050
TLRLRFQWGQ DVLQVIDEDQ PLNWWFLHLA DDSALPEEQK LLELQRRDLA
1060 1070 1080 1090 1100
EPYDLAAGSL FRIYLIEHSS TRFSCLFSCH HAILDGWSLP LLFRKTHGTY
1110 1120 1130 1140 1150
LHLLHGHSLR TLEDPYRQSQ QYLQDHREDH LRYWAGIVNQ IEERCDMNAL
1160 1170 1180 1190 1200
LNERSRYKIQ LADYDKVEDQ QQLTLTVPDA SWLSKLRQTC SAQGITLHSI
1210 1220 1230 1240 1250
LQFVWHAVLH AYGGGTHTVT GTTISGRNLP VSGIERSVGL YINTLPLVIN
1260 1270 1280 1290 1300
QLAYKNKTVL EAIRDVQAIV NGMNSRGNVE LGRLQKNELK HGLFDSLFVL
1310 1320 1330 1340 1350
ENYPILDKSE EMRQKSELKY TIEGNIEKLD YPLAVIAREV DLTGGFTFTI
1360 1370 1380 1390 1400
CYARELFDEI VISELLQMVR DTLLQVAKHL DDPVRSLEYL SSAQMAQLDA
1410 1420 1430 1440 1450
WNATDAEFPD TTLHAMFEKE AAQKPDKVAV VYEQRSLTYR QLNERANRMA
1460 1470 1480 1490 1500
HQLKSDISPK PNSIIALVVD KSEHMIATIL AVWKTGGAYV PIDPEYPDDR
1510 1520 1530 1540 1550
IRYILEDTSA IAVISDACYL SRIQELAGES VRLYRSDIST QTDGNWSVSN
1560 1570 1580 1590 1600
PAPSSTSTDL AYIIYTSGTT GKPKGVMVEH HGVVNLQISL SKTFGLRDTD
1610 1620 1630 1640 1650
DEVILSFSNY VFDHFVEQMT DAILNGQTLV MLNDAMRSDK ERLYQYIETN
1660 1670 1680 1690 1700
RVTYLSGTPS VISMYEFSRF KDHLRRVDCV GEAFSQPVFD QIRDTFQGLI
1710 1720 1730 1740 1750
INGYGPTEIS ITTHKRLYPF PERRTDKSIG QQIGNSTSYV LNADMKRVPI
1760 1770 1780 1790 1800
GAVGELYLGG EGVARGYHNR PEVTAERFLR NPFQTDSERQ NGRNSRLYRT
1810 1820 1830 1840 1850
GDLVRWIPGS NGEIEYLGRN DFQVKIRGLR IELGEIEAVM SSHPDIKQSV
1860 1870 1880 1890 1900
VIAKSGKEGD QKFLVGYFVA SSPLSPGAIR RFMQSRLPGY MIPSSFIPIS
1910 1920 1930 1940 1950
SLPVTPSGKL DTKALPTAEE KGAMNVLAPR NEIESILCGI WAGLLDISAQ
1960 1970 1980 1990 2000
TIGSDSDFFT LGGDSLKSTK LSFKIHEVFG RTISVSALFR HRTIESLAHL
2010 2020 2030 2040 2050
IMNNVGDIQE ITPVDYDNRR KIAVSPAQER LLFIHELEGG GNAYNIDAAF
2060 2070 2080 2090 2100
ELPPYIDQSR VEEALYTILS RHEALRTFLL RDQATGTFYQ KILTTDEAKC
2110 2120 2130 2140 2150
MLIIEKSAVS TIDQIDSIVG RLSQHIFRLD SELPWLAHIV THKTGNLYLT
2160 2170 2180 2190 2200
LSFHHTCFDA WSLKIFEREL RVFCASNEKG GNMPILPMPQ VQYKEYAEHH
2210 2220 2230 2240 2250
RRRLGKNQIQ KLSDFWLQRL DGLEPLQLLP DYPRPAQFNY DGGDLSVILD
2260 2270 2280 2290 2300
GVVLETLRGI AKDHGVTLYA VLLAVYCLML STYTHQVDIA VGVPISHRTH
2310 2320 2330 2340 2350
PLFQSIVGFF VNMVVVRVDV KDFAVHDLIR RVMKALVDAQ LHQDMPFQDV
2360 2370 2380 2390 2400
TKLLRVDNDA SRHPLVQTVF NFESDMDKEF ETTPSIQDTA TIAPYQSVQR
2410 2420 2430 2440 2450
IKSVAKFDLN ATATESGSAL KINFNYATSL FRKETIQGFL ETYRHLLLQL
2460 2470 2480 2490 2500
SYLGSQGLKE DTKLLLVRPE EMSGPHLPLA GLSNGAETLE AISLSRAFEF
2510 2520 2530 2540 2550
EAFRVPDRAA VVQGDKSLSY TELNKRANQL ARYIQSVAHL RPDDKVLLIL
2560 2570 2580 2590 2600
DKSIDMIICI LAIWKTGSAY VPLDPSYPKE RVQCISEVVQ AKILITESRY
2610 2620 2630 2640 2650
ASAWGSQTST ILAIDSPKVS NMVNNQATHN LPNIAGIKNL AYIIFTSGTS
2660 2670 2680 2690 2700
GKPKGVLVEQ GGVLHLRDAL RKRYFGIECN EYHAVLFLSN YVFDFSIEQL
2710 2720 2730 2740 2750
VLSIMSGHKL IIPEGEFVAD DEFYITANGQ RLSYLSGTPS LLQQIDLARL
2760 2770 2780 2790 2800
NHLQVVTAAG EQLHAAQFNK LRSGFRGPIY NAYGITETTV YNIVSEFSAQ
2810 2820 2830 2840 2850
SQFENALREL LPGTRAYLLN HATQPVPMNA VGELYLAGDC VARGYLNQPV
2860 2870 2880 2890 2900
LTGDRFIQNP FQTEQDIASG SYPRLYRTGD LFRCRLDRQH QPYLEYLGRA
2910 2920 2930 2940 2950
DLQVKIRGYR IEPSEVQNVL ASCPGVRECA VVAKYENTDA YSRIAKFLVG
2960 2970 2980 2990 3000
YYTPDTETVS DSSILAHMKS KLPAYMVPKY LCRLEGGLPV TINGKLDVRK
3010 3020 3030 3040 3050
LPDIGNPQHQ ISYNPPRDVL EADLCRLWAS ALGTERCGID DDLFRLGGDS
3060 3070 3080 3090 3100
ITALHLAAQI HHQIGRKVTV RDIFDHPTIR GIHDNVMVKL VPHNVPQFQA
3110 3120 3130 3140 3150
EQQTVLGDAP LLPIQTWFLS KSLQHPSHWN HTFYLRTPEL DVTTLSTAVA
3160 3170 3180 3190 3200
ELQLYHDAFR MRLRQIDGRT VQCFADDISP VQLRVLNVKD VDGSAAIDQQ
3210 3220 3230 3240 3250
LQKYQSDFDL EKGPICAAAY LHGYEDRSAR VWFSVHHIII DIVSWQILAR
3260 3270 3280 3290 3300
DLQILYEGGT LGRKSSSVRQ WAEALQSYQG SASERAYWEG LLAQTAANIS
3310 3320 3330 3340 3350
ALPPVTGTRT RLARTWSDDR TVILLNEASN QNASIQDLLL AAVGLALQQV
3360 3370 3380 3390 3400
TPGSPSMITL EGHGREEIVD PTLDLSRTLG WFTSMYPFEI PPLNVETLSQ
3410 3420 3430 3440 3450
GIASLRECLR QVPARGIGFG SLYGYCKHQM PQVTFNYLGQ LTSKQSITDQ
3460 3470 3480 3490 3500
WALAVGDGEM QYGLTTSPAD RDQSSFAVDI TASCVNGALS VEMNSAWSLE
3510 3520 3530 3540 3550
KSMRFISRIE EVLNMILSGT LAQQATPVLT PQVFNEEMYT PYFEFSKTPR
3560 3570 3580 3590 3600
RGPILFLLPP GEGGAESYFN NIVKHLPTTN MVVFNNYYLH SKSLNTFEKL
3610 3620 3630 3640 3650
AEMYLGHIRQ IQPDGPYHFI GWSFGGTIAM EISRQLVGLG STIGLLGIID
3660 3670 3680 3690 3700
TYFNVPGATR AIGLGDTEVL DPIHHISQPE PADFQCLPAS TDYIILFKAT
3710 3720 3730 3740 3750
RVNDKFQSEN QRRLYEYYDK TLLNDLDWLL PGASNIHLVR LEEDTHFSWA
3760 3770
TNPRQIAHVC STIEKFLARY
Length:3,770
Mass (Da):422,502
Last modified:May 26, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB31873DD4106D7B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1941W → S in AAA03914 (PubMed:2061333).Curated1
Sequence conflicti1941W → S in CAA38631 (PubMed:2061333).Curated1
Sequence conflicti1941W → S AA sequence (PubMed:2061333).Curated1
Sequence conflicti2177 – 2178NE → KQ in AAA03914 (PubMed:2061333).Curated2
Sequence conflicti2177 – 2178NE → KQ in CAA38631 (PubMed:2061333).Curated2
Sequence conflicti2335A → P in AAA03914 (PubMed:2061333).Curated1
Sequence conflicti2335A → P in CAA38631 (PubMed:2061333).Curated1
Sequence conflicti2869S → C in AAA03914 (PubMed:2061333).Curated1
Sequence conflicti2869S → C in CAA38631 (PubMed:2061333).Curated1
Sequence conflicti3116T → I in AAA03914 (PubMed:2061333).Curated1
Sequence conflicti3116T → I in CAA38631 (PubMed:2061333).Curated1
Sequence conflicti3116T → I AA sequence (PubMed:2061333).Curated1
Sequence conflicti3139E → D in CAA38631 (PubMed:2061333).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S40212 Genomic DNA Translation: AAA03914.1
X54853 Genomic DNA Translation: CAA38631.1
AACD01000045 Genomic DNA Translation: EAA62968.1
BN001306 Genomic DNA Translation: CBF84349.1

Protein sequence database of the Protein Information Resource

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PIRi
A40889

NCBI Reference Sequences

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RefSeqi
XP_660225.1, XM_655133.1

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
CBF84349; CBF84349; ANIA_02621
EAA62968; EAA62968; AN2621.2

Database of genes from NCBI RefSeq genomes

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GeneIDi
2874260

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ani:AN2621.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S40212 Genomic DNA Translation: AAA03914.1
X54853 Genomic DNA Translation: CAA38631.1
AACD01000045 Genomic DNA Translation: EAA62968.1
BN001306 Genomic DNA Translation: CBF84349.1
PIRiA40889
RefSeqiXP_660225.1, XM_655133.1

3D structure databases

SMRiP27742
ModBaseiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00010505

Protein family/group databases

ESTHERiemeni-acvs, Thioesterase

Proteomic databases

PRIDEiP27742

Genome annotation databases

EnsemblFungiiCBF84349; CBF84349; ANIA_02621
EAA62968; EAA62968; AN2621.2
GeneIDi2874260
KEGGiani:AN2621.2

Phylogenomic databases

eggNOGiKOG1176, Eukaryota
KOG1178, Eukaryota
HOGENOMiCLU_000022_0_0_1
InParanoidiP27742
OMAiNRQHWNQ
OrthoDBi4243at2759

Enzyme and pathway databases

UniPathwayiUPA00149;UER00239

Family and domain databases

Gene3Di1.10.1200.10, 3 hits
3.30.559.10, 3 hits
3.40.50.12780, 3 hits
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR001031, Thioesterase
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 3 hits
PF00550, PP-binding, 3 hits
PF00975, Thioesterase, 1 hit
SMARTiView protein in SMART
SM00823, PKS_PP, 3 hits
SUPFAMiSSF47336, SSF47336, 3 hits
SSF53474, SSF53474, 1 hit
TIGRFAMsiTIGR01733, AA-adenyl-dom, 3 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACVS_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27742
Secondary accession number(s): C8VHS8, Q4J6A8, Q5BA09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: May 26, 2009
Last modified: December 2, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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