CD82

Functionⁱ

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

GO - Biological processⁱ

cell surface receptor signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SIGNORⁱ	P27701

SIGNORⁱ

P27701

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CD82 antigen Alternative name(s): C33 antigen IA4 Inducible membrane protein R2 Metastasis suppressor Kangai-1 Suppressor of tumorigenicity 6 protein Tetraspanin-27 Short name: Tspan-27 CD_antigen: CD82
Gene namesⁱ	Name:CD82 Synonyms:KAI1, SAR2, ST6, TSPAN27
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000085117.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6210 CD82
MIMⁱ	600623 gene
neXtProtⁱ	NX_P27701

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 11	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	12 – 32	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	33 – 53	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	54 – 72	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	73 – 83	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	84 – 110	HelicalSequence analysisAdd BLAST	27
Topological domainⁱ	111 – 228	ExtracellularSequence analysisAdd BLAST	118
Transmembraneⁱ	229 – 250	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	251 – 267	CytoplasmicSequence analysisAdd BLAST	17

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3732
MalaCards human disease database More...MalaCardsⁱ	CD82
Open Targets More...OpenTargetsⁱ	ENSG00000085117
PharmGKBⁱ	PA142672155

Polymorphism and mutation databases

BioMutaⁱ	CD82
DMDMⁱ	131775

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219226	1 – 267	CD82 antigenAdd BLAST		267

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	129	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	157	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	198	N-linked (GlcNAc...) asparagine1 Publication	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	P27701
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P27701
PaxDbⁱ	P27701
PeptideAtlas More...PeptideAtlasⁱ	P27701
PRIDEⁱ	P27701
ProteomicsDBⁱ	54407

PTM databases

iPTMnetⁱ	P27701
PhosphoSitePlusⁱ	P27701
SwissPalmⁱ	P27701

Expressionⁱ

Tissue specificityⁱ

Lymphoid specific.

Gene expression databases

Bgeeⁱ	ENSG00000085117
CleanExⁱ	HS_CD82
ExpressionAtlasⁱ	P27701 baseline and differential
Genevisibleⁱ	P27701 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002508 HPA028900 HPA061418

HPAⁱ

CAB002508
HPA028900
HPA061418

Interactionⁱ

Subunit structureⁱ

Interacts directly with IGSF8.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
VANGL1	Q8TAA9	6	EBI-682379,EBI-682393

With

Entry

#Exp.

IntAct

Notes

VANGL1

Q8TAA9

6

EBI-682379,EBI-682393

Protein-protein interaction databases

BioGridⁱ	109935, 24 interactors
IntActⁱ	P27701, 8 interactors
STRINGⁱ	9606.ENSP00000227155

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P27701
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137858
HOGENOMⁱ	HOG000230651
HOVERGENⁱ	HBG002324
InParanoidⁱ	P27701
KEGG Orthology (KO) More...KOⁱ	K06509
OMAⁱ	QVKCCGW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G4W
PhylomeDBⁱ	P27701
TreeFamⁱ	TF352892

Family and domain databases

Gene3Dⁱ	1.10.1450.10, 1 hit
InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR
SUPFAMⁱ	SSF48652 SSF48652, 1 hit
PROSITEⁱ	View protein in PROSITE PS00421 TM4_1, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: P27701-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSACIKVTK YFLFLFNLIF FILGAVILGF GVWILADKSS FISVLQTSSS 
        60         70         80         90        100
SLRMGAYVFI GVGAVTMLMG FLGCIGAVNE VRCLLGLYFA FLLLILIAQV 
       110        120        130        140        150
TAGALFYFNM GKLKQEMGGI VTELIRDYNS SREDSLQDAW DYVQAQVKCC 
       160        170        180        190        200
GWVSFYNWTD NAELMNRPEV TYPCSCEVKG EEDNSLSVRK GFCEAPGNRT 
       210        220        230        240        250
QSGNHPEDWP VYQEGCMEKV QAWLQENLGI ILGVGVGVAI IELLGMVLSI 
       260 
CLCRHVHSED YSKVPKY

Length:267

Mass (Da):29,626

Last modified:August 1, 1992 - v1

Checksum:ⁱFC379855BD1CABDE

GO

Isoform 2 (identifier: P27701-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
88-112: Missing.

« Hide

        10         20         30         40         50
MGSACIKVTK YFLFLFNLIF FILGAVILGF GVWILADKSS FISVLQTSSS 
        60         70         80         90        100
SLRMGAYVFI GVGAVTMLMG FLGCIGAVNE VRCLLGLLKQ EMGGIVTELI 
       110        120        130        140        150
RDYNSSREDS LQDAWDYVQA QVKCCGWVSF YNWTDNAELM NRPEVTYPCS 
       160        170        180        190        200
CEVKGEEDNS LSVRKGFCEA PGNRTQSGNH PEDWPVYQEG CMEKVQAWLQ 
       210        220        230        240 
ENLGIILGVG VGVAIIELLG MVLSICLCRH VHSEDYSKVP KY

Show »

Length:242

Mass (Da):26,818

Checksum:ⁱE80ECE34CFFF383D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	124	L → P in AAP76181 (Ref. 4) Curated		1
Sequence conflictⁱ	240 – 241	II → MV in AAB23825 (PubMed:1401919).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052326	241	I → V3 PublicationsCorresponds to variant dbSNP:rs1139971Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045656	88 – 112	Missing in isoform 2. 1 PublicationAdd BLAST		25

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53795 mRNA Translation: CAA37804.1 S48196 mRNA Translation: AAB23825.1 U20770 mRNA Translation: AAC50133.1 AY303776 mRNA Translation: AAP76181.1 U67274 U67273 Genomic DNA Translation: AAC51205.1 CR542255 mRNA Translation: CAG47051.1 AC010768 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68063.1 CH471064 Genomic DNA Translation: EAW68064.1 BC000726 mRNA Translation: AAH00726.1 BC001821 mRNA Translation: AAH01821.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31469.1 [P27701-2] CCDS7909.1 [P27701-1]
PIRⁱ	I38942 A46493
NCBI Reference Sequences More...RefSeqⁱ	NP_001020015.1, NM_001024844.1 [P27701-2] NP_002222.1, NM_002231.3 [P27701-1] XP_006718286.1, XM_006718223.2 [P27701-1]
UniGeneⁱ	Hs.527778

Genome annotation databases

Ensemblⁱ	ENST00000227155; ENSP00000227155; ENSG00000085117 [P27701-1] ENST00000342935; ENSP00000339686; ENSG00000085117 [P27701-2]
GeneIDⁱ	3732
KEGGⁱ	hsa:3732
UCSC genome browser More...UCSCⁱ	uc001myc.4 human [P27701-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P27701	Tetraspanin (Fragment)		HUMAN		267
Tetraspanin		CALJA		267
Tetraspanin		PONAB		267
Tetraspanin		MACMU		267
Tetraspanin		Cebus capucinus imitator		267
+24
P27701-2	Tetraspanin		PANTR		242
Tetraspanin		CALJA		242
Tetraspanin		Cebus capucinus imitator		242
Tetraspanin		COLAP		242
Tetraspanin		PONAB		242
+12

Protein	Similar proteins		Species	Score	Length
P27701	Tetraspanin		CERAT		267
Tetraspanin		CHLSB		267
Tetraspanin		COLAP		267
Tetraspanin		PAPAN		267
Tetraspanin		PONAB		267
+163
P27701-2	Tetraspanin		NOMLE		242
Tetraspanin		AOTNA		242
Tetraspanin		MANLE		242
Tetraspanin		Cebus capucinus imitator		242
Tetraspanin		CALJA		242
+14

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X53795 mRNA Translation: CAA37804.1 S48196 mRNA Translation: AAB23825.1 U20770 mRNA Translation: AAC50133.1 AY303776 mRNA Translation: AAP76181.1 U67274 U67273 Genomic DNA Translation: AAC51205.1 CR542255 mRNA Translation: CAG47051.1 AC010768 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68063.1 CH471064 Genomic DNA Translation: EAW68064.1 BC000726 mRNA Translation: AAH00726.1 BC001821 mRNA Translation: AAH01821.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31469.1 [P27701-2] CCDS7909.1 [P27701-1]
PIRⁱ	I38942 A46493
NCBI Reference Sequences More...RefSeqⁱ	NP_001020015.1, NM_001024844.1 [P27701-2] NP_002222.1, NM_002231.3 [P27701-1] XP_006718286.1, XM_006718223.2 [P27701-1]
UniGeneⁱ	Hs.527778

3D structure databases

ProteinModelPortalⁱ	P27701
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109935, 24 interactors
IntActⁱ	P27701, 8 interactors
STRINGⁱ	9606.ENSP00000227155

PTM databases

iPTMnetⁱ	P27701
PhosphoSitePlusⁱ	P27701
SwissPalmⁱ	P27701

Polymorphism and mutation databases

BioMutaⁱ	CD82
DMDMⁱ	131775

Proteomic databases

EPDⁱ	P27701
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P27701
PaxDbⁱ	P27701
PeptideAtlas More...PeptideAtlasⁱ	P27701
PRIDEⁱ	P27701
ProteomicsDBⁱ	54407

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3732
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000227155; ENSP00000227155; ENSG00000085117 [P27701-1] ENST00000342935; ENSP00000339686; ENSG00000085117 [P27701-2]
GeneIDⁱ	3732
KEGGⁱ	hsa:3732
UCSC genome browser More...UCSCⁱ	uc001myc.4 human [P27701-1]

Organism-specific databases

CTDⁱ	3732
DisGeNET More...DisGeNETⁱ	3732
EuPathDBⁱ	HostDB:ENSG00000085117.11
GeneCardsⁱ	CD82
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6210 CD82
Human Protein Atlas More...HPAⁱ	CAB002508 HPA028900 HPA061418
MalaCards human disease database More...MalaCardsⁱ	CD82
MIMⁱ	600623 gene
neXtProtⁱ	NX_P27701
Open Targets More...OpenTargetsⁱ	ENSG00000085117
PharmGKBⁱ	PA142672155
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3882 Eukaryota ENOG4111IRY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137858
HOGENOMⁱ	HOG000230651
HOVERGENⁱ	HBG002324
InParanoidⁱ	P27701
KEGG Orthology (KO) More...KOⁱ	K06509
OMAⁱ	QVKCCGW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G4W
PhylomeDBⁱ	P27701
TreeFamⁱ	TF352892

Enzyme and pathway databases

SIGNORⁱ	P27701

SIGNORⁱ

P27701

Miscellaneous databases

ChiTaRSⁱ	CD82 human
GeneWikiⁱ	CD82_(gene)
GenomeRNAiⁱ	3732
Protein Ontology More...PROⁱ	PR:P27701
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000085117
CleanExⁱ	HS_CD82
ExpressionAtlasⁱ	P27701 baseline and differential
Genevisibleⁱ	P27701 HS

Family and domain databases

Gene3Dⁱ	1.10.1450.10, 1 hit
InterProⁱ	View protein in InterPro IPR000301 Tetraspanin IPR018499 Tetraspanin/Peripherin IPR018503 Tetraspanin_CS IPR008952 Tetraspanin_EC2_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00335 Tetraspannin, 1 hit
PIRSFⁱ	PIRSF002419 Tetraspanin, 1 hit
PRINTSⁱ	PR00259 TMFOUR
SUPFAMⁱ	SSF48652 SSF48652, 1 hit
PROSITEⁱ	View protein in PROSITE PS00421 TM4_1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD82_HUMAN
Accessionⁱ	P27701Primary (citable) accession number: P27701 Secondary accession number(s): D3DQN6 , E9PC70, Q7Z2D4, Q7Z5N2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	August 1, 1992
	Last modified:	July 18, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P27701 (CD82_HUMAN)

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CD82 antigen

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ