UniProtKB - P27705 (MIG1_YEAST)
Protein
Regulatory protein MIG1
Gene
MIG1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in glucose repression of the SUC, GAL and MAL genes as well as of the CAT8 gene. Binds to two sites in the upstream region of SUC2.
Miscellaneous
Present with 830 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 38 – 60 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 66 – 90 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: SGD
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: SGD
- sequence-specific DNA binding Source: SGD
GO - Biological processi
- carbohydrate metabolic process Source: UniProtKB-KW
- carbon catabolite repression of transcription from RNA polymerase II promoter by glucose Source: SGD
- negative regulation of transcription by RNA polymerase II Source: SGD
- negative regulation of transcription from RNA polymerase II promoter by glucose Source: SGD
- positive regulation of filamentous growth of a population of unicellular organisms in response to starvation Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Carbohydrate metabolism, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Regulatory protein MIG1Alternative name(s): Regulatory protein CAT4 |
Gene namesi | Name:MIG1 Synonyms:CAT4, SSN1 Ordered Locus Names:YGL035C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003003, MIG1 |
VEuPathDBi | FungiDB:YGL035C |
Subcellular locationi
Nucleus
Nucleus
- nuclear envelope lumen Source: SGD
- nucleus Source: SGD
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046881 | 1 – 504 | Regulatory protein MIG1Add BLAST | 504 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 278 | PhosphoserineCombined sources | 1 | |
Modified residuei | 302 | PhosphoserineCombined sources | 1 | |
Modified residuei | 310 | PhosphoserineCombined sources | 1 | |
Modified residuei | 311 | PhosphoserineCombined sources | 1 | |
Modified residuei | 314 | PhosphoserineCombined sources | 1 | |
Modified residuei | 377 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P27705 |
PaxDbi | P27705 |
PRIDEi | P27705 |
PTM databases
iPTMneti | P27705 |
Interactioni
Binary interactionsi
P27705
With | #Exp. | IntAct |
---|---|---|
HSP82 [P02829] | 3 | EBI-10913,EBI-8659 |
Protein-protein interaction databases
BioGRIDi | 33212, 263 interactors |
DIPi | DIP-665N |
IntActi | P27705, 13 interactors |
MINTi | P27705 |
STRINGi | 4932.YGL035C |
Miscellaneous databases
RNActi | P27705, protein |
Structurei
3D structure databases
SMRi | P27705 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P27705 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 253 – 260 | Gln-rich | 8 | |
Compositional biasi | 411 – 444 | Asn/Gln-richAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the creA/MIG C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 38 – 60 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 66 – 90 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000169836 |
HOGENOMi | CLU_047856_0_0_1 |
InParanoidi | P27705 |
OMAi | ASMHANG |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P27705-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSPYPMTQV SNVDDGSLLK ESKSKSKVAA KSEAPRPHAC PICHRAFHRL
60 70 80 90 100
EHQTRHMRIH TGEKPHACDF PGCVKRFSRS DELTRHRRIH TNSHPRGKRG
110 120 130 140 150
RKKKVVGSPI NSASSSATSI PDLNTANFSP PLPQQHLSPL IPIAIAPKEN
160 170 180 190 200
SSRSSTRKGR KTKFEIGESG GNDPYMVSSP KTMAKIPVSV KPPPSLALNN
210 220 230 240 250
MNYQTSSAST ALSSLSNSHS GSRLKLNALS SLQMMTPIAS SAPRTVFIDG
260 270 280 290 300
PEQKQLQQQQ NSLSPRYSNT VILPRPRSLT DFQGLNNANP NNNGSLRAQT
310 320 330 340 350
QSSVQLKRPS SVLSLNDLLV GQRNTNESDS DFTTGGEDEE DGLKDPSNSS
360 370 380 390 400
IDNLEQDYLQ EQSRKKSKTS TPTTMLSRST SGTNLHTLGY VMNQNHLHFS
410 420 430 440 450
SSSPDFQKEL NNRLLNVQQQ QQEQHTLLQS QNTSNQSQNQ NQNQMMASSS
460 470 480 490 500
SLSTTPLLLS PRVNMINTAI STQQTPISQS DSQVQELETL PPIRSLPLPF
PHMD
Sequence cautioni
The sequence CAA39084 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55734 Genomic DNA Translation: CAA39266.1 X55442 Genomic DNA Translation: CAA39084.1 Frameshift. Z72557 Genomic DNA Translation: CAA96736.1 AY693159 Genomic DNA Translation: AAT93178.1 BK006941 Genomic DNA Translation: DAA08065.1 |
PIRi | S17248 |
RefSeqi | NP_011480.1, NM_001180900.1 |
Genome annotation databases
EnsemblFungii | YGL035C_mRNA; YGL035C; YGL035C |
GeneIDi | 852848 |
KEGGi | sce:YGL035C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55734 Genomic DNA Translation: CAA39266.1 X55442 Genomic DNA Translation: CAA39084.1 Frameshift. Z72557 Genomic DNA Translation: CAA96736.1 AY693159 Genomic DNA Translation: AAT93178.1 BK006941 Genomic DNA Translation: DAA08065.1 |
PIRi | S17248 |
RefSeqi | NP_011480.1, NM_001180900.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1T5W | X-ray | 2.40 | C/F | 455-462 | [»] | |
1T5X | X-ray | 2.50 | C | 455-462 | [»] | |
SMRi | P27705 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33212, 263 interactors |
DIPi | DIP-665N |
IntActi | P27705, 13 interactors |
MINTi | P27705 |
STRINGi | 4932.YGL035C |
PTM databases
iPTMneti | P27705 |
Proteomic databases
MaxQBi | P27705 |
PaxDbi | P27705 |
PRIDEi | P27705 |
Genome annotation databases
EnsemblFungii | YGL035C_mRNA; YGL035C; YGL035C |
GeneIDi | 852848 |
KEGGi | sce:YGL035C |
Organism-specific databases
SGDi | S000003003, MIG1 |
VEuPathDBi | FungiDB:YGL035C |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000169836 |
HOGENOMi | CLU_047856_0_0_1 |
InParanoidi | P27705 |
OMAi | ASMHANG |
Miscellaneous databases
EvolutionaryTracei | P27705 |
PROi | PR:P27705 |
RNActi | P27705, protein |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 2 hits |
SUPFAMi | SSF57667, SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MIG1_YEAST | |
Accessioni | P27705Primary (citable) accession number: P27705 Secondary accession number(s): D6VUA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 190 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families