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Protein

60S ribosomal protein L10

Gene

RPL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788).1 Publication2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: MGI
  • translation regulator activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Ribonucleoprotein, Ribosomal protein
Biological processTranslation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

SIGNOR Signaling Network Open Resource

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SIGNORi
P27635

Protein family/group databases

MoonProt database of moonlighting proteins

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MoonProti
P27635

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S ribosomal protein L10Curated
Alternative name(s):
Laminin receptor homolog
Large ribosomal subunit protein uL161 Publication
Protein QM
Ribosomal protein L10Imported
Tumor suppressor QM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPL10Imported
Synonyms:DXS648E, QM
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000147403.16

Human Gene Nomenclature Database

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HGNCi
HGNC:10298 RPL10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
312173 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P27635

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autism, X-linked 5 (AUTSX5)3 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms.
Disease descriptionA complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
See also OMIM:300847
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027795206L → M in AUTSX5; associated with disease susceptibility; no effect on function; rescues embryonic brain development when expressed in a zebrafish heterologous system. 2 Publications1
Natural variantiVAR_027796213H → Q in AUTSX5; associated with disease susceptibility; no effect on function; rescues embryonic brain development when expressed in a zebrafish heterologous system. 3 Publications1
Mental retardation, X-linked, syndromic, 35 (MRXS35)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
See also OMIM:300998
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07928864A → V in MRXS35; increased the formation of actively translating ribosomes when expressed in a yeast heterologous system. 1 Publication1
Natural variantiVAR_07928978K → E in MRXS35; loss of function; fails to rescue embryonic brain development when expressed in a zebrafish heterologous system. 1 Publication1
Natural variantiVAR_079290161G → S in MRXS35; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Autism, Autism spectrum disorder, Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

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DisGeNETi
6134

MalaCards human disease database

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MalaCardsi
RPL10
MIMi300847 phenotype
300998 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
459070 X-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome
435938 X-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34660

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RPL10

Domain mapping of disease mutations (DMDM)

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DMDMi
148887414

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001471052 – 21460S ribosomal protein L10Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32CitrullineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki188Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P27635

MaxQB - The MaxQuant DataBase

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MaxQBi
P27635

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P27635

PeptideAtlas

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PeptideAtlasi
P27635

PRoteomics IDEntifications database

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PRIDEi
P27635

ProteomicsDB human proteome resource

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ProteomicsDBi
54403

Consortium for Top Down Proteomics

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TopDownProteomicsi
P27635

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P27635

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P27635

SwissPalm database of S-palmitoylation events

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SwissPalmi
P27635

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P27635

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Down-regulated during adipocyte, kidney, and heart differentiation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000147403 Expressed in 125 organ(s), highest expression level in right ovary

CleanEx database of gene expression profiles

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CleanExi
HS_RPL10

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P27635 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P27635 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB010339
HPA011311

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SRCP129316EBI-352398,EBI-621482

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112054, 377 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P27635

Database of interacting proteins

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DIPi
DIP-1133N

Protein interaction database and analysis system

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IntActi
P27635, 301 interactors

Molecular INTeraction database

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MINTi
P27635

STRING: functional protein association networks

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STRINGi
9606.ENSP00000341730

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P27635

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P27635

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P27635

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0857 Eukaryota
COG0197 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002287

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P27635

KEGG Orthology (KO)

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KOi
K02866

Database of Orthologous Groups

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OrthoDBi
EOG091G0H9M

Database for complete collections of gene phylogenies

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PhylomeDBi
P27635

TreeFam database of animal gene trees

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TreeFami
TF300082

Family and domain databases

Conserved Domains Database

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CDDi
cd01433 Ribosomal_L16_L10e, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.90.1170.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001197 Ribosomal_L10e
IPR016180 Ribosomal_L10e/L16
IPR036920 Ribosomal_L10e/L16_sf
IPR018255 Ribosomal_L10e_CS

The PANTHER Classification System

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PANTHERi
PTHR11726 PTHR11726, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00252 Ribosomal_L16, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF005590 Ribosomal_L10, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54686 SSF54686, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00279 uL16_euk_arch, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01257 RIBOSOMAL_L10E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P27635-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLCG
60 70 80 90 100
HMVSDEYEQL SSEALEAARI CANKYMVKSC GKDGFHIRVR LHPFHVIRIN
110 120 130 140 150
KMLSCAGADR LQTGMRGAFG KPQGTVARVH IGQVIMSIRT KLQNKEHVIE
160 170 180 190 200
ALRRAKFKFP GRQKIHISKK WGFTKFNADE FEDMVAEKRL IPDGCGVKYI
210
PNRGPLDKWR ALHS
Length:214
Mass (Da):24,604
Last modified:June 12, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0860CECC91DF74FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WV22A0A087WV22_HUMAN
60S ribosomal protein L10
RPL10
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X1WI28X1WI28_HUMAN
60S ribosomal protein L10
RPL10
200Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W7C6F8W7C6_HUMAN
60S ribosomal protein L10
RPL10
163Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8A6G2B8A6G2_HUMAN
60S ribosomal protein L10
RPL10
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6QRI9A6QRI9_HUMAN
60S ribosomal protein L10
RPL10
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C123H7C123_HUMAN
60S ribosomal protein L10
RPL10
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2C5H7C2C5_HUMAN
60S ribosomal protein L10
RPL10
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2U2H7C2U2_HUMAN
60S ribosomal protein L10
RPL10
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB22173 differs from that shown. Reason: Frameshift at position 124.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23Missing in AAL88713 (PubMed:12138090).Curated1
Sequence conflicti157F → L in BAD97029 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07928864A → V in MRXS35; increased the formation of actively translating ribosomes when expressed in a yeast heterologous system. 1 Publication1
Natural variantiVAR_07928978K → E in MRXS35; loss of function; fails to rescue embryonic brain development when expressed in a zebrafish heterologous system. 1 Publication1
Natural variantiVAR_079290161G → S in MRXS35; unknown pathological significance. 1 Publication1
Natural variantiVAR_006922202N → S Polymorphism; rescued embryonic brain development when expressed in a zebrafish heterologous system. 11 PublicationsCorresponds to variant dbSNP:rs4909Ensembl.1
Natural variantiVAR_027795206L → M in AUTSX5; associated with disease susceptibility; no effect on function; rescues embryonic brain development when expressed in a zebrafish heterologous system. 2 Publications1
Natural variantiVAR_027796213H → Q in AUTSX5; associated with disease susceptibility; no effect on function; rescues embryonic brain development when expressed in a zebrafish heterologous system. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M64241 mRNA Translation: AAA63253.1
M81806 Genomic DNA Translation: AAA36021.1
M73791 mRNA Translation: AAA36378.1
S64169, S64168 Genomic DNA Translation: AAB27665.1
AF486812 mRNA Translation: AAL88713.1
DQ369703 mRNA Translation: ABC88559.1
DQ369704 mRNA Translation: ABC88560.1
DQ369705 mRNA Translation: ABC88561.1
DQ369706 mRNA Translation: ABC88562.1
DQ369707 mRNA Translation: ABC88563.1
DQ369708 mRNA Translation: ABC88564.1
DQ369709 mRNA Translation: ABC88565.1
DQ369710 mRNA Translation: ABC88566.1
DQ369711 mRNA Translation: ABC88567.1
DQ369712 mRNA Translation: ABC88568.1
DQ369713 mRNA Translation: ABC88569.1
DQ369714 mRNA Translation: ABC88570.1
DQ369715 mRNA Translation: ABC88571.1
DQ369716 mRNA Translation: ABC88572.1
CR456797 mRNA Translation: CAG33078.1
CR542069 mRNA Translation: CAG46866.1
AK223309 mRNA Translation: BAD97029.1
L44140 Genomic DNA Translation: AAA92646.1
BX936346 Genomic DNA No translation available.
BX936347 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72737.1
CH471172 Genomic DNA Translation: EAW72739.1
BC003358 mRNA Translation: AAH03358.1
BC026276 mRNA Translation: AAH26276.1
BC071918 mRNA Translation: AAH71918.1
S35960 mRNA Translation: AAB22173.1 Frameshift.
AB007170 Genomic DNA Translation: BAA28595.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14746.1

Protein sequence database of the Protein Information Resource

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PIRi
A42735

NCBI Reference Sequences

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RefSeqi
NP_001243506.2, NM_001256577.2
NP_001243509.2, NM_001256580.2
NP_001290553.1, NM_001303624.1
NP_001290554.1, NM_001303625.1
NP_001290555.1, NM_001303626.1
NP_006004.3, NM_006013.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.534404
Hs.739235

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000344746; ENSP00000341730; ENSG00000147403
ENST00000369817; ENSP00000358832; ENSG00000147403
ENST00000424325; ENSP00000413436; ENSG00000147403

Database of genes from NCBI RefSeq genomes

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GeneIDi
6134

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6134

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64241 mRNA Translation: AAA63253.1
M81806 Genomic DNA Translation: AAA36021.1
M73791 mRNA Translation: AAA36378.1
S64169, S64168 Genomic DNA Translation: AAB27665.1
AF486812 mRNA Translation: AAL88713.1
DQ369703 mRNA Translation: ABC88559.1
DQ369704 mRNA Translation: ABC88560.1
DQ369705 mRNA Translation: ABC88561.1
DQ369706 mRNA Translation: ABC88562.1
DQ369707 mRNA Translation: ABC88563.1
DQ369708 mRNA Translation: ABC88564.1
DQ369709 mRNA Translation: ABC88565.1
DQ369710 mRNA Translation: ABC88566.1
DQ369711 mRNA Translation: ABC88567.1
DQ369712 mRNA Translation: ABC88568.1
DQ369713 mRNA Translation: ABC88569.1
DQ369714 mRNA Translation: ABC88570.1
DQ369715 mRNA Translation: ABC88571.1
DQ369716 mRNA Translation: ABC88572.1
CR456797 mRNA Translation: CAG33078.1
CR542069 mRNA Translation: CAG46866.1
AK223309 mRNA Translation: BAD97029.1
L44140 Genomic DNA Translation: AAA92646.1
BX936346 Genomic DNA No translation available.
BX936347 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72737.1
CH471172 Genomic DNA Translation: EAW72739.1
BC003358 mRNA Translation: AAH03358.1
BC026276 mRNA Translation: AAH26276.1
BC071918 mRNA Translation: AAH71918.1
S35960 mRNA Translation: AAB22173.1 Frameshift.
AB007170 Genomic DNA Translation: BAA28595.1
CCDSiCCDS14746.1
PIRiA42735
RefSeqiNP_001243506.2, NM_001256577.2
NP_001243509.2, NM_001256580.2
NP_001290553.1, NM_001303624.1
NP_001290554.1, NM_001303625.1
NP_001290555.1, NM_001303626.1
NP_006004.3, NM_006013.4
UniGeneiHs.534404
Hs.739235

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PA2X-ray2.50A/B34-182[»]
5AJ0electron microscopy3.50AI1-214[»]
ProteinModelPortaliP27635
SMRiP27635
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112054, 377 interactors
CORUMiP27635
DIPiDIP-1133N
IntActiP27635, 301 interactors
MINTiP27635
STRINGi9606.ENSP00000341730

Protein family/group databases

MoonProtiP27635

PTM databases

iPTMnetiP27635
PhosphoSitePlusiP27635
SwissPalmiP27635

Polymorphism and mutation databases

BioMutaiRPL10
DMDMi148887414

Proteomic databases

EPDiP27635
MaxQBiP27635
PaxDbiP27635
PeptideAtlasiP27635
PRIDEiP27635
ProteomicsDBi54403
TopDownProteomicsiP27635

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6134
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344746; ENSP00000341730; ENSG00000147403
ENST00000369817; ENSP00000358832; ENSG00000147403
ENST00000424325; ENSP00000413436; ENSG00000147403
GeneIDi6134
KEGGihsa:6134

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6134
DisGeNETi6134
EuPathDBiHostDB:ENSG00000147403.16

GeneCards: human genes, protein and diseases

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GeneCardsi
RPL10

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0017152
HIX0202878
HGNCiHGNC:10298 RPL10
HPAiCAB010339
HPA011311
MalaCardsiRPL10
MIMi300847 phenotype
300998 phenotype
312173 gene
neXtProtiNX_P27635
Orphaneti459070 X-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome
435938 X-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome
PharmGKBiPA34660

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0857 Eukaryota
COG0197 LUCA
HOVERGENiHBG002287
InParanoidiP27635
KOiK02866
OrthoDBiEOG091G0H9M
PhylomeDBiP27635
TreeFamiTF300082

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP27635

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RPL10 human
EvolutionaryTraceiP27635

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RPL10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6134
PMAP-CutDBiP27635

Protein Ontology

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PROi
PR:P27635

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147403 Expressed in 125 organ(s), highest expression level in right ovary
CleanExiHS_RPL10
ExpressionAtlasiP27635 baseline and differential
GenevisibleiP27635 HS

Family and domain databases

CDDicd01433 Ribosomal_L16_L10e, 1 hit
Gene3Di3.90.1170.10, 1 hit
InterProiView protein in InterPro
IPR001197 Ribosomal_L10e
IPR016180 Ribosomal_L10e/L16
IPR036920 Ribosomal_L10e/L16_sf
IPR018255 Ribosomal_L10e_CS
PANTHERiPTHR11726 PTHR11726, 1 hit
PfamiView protein in Pfam
PF00252 Ribosomal_L16, 1 hit
PIRSFiPIRSF005590 Ribosomal_L10, 1 hit
SUPFAMiSSF54686 SSF54686, 1 hit
TIGRFAMsiTIGR00279 uL16_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS01257 RIBOSOMAL_L10E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27635
Secondary accession number(s): A3KQT0
, D3DWW6, Q16470, Q2HXT7, Q53FH7, Q6FGN8, Q8TDA5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: June 12, 2007
Last modified: December 5, 2018
This is version 197 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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