Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 182 (12 Aug 2020)
Sequence version 1 (01 Aug 1992)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Deoxycytidine kinase

Gene

DCK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).5 Publications

Caution

Was shown to be phosphorylated and activated by CSNK1D/CK1 in vitro but probably not in vivo.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=6.2 µM for deoxycytidine (dC)1 Publication
  2. KM=15.5 µM for cytarabine (araC)1 Publication
  3. KM=22 µM for gemcitabine (dC)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei53Substrate1
    Binding sitei86Substrate1
    Binding sitei97Substrate1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei127Proton acceptorSequence analysis1
    Binding sitei128Substrate1
    Binding sitei133Substrate1
    Binding sitei197Substrate1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi28 – 36ATP9
    Nucleotide bindingi188 – 192ATP5
    Nucleotide bindingi240 – 242ATP3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS08100-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.74, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    P27707

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-73614, Pyrimidine salvage
    R-HSA-74217, Purine salvage

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P27707

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Deoxycytidine kinase (EC:2.7.1.745 Publications)
    Short name:
    dCK
    Alternative name(s):
    Deoxyadenosine kinase (EC:2.7.1.763 Publications)
    Deoxyguanosine kinase (EC:2.7.1.1132 Publications)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:DCK
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000156136.9

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:2704, DCK

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    125450, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P27707

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi100A → V: Strongly increased catalytic efficiency towards deoxycytidine; when associated with M-104 and A-133. 1 Publication1
    Mutagenesisi104R → L: Strongly increased catalytic efficiency towards deoxythymidine; when associated with A-133. 3 Publications1
    Mutagenesisi104R → M: Strongly increased catalytic efficiency towards deoxycytidine; when associated with V-100 and A-133. 3 Publications1
    Mutagenesisi133D → A: Strongly increased catalytic efficiency towards deoxycytidine; when associated with V-100 and M-104. Strongly increased catalytic efficiency towards deoxythymidine; when associated with L-104. 3 Publications1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    1633

    Open Targets

    More...
    OpenTargetsi
    ENSG00000156136

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA137

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P27707, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL2447

    Drug and drug target database

    More...
    DrugBanki
    DB02594, 2'-Deoxycytidine
    DB00242, Cladribine
    DB00631, Clofarabine
    DB00987, Cytarabine
    DB01262, Decitabine
    DB05494, Elacytarabine
    DB00879, Emtricitabine
    DB01073, Fludarabine
    DB00441, Gemcitabine
    DB00709, Lamivudine
    DB01280, Nelarabine
    DB00642, Pemetrexed
    DB04961, Troxacitabine
    DB00943, Zalcitabine

    DrugCentral

    More...
    DrugCentrali
    P27707

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    DCK

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    118447

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001750901 – 260Deoxycytidine kinaseAdd BLAST260

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11Phosphoserine; by CK11 Publication1
    Modified residuei15Phosphoserine; by CK11 Publication1
    Modified residuei72Phosphothreonine; by CK11 Publication1
    Modified residuei74PhosphoserineCombined sources1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P27707

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P27707

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P27707

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P27707

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P27707

    PeptideAtlas

    More...
    PeptideAtlasi
    P27707

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P27707

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    54408

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P27707

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P27707

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000156136, Expressed in liver and 238 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P27707, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P27707, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000156136, Tissue enhanced (lymphoid)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    5 Publications

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    108001, 34 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P27707, 6 interactors

    Molecular INTeraction database

    More...
    MINTi
    P27707

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000286648

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P27707

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    P27707, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1260
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P27707

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P27707

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the DCK/DGK family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG4235, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157321

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_030466_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P27707

    KEGG Orthology (KO)

    More...
    KOi
    K00893

    Database of Orthologous Groups

    More...
    OrthoDBi
    1505356at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P27707

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF324413

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01673, dNK, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002624, DCK/DGK
    IPR031314, DNK_dom
    IPR027417, P-loop_NTPase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01712, dNK, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000705, DNK, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540, SSF52540, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

    P27707-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MATPPKRSCP SFSASSEGTR IKKISIEGNI AAGKSTFVNI LKQLCEDWEV
    60 70 80 90 100
    VPEPVARWCN VQSTQDEFEE LTMSQKNGGN VLQMMYEKPE RWSFTFQTYA
    110 120 130 140 150
    CLSRIRAQLA SLNGKLKDAE KPVLFFERSV YSDRYIFASN LYESECMNET
    160 170 180 190 200
    EWTIYQDWHD WMNNQFGQSL ELDGIIYLQA TPETCLHRIY LRGRNEEQGI
    210 220 230 240 250
    PLEYLEKLHY KHESWLLHRT LKTNFDYLQE VPILTLDVNE DFKDKYESLV
    260
    EKVKEFLSTL
    Length:260
    Mass (Da):30,519
    Last modified:August 1, 1992 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i626B9D2D6BED8DBC
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    D6RCP9D6RCP9_HUMAN
    Deoxycytidine kinase
    DCK
    199Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RFG8D6RFG8_HUMAN
    Deoxycytidine kinase
    DCK
    317Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RG38D6RG38_HUMAN
    Deoxycytidine kinase
    DCK
    48Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6R9C6D6R9C6_HUMAN
    Deoxycytidine kinase
    DCK
    15Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti122P → S in AAV38744 (Ref. 4) Curated1
    Sequence conflicti122P → S in AAV38745 (Ref. 4) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M60527 mRNA Translation: AAA35752.1
    AK313523 mRNA Translation: BAG36303.1
    CR536527 mRNA Translation: CAG38764.1
    CR541876 mRNA Translation: CAG46674.1
    BT019941 mRNA Translation: AAV38744.1
    BT019942 mRNA Translation: AAV38745.1
    CH471057 Genomic DNA Translation: EAX05637.1
    BC103764 mRNA Translation: AAI03765.1
    BC114617 mRNA Translation: AAI14618.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS3548.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A38585

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000779.1, NM_000788.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000286648; ENSP00000286648; ENSG00000156136

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1633

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:1633

    UCSC genome browser

    More...
    UCSCi
    uc003hfx.4, human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M60527 mRNA Translation: AAA35752.1
    AK313523 mRNA Translation: BAG36303.1
    CR536527 mRNA Translation: CAG38764.1
    CR541876 mRNA Translation: CAG46674.1
    BT019941 mRNA Translation: AAV38744.1
    BT019942 mRNA Translation: AAV38745.1
    CH471057 Genomic DNA Translation: EAX05637.1
    BC103764 mRNA Translation: AAI03765.1
    BC114617 mRNA Translation: AAI14618.1
    CCDSiCCDS3548.1
    PIRiA38585
    RefSeqiNP_000779.1, NM_000788.2

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1P5ZX-ray1.60B1-260[»]
    1P60X-ray1.96A/B1-260[»]
    1P61X-ray2.21B1-260[»]
    1P62X-ray1.90B1-260[»]
    2A2ZX-ray3.02A/B/C/D1-260[»]
    2A30X-ray3.02A/B/C/D1-260[»]
    2A7QX-ray2.55A1-260[»]
    2NO0X-ray1.80A/B1-260[»]
    2NO1X-ray1.91A/B1-260[»]
    2NO6X-ray1.90A/B1-260[»]
    2NO7X-ray1.70A/B1-260[»]
    2NO9X-ray2.15A/B1-260[»]
    2NOAX-ray1.80A/B1-260[»]
    2QRNX-ray3.40A/B/C/D1-260[»]
    2QROX-ray3.45A/B/C/D1-260[»]
    2ZI3X-ray2.30A/B1-260[»]
    2ZI4X-ray2.10A1-260[»]
    2ZI5X-ray1.77A/B/C/D1-260[»]
    2ZI6X-ray1.77A/B/C/D1-260[»]
    2ZI7X-ray1.97A/B1-260[»]
    2ZI9X-ray2.51A/B1-260[»]
    2ZIAX-ray1.80A/B1-260[»]
    3HP1X-ray2.31A1-260[»]
    3IPXX-ray2.00A20-260[»]
    3IPYX-ray2.54A/B20-260[»]
    3KFXX-ray1.96A/B1-260[»]
    3MJRX-ray2.10A/B/C/D1-260[»]
    3QEJX-ray2.49A/B1-260[»]
    3QENX-ray2.00A/B1-260[»]
    3QEOX-ray1.90A/B1-260[»]
    4JLJX-ray2.00A/B1-260[»]
    4JLKX-ray1.89A/B1-260[»]
    4JLMX-ray2.18A/B1-260[»]
    4JLNX-ray2.15A/B1-260[»]
    4KCGX-ray2.09A/B1-260[»]
    4L5BX-ray1.94A/B1-260[»]
    4Q18X-ray2.00A/B1-260[»]
    4Q19X-ray2.09A/B1-260[»]
    4Q1AX-ray1.90A/B1-260[»]
    4Q1BX-ray2.15A/B1-260[»]
    4Q1CX-ray2.00A/B1-260[»]
    4Q1DX-ray2.00A/B1-260[»]
    4Q1EX-ray1.85A/B1-260[»]
    4Q1FX-ray2.10A/B1-260[»]
    5MQJX-ray3.70A/B/C/D2-260[»]
    5MQLX-ray3.25A/B/C/D1-260[»]
    5MQTX-ray3.20A/B/C/D1-260[»]
    SMRiP27707
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi108001, 34 interactors
    IntActiP27707, 6 interactors
    MINTiP27707
    STRINGi9606.ENSP00000286648

    Chemistry databases

    BindingDBiP27707
    ChEMBLiCHEMBL2447
    DrugBankiDB02594, 2'-Deoxycytidine
    DB00242, Cladribine
    DB00631, Clofarabine
    DB00987, Cytarabine
    DB01262, Decitabine
    DB05494, Elacytarabine
    DB00879, Emtricitabine
    DB01073, Fludarabine
    DB00441, Gemcitabine
    DB00709, Lamivudine
    DB01280, Nelarabine
    DB00642, Pemetrexed
    DB04961, Troxacitabine
    DB00943, Zalcitabine
    DrugCentraliP27707

    PTM databases

    iPTMnetiP27707
    PhosphoSitePlusiP27707

    Polymorphism and mutation databases

    BioMutaiDCK
    DMDMi118447

    Proteomic databases

    EPDiP27707
    jPOSTiP27707
    MassIVEiP27707
    MaxQBiP27707
    PaxDbiP27707
    PeptideAtlasiP27707
    PRIDEiP27707
    ProteomicsDBi54408

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    12905, 579 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    1633

    Genome annotation databases

    EnsembliENST00000286648; ENSP00000286648; ENSG00000156136
    GeneIDi1633
    KEGGihsa:1633
    UCSCiuc003hfx.4, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    1633
    DisGeNETi1633
    EuPathDBiHostDB:ENSG00000156136.9

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    DCK
    HGNCiHGNC:2704, DCK
    HPAiENSG00000156136, Tissue enhanced (lymphoid)
    MIMi125450, gene
    neXtProtiNX_P27707
    OpenTargetsiENSG00000156136
    PharmGKBiPA137

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG4235, Eukaryota
    GeneTreeiENSGT00940000157321
    HOGENOMiCLU_030466_1_1_1
    InParanoidiP27707
    KOiK00893
    OrthoDBi1505356at2759
    PhylomeDBiP27707
    TreeFamiTF324413

    Enzyme and pathway databases

    BioCyciMetaCyc:HS08100-MONOMER
    BRENDAi2.7.1.74, 2681
    PathwayCommonsiP27707
    ReactomeiR-HSA-73614, Pyrimidine salvage
    R-HSA-74217, Purine salvage
    SABIO-RKiP27707

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    1633, 6 hits in 870 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    DCK, human
    EvolutionaryTraceiP27707

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    Deoxycytidine_kinase

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    1633
    PharosiP27707, Tchem

    Protein Ontology

    More...
    PROi
    PR:P27707
    RNActiP27707, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000156136, Expressed in liver and 238 other tissues
    ExpressionAtlasiP27707, baseline and differential
    GenevisibleiP27707, HS

    Family and domain databases

    CDDicd01673, dNK, 1 hit
    InterProiView protein in InterPro
    IPR002624, DCK/DGK
    IPR031314, DNK_dom
    IPR027417, P-loop_NTPase
    PfamiView protein in Pfam
    PF01712, dNK, 1 hit
    PIRSFiPIRSF000705, DNK, 1 hit
    SUPFAMiSSF52540, SSF52540, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCK_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27707
    Secondary accession number(s): B2R8V6, Q5TZY7, Q6FI11
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: August 1, 1992
    Last modified: August 12, 2020
    This is version 182 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing, Reference proteome

    Documents

    1. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again