UniProtKB - P27701 (CD82_HUMAN)
Protein
CD82 antigen
Gene
CD82
Organism
Homo sapiens (Human)
Status
Functioni
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.
Enzyme and pathway databases
PathwayCommonsi | P27701 |
SIGNORi | P27701 |
Names & Taxonomyi
Protein namesi | Recommended name: CD82 antigenAlternative name(s): C33 antigen IA4 Inducible membrane protein R2 Metastasis suppressor Kangai-1 Suppressor of tumorigenicity 6 protein Tetraspanin-27 Short name: Tspan-27 CD_antigen: CD82 |
Gene namesi | Name:CD82 Synonyms:KAI1, SAR2, ST6, TSPAN27 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6210, CD82 |
MIMi | 600623, gene |
neXtProti | NX_P27701 |
VEuPathDBi | HostDB:ENSG00000085117.11 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 33 – 53 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 54 – 72 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 73 – 83 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 84 – 110 | HelicalSequence analysisAdd BLAST | 27 | |
Topological domaini | 111 – 228 | ExtracellularSequence analysisAdd BLAST | 118 | |
Transmembranei | 229 – 250 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 251 – 267 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3732 |
OpenTargetsi | ENSG00000085117 |
PharmGKBi | PA142672155 |
Miscellaneous databases
Pharosi | P27701, Tbio |
Genetic variation databases
BioMutai | CD82 |
DMDMi | 131775 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219226 | 1 – 267 | CD82 antigenAdd BLAST | 267 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 129 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 157 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 198 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | P27701 |
jPOSTi | P27701 |
MassIVEi | P27701 |
MaxQBi | P27701 |
PaxDbi | P27701 |
PeptideAtlasi | P27701 |
PRIDEi | P27701 |
ProteomicsDBi | 19382 54407 [P27701-1] |
PTM databases
GlyConnecti | 1089, 2 N-Linked glycans (1 site) |
GlyGeni | P27701, 3 sites |
iPTMneti | P27701 |
PhosphoSitePlusi | P27701 |
SwissPalmi | P27701 |
Expressioni
Tissue specificityi
Lymphoid specific.
Gene expression databases
Bgeei | ENSG00000085117, Expressed in esophagus and 244 other tissues |
ExpressionAtlasi | P27701, baseline and differential |
Genevisiblei | P27701, HS |
Organism-specific databases
HPAi | ENSG00000085117, Low tissue specificity |
Interactioni
Subunit structurei
Interacts directly with IGSF8.
1 PublicationBinary interactionsi
Hide detailsP27701
With | #Exp. | IntAct |
---|---|---|
FFAR2 [O15552] | 3 | EBI-682379,EBI-2833872 |
KLRC1 [P26715] | 3 | EBI-682379,EBI-9018187 |
SMIM3 [Q9BZL3] | 3 | EBI-682379,EBI-741850 |
TIMP1 [P01033] | 11 | EBI-682379,EBI-712536 |
VANGL1 [Q8TAA9] | 6 | EBI-682379,EBI-682393 |
Protein-protein interaction databases
BioGRIDi | 109935, 36 interactors |
IntActi | P27701, 20 interactors |
MINTi | P27701 |
STRINGi | 9606.ENSP00000227155 |
Miscellaneous databases
RNActi | P27701, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the tetraspanin (TM4SF) family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000158481 |
InParanoidi | P27701 |
OMAi | CRHIHSE |
OrthoDBi | 1207549at2759 |
PhylomeDBi | P27701 |
TreeFami | TF352892 |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P27701-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSACIKVTK YFLFLFNLIF FILGAVILGF GVWILADKSS FISVLQTSSS
60 70 80 90 100
SLRMGAYVFI GVGAVTMLMG FLGCIGAVNE VRCLLGLYFA FLLLILIAQV
110 120 130 140 150
TAGALFYFNM GKLKQEMGGI VTELIRDYNS SREDSLQDAW DYVQAQVKCC
160 170 180 190 200
GWVSFYNWTD NAELMNRPEV TYPCSCEVKG EEDNSLSVRK GFCEAPGNRT
210 220 230 240 250
QSGNHPEDWP VYQEGCMEKV QAWLQENLGI ILGVGVGVAI IELLGMVLSI
260
CLCRHVHSED YSKVPKY
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PJC7 | E9PJC7_HUMAN | Tetraspanin | CD82 | 157 | Annotation score: | ||
E9PM43 | E9PM43_HUMAN | CD82 antigen | CD82 | 179 | Annotation score: | ||
E9PJB7 | E9PJB7_HUMAN | CD82 antigen | CD82 | 104 | Annotation score: | ||
E9PJ45 | E9PJ45_HUMAN | CD82 antigen | CD82 | 161 | Annotation score: | ||
E9PP61 | E9PP61_HUMAN | CD82 antigen | CD82 | 68 | Annotation score: | ||
E9PJK9 | E9PJK9_HUMAN | CD82 antigen | CD82 | 108 | Annotation score: | ||
E9PJ59 | E9PJ59_HUMAN | CD82 antigen | CD82 | 38 | Annotation score: | ||
H0YD57 | H0YD57_HUMAN | CD82 antigen | CD82 | 57 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 124 | L → P in AAP76181 (Ref. 4) Curated | 1 | |
Sequence conflicti | 240 – 241 | II → MV in AAB23825 (PubMed:1401919).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052326 | 241 | I → V3 PublicationsCorresponds to variant dbSNP:rs1139971Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045656 | 88 – 112 | Missing in isoform 2. 1 PublicationAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53795 mRNA Translation: CAA37804.1 S48196 mRNA Translation: AAB23825.1 U20770 mRNA Translation: AAC50133.1 AY303776 mRNA Translation: AAP76181.1 U67274 , U67268, U67269, U67270, U67271, U67272, U67273 Genomic DNA Translation: AAC51205.1 CR542255 mRNA Translation: CAG47051.1 AC010768 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68063.1 CH471064 Genomic DNA Translation: EAW68064.1 BC000726 mRNA Translation: AAH00726.1 BC001821 mRNA Translation: AAH01821.1 |
CCDSi | CCDS31469.1 [P27701-2] CCDS7909.1 [P27701-1] |
PIRi | I38942, A46493 |
RefSeqi | NP_001020015.1, NM_001024844.1 [P27701-2] NP_002222.1, NM_002231.3 [P27701-1] XP_006718286.1, XM_006718223.2 [P27701-1] |
Genome annotation databases
Ensembli | ENST00000227155; ENSP00000227155; ENSG00000085117 [P27701-1] ENST00000342935; ENSP00000339686; ENSG00000085117 [P27701-2] |
GeneIDi | 3732 |
KEGGi | hsa:3732 |
UCSCi | uc001myc.4, human [P27701-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X53795 mRNA Translation: CAA37804.1 S48196 mRNA Translation: AAB23825.1 U20770 mRNA Translation: AAC50133.1 AY303776 mRNA Translation: AAP76181.1 U67274 , U67268, U67269, U67270, U67271, U67272, U67273 Genomic DNA Translation: AAC51205.1 CR542255 mRNA Translation: CAG47051.1 AC010768 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68063.1 CH471064 Genomic DNA Translation: EAW68064.1 BC000726 mRNA Translation: AAH00726.1 BC001821 mRNA Translation: AAH01821.1 |
CCDSi | CCDS31469.1 [P27701-2] CCDS7909.1 [P27701-1] |
PIRi | I38942, A46493 |
RefSeqi | NP_001020015.1, NM_001024844.1 [P27701-2] NP_002222.1, NM_002231.3 [P27701-1] XP_006718286.1, XM_006718223.2 [P27701-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109935, 36 interactors |
IntActi | P27701, 20 interactors |
MINTi | P27701 |
STRINGi | 9606.ENSP00000227155 |
PTM databases
GlyConnecti | 1089, 2 N-Linked glycans (1 site) |
GlyGeni | P27701, 3 sites |
iPTMneti | P27701 |
PhosphoSitePlusi | P27701 |
SwissPalmi | P27701 |
Genetic variation databases
BioMutai | CD82 |
DMDMi | 131775 |
Proteomic databases
EPDi | P27701 |
jPOSTi | P27701 |
MassIVEi | P27701 |
MaxQBi | P27701 |
PaxDbi | P27701 |
PeptideAtlasi | P27701 |
PRIDEi | P27701 |
ProteomicsDBi | 19382 54407 [P27701-1] |
Protocols and materials databases
Antibodypediai | 3743, 634 antibodies |
DNASUi | 3732 |
Genome annotation databases
Ensembli | ENST00000227155; ENSP00000227155; ENSG00000085117 [P27701-1] ENST00000342935; ENSP00000339686; ENSG00000085117 [P27701-2] |
GeneIDi | 3732 |
KEGGi | hsa:3732 |
UCSCi | uc001myc.4, human [P27701-1] |
Organism-specific databases
CTDi | 3732 |
DisGeNETi | 3732 |
GeneCardsi | CD82 |
HGNCi | HGNC:6210, CD82 |
HPAi | ENSG00000085117, Low tissue specificity |
MIMi | 600623, gene |
neXtProti | NX_P27701 |
OpenTargetsi | ENSG00000085117 |
PharmGKBi | PA142672155 |
VEuPathDBi | HostDB:ENSG00000085117.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3882, Eukaryota |
GeneTreei | ENSGT00940000158481 |
InParanoidi | P27701 |
OMAi | CRHIHSE |
OrthoDBi | 1207549at2759 |
PhylomeDBi | P27701 |
TreeFami | TF352892 |
Enzyme and pathway databases
PathwayCommonsi | P27701 |
SIGNORi | P27701 |
Miscellaneous databases
BioGRID-ORCSi | 3732, 3 hits in 996 CRISPR screens |
ChiTaRSi | CD82, human |
GeneWikii | CD82_(gene) |
GenomeRNAii | 3732 |
Pharosi | P27701, Tbio |
PROi | PR:P27701 |
RNActi | P27701, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000085117, Expressed in esophagus and 244 other tissues |
ExpressionAtlasi | P27701, baseline and differential |
Genevisiblei | P27701, HS |
Family and domain databases
Gene3Di | 1.10.1450.10, 1 hit |
InterProi | View protein in InterPro IPR000301, Tetraspanin IPR018499, Tetraspanin/Peripherin IPR018503, Tetraspanin_CS IPR008952, Tetraspanin_EC2_sf |
Pfami | View protein in Pfam PF00335, Tetraspanin, 1 hit |
PIRSFi | PIRSF002419, Tetraspanin, 1 hit |
PRINTSi | PR00259, TMFOUR |
SUPFAMi | SSF48652, SSF48652, 1 hit |
PROSITEi | View protein in PROSITE PS00421, TM4_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD82_HUMAN | |
Accessioni | P27701Primary (citable) accession number: P27701 Secondary accession number(s): D3DQN6 Q7Z5N2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families