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Protein

60S ribosomal protein L10

Gene

RPL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788).1 Publication2 Publications

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: MGI
  • translation regulator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein, Ribosomal protein
Biological processTranslation regulation

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP27635

Protein family/group databases

MoonProtiP27635

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L10Curated
Alternative name(s):
Laminin receptor homolog
Large ribosomal subunit protein uL161 Publication
Protein QM
Ribosomal protein L10Imported
Tumor suppressor QM
Gene namesi
Name:RPL10Imported
Synonyms:DXS648E, QM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147403.16
HGNCiHGNC:10298 RPL10
MIMi312173 gene
neXtProtiNX_P27635

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Autism, X-linked 5 (AUTSX5)3 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms.
Disease descriptionA complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
See also OMIM:300847
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027795206L → M in AUTSX5; associated with disease susceptibility; no effect on function; rescues embryonic brain development when expressed in a zebrafish heterologous system. 2 Publications1
Natural variantiVAR_027796213H → Q in AUTSX5; associated with disease susceptibility; no effect on function; rescues embryonic brain development when expressed in a zebrafish heterologous system. 3 Publications1
Mental retardation, X-linked, syndromic, 35 (MRXS35)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
See also OMIM:300998
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07928864A → V in MRXS35; increased the formation of actively translating ribosomes when expressed in a yeast heterologous system. 1 Publication1
Natural variantiVAR_07928978K → E in MRXS35; loss of function; fails to rescue embryonic brain development when expressed in a zebrafish heterologous system. 1 Publication1
Natural variantiVAR_079290161G → S in MRXS35; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Autism, Autism spectrum disorder, Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi6134
GeneReviewsiRPL10
MalaCardsiRPL10
MIMi300847 phenotype
300998 phenotype
Orphaneti459070 X-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome
435938 X-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome
PharmGKBiPA34660

Polymorphism and mutation databases

BioMutaiRPL10
DMDMi148887414

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001471052 – 21460S ribosomal protein L10Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32CitrullineBy similarity1
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP27635
MaxQBiP27635
PaxDbiP27635
PeptideAtlasiP27635
PRIDEiP27635
ProteomicsDBi54403
TopDownProteomicsiP27635

PTM databases

iPTMnetiP27635
PhosphoSitePlusiP27635
SwissPalmiP27635

Miscellaneous databases

PMAP-CutDBiP27635

Expressioni

Developmental stagei

Down-regulated during adipocyte, kidney, and heart differentiation.

Gene expression databases

BgeeiENSG00000147403 Expressed in 125 organ(s), highest expression level in right ovary
CleanExiHS_RPL10
ExpressionAtlasiP27635 baseline and differential
GenevisibleiP27635 HS

Organism-specific databases

HPAiCAB010339
HPA011311

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRCP129316EBI-352398,EBI-621482

Protein-protein interaction databases

BioGridi112054, 374 interactors
CORUMiP27635
DIPiDIP-1133N
IntActiP27635, 300 interactors
MINTiP27635
STRINGi9606.ENSP00000341730

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP27635
SMRiP27635
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27635

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0857 Eukaryota
COG0197 LUCA
HOVERGENiHBG002287
InParanoidiP27635
KOiK02866
OrthoDBiEOG091G0H9M
PhylomeDBiP27635
TreeFamiTF300082

Family and domain databases

CDDicd01433 Ribosomal_L16_L10e, 1 hit
Gene3Di3.90.1170.10, 1 hit
InterProiView protein in InterPro
IPR001197 Ribosomal_L10e
IPR016180 Ribosomal_L10e/L16
IPR036920 Ribosomal_L10e/L16_sf
IPR018255 Ribosomal_L10e_CS
PANTHERiPTHR11726 PTHR11726, 1 hit
PfamiView protein in Pfam
PF00252 Ribosomal_L16, 1 hit
PIRSFiPIRSF005590 Ribosomal_L10, 1 hit
SUPFAMiSSF54686 SSF54686, 1 hit
TIGRFAMsiTIGR00279 uL16_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS01257 RIBOSOMAL_L10E, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P27635-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG
60 70 80 90 100
HMVSDEYEQL SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN
110 120 130 140 150
KMLSCAGADR LQTGMRGAFG KPQGTVARVH IGQVIMSIRT KLQNKEHVIE
160 170 180 190 200
ALRRAKFKFP GRQKIHISKK WGFTKFNADE FEDMVAEKRL IPDGCGVKYI
210
PNRGPLDKWR ALHS
Length:214
Mass (Da):24,604
Last modified:June 12, 2007 - v4
Checksum:i0860CECC91DF74FE
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WV22A0A087WV22_HUMAN
60S ribosomal protein L10
RPL10
178Annotation score:
X1WI28X1WI28_HUMAN
60S ribosomal protein L10
RPL10
200Annotation score:
F8W7C6F8W7C6_HUMAN
60S ribosomal protein L10
RPL10
163Annotation score:
B8A6G2B8A6G2_HUMAN
60S ribosomal protein L10
RPL10
108Annotation score:
A6QRI9A6QRI9_HUMAN
60S ribosomal protein L10
RPL10
181Annotation score:
H7C123H7C123_HUMAN
60S ribosomal protein L10
RPL10
91Annotation score:
H7C2C5H7C2C5_HUMAN
60S ribosomal protein L10
RPL10
131Annotation score:
H7C2U2H7C2U2_HUMAN
60S ribosomal protein L10
RPL10
28Annotation score:

Sequence cautioni

The sequence AAB22173 differs from that shown. Reason: Frameshift at position 124.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23Missing in AAL88713 (PubMed:12138090).Curated1
Sequence conflicti157F → L in BAD97029 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07928864A → V in MRXS35; increased the formation of actively translating ribosomes when expressed in a yeast heterologous system. 1 Publication1
Natural variantiVAR_07928978K → E in MRXS35; loss of function; fails to rescue embryonic brain development when expressed in a zebrafish heterologous system. 1 Publication1
Natural variantiVAR_079290161G → S in MRXS35; unknown pathological significance. 1 Publication1
Natural variantiVAR_006922202N → S Polymorphism; rescued embryonic brain development when expressed in a zebrafish heterologous system. 11 PublicationsCorresponds to variant dbSNP:rs4909Ensembl.1
Natural variantiVAR_027795206L → M in AUTSX5; associated with disease susceptibility; no effect on function; rescues embryonic brain development when expressed in a zebrafish heterologous system. 2 Publications1
Natural variantiVAR_027796213H → Q in AUTSX5; associated with disease susceptibility; no effect on function; rescues embryonic brain development when expressed in a zebrafish heterologous system. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64241 mRNA Translation: AAA63253.1
M81806 Genomic DNA Translation: AAA36021.1
M73791 mRNA Translation: AAA36378.1
S64169, S64168 Genomic DNA Translation: AAB27665.1
AF486812 mRNA Translation: AAL88713.1
DQ369703 mRNA Translation: ABC88559.1
DQ369704 mRNA Translation: ABC88560.1
DQ369705 mRNA Translation: ABC88561.1
DQ369706 mRNA Translation: ABC88562.1
DQ369707 mRNA Translation: ABC88563.1
DQ369708 mRNA Translation: ABC88564.1
DQ369709 mRNA Translation: ABC88565.1
DQ369710 mRNA Translation: ABC88566.1
DQ369711 mRNA Translation: ABC88567.1
DQ369712 mRNA Translation: ABC88568.1
DQ369713 mRNA Translation: ABC88569.1
DQ369714 mRNA Translation: ABC88570.1
DQ369715 mRNA Translation: ABC88571.1
DQ369716 mRNA Translation: ABC88572.1
CR456797 mRNA Translation: CAG33078.1
CR542069 mRNA Translation: CAG46866.1
AK223309 mRNA Translation: BAD97029.1
L44140 Genomic DNA Translation: AAA92646.1
BX936346 Genomic DNA No translation available.
BX936347 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72737.1
CH471172 Genomic DNA Translation: EAW72739.1
BC003358 mRNA Translation: AAH03358.1
BC026276 mRNA Translation: AAH26276.1
BC071918 mRNA Translation: AAH71918.1
S35960 mRNA Translation: AAB22173.1 Frameshift.
AB007170 Genomic DNA Translation: BAA28595.1
CCDSiCCDS14746.1
PIRiA42735
RefSeqiNP_001243506.2, NM_001256577.2
NP_001243509.2, NM_001256580.2
NP_001290553.1, NM_001303624.1
NP_001290554.1, NM_001303625.1
NP_001290555.1, NM_001303626.1
NP_006004.3, NM_006013.4
UniGeneiHs.534404
Hs.739235

Genome annotation databases

EnsembliENST00000344746; ENSP00000341730; ENSG00000147403
ENST00000369817; ENSP00000358832; ENSG00000147403
ENST00000424325; ENSP00000413436; ENSG00000147403
GeneIDi6134
KEGGihsa:6134

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64241 mRNA Translation: AAA63253.1
M81806 Genomic DNA Translation: AAA36021.1
M73791 mRNA Translation: AAA36378.1
S64169, S64168 Genomic DNA Translation: AAB27665.1
AF486812 mRNA Translation: AAL88713.1
DQ369703 mRNA Translation: ABC88559.1
DQ369704 mRNA Translation: ABC88560.1
DQ369705 mRNA Translation: ABC88561.1
DQ369706 mRNA Translation: ABC88562.1
DQ369707 mRNA Translation: ABC88563.1
DQ369708 mRNA Translation: ABC88564.1
DQ369709 mRNA Translation: ABC88565.1
DQ369710 mRNA Translation: ABC88566.1
DQ369711 mRNA Translation: ABC88567.1
DQ369712 mRNA Translation: ABC88568.1
DQ369713 mRNA Translation: ABC88569.1
DQ369714 mRNA Translation: ABC88570.1
DQ369715 mRNA Translation: ABC88571.1
DQ369716 mRNA Translation: ABC88572.1
CR456797 mRNA Translation: CAG33078.1
CR542069 mRNA Translation: CAG46866.1
AK223309 mRNA Translation: BAD97029.1
L44140 Genomic DNA Translation: AAA92646.1
BX936346 Genomic DNA No translation available.
BX936347 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72737.1
CH471172 Genomic DNA Translation: EAW72739.1
BC003358 mRNA Translation: AAH03358.1
BC026276 mRNA Translation: AAH26276.1
BC071918 mRNA Translation: AAH71918.1
S35960 mRNA Translation: AAB22173.1 Frameshift.
AB007170 Genomic DNA Translation: BAA28595.1
CCDSiCCDS14746.1
PIRiA42735
RefSeqiNP_001243506.2, NM_001256577.2
NP_001243509.2, NM_001256580.2
NP_001290553.1, NM_001303624.1
NP_001290554.1, NM_001303625.1
NP_001290555.1, NM_001303626.1
NP_006004.3, NM_006013.4
UniGeneiHs.534404
Hs.739235

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PA2X-ray2.50A/B34-182[»]
5AJ0electron microscopy3.50AI1-214[»]
ProteinModelPortaliP27635
SMRiP27635
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112054, 374 interactors
CORUMiP27635
DIPiDIP-1133N
IntActiP27635, 300 interactors
MINTiP27635
STRINGi9606.ENSP00000341730

Protein family/group databases

MoonProtiP27635

PTM databases

iPTMnetiP27635
PhosphoSitePlusiP27635
SwissPalmiP27635

Polymorphism and mutation databases

BioMutaiRPL10
DMDMi148887414

Proteomic databases

EPDiP27635
MaxQBiP27635
PaxDbiP27635
PeptideAtlasiP27635
PRIDEiP27635
ProteomicsDBi54403
TopDownProteomicsiP27635

Protocols and materials databases

DNASUi6134
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344746; ENSP00000341730; ENSG00000147403
ENST00000369817; ENSP00000358832; ENSG00000147403
ENST00000424325; ENSP00000413436; ENSG00000147403
GeneIDi6134
KEGGihsa:6134

Organism-specific databases

CTDi6134
DisGeNETi6134
EuPathDBiHostDB:ENSG00000147403.16
GeneCardsiRPL10
GeneReviewsiRPL10
H-InvDBiHIX0017152
HIX0202878
HGNCiHGNC:10298 RPL10
HPAiCAB010339
HPA011311
MalaCardsiRPL10
MIMi300847 phenotype
300998 phenotype
312173 gene
neXtProtiNX_P27635
Orphaneti459070 X-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome
435938 X-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome
PharmGKBiPA34660
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0857 Eukaryota
COG0197 LUCA
HOVERGENiHBG002287
InParanoidiP27635
KOiK02866
OrthoDBiEOG091G0H9M
PhylomeDBiP27635
TreeFamiTF300082

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP27635

Miscellaneous databases

ChiTaRSiRPL10 human
EvolutionaryTraceiP27635
GeneWikiiRPL10
GenomeRNAii6134
PMAP-CutDBiP27635
PROiPR:P27635
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147403 Expressed in 125 organ(s), highest expression level in right ovary
CleanExiHS_RPL10
ExpressionAtlasiP27635 baseline and differential
GenevisibleiP27635 HS

Family and domain databases

CDDicd01433 Ribosomal_L16_L10e, 1 hit
Gene3Di3.90.1170.10, 1 hit
InterProiView protein in InterPro
IPR001197 Ribosomal_L10e
IPR016180 Ribosomal_L10e/L16
IPR036920 Ribosomal_L10e/L16_sf
IPR018255 Ribosomal_L10e_CS
PANTHERiPTHR11726 PTHR11726, 1 hit
PfamiView protein in Pfam
PF00252 Ribosomal_L16, 1 hit
PIRSFiPIRSF005590 Ribosomal_L10, 1 hit
SUPFAMiSSF54686 SSF54686, 1 hit
TIGRFAMsiTIGR00279 uL16_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS01257 RIBOSOMAL_L10E, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL10_HUMAN
AccessioniPrimary (citable) accession number: P27635
Secondary accession number(s): A3KQT0
, D3DWW6, Q16470, Q2HXT7, Q53FH7, Q6FGN8, Q8TDA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: June 12, 2007
Last modified: November 7, 2018
This is version 196 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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