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Protein

cAMP-responsive element modulator

Gene

Crem

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Isoform 2, isoform 3 and isoform 4 are repressors, while isoform 1 is an activator. Plays a role in spermatogenesis and is involved in spermatid maturation. Binding of isoform 1 (activator) to CRE is increased by CREB3L4. The CREM isoform 1-CREB3L4 heterodimer functions through CRE and may recruit HIRA to CRE to regulate histone exchange (PubMed:16595651).1 Publication
Isoform 11: Plays a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.2 Publications

Miscellaneous

CREM-null deficient mice display male infertility: while spermatogonia differentiate normally into round spermatids, all the elongating spermatids are eliminated by apoptosis during spermiogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processBiological rhythms, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element modulator
Alternative name(s):
Inducible cAMP early repressor
Short name:
ICER
Gene namesi
Name:Crem
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:88495 Crem

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi116S → M: Loss of in vitro phosphorylation by TSSK4. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766081 – 357cAMP-responsive element modulatorAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei116Phosphoserine1 Publication1
Modified residuei142PhosphoserineBy similarity1
Modified residuei284PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1

Post-translational modificationi

Stimulated by phosphorylation (By similarity). Phosphorylated on Ser-116 by TSSK4 in vitro.By similarity1 Publication
Ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP27699
PaxDbiP27699
PRIDEiP27699

PTM databases

iPTMnetiP27699
PhosphoSitePlusiP27699

Expressioni

Tissue specificityi

Expressed in the testis.1 Publication

Developmental stagei

In premeiotic germ cells, expressed at low amounts in the antagonist form. Subsequently, during spermatogenesis, isoform 1 (activator) is generated exclusively and in extremely high amounts.

Inductioni

Isoform 11 is expressed in a circadian manner in the adrenal gland with an expression peak at ZT20 (at protein level). It is induced by cAMP in an immediate-early fashion and can repress its own production via a negative autoregulatory mechanism.2 Publications

Gene expression databases

BgeeiENSMUSG00000063889 Expressed in 239 organ(s), highest expression level in testis
CleanExiMM_CREM
ExpressionAtlasiP27699 baseline and differential
GenevisibleiP27699 MM

Interactioni

Subunit structurei

Binds DNA as a dimer (By similarity). Interacts with CDC34 (By similarity). Interacts with FHL5 (PubMed:10086359). May interact with TSSK4 (PubMed:26940607). Isoform 1 forms a heterodimer with CREB3L4 (PubMed:16595651).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Hdac1O091063EBI-8744406,EBI-301912

Protein-protein interaction databases

BioGridi198877, 6 interactors
IntActiP27699, 3 interactors
STRINGi10090.ENSMUSP00000121233

Structurei

3D structure databases

ProteinModelPortaliP27699
SMRiP27699
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 160KIDPROSITE-ProRule annotationAdd BLAST60
Domaini299 – 357bZIPPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni300 – 325Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni327 – 348Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family.Curated

Phylogenomic databases

eggNOGiKOG3584 Eukaryota
ENOG410ZZJZ LUCA
GeneTreeiENSGT00390000008655
HOGENOMiHOG000007365
HOVERGENiHBG053150
InParanoidiP27699
KOiK09052
OrthoDBiEOG091G0FTJ
PhylomeDBiP27699
TreeFamiTF106464

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR003102 Coactivator_CBP_pKID
IPR001630 Leuzip_CREB
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF02173 pKID, 1 hit
PRINTSiPR00041 LEUZIPPRCREB
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
PS50953 KID, 1 hit

Sequences (11+)i

Sequence statusi: Complete.

This entry describes 11 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 11 described isoforms and 28 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P27699-1) [UniParc]FASTAAdd to basket
Also known as: CREM-BCEFGgammaHIbeta, Tau

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKCGRKKYM RTNVRQMTME TVESQQDRSV TRSVAEHSSA HMQTGQISVP
60 70 80 90 100
TLAQVSVAGS GTGRGSPAVT LVQLPSGQTV QVQGVIQTPH PSVIQSPQIQ
110 120 130 140 150
TVQVATIAET DDSADSEVID SHKRREILSR RPSYRKILNE LSSDVPGIPK
160 170 180 190 200
IEEEKSEEEG TPPNIATMAV PTSIYQTSTG QYIAIAQGGT IQISNPGSDG
210 220 230 240 250
VQGLQALTMT NSGAPPPGAT IVQYAAQSAD GTQQFFVPGS QVVVQDEETD
260 270 280 290 300
LAPSHMAAAT GDMPTYQIRA PTTALPQGVV MAASPGSLHS PQQLAEEATR
310 320 330 340 350
KRELRLMKNR EAAKECRRRK KEYVKCLESR VAVLEVQNKK LIEELETLKD

ICSPKTD
Length:357
Mass (Da):38,516
Last modified:September 22, 2009 - v2
Checksum:i0B387B7247113088
GO
Isoform 2 (identifier: P27699-2) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:245
Mass (Da):27,473
Checksum:iA508BB074EAEA8A6
GO
Isoform 3 (identifier: P27699-3) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-245: Missing.
     246-246: D → N

Show »
Length:245
Mass (Da):27,389
Checksum:iF85FB7D3B0451514
GO
Isoform 4 (identifier: P27699-4) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T

Show »
Length:233
Mass (Da):26,123
Checksum:i9645439A10824456
GO
Isoform 5 (identifier: P27699-5) [UniParc]FASTAAdd to basket
Also known as: Tau Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     246-257: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:345
Mass (Da):37,303
Checksum:i508E5448D03B5F8D
GO
Isoform 6 (identifier: P27699-6) [UniParc]FASTAAdd to basket
Also known as: Tau 2 Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:308
Mass (Da):33,698
Checksum:i438CD86068BA7DAF
GO
Isoform 7 (identifier: P27699-7) [UniParc]FASTAAdd to basket
Also known as: Tau 1 Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     183-245: Missing.
     246-246: D → N
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:294
Mass (Da):32,376
Checksum:iC637D53AC9A9BCF8
GO
Isoform 8 (identifier: P27699-8) [UniParc]FASTAAdd to basket
Also known as: Tau 1 Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:282
Mass (Da):31,109
Checksum:i46A1DA7CDA89F4B5
GO
Isoform 9 (identifier: P27699-9) [UniParc]FASTAAdd to basket
Also known as: Tau 1 Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     183-257: Missing.
     258-258: A → T

Show »
Length:282
Mass (Da):31,025
Checksum:i1BF6D6A824624907
GO
Isoform 10 (identifier: P27699-10) [UniParc]FASTAAdd to basket
Also known as: Alpha Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     55-103: Missing.
     183-257: Missing.
     258-258: A → T
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Show »
Length:233
Mass (Da):26,207
Checksum:iCB124F4EEE69F9E4
GO
Isoform 11 (identifier: P27699-11) [UniParc]FASTAAdd to basket
Also known as: Icer Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: MSKCGRKKYM...FVPGSQVVVQ → MAVTGDET
     314-357: KECRRRKKEY...LKDICSPKTD → RECRRKKKEY...LKDLYCHKAE

Note: Produced by alternative promoter usage.
Show »
Length:120
Mass (Da):13,437
Checksum:i6A84CA55E6C049F1
GO

Computationally mapped potential isoform sequencesi

There are 28 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PV35E9PV35_MOUSE
cAMP-responsive element modulator
Crem
304Annotation score:
D3Z7M6D3Z7M6_MOUSE
cAMP-responsive element modulator
Crem
329Annotation score:
D3Z011D3Z011_MOUSE
cAMP-responsive element modulator
Crem
280Annotation score:
D3Z326D3Z326_MOUSE
cAMP-responsive element modulator
Crem
102Annotation score:
D3YXV5D3YXV5_MOUSE
cAMP-responsive element modulator
Crem
296Annotation score:
F6VJ22F6VJ22_MOUSE
cAMP-responsive element modulator
Crem
113Annotation score:
F6QWT6F6QWT6_MOUSE
cAMP-responsive element modulator
Crem
125Annotation score:
D3Z2U7D3Z2U7_MOUSE
cAMP-responsive element modulator
Crem
341Annotation score:
D3Z6A5D3Z6A5_MOUSE
cAMP-responsive element modulator
Crem
119Annotation score:
E9PWV9E9PWV9_MOUSE
cAMP-responsive element modulator
Crem
304Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence AAA17495 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA17496 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA17497 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAV28551 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAV28552 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAV28553 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAV28554 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAV28555 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAV28556 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559871 – 245MSKCG…QVVVQ → MAVTGDET in isoform 11. 1 PublicationAdd BLAST245
Alternative sequenceiVSP_00060255 – 103Missing in isoform 2, isoform 3, isoform 4, isoform 6 and isoform 10. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_000605183 – 257Missing in isoform 4, isoform 8, isoform 9 and isoform 10. 2 PublicationsAdd BLAST75
Alternative sequenceiVSP_000603183 – 245Missing in isoform 2, isoform 3 and isoform 7. 2 PublicationsAdd BLAST63
Alternative sequenceiVSP_038016246 – 257Missing in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_000604246D → N in isoform 2, isoform 3 and isoform 7. 2 Publications1
Alternative sequenceiVSP_000606258A → T in isoform 4, isoform 8, isoform 9 and isoform 10. 2 Publications1
Alternative sequenceiVSP_000607314 – 357KECRR…SPKTD → RECRRKKKEYVKCLENRVAV LENQNKTLIEELKALKDLYC HKAE in isoform 2, isoform 5, isoform 6, isoform 7, isoform 8, isoform 10 and isoform 11. 3 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311667 mRNA Translation: CAC34846.1
AC117589 Genomic DNA No translation available.
M60285 mRNA Translation: AAA17495.1 Different initiation.
M60285 mRNA Translation: AAA17496.1 Different initiation.
M60285 mRNA Translation: AAA17497.1 Different initiation.
AY738715 mRNA Translation: AAV28551.1 Different initiation.
AY738716 mRNA Translation: AAV28552.1 Different initiation.
AY738717 mRNA Translation: AAV28553.1 Different initiation.
AY738718 mRNA Translation: AAV28554.1 Different initiation.
AY738719 mRNA Translation: AAV28555.1 Different initiation.
AY738721 mRNA Translation: AAV28556.1 Different initiation.
CCDSiCCDS29031.2 [P27699-2]
CCDS50214.1 [P27699-7]
CCDS50215.1 [P27699-1]
CCDS70862.1 [P27699-6]
CCDS70863.1 [P27699-8]
CCDS70864.1 [P27699-5]
PIRiA37944
B37944
C37944
S20827
RefSeqiNP_001104320.1, NM_001110850.2 [P27699-10]
NP_001104324.2, NM_001110854.1
NP_001104325.2, NM_001110855.1
NP_001104326.1, NM_001110856.2 [P27699-7]
NP_001104327.1, NM_001110857.2 [P27699-3]
NP_001104328.1, NM_001110858.2 [P27699-4]
NP_001104329.1, NM_001110859.2 [P27699-1]
NP_001258432.1, NM_001271503.1 [P27699-9]
NP_001258433.1, NM_001271504.1 [P27699-8]
NP_001258434.1, NM_001271505.1 [P27699-6]
NP_001258435.1, NM_001271506.1 [P27699-5]
NP_038526.2, NM_013498.3 [P27699-2]
XP_006525618.1, XM_006525555.3 [P27699-1]
XP_006525619.1, XM_006525556.3 [P27699-5]
XP_006525624.1, XM_006525561.3 [P27699-6]
XP_006525628.1, XM_006525565.3 [P27699-7]
XP_006525630.1, XM_006525567.3 [P27699-8]
XP_006525631.1, XM_006525568.3 [P27699-9]
XP_006525636.1, XM_006525573.3 [P27699-2]
XP_006525637.1, XM_006525574.3 [P27699-3]
XP_006525638.1, XM_006525575.3 [P27699-10]
XP_006525639.1, XM_006525576.3 [P27699-4]
UniGeneiMm.5244

Genome annotation databases

EnsembliENSMUST00000025069; ENSMUSP00000025069; ENSMUSG00000063889 [P27699-5]
ENSMUST00000082141; ENSMUSP00000080780; ENSMUSG00000063889 [P27699-6]
ENSMUST00000150235; ENSMUSP00000121233; ENSMUSG00000063889 [P27699-1]
ENSMUST00000154135; ENSMUSP00000122051; ENSMUSG00000063889 [P27699-2]
ENSMUST00000154470; ENSMUSP00000118128; ENSMUSG00000063889 [P27699-8]
ENSMUST00000165086; ENSMUSP00000127353; ENSMUSG00000063889 [P27699-7]
GeneIDi12916
KEGGimmu:12916
UCSCiuc008dxp.2 mouse [P27699-8]
uc008dxq.2 mouse [P27699-9]
uc008dxr.2 mouse [P27699-5]
uc008dxs.2 mouse [P27699-6]
uc033hfn.1 mouse [P27699-1]
uc033hfo.1 mouse [P27699-4]
uc033hfp.1 mouse [P27699-7]
uc033hfq.1 mouse [P27699-2]
uc033hfr.1 mouse [P27699-3]
uc033hfs.1 mouse [P27699-10]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311667 mRNA Translation: CAC34846.1
AC117589 Genomic DNA No translation available.
M60285 mRNA Translation: AAA17495.1 Different initiation.
M60285 mRNA Translation: AAA17496.1 Different initiation.
M60285 mRNA Translation: AAA17497.1 Different initiation.
AY738715 mRNA Translation: AAV28551.1 Different initiation.
AY738716 mRNA Translation: AAV28552.1 Different initiation.
AY738717 mRNA Translation: AAV28553.1 Different initiation.
AY738718 mRNA Translation: AAV28554.1 Different initiation.
AY738719 mRNA Translation: AAV28555.1 Different initiation.
AY738721 mRNA Translation: AAV28556.1 Different initiation.
CCDSiCCDS29031.2 [P27699-2]
CCDS50214.1 [P27699-7]
CCDS50215.1 [P27699-1]
CCDS70862.1 [P27699-6]
CCDS70863.1 [P27699-8]
CCDS70864.1 [P27699-5]
PIRiA37944
B37944
C37944
S20827
RefSeqiNP_001104320.1, NM_001110850.2 [P27699-10]
NP_001104324.2, NM_001110854.1
NP_001104325.2, NM_001110855.1
NP_001104326.1, NM_001110856.2 [P27699-7]
NP_001104327.1, NM_001110857.2 [P27699-3]
NP_001104328.1, NM_001110858.2 [P27699-4]
NP_001104329.1, NM_001110859.2 [P27699-1]
NP_001258432.1, NM_001271503.1 [P27699-9]
NP_001258433.1, NM_001271504.1 [P27699-8]
NP_001258434.1, NM_001271505.1 [P27699-6]
NP_001258435.1, NM_001271506.1 [P27699-5]
NP_038526.2, NM_013498.3 [P27699-2]
XP_006525618.1, XM_006525555.3 [P27699-1]
XP_006525619.1, XM_006525556.3 [P27699-5]
XP_006525624.1, XM_006525561.3 [P27699-6]
XP_006525628.1, XM_006525565.3 [P27699-7]
XP_006525630.1, XM_006525567.3 [P27699-8]
XP_006525631.1, XM_006525568.3 [P27699-9]
XP_006525636.1, XM_006525573.3 [P27699-2]
XP_006525637.1, XM_006525574.3 [P27699-3]
XP_006525638.1, XM_006525575.3 [P27699-10]
XP_006525639.1, XM_006525576.3 [P27699-4]
UniGeneiMm.5244

3D structure databases

ProteinModelPortaliP27699
SMRiP27699
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198877, 6 interactors
IntActiP27699, 3 interactors
STRINGi10090.ENSMUSP00000121233

PTM databases

iPTMnetiP27699
PhosphoSitePlusiP27699

Proteomic databases

MaxQBiP27699
PaxDbiP27699
PRIDEiP27699

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025069; ENSMUSP00000025069; ENSMUSG00000063889 [P27699-5]
ENSMUST00000082141; ENSMUSP00000080780; ENSMUSG00000063889 [P27699-6]
ENSMUST00000150235; ENSMUSP00000121233; ENSMUSG00000063889 [P27699-1]
ENSMUST00000154135; ENSMUSP00000122051; ENSMUSG00000063889 [P27699-2]
ENSMUST00000154470; ENSMUSP00000118128; ENSMUSG00000063889 [P27699-8]
ENSMUST00000165086; ENSMUSP00000127353; ENSMUSG00000063889 [P27699-7]
GeneIDi12916
KEGGimmu:12916
UCSCiuc008dxp.2 mouse [P27699-8]
uc008dxq.2 mouse [P27699-9]
uc008dxr.2 mouse [P27699-5]
uc008dxs.2 mouse [P27699-6]
uc033hfn.1 mouse [P27699-1]
uc033hfo.1 mouse [P27699-4]
uc033hfp.1 mouse [P27699-7]
uc033hfq.1 mouse [P27699-2]
uc033hfr.1 mouse [P27699-3]
uc033hfs.1 mouse [P27699-10]

Organism-specific databases

CTDi1390
MGIiMGI:88495 Crem

Phylogenomic databases

eggNOGiKOG3584 Eukaryota
ENOG410ZZJZ LUCA
GeneTreeiENSGT00390000008655
HOGENOMiHOG000007365
HOVERGENiHBG053150
InParanoidiP27699
KOiK09052
OrthoDBiEOG091G0FTJ
PhylomeDBiP27699
TreeFamiTF106464

Miscellaneous databases

ChiTaRSiCrem mouse
PROiPR:P27699
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063889 Expressed in 239 organ(s), highest expression level in testis
CleanExiMM_CREM
ExpressionAtlasiP27699 baseline and differential
GenevisibleiP27699 MM

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR003102 Coactivator_CBP_pKID
IPR001630 Leuzip_CREB
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF02173 pKID, 1 hit
PRINTSiPR00041 LEUZIPPRCREB
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
PS50953 KID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCREM_MOUSE
AccessioniPrimary (citable) accession number: P27699
Secondary accession number(s): P27698
, Q5XTP8, Q5XTP9, Q5XTQ0, Q5XTQ1, Q5XTQ2, Q5XTQ3, Q99JF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 22, 2009
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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