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Entry version 174 (12 Aug 2020)
Sequence version 4 (29 Mar 2004)
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Protein

Phorbol ester/diacylglycerol-binding protein unc-13

Gene

unc-13

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions (PubMed:2062851). One such function could be the release of neurotransmitter from neurons (PubMed:2062851). Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt, (PubMed:17891142).2 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1173Calcium 1PROSITE-ProRule annotation1
Metal bindingi1173Calcium 2PROSITE-ProRule annotation1
Metal bindingi1179Calcium 1PROSITE-ProRule annotation1
Metal bindingi1225Calcium 1PROSITE-ProRule annotation1
Metal bindingi1225Calcium 2PROSITE-ProRule annotation1
Metal bindingi1227Calcium 1PROSITE-ProRule annotation1
Metal bindingi1227Calcium 2PROSITE-ProRule annotation1
Metal bindingi1244Calcium 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri693 – 742Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri1034 – 1084Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-181429, Serotonin Neurotransmitter Release Cycle
R-CEL-181430, Norepinephrine Neurotransmitter Release Cycle
R-CEL-210500, Glutamate Neurotransmitter Release Cycle
R-CEL-212676, Dopamine Neurotransmitter Release Cycle
R-CEL-264642, Acetylcholine Neurotransmitter Release Cycle

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.1.1.3, the synaptosomal vesicle fusion pore (svf-pore) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phorbol ester/diacylglycerol-binding protein unc-13
Alternative name(s):
Uncoordinated protein 13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-13
ORF Names:ZK524.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
ZK524.2a ; CE15371 ; WBGene00006752 ; unc-13
ZK524.2c ; CE34624 ; WBGene00006752 ; unc-13
ZK524.2d ; CE34625 ; WBGene00006752 ; unc-13
ZK524.2e ; CE34626 ; WBGene00006752 ; unc-13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit diverse nervous system defects.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001885831 – 2155Phorbol ester/diacylglycerol-binding protein unc-13Add BLAST2155

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P27715

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27715

PeptideAtlas

More...
PeptideAtlasi
P27715

PRoteomics IDEntifications database

More...
PRIDEi
P27715

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006752, Expressed in multi-cellular organism and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P27715, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cmd-1 in the presence of Ca2+.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.ZK524.2d

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27715

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 114C2 1PROSITE-ProRule annotationAdd BLAST114
Domaini1140 – 1268C2 2PROSITE-ProRule annotationAdd BLAST129
Domaini1552 – 1695MHD1PROSITE-ProRule annotationAdd BLAST144
Domaini1798 – 1954MHD2PROSITE-ProRule annotationAdd BLAST157
Domaini1969 – 2097C2 3PROSITE-ProRule annotationAdd BLAST129

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The phorbol ester binding activity is zinc and calcium-dependent.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the unc-13 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri693 – 742Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST50
Zinc fingeri1034 – 1084Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1011, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168389

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27715

Identification of Orthologs from Complete Genome Data

More...
OMAi
QELWHNA

Database of Orthologous Groups

More...
OrthoDBi
117172at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27715

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029, C1, 1 hit
cd04027, C2B_Munc13, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010439, CAPS_dom
IPR020454, DAG/PE-bd
IPR014770, Munc13_1
IPR014772, Munc13_dom-2
IPR019558, Munc13_subgr_dom-2
IPR002219, PE/DAG-bd
IPR027080, Unc-13
IPR037302, Unc-13_C2B

The PANTHER Classification System

More...
PANTHERi
PTHR10480, PTHR10480, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130, C1_1, 1 hit
PF00168, C2, 3 hits
PF06292, DUF1041, 1 hit
PF10540, Membr_traf_MHD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00360, C2DOMAIN
PR00008, DAGPEDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00239, C2, 3 hits
SM01145, DUF1041, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 3 hits
PS51258, MHD1, 1 hit
PS51259, MHD2, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 6 (identifier: P27715-6) [UniParc]FASTAAdd to basket
Also known as: d

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDVGDYNDD QLSDGMSMRL LCITIKKARL QGAVDEFNSY VTVKLQTVKS
60 70 80 90 100
TTVAVRGNLP CWEQEFIFET NRPDDGMVLE LWAKGVLWDK LIGVHYMPLS
110 120 130 140 150
EIRYSNAAGS GQWLQMDHEL ETRNGQTVGT RGPTGHNLLT DVRFELPFDV
160 170 180 190 200
QGHDEDIQSR LLALNGLIEH DQLGPNNHHR APFNHSGLSE DSDYTSDVSV
210 220 230 240 250
PVNHHQLHPN SSAHQYESHL HPHRTRQLLH TREGAASYED EEDAYHARHQ
260 270 280 290 300
PESDDYNHQD TYDQHSSYYN DEYAPSGSSS QYQRQGYQDQ DQQHQNIYED
310 320 330 340 350
TVTPVREFGE SAVPPAASSS RRQFDQVYGY ASSSEERYDT PMSSGRLPRD
360 370 380 390 400
EPILEHSEPE YVYDQNGYPE EDNYGINPTY SEDHFEGQTN DYSTTHQEPN
410 420 430 440 450
DFRNDYNSSY QREYWNESEP LSYNSRPPNG HIRTGANTWR EPSTSSRPTS
460 470 480 490 500
SQAWNYQDDT HQYDEVDRGS RVSFTRTPSV DRTDRPSESG GGFYDEMSES
510 520 530 540 550
GRPGRPDSHH NWRYDSIQEE DNEKDNWKQH VEGYEEGQEE KQKDNQKPND
560 570 580 590 600
HSAASPQDHY HRSDSTAQQD FGNNIVRQTI QEEEEKRNYQ ELWHNAYKRV
610 620 630 640 650
CADLGIKSSQ ASLVATTGGT LLQNLFLYRP KLAPAGHGAT ASQFQSPAGA
660 670 680 690 700
TRFYANHNNN NNNVSKNELD STTETPPDPS RTPSTSSMNP VPSLAVPMSP
710 720 730 740 750
GPYLNSDPPS PVSPNPQIKR SIYRIKESYE DRNGGRERIY TTNLVSVYLE
760 770 780 790 800
KMKPPDELEE GSSGSMRETQ NEIKNGTQLH NAESNIFFPQ DSVPKSISYN
810 820 830 840 850
AGNLKNTSIT TSKTSSAITN HSSLPPQPPS KPASRDSDPM KQLLTFSKSF
860 870 880 890 900
KKVRRVRSAM PRRRKRKRVK IKKSRSCPIL WKTEKTPHPM KSKSMTCIRI
910 920 930 940 950
PKKTVIAPLR KEIKIVRMKP PAARCESDSK AHKKKNLLDV YKDMGKSTVL
960 970 980 990 1000
DGNGSSAANA FYKSIDAAPN MNVARTKTSI PLVSELVLKT MATKRAQAGL
1010 1020 1030 1040 1050
ANAARTTFSD TELKTHVYKK TLQALIYPIS ATTPHNFATT TFQTPTFCYE
1060 1070 1080 1090 1100
CEGLLWGLAR QGLRCTQCQV KVHDKCRELL SADCLQRAAE KSTKHGEADR
1110 1120 1130 1140 1150
TQSLVNVIRD RMKIQEQNKP EVFQMIRTVF DVDENIQKET LKTVKASILE
1160 1170 1180 1190 1200
GSSKWSAKIT LTVLCAQGLI AKDKTGKSDP YVTAQVGKTK RRTRTIHQEL
1210 1220 1230 1240 1250
NPVWNEKFHF ECHNSTDRIK VRVWDEDNDL KSKLRQKLTR ESDDFLGQTV
1260 1270 1280 1290 1300
IEVRTLSGEM DVWYNLEKRT DKSAVSGAIR LHINVEIKGE EKLAPYHVQY
1310 1320 1330 1340 1350
TCLHEHLFAA HCVDEEVKLP KVRGEDSWKV CFQETGQEIA EEFAMRYGIE
1360 1370 1380 1390 1400
SIYQAMTHFA CLCTRYMCAG VPAVLSTLLA NINAYYAHTT ATSAVSAPDR
1410 1420 1430 1440 1450
FAASNFGKER FVKLLDQLHN SLRIDLSAYR NHFPSSSPAK LQDLKSTVDL
1460 1470 1480 1490 1500
LTSITFFRMK VLELASPPRA STVVRECAKA CMQQTYQLMF ESCAEQFPIL
1510 1520 1530 1540 1550
DTSVQFWYEF IDYIMRVIEE DQKNYTPALN QFPQELNVGN LSAETLWSMY
1560 1570 1580 1590 1600
KNDLKMALEE HAQKKRCKTP EYMNLYFKVK GFYFKYVADL STYKSSIPEF
1610 1620 1630 1640 1650
PAWFIPFVMD WLNENDEHSM DILRNAYNVD KADNFPQTSE HTKFSNSVVD
1660 1670 1680 1690 1700
VFTQLNAALK LLKQMDCPNP EVAADMMKRF SKTLNKVLLA YADMVQKDFP
1710 1720 1730 1740 1750
KFAHDEKLAC ILMNNVQQLR VQLEKIYETM GGAELDEHIG QVLTVLQKKL
1760 1770 1780 1790 1800
NSVLDRLSAE FVTTLEPHIH EQTIKLGMLL VKIKGPQLQK TQVQPEADAV
1810 1820 1830 1840 1850
LEPLMDLLEG SLRRYADQCE KTVLKYILKE LWKITIVNME KRVVLPPLSD
1860 1870 1880 1890 1900
KALLKQLPNA KIGDVTKLMS TNIQSIKGMN SVKDMMDMAR ESEKSLTPRQ
1910 1920 1930 1940 1950
CTVLDCALDA IKDSFHASGK GLKKSFFEKS PELQSLKYAL SLYTQTTEQL
1960 1970 1980 1990 2000
IKTFITSQRQ QDLPSQEQPV GEVSVQVDLF SHPGTGEQKV TVKILAANDL
2010 2020 2030 2040 2050
RWQTSSAFKP FVEVHLVGPH LSDKKRKWST KTKAGNWAPK FNETFHFFLG
2060 2070 2080 2090 2100
NEGEPEHYEL MFQVKDYCFA RDDRVVGVGV LQLSSVVDQA GSCAMWVQLG
2110 2120 2130 2140 2150
TRLHIDETGL ILLRILSQRQ TDEVAKDFVR LKTECRYETE TVMAASASSQ

NINRT
Length:2,155
Mass (Da):245,231
Last modified:March 29, 2004 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB660C5926F1D26A2
GO
Isoform 1 (identifier: P27715-1) [UniParc]FASTAAdd to basket
Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     609-947: Missing.
     987-989: Missing.

Show »
Length:1,813
Mass (Da):207,251
Checksum:i649D1B39F18ACFD2
GO
Isoform 2 (identifier: P27715-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     609-947: Missing.
     1629-1647: VDKADNFPQTSEHTKFSNS → CRQADTSHKHQNTQILEH

Show »
Length:1,815
Mass (Da):207,586
Checksum:i7985FE38FE754336
GO
Isoform 3 (identifier: P27715-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.

Show »
Length:2,140
Mass (Da):243,591
Checksum:iEB86DDE71B5D98AF
GO
Isoform 5 (identifier: P27715-5) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     1-341: Missing.
     609-947: Missing.

Show »
Length:1,475
Mass (Da):168,697
Checksum:i654E35E22754B310
GO
Isoform 7 (identifier: P27715-7) [UniParc]FASTAAdd to basket
Also known as: e

The sequence of this isoform differs from the canonical sequence as follows:
     609-947: Missing.

Show »
Length:1,816
Mass (Da):207,591
Checksum:i65DEC63A1157E67D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5EDN9G5EDN9_CAEEL
Phorbol ester/diacylglycerol-bindin...
unc-13 CELE_ZK524.2, ZK524.2
1,819Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C3NSH2A0A1C3NSH2_CAEEL
Phorbol ester/diacylglycerol-bindin...
unc-13 CELE_ZK524.2, ZK524.2
1,801Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C3NSI0A0A1C3NSI0_CAEEL
Phorbol ester/diacylglycerol-bindin...
unc-13 CELE_ZK524.2, ZK524.2
1,472Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C3NSJ3A0A1C3NSJ3_CAEEL
Phorbol ester/diacylglycerol-bindin...
unc-13 CELE_ZK524.2, ZK524.2
1,465Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C3NSL4A0A1C3NSL4_CAEEL
Phorbol ester/diacylglycerol-bindin...
unc-13 CELE_ZK524.2, ZK524.2
1,798Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C3NSN5A0A1C3NSN5_CAEEL
Phorbol ester/diacylglycerol-bindin...
unc-13 CELE_ZK524.2, ZK524.2
1,816Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti157I → V in AAA93094 (PubMed:2062851).Curated1
Sequence conflicti1873I → N in AAA93094 (PubMed:2062851).Curated1
Sequence conflicti1990V → A in AAA93094 (PubMed:2062851).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0097241 – 341Missing in isoform 5. CuratedAdd BLAST341
Alternative sequenceiVSP_0044851 – 15Missing in isoform 3. CuratedAdd BLAST15
Alternative sequenceiVSP_009726609 – 947Missing in isoform 1, isoform 2, isoform 5 and isoform 7. 1 PublicationAdd BLAST339
Alternative sequenceiVSP_009727987 – 989Missing in isoform 1. Curated3
Alternative sequenceiVSP_0097281629 – 1647VDKAD…KFSNS → CRQADTSHKHQNTQILEH in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M62830 mRNA Translation: AAA93094.1
U50735 Genomic DNA Translation: AAA99780.1
U50735 Genomic DNA Translation: AAA99781.1
Z73912, Z79694, Z92779 Genomic DNA Translation: CAA98147.1
Z73912, Z92779 Genomic DNA Translation: CAD56619.2
Z73912, Z79694, Z92779 Genomic DNA Translation: CAD90190.2
Z73912, Z79694, Z92779 Genomic DNA Translation: CAE11317.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A41101
T19295
T27886

NCBI Reference Sequences

More...
RefSeqi
NP_001021871.1, NM_001026700.1 [P27715-1]
NP_001021872.1, NM_001026701.1
NP_001021873.1, NM_001026702.1 [P27715-6]
NP_001021874.1, NM_001026703.2 [P27715-7]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK524.2a.1; ZK524.2a.1; WBGene00006752 [P27715-1]
ZK524.2c.1; ZK524.2c.1; WBGene00006752 [P27715-5]
ZK524.2d.1; ZK524.2d.1; WBGene00006752 [P27715-6]
ZK524.2e.1; ZK524.2e.1; WBGene00006752 [P27715-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
172497

UCSC genome browser

More...
UCSCi
ZK524.2e, c. elegans [P27715-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62830 mRNA Translation: AAA93094.1
U50735 Genomic DNA Translation: AAA99780.1
U50735 Genomic DNA Translation: AAA99781.1
Z73912, Z79694, Z92779 Genomic DNA Translation: CAA98147.1
Z73912, Z92779 Genomic DNA Translation: CAD56619.2
Z73912, Z79694, Z92779 Genomic DNA Translation: CAD90190.2
Z73912, Z79694, Z92779 Genomic DNA Translation: CAE11317.1
PIRiA41101
T19295
T27886
RefSeqiNP_001021871.1, NM_001026700.1 [P27715-1]
NP_001021872.1, NM_001026701.1
NP_001021873.1, NM_001026702.1 [P27715-6]
NP_001021874.1, NM_001026703.2 [P27715-7]

3D structure databases

SMRiP27715
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.ZK524.2d

Protein family/group databases

TCDBi1.F.1.1.3, the synaptosomal vesicle fusion pore (svf-pore) family

Proteomic databases

EPDiP27715
PaxDbiP27715
PeptideAtlasiP27715
PRIDEiP27715

Genome annotation databases

EnsemblMetazoaiZK524.2a.1; ZK524.2a.1; WBGene00006752 [P27715-1]
ZK524.2c.1; ZK524.2c.1; WBGene00006752 [P27715-5]
ZK524.2d.1; ZK524.2d.1; WBGene00006752 [P27715-6]
ZK524.2e.1; ZK524.2e.1; WBGene00006752 [P27715-7]
GeneIDi172497
UCSCiZK524.2e, c. elegans [P27715-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43841
WormBaseiZK524.2a ; CE15371 ; WBGene00006752 ; unc-13
ZK524.2c ; CE34624 ; WBGene00006752 ; unc-13
ZK524.2d ; CE34625 ; WBGene00006752 ; unc-13
ZK524.2e ; CE34626 ; WBGene00006752 ; unc-13

Phylogenomic databases

eggNOGiKOG1011, Eukaryota
GeneTreeiENSGT00940000168389
InParanoidiP27715
OMAiQELWHNA
OrthoDBi117172at2759
PhylomeDBiP27715

Enzyme and pathway databases

ReactomeiR-CEL-181429, Serotonin Neurotransmitter Release Cycle
R-CEL-181430, Norepinephrine Neurotransmitter Release Cycle
R-CEL-210500, Glutamate Neurotransmitter Release Cycle
R-CEL-212676, Dopamine Neurotransmitter Release Cycle
R-CEL-264642, Acetylcholine Neurotransmitter Release Cycle

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P27715

Gene expression databases

BgeeiWBGene00006752, Expressed in multi-cellular organism and 4 other tissues
ExpressionAtlasiP27715, baseline and differential

Family and domain databases

CDDicd00029, C1, 1 hit
cd04027, C2B_Munc13, 1 hit
Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR010439, CAPS_dom
IPR020454, DAG/PE-bd
IPR014770, Munc13_1
IPR014772, Munc13_dom-2
IPR019558, Munc13_subgr_dom-2
IPR002219, PE/DAG-bd
IPR027080, Unc-13
IPR037302, Unc-13_C2B
PANTHERiPTHR10480, PTHR10480, 3 hits
PfamiView protein in Pfam
PF00130, C1_1, 1 hit
PF00168, C2, 3 hits
PF06292, DUF1041, 1 hit
PF10540, Membr_traf_MHD, 1 hit
PRINTSiPR00360, C2DOMAIN
PR00008, DAGPEDOMAIN
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00239, C2, 3 hits
SM01145, DUF1041, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 3 hits
PS51258, MHD1, 1 hit
PS51259, MHD2, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC13_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27715
Secondary accession number(s): O17665
, Q23512, Q7YSR2, Q867Z2, Q8I095
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: March 29, 2004
Last modified: August 12, 2020
This is version 174 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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