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Entry version 99 (18 Sep 2019)
Sequence version 1 (01 Aug 1992)
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Protein

RNA-directed RNA polymerase

Gene
N/A
Organism
Apple chlorotic leaf spot virus (isolate plum P863) (ACLSV)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in viral RNA replication.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1059 – 1066ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Alternative name(s):
216.5 kDa protein
ORF1 protein
RNA replicase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiApple chlorotic leaf spot virus (isolate plum P863) (ACLSV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri73473 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaTymoviralesBetaflexiviridaeTrivirinaeTrichovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCrataegus (hawthorn) [TaxID: 23159]
Cydonia oblonga (Quince) (Pyrus cydonia) [TaxID: 36610]
Malus sylvestris [TaxID: 3752]
Prunus armeniaca (Apricot) (Armeniaca vulgaris) [TaxID: 36596]
Prunus domestica (Garden plum) [TaxID: 3758]
Prunus persica (Peach) (Amygdalus persica) [TaxID: 3760]
Prunus spinosa (Blackthorn) (Prunus domestica var. spinosa) [TaxID: 114937]
Pyrus communis (Pear) (Pyrus domestica) [TaxID: 23211]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007025 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002225421 – 1884RNA-directed RNA polymeraseAdd BLAST1884

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P27738

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 232Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST170
Domaini747 – 835Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST89
Domaini1032 – 1191(+)RNA virus helicase ATP-bindingAdd BLAST160
Domaini1192 – 1336(+)RNA virus helicase C-terminalAdd BLAST145
Domaini1633 – 1740RdRp catalyticPROSITE-ProRule annotationAdd BLAST108

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.590, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR037151 AlkB-like_sf
IPR002588 Alphavirus-like_MT_dom
IPR005123 Oxoglu/Fe-dep_dioxygenase
IPR027417 P-loop_NTPase
IPR008744 RNA-dir_pol_ACLSV
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05413 Peptidase_C34, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS51471 FE2OG_OXY, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P27738-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFSYRTPQE ELLSRLPQSQ QEVISGFQYE RIQKEEEKKV ENFSFYLPEK
60 70 80 90 100
TREWFTKSGV YLSPFAYVNH SHPGCKTLEN HLLFNVVASY ISKYSYVACL
110 120 130 140 150
SIKSNKMSKM ERLGPNSVKT YDILNRLVTA KDKARYGPLA KPERSPCPKK
160 170 180 190 200
TNIFIHDEIH YWSRDQLETF LQVHRPKNLW ATLVFPPEIL AGYKSSVLPF
210 220 230 240 250
LYQFEIHGKD LVYMPDGVRS ESYTQPLENG FLLSSSSIII KNRVTGVEIR
260 270 280 290 300
YQVSLVYSLG SHHLFHIYPA EDLMKEEVRR FGPYDLFDVG SLFVKPVRVP
310 320 330 340 350
IQDFPLSVFK KIFIYMSSLK KPDVQSAVAK LRQLSDADIS IESVFMIQEF
360 370 380 390 400
ASRIEKNGVE SWSCSFWGCM KDWFFDKLPY REVLEKIGLA DDFTRRLMKI
410 420 430 440 450
KPLAFDIHTT DRPLTVRMII DQIWEERLSS FDNISNIVFY GRREWLNNGV
460 470 480 490 500
LPKVKKKGLA KLIPGREVDS HNYPREIYSD LLSSTSIWRS YDDDFRHRSA
510 520 530 540 550
SPLVILRSNR AYSEAAKFSS NCLSLCAAPC DEVIARTPFE LNHRREKKEL
560 570 580 590 600
SLKCLDFHIK KMKVKNVLEL EVKLRERNTR ISLSKKGVKK AGRSRMIPVH
610 620 630 640 650
LLKPTCGEGN GKPEERNKEE AKIPMNEGTS KEEKGSEPPH SEVKREGVRL
660 670 680 690 700
DEQHISEPLL SFKLDDFVGR EKLCSAGLIK TVGNDYLLLA RQIECMPLSQ
710 720 730 740 750
LRGKKAAYFC LDFPMVYFHD KVSYPTFEAT GEIRHVMMKA RSKWGIDFNS
760 770 780 790 800
ALIQVYNDGC RLPLHSDNEE CYDDDGILTI NVVGDAKFHT TCHDEVIDLK
810 820 830 840 850
QGNEILMPAG YQKKNRHAVE VASEGRTSVT LRVHKRDFSF ESKLRFIKGK
860 870 880 890 900
FDCLFVSVAE IIHKKPEEIM MFIPHIMDRC VSNRGCSLDD AKAICEKYEI
910 920 930 940 950
KIECEGDCGL VECGTSGLSI GRMLLRGNHF SVASVRRSSM DSLANSSKEI
960 970 980 990 1000
KSDGVLDHVT FNFHKRLKLV EPDLTNADIK VDSSRAGKLL KSLMDGMTGI
1010 1020 1030 1040 1050
VSHNSTHEGW RMIKGINSTS EMRSFMNMVR GQIEEPKSDL FDKVQELNFM
1060 1070 1080 1090 1100
KVKIYGIFGF AGSGKSHAIQ NLIQTEFKGS QGIMVICPRR FLAKDWSEKG
1110 1120 1130 1140 1150
VDEKDIKTFE SALKSDVKGK RLFILDEISL LPKGFTDLLM LKMHMEGILK
1160 1170 1180 1190 1200
KSTIVCIGDP LQAGYFCPKD DNYLSREGEI KRLFKGGVNY KWYSYRINKF
1210 1220 1230 1240 1250
IAKKLAIETM NDFIGIDEQS SIYKDMPSAH HFMEKKGNHI EVILVASMVE
1260 1270 1280 1290 1300
KELYSNYGNV MTFGESQGLT FNCGVIVLSE EAKLCSDAHI MVAITRFRRG
1310 1320 1330 1340 1350
FCFALGSKGS KEDYMRSMKS GLLQRICSGV GASKEFILGS SSVNLILSEK
1360 1370 1380 1390 1400
DIAKGAGIDE MDREARLEGD VWLKSMIYLG KRYHMVEPLG QVIKLTDDAI
1410 1420 1430 1440 1450
KCHIPVCSSQ TLGPELDNIQ AREYREFKGK NGWSNQFREE AGPNWKFPYK
1460 1470 1480 1490 1500
VNQAMSYEAV YPRHKMDDDL TFLAAIKKRL RFDNVANNYA KFKAAESRGK
1510 1520 1530 1540 1550
YLTKIFLKHV PIKCGRDQRL LDQCRQEFEE TKLSKSAATI GAHSQRSDSD
1560 1570 1580 1590 1600
WPLDKIFLFM KSQLCTKFEK RFTEAKAGQT LACFPHKILV EFSPWCRYTE
1610 1620 1630 1640 1650
KVLTANLPDN YYIHQRKNFS ELEDFARRFS NGSICVESDY TAFDVSQDHT
1660 1670 1680 1690 1700
ILAFEVELLR HFGWDDRVLQ SYIKMKCTLG CRLGGFAIMR FTGEFSTFLF
1710 1720 1730 1740 1750
NTLANMVFTF CRYEVPDGTP ICFAGDDMCA LRNLREIDTH EFILSKLSLK
1760 1770 1780 1790 1800
AKVNRTKVPM FCGWRLCCDG LIKEPCLIYE RLQVAIENGR LMDVIDSYFL
1810 1820 1830 1840 1850
EFSFAYKLGE RLYSHLEIEQ LNYHQVLTRF FIRNKHLLRG DSRHNISELE
1860 1870 1880
WLSDEDGDND KGSQIEDRRR GYSNCWGEKL QNLF
Length:1,884
Mass (Da):216,562
Last modified:August 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i966A9F5DBA300258
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti347I → V. 1
Natural varianti591A → P. 1
Natural varianti594S → L. 1
Natural varianti666D → R. 1
Natural varianti1598Y → H. 1
Natural varianti1623E → K. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M58152 Genomic RNA Translation: AAA42587.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A45353

NCBI Reference Sequences

More...
RefSeqi
NP_040551.1, NC_001409.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1493999

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1493999

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58152 Genomic RNA Translation: AAA42587.1
PIRiA45353
RefSeqiNP_040551.1, NC_001409.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiP27738

Genome annotation databases

GeneIDi1493999
KEGGivg:1493999

Family and domain databases

Gene3Di2.60.120.590, 1 hit
InterProiView protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR037151 AlkB-like_sf
IPR002588 Alphavirus-like_MT_dom
IPR005123 Oxoglu/Fe-dep_dioxygenase
IPR027417 P-loop_NTPase
IPR008744 RNA-dir_pol_ACLSV
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol
PfamiView protein in Pfam
PF05413 Peptidase_C34, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS51471 FE2OG_OXY, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDRP_ACLSP
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27738
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 18, 2019
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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