Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - P27699 (CREM_MOUSE)

Entry version 178 (25 May 2022)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
Add a publicationFeedback
Protein

cAMP-responsive element modulator

Gene

Crem

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (PubMed:16595651).

1 Publication

Plays a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.

2 Publications

Miscellaneous

CREM-null deficient mice display male infertility: while spermatogonia differentiate normally into round spermatids, all the elongating spermatids are eliminated by apoptosis during spermiogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
cAMP-responsive element modulator
Alternative name(s):
Inducible cAMP early repressor
Short name:
ICER
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Crem
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:88495, Crem

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000063889

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi116S → M: Loss of in vitro phosphorylation by TSSK4. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000766081 – 357cAMP-responsive element modulatorAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei116Phosphoserine1 Publication1
Modified residuei142PhosphoserineBy similarity1
Modified residuei284PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Stimulated by phosphorylation (By similarity). Phosphorylated on Ser-116 by TSSK4 in vitro.By similarity1 Publication
Ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P27699

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P27699

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		284124 [P27699-1]
284125 [P27699-2]
284126 [P27699-3]
284127 [P27699-4]
284128 [P27699-5]
284129 [P27699-6]
284130 [P27699-7]
284131 [P27699-8]
284132 [P27699-9]
284133 [P27699-10]
284134 [P27699-11]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P27699

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P27699

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the testis.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In premeiotic germ cells, expressed at low amounts in the antagonist form. Subsequently, during spermatogenesis, isoform 1 (activator) is generated exclusively and in extremely high amounts.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 11 is expressed in a circadian manner in the adrenal gland with an expression peak at ZT20 (at protein level). It is induced by cAMP in an immediate-early fashion and can repress its own production via a negative autoregulatory mechanism.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000063889, Expressed in testis and 270 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P27699, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P27699, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a dimer (By similarity).

Interacts with CDC34 (By similarity).

Interacts with FHL5 (PubMed:10086359). May interact with TSSK4 (PubMed:26940607). Isoform 1 forms a heterodimer with CREB3L4 (PubMed:16595651).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		198877, 6 interactors

Protein interaction database and analysis system

More...IntActi		P27699, 3 interactors

Molecular INTeraction database

More...MINTi		P27699

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000121233

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P27699, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P27699

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P27699

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 160KIDPROSITE-ProRule annotationAdd BLAST60
Domaini299 – 357bZIPPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 43DisorderedSequence analysisAdd BLAST24
Regioni300 – 325Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni327 – 348Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3584, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156952

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P27699

Database of Orthologous Groups

More...OrthoDBi		957343at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P27699

TreeFam database of animal gene trees

More...TreeFami		TF106464

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004827, bZIP
IPR046347, bZIP_sf
IPR003102, Coactivator_CBP_pKID
IPR001630, Leuzip_CREB

The PANTHER Classification System

More...PANTHERi		PTHR45879, PTHR45879, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00170, bZIP_1, 1 hit
PF02173, pKID, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00338, BRLZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57959, SSF57959, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit
PS50953, KID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 11 described isoforms and 28 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P27699-1) [UniParc]FASTAAdd to basket
Also known as: CREM-BCEFGgammaHIbeta, Tau

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP 
        60         70         80         90        100
TLAQVSVAGS GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ 
       110        120        130        140        150
TVQVATIAET DDSADSEVID SHKRREILSR RPSYRKILNE LSSDVPGIPK 
       160        170        180        190        200
IEEEKSEEEG TPPNIATMAV PTSIYQTSTG QYIAIAQGGT IQISNPGSDG 
       210        220        230        240        250
VQGLQALTMT NSGAPPPGAT IVQYAAQSAD GTQQFFVPGS QVVVQDEETD 
       260        270        280        290        300
LAPSHMAAAT GDMPTYQIRA PTTALPQGVV MAASPGSLHS PQQLAEEATR 
       310        320        330        340        350
KRELRLMKNR EAAKECRRRK KEYVKCLESR VAVLEVQNKK LIEELETLKD 

ICSPKTD
Length:357
Mass (Da):38,516
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B387B7247113088
GO
Isoform 2 (identifier: P27699-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:245
Mass (Da):27,473
Checksum:iA508BB074EAEA8A6
GO
Isoform 3 (identifier: P27699-3) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N

Show »
Length:245
Mass (Da):27,389
Checksum:iF85FB7D3B0451514
GO
Isoform 4 (identifier: P27699-4) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T

Show »
Length:233
Mass (Da):26,123
Checksum:i9645439A10824456
GO
Isoform 5 (identifier: P27699-5) [UniParc]FASTAAdd to basket
Also known as: Tau Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     246-257: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:345
Mass (Da):37,303
Checksum:i508E5448D03B5F8D
GO
Isoform 6 (identifier: P27699-6) [UniParc]FASTAAdd to basket
Also known as: Tau 2 Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:308
Mass (Da):33,698
Checksum:i438CD86068BA7DAF
GO
Isoform 7 (identifier: P27699-7) [UniParc]FASTAAdd to basket
Also known as: Tau 1 Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:294
Mass (Da):32,376
Checksum:iC637D53AC9A9BCF8
GO
Isoform 8 (identifier: P27699-8) [UniParc]FASTAAdd to basket
Also known as: Tau 1 Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:282
Mass (Da):31,109
Checksum:i46A1DA7CDA89F4B5
GO
Isoform 9 (identifier: P27699-9) [UniParc]FASTAAdd to basket
Also known as: Tau 1 Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T

Show »
Length:282
Mass (Da):31,025
Checksum:i1BF6D6A824624907
GO
Isoform 10 (identifier: P27699-10) [UniParc]FASTAAdd to basket
Also known as: Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:233
Mass (Da):26,207
Checksum:iCB124F4EEE69F9E4
GO
Isoform 11 (identifier: P27699-11) [UniParc]FASTAAdd to basket
Also known as: Icer Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: MSKCGRKKYM...FVPGSQVVVQ → MAVTGDET
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Note: Produced by alternative promoter usage.Curated
Show »
Length:120
Mass (Da):13,437
Checksum:i6A84CA55E6C049F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 28 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J1S0A0A0R4J1S0_MOUSE
cAMP-responsive element modulator
Crem
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J1V7A0A0R4J1V7_MOUSE
cAMP-responsive element modulator
Crem
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2U7D3Z2U7_MOUSE
cAMP-responsive element modulator
Crem
341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YXV5D3YXV5_MOUSE
cAMP-responsive element modulator
Crem
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q346F6Q346_MOUSE
cAMP-responsive element modulator
Crem
284Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RB97F6RB97_MOUSE
cAMP-responsive element modulator
Crem
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6U9F5F6U9F5_MOUSE
cAMP-responsive element modulator
Crem
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6QKL8F6QKL8_MOUSE
cAMP-responsive element modulator
Crem
335Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6W4F5F6W4F5_MOUSE
cAMP-responsive element modulator
Crem
298Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XRJ7F6XRJ7_MOUSE
cAMP-responsive element modulator
Crem
331Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA17495 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA17496 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA17497 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAV28551 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAV28552 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAV28553 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAV28554 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAV28555 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAV28556 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0559871 – 245MSKCG…QVVVQ → MAVTGDET in isoform 11. 1 PublicationAdd BLAST245
Alternative sequenceiVSP_00060255 – 103Missing in isoform 2, isoform 3, isoform 4, isoform 6 and isoform 10. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_000605183 – 257Missing in isoform 4, isoform 8, isoform 9 and isoform 10. 2 PublicationsAdd BLAST75
Alternative sequenceiVSP_000603183 – 245Missing in isoform 2, isoform 3 and isoform 7. 2 PublicationsAdd BLAST63
Alternative sequenceiVSP_038016246 – 257Missing in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_000604246D → N in isoform 2, isoform 3 and isoform 7. 2 Publications1
Alternative sequenceiVSP_000606258A → T in isoform 4, isoform 8, isoform 9 and isoform 10. 2 Publications1
Alternative sequenceiVSP_000607314 – 357KECRR…SPKTD → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKAE in isoform 2, isoform 5, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 11. 3 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ311667 mRNA Translation: CAC34846.1
AC117589 Genomic DNA No translation available.
M60285 mRNA Translation: AAA17495.1 Different initiation.
M60285 mRNA Translation: AAA17496.1 Different initiation.
M60285 mRNA Translation: AAA17497.1 Different initiation.
AY738715 mRNA Translation: AAV28551.1 Different initiation.
AY738716 mRNA Translation: AAV28552.1 Different initiation.
AY738717 mRNA Translation: AAV28553.1 Different initiation.
AY738718 mRNA Translation: AAV28554.1 Different initiation.
AY738719 mRNA Translation: AAV28555.1 Different initiation.
AY738721 mRNA Translation: AAV28556.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS29031.2 [P27699-2]
CCDS50214.1 [P27699-7]
CCDS50215.1 [P27699-1]
CCDS70862.1 [P27699-6]
CCDS70863.1 [P27699-8]
CCDS70864.1 [P27699-5]

Protein sequence database of the Protein Information Resource

More...PIRi		A37944
B37944
C37944
S20827

NCBI Reference Sequences

More...RefSeqi		NP_001104320.1, NM_001110850.2 [P27699-10]
NP_001104324.2, NM_001110854.1
NP_001104325.2, NM_001110855.1
NP_001104326.1, NM_001110856.2 [P27699-7]
NP_001104327.1, NM_001110857.2 [P27699-3]
NP_001104328.1, NM_001110858.2 [P27699-4]
NP_001104329.1, NM_001110859.2 [P27699-1]
NP_001258432.1, NM_001271503.1 [P27699-9]
NP_001258433.1, NM_001271504.1 [P27699-8]
NP_001258434.1, NM_001271505.1 [P27699-6]
NP_001258435.1, NM_001271506.1 [P27699-5]
NP_038526.2, NM_013498.3 [P27699-2]
XP_006525618.1, XM_006525555.3 [P27699-1]
XP_006525619.1, XM_006525556.3 [P27699-5]
XP_006525624.1, XM_006525561.3 [P27699-6]
XP_006525628.1, XM_006525565.3 [P27699-7]
XP_006525630.1, XM_006525567.3 [P27699-8]
XP_006525631.1, XM_006525568.3 [P27699-9]
XP_006525636.1, XM_006525573.3 [P27699-2]
XP_006525637.1, XM_006525574.3 [P27699-3]
XP_006525638.1, XM_006525575.3 [P27699-10]
XP_006525639.1, XM_006525576.3 [P27699-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000025069; ENSMUSP00000025069; ENSMUSG00000063889 [P27699-5]
ENSMUST00000082141; ENSMUSP00000080780; ENSMUSG00000063889 [P27699-6]
ENSMUST00000150235; ENSMUSP00000121233; ENSMUSG00000063889 [P27699-1]
ENSMUST00000154135; ENSMUSP00000122051; ENSMUSG00000063889 [P27699-2]
ENSMUST00000154470; ENSMUSP00000118128; ENSMUSG00000063889 [P27699-8]
ENSMUST00000165086; ENSMUSP00000127353; ENSMUSG00000063889 [P27699-7]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		12916

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:12916

UCSC genome browser

More...UCSCi		uc008dxp.2, mouse [P27699-8]
uc008dxq.2, mouse [P27699-9]
uc008dxr.2, mouse [P27699-5]
uc008dxs.2, mouse [P27699-6]
uc033hfn.1, mouse [P27699-1]
uc033hfo.1, mouse [P27699-4]
uc033hfp.1, mouse [P27699-7]
uc033hfq.1, mouse [P27699-2]
uc033hfr.1, mouse [P27699-3]
uc033hfs.1, mouse [P27699-10]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311667 mRNA Translation: CAC34846.1
AC117589 Genomic DNA No translation available.
M60285 mRNA Translation: AAA17495.1 Different initiation.
M60285 mRNA Translation: AAA17496.1 Different initiation.
M60285 mRNA Translation: AAA17497.1 Different initiation.
AY738715 mRNA Translation: AAV28551.1 Different initiation.
AY738716 mRNA Translation: AAV28552.1 Different initiation.
AY738717 mRNA Translation: AAV28553.1 Different initiation.
AY738718 mRNA Translation: AAV28554.1 Different initiation.
AY738719 mRNA Translation: AAV28555.1 Different initiation.
AY738721 mRNA Translation: AAV28556.1 Different initiation.
CCDSiCCDS29031.2 [P27699-2]
CCDS50214.1 [P27699-7]
CCDS50215.1 [P27699-1]
CCDS70862.1 [P27699-6]
CCDS70863.1 [P27699-8]
CCDS70864.1 [P27699-5]
PIRiA37944
B37944
C37944
S20827
RefSeqiNP_001104320.1, NM_001110850.2 [P27699-10]
NP_001104324.2, NM_001110854.1
NP_001104325.2, NM_001110855.1
NP_001104326.1, NM_001110856.2 [P27699-7]
NP_001104327.1, NM_001110857.2 [P27699-3]
NP_001104328.1, NM_001110858.2 [P27699-4]
NP_001104329.1, NM_001110859.2 [P27699-1]
NP_001258432.1, NM_001271503.1 [P27699-9]
NP_001258433.1, NM_001271504.1 [P27699-8]
NP_001258434.1, NM_001271505.1 [P27699-6]
NP_001258435.1, NM_001271506.1 [P27699-5]
NP_038526.2, NM_013498.3 [P27699-2]
XP_006525618.1, XM_006525555.3 [P27699-1]
XP_006525619.1, XM_006525556.3 [P27699-5]
XP_006525624.1, XM_006525561.3 [P27699-6]
XP_006525628.1, XM_006525565.3 [P27699-7]
XP_006525630.1, XM_006525567.3 [P27699-8]
XP_006525631.1, XM_006525568.3 [P27699-9]
XP_006525636.1, XM_006525573.3 [P27699-2]
XP_006525637.1, XM_006525574.3 [P27699-3]
XP_006525638.1, XM_006525575.3 [P27699-10]
XP_006525639.1, XM_006525576.3 [P27699-4]

3D structure databases

AlphaFoldDBiP27699
SMRiP27699
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi198877, 6 interactors
IntActiP27699, 3 interactors
MINTiP27699
STRINGi10090.ENSMUSP00000121233

PTM databases

iPTMnetiP27699
PhosphoSitePlusiP27699

Proteomic databases

MaxQBiP27699
PaxDbiP27699
ProteomicsDBi284124 [P27699-1]
284125 [P27699-2]
284126 [P27699-3]
284127 [P27699-4]
284128 [P27699-5]
284129 [P27699-6]
284130 [P27699-7]
284131 [P27699-8]
284132 [P27699-9]
284133 [P27699-10]
284134 [P27699-11]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4333, 425 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		12916

Genome annotation databases

EnsembliENSMUST00000025069; ENSMUSP00000025069; ENSMUSG00000063889 [P27699-5]
ENSMUST00000082141; ENSMUSP00000080780; ENSMUSG00000063889 [P27699-6]
ENSMUST00000150235; ENSMUSP00000121233; ENSMUSG00000063889 [P27699-1]
ENSMUST00000154135; ENSMUSP00000122051; ENSMUSG00000063889 [P27699-2]
ENSMUST00000154470; ENSMUSP00000118128; ENSMUSG00000063889 [P27699-8]
ENSMUST00000165086; ENSMUSP00000127353; ENSMUSG00000063889 [P27699-7]
GeneIDi12916
KEGGimmu:12916
UCSCiuc008dxp.2, mouse [P27699-8]
uc008dxq.2, mouse [P27699-9]
uc008dxr.2, mouse [P27699-5]
uc008dxs.2, mouse [P27699-6]
uc033hfn.1, mouse [P27699-1]
uc033hfo.1, mouse [P27699-4]
uc033hfp.1, mouse [P27699-7]
uc033hfq.1, mouse [P27699-2]
uc033hfr.1, mouse [P27699-3]
uc033hfs.1, mouse [P27699-10]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1390
MGIiMGI:88495, Crem
VEuPathDBiHostDB:ENSMUSG00000063889

Phylogenomic databases

eggNOGiKOG3584, Eukaryota
GeneTreeiENSGT00940000156952
InParanoidiP27699
OrthoDBi957343at2759
PhylomeDBiP27699
TreeFamiTF106464

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		12916, 1 hit in 69 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Crem, mouse

Protein Ontology

More...PROi		PR:P27699
RNActiP27699, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000063889, Expressed in testis and 270 other tissues
ExpressionAtlasiP27699, baseline and differential
GenevisibleiP27699, MM

Family and domain databases

InterProiView protein in InterPro
IPR004827, bZIP
IPR046347, bZIP_sf
IPR003102, Coactivator_CBP_pKID
IPR001630, Leuzip_CREB
PANTHERiPTHR45879, PTHR45879, 1 hit
PfamiView protein in Pfam
PF00170, bZIP_1, 1 hit
PF02173, pKID, 1 hit
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
SUPFAMiSSF57959, SSF57959, 1 hit
PROSITEiView protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit
PS50953, KID, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCREM_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27699
Secondary accession number(s): P27698
, Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3, Q99JF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 22, 2009
Last modified: May 25, 2022
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again