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Entry version 190 (12 Aug 2020)
Sequence version 2 (11 Jul 2002)
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Protein

Collagen alpha-1(VIII) chain

Gene

COL8A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.1 Publication
Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.1 Publication

Miscellaneous

Four consecutive Gly-Pro-Pro triplets are present at the C-terminus of the triple-helical region. These may provide the high thermal stability of this region.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Cell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P27658

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1442490, Collagen degradation
R-HSA-1650814, Collagen biosynthesis and modifying enzymes
R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures
R-HSA-216083, Integrin cell surface interactions
R-HSA-8948216, Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(VIII) chain
Alternative name(s):
Endothelial collagen
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL8A1
Synonyms:C3orf7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000144810.15

Human Gene Nomenclature Database

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HGNCi
HGNC:2215, COL8A1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
120251, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P27658

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1295

Open Targets

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OpenTargetsi
ENSG00000144810

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26731

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P27658, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
COL8A1

Domain mapping of disease mutations (DMDM)

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DMDMi
21903375

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000576228 – 744Collagen alpha-1(VIII) chainAdd BLAST717
ChainiPRO_0000390484572 – 744VastatinAdd BLAST173

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin.1 Publication

Keywords - PTMi

Hydroxylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P27658

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P27658

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P27658

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27658

PeptideAtlas

More...
PeptideAtlasi
P27658

PRoteomics IDEntifications database

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PRIDEi
P27658

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
54404

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P27658, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P27658

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P27658

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed primarily in the subendothelium of large blood vessels. Also expressed in arterioles and venules in muscle, heart, kidney, spleen, umbilical cord, liver and lung and is also found in connective tissue layers around hair follicles, around nerve bundles in muscle, in the dura of the optic nerve, in cornea and sclera, and in the perichondrium of cartilaginous tissues. In the kidney, expressed in mesangial cells, glomerular endothelial cells, and tubular epithelial cells. Also expressed in mast cells, and in astrocytes during the repair process. Expressed in Descemet's membrane. Specifically expressed in peritoneal fibroblasts and mesothelial cells.3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during vascular injury, in atherosclerosis and in diabetes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000144810, Expressed in pigmented layer of retina and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P27658, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P27658, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000144810, Tissue enhanced (thyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. Four homotrimers can form a tetrahedron stabilized by central interacting C-terminal NC1 trimers.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P27658
With#Exp.IntAct
ARMC5 [Q96C12]3EBI-747133,EBI-6425121
BPIFA1 [Q9NP55]3EBI-747133,EBI-953896
C11orf1 [Q9H5F2]3EBI-747133,EBI-718615
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-747133,EBI-11976299
C22orf39 [Q6P5X5]3EBI-747133,EBI-7317823
CCN3 [P48745]3EBI-747133,EBI-3904822
CEP55 [Q53EZ4]3EBI-747133,EBI-747776
CIDEB [Q9UHD4]3EBI-747133,EBI-7062247
CREB5 - isoform 3 [Q02930-3]6EBI-747133,EBI-10192698
CYSRT1 [A8MQ03]6EBI-747133,EBI-3867333
DPEP2NB [A0A0U1RQF7]3EBI-747133,EBI-18398199
FAM86C1 - isoform 2 [Q9NVL1-2]5EBI-747133,EBI-12845222
FBLN2 [P98095]3EBI-747133,EBI-947973
FBXO34 [Q9NWN3]3EBI-747133,EBI-719816
FRS3 [O43559]3EBI-747133,EBI-725515
GLRX3 [O76003]3EBI-747133,EBI-374781
GSC2 [O15499]3EBI-747133,EBI-19954058
HOXA1 [P49639]6EBI-747133,EBI-740785
INCA1 [Q0VD86]9EBI-747133,EBI-6509505
KLHL20 [Q9BS75]3EBI-747133,EBI-10693436
KPRP [Q5T749]3EBI-747133,EBI-10981970
KRT37 [O76014]3EBI-747133,EBI-1045716
KRT40 [Q6A162]3EBI-747133,EBI-10171697
KRT82 [Q9NSB4]3EBI-747133,EBI-1045341
KRTAP10-7 [P60409]3EBI-747133,EBI-10172290
KRTAP10-8 [P60410]8EBI-747133,EBI-10171774
KRTAP12-3 [P60328]3EBI-747133,EBI-11953334
KRTAP13-3 [Q3SY46]3EBI-747133,EBI-10241252
KRTAP19-2 [Q3LHN2]3EBI-747133,EBI-12196745
KRTAP19-5 [Q3LI72]3EBI-747133,EBI-1048945
KRTAP19-7 [Q3SYF9]3EBI-747133,EBI-10241353
KRTAP26-1 [Q6PEX3]4EBI-747133,EBI-3957672
KRTAP3-2 [Q9BYR7]3EBI-747133,EBI-751260
KRTAP5-6 [Q6L8G9]3EBI-747133,EBI-10250562
KRTAP5-7 [Q6L8G8]3EBI-747133,EBI-11987425
KRTAP5-9 [P26371]3EBI-747133,EBI-3958099
KRTAP6-2 [Q3LI66]5EBI-747133,EBI-11962084
KRTAP9-2 [Q9BYQ4]3EBI-747133,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-747133,EBI-1043191
LIMS1 - isoform 3 [P48059-3]3EBI-747133,EBI-12864460
MAJIN - isoform 1 [Q3KP22-3]3EBI-747133,EBI-18015780
NADSYN1 [Q6IA69]3EBI-747133,EBI-748610
NOTCH2NLA [Q7Z3S9]3EBI-747133,EBI-945833
NOTCH2NLC [P0DPK4]5EBI-747133,EBI-22310682
OTX1 [P32242]3EBI-747133,EBI-740446
PLSCR3 [Q9NRY6]3EBI-747133,EBI-750734
POF1B - isoform 1 [Q8WVV4-1]3EBI-747133,EBI-11986735
POU4F2 [Q12837]5EBI-747133,EBI-17236143
RBPMS - isoform C [Q93062-3]3EBI-747133,EBI-740343
REL [Q04864]3EBI-747133,EBI-307352
RGS20 - isoform 5 [O76081-6]3EBI-747133,EBI-10178530
RHBDD2 - isoform 3 [Q6NTF9-3]3EBI-747133,EBI-17589229
SLC35A2 - isoform 3 [P78381-3]3EBI-747133,EBI-13307533
SMRP1 [Q8NCR6]3EBI-747133,EBI-10269322
SP4 [Q02446]3EBI-747133,EBI-10198587
SPATA8 [Q6RVD6]3EBI-747133,EBI-8635958
SPRY4 [Q9C004]3EBI-747133,EBI-354861
TRIM35 - isoform 2 [Q9UPQ4-2]3EBI-747133,EBI-17716262
UBQLN2 [Q9UHD9]3EBI-747133,EBI-947187
VAC14 [Q08AM6]7EBI-747133,EBI-2107455
WFDC5 [Q8TCV5]3EBI-747133,EBI-12175871
ZNF774 [Q6NX45]3EBI-747133,EBI-10251462
ZNHIT1 [O43257]3EBI-747133,EBI-347522

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
107692, 22 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1745, Collagen type VIII trimer variant 1
CPX-1746, Collagen type VIII trimer variant 2

Protein interaction database and analysis system

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IntActi
P27658, 70 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000261037

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P27658, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27658

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini611 – 744C1qPROSITE-ProRule annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 117Nonhelical region (NC2)Add BLAST89
Regioni118 – 571Triple-helical region (COL1)Add BLAST454
Regioni572 – 744Nonhelical region (NC1)Add BLAST173

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QRFR, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158272

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_001074_21_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P27658

KEGG Orthology (KO)

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KOi
K23455

Identification of Orthologs from Complete Genome Data

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OMAi
HNGNQDY

Database of Orthologous Groups

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OrthoDBi
1167208at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P27658

TreeFam database of animal gene trees

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TreeFami
TF334029

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.40, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001073, C1q_dom
IPR008160, Collagen
IPR008983, Tumour_necrosis_fac-like_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00386, C1q, 1 hit
PF01391, Collagen, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00007, COMPLEMNTC1Q

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00110, C1Q, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49842, SSF49842, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50871, C1Q, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P27658-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLPGPLQL LGVLLTISLS SIRLIQAGAY YGIKPLPPQI PPQMPPQIPQ
60 70 80 90 100
YQPLGQQVPH MPLAKDGLAM GKEMPHLQYG KEYPHLPQYM KEIQPAPRMG
110 120 130 140 150
KEAVPKKGKE IPLASLRGEQ GPRGEPGPRG PPGPPGLPGH GIPGIKGKPG
160 170 180 190 200
PQGYPGVGKP GMPGMPGKPG AMGMPGAKGE IGQKGEIGPM GIPGPQGPPG
210 220 230 240 250
PHGLPGIGKP GGPGLPGQPG PKGDRGPKGL PGPQGLRGPK GDKGFGMPGA
260 270 280 290 300
PGVKGPPGMH GPPGPVGLPG VGKPGVTGFP GPQGPLGKPG APGEPGPQGP
310 320 330 340 350
IGVPGVQGPP GIPGIGKPGQ DGIPGQPGFP GGKGEQGLPG LPGPPGLPGI
360 370 380 390 400
GKPGFPGPKG DRGMGGVPGA LGPRGEKGPI GAPGIGGPPG EPGLPGIPGP
410 420 430 440 450
MGPPGAIGFP GPKGEGGIVG PQGPPGPKGE PGLQGFPGKP GFLGEVGPPG
460 470 480 490 500
MRGLPGPIGP KGEAGQKGVP GLPGVPGLLG PKGEPGIPGD QGLQGPPGIP
510 520 530 540 550
GIGGPSGPIG PPGIPGPKGE PGLPGPPGFP GIGKPGVAGL HGPPGKPGAL
560 570 580 590 600
GPQGQPGLPG PPGPPGPPGP PAVMPPTPPP QGEYLPDMGL GIDGVKPPHA
610 620 630 640 650
YGAKKGKNGG PAYEMPAFTA ELTAPFPPVG APVKFNKLLY NGRQNYNPQT
660 670 680 690 700
GIFTCEVPGV YYFAYHVHCK GGNVWVALFK NNEPVMYTYD EYKKGFLDQA
710 720 730 740
SGSAVLLLRP GDRVFLQMPS EQAAGLYAGQ YVHSSFSGYL LYPM
Length:744
Mass (Da):73,364
Last modified:July 11, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2BC1B0955DE2C9A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZI0A0A087WZI0_HUMAN
Collagen alpha-1(VIII) chain
COL8A1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTN9C9JTN9_HUMAN
Collagen alpha-1(VIII) chain
COL8A1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti262P → L in CAA40748 (PubMed:2029894).Curated1
Sequence conflicti297P → R in CAA40748 (PubMed:2029894).Curated1
Sequence conflicti344P → A in CAA40748 (PubMed:2029894).Curated1
Sequence conflicti382A → S in CAA40748 (PubMed:2029894).Curated1
Sequence conflicti388P → S in CAA40748 (PubMed:2029894).Curated1
Sequence conflicti454L → F in CAA40748 (PubMed:2029894).Curated1
Sequence conflicti464A → H in CAA40748 (PubMed:2029894).Curated1
Sequence conflicti601Y → T in CAA40748 (PubMed:2029894).Curated1
Sequence conflicti631A → G in CAA40748 (PubMed:2029894).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X57527 mRNA Translation: CAA40748.1
BT009917 mRNA Translation: AAP88919.1
CH471052 Genomic DNA Translation: EAW79837.1
CH471052 Genomic DNA Translation: EAW79838.1
CH471052 Genomic DNA Translation: EAW79840.1
BC013581 mRNA Translation: AAH13581.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2934.1

Protein sequence database of the Protein Information Resource

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PIRi
S15435

NCBI Reference Sequences

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RefSeqi
NP_001841.2, NM_001850.4
NP_065084.2, NM_020351.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261037; ENSP00000261037; ENSG00000144810
ENST00000273342; ENSP00000273342; ENSG00000144810
ENST00000652472; ENSP00000498483; ENSG00000144810

Database of genes from NCBI RefSeq genomes

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GeneIDi
1295

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1295

UCSC genome browser

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UCSCi
uc003dtg.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57527 mRNA Translation: CAA40748.1
BT009917 mRNA Translation: AAP88919.1
CH471052 Genomic DNA Translation: EAW79837.1
CH471052 Genomic DNA Translation: EAW79838.1
CH471052 Genomic DNA Translation: EAW79840.1
BC013581 mRNA Translation: AAH13581.1
CCDSiCCDS2934.1
PIRiS15435
RefSeqiNP_001841.2, NM_001850.4
NP_065084.2, NM_020351.3

3D structure databases

SMRiP27658
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107692, 22 interactors
ComplexPortaliCPX-1745, Collagen type VIII trimer variant 1
CPX-1746, Collagen type VIII trimer variant 2
IntActiP27658, 70 interactors
STRINGi9606.ENSP00000261037

PTM databases

GlyGeniP27658, 1 site, 1 O-linked glycan (1 site)
iPTMnetiP27658
PhosphoSitePlusiP27658

Polymorphism and mutation databases

BioMutaiCOL8A1
DMDMi21903375

Proteomic databases

EPDiP27658
jPOSTiP27658
MassIVEiP27658
PaxDbiP27658
PeptideAtlasiP27658
PRIDEiP27658
ProteomicsDBi54404

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32194, 186 antibodies

The DNASU plasmid repository

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DNASUi
1295

Genome annotation databases

EnsembliENST00000261037; ENSP00000261037; ENSG00000144810
ENST00000273342; ENSP00000273342; ENSG00000144810
ENST00000652472; ENSP00000498483; ENSG00000144810
GeneIDi1295
KEGGihsa:1295
UCSCiuc003dtg.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1295
DisGeNETi1295
EuPathDBiHostDB:ENSG00000144810.15

GeneCards: human genes, protein and diseases

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GeneCardsi
COL8A1
HGNCiHGNC:2215, COL8A1
HPAiENSG00000144810, Tissue enhanced (thyroid)
MIMi120251, gene
neXtProtiNX_P27658
OpenTargetsiENSG00000144810
PharmGKBiPA26731

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QRFR, Eukaryota
GeneTreeiENSGT00940000158272
HOGENOMiCLU_001074_21_0_1
InParanoidiP27658
KOiK23455
OMAiHNGNQDY
OrthoDBi1167208at2759
PhylomeDBiP27658
TreeFamiTF334029

Enzyme and pathway databases

PathwayCommonsiP27658
ReactomeiR-HSA-1442490, Collagen degradation
R-HSA-1650814, Collagen biosynthesis and modifying enzymes
R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures
R-HSA-216083, Integrin cell surface interactions
R-HSA-8948216, Collagen chain trimerization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
1295, 2 hits in 865 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COL8A1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Collagen,_type_VIII,_alpha_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1295
PharosiP27658, Tbio

Protein Ontology

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PROi
PR:P27658
RNActiP27658, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144810, Expressed in pigmented layer of retina and 191 other tissues
ExpressionAtlasiP27658, baseline and differential
GenevisibleiP27658, HS

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073, C1q_dom
IPR008160, Collagen
IPR008983, Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00386, C1q, 1 hit
PF01391, Collagen, 2 hits
PRINTSiPR00007, COMPLEMNTC1Q
SMARTiView protein in SMART
SM00110, C1Q, 1 hit
SUPFAMiSSF49842, SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871, C1Q, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO8A1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27658
Secondary accession number(s): D3DN42, Q53XI6, Q96D07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 11, 2002
Last modified: August 12, 2020
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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