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Entry version 209 (07 Oct 2020)
Sequence version 2 (28 Feb 2003)
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Protein

Dynamin

Gene

shi

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting.

Miscellaneous

Shibire mutation is the cause of temperature-sensitive paralysis. This is believed to be due to a reversible block of endocytosis, which prevents membrane cycling and thus depletes synaptic vesicles.
'Shibire' means 'paralyzed' in Japanese.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi33 – 41GTPBy similarity9
Nucleotide bindingi200 – 206GTPBy similarity7
Nucleotide bindingi231 – 234GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Motor protein
Biological processEndocytosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.5.5, 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1169408, ISG15 antiviral mechanism
R-DME-190873, Gap junction degradation
R-DME-196025, Formation of annular gap junctions
R-DME-432720, Lysosome Vesicle Biogenesis
R-DME-432722, Golgi Associated Vesicle Biogenesis
R-DME-437239, Recycling pathway of L1
R-DME-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynamin (EC:3.6.5.5)
Alternative name(s):
Protein shibire
dDyn
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:shi
ORF Names:CG18102
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003392, shi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi141G → S in allele shi-TS2; temperature sensitive larval and adult paralysis. 1 Publication1
Mutagenesisi268G → D in allele shi-TS1; temperature sensitive larval and adult paralysis. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002065761 – 877DynaminAdd BLAST877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei756Phosphoserine1 Publication1
Modified residuei764Phosphoserine1 Publication1
Modified residuei767Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27619

PRoteomics IDEntifications database

More...
PRIDEi
P27619

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P27619

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003392, Expressed in head and 45 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P27619, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P27619, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
69991, 54 interactors

Database of interacting proteins

More...
DIPi
DIP-17621N

Protein interaction database and analysis system

More...
IntActi
P27619, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305866

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27619

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 289Dynamin-type GPROSITE-ProRule annotationAdd BLAST267
Domaini513 – 621PHPROSITE-ProRule annotationAdd BLAST109
Domaini650 – 741GEDPROSITE-ProRule annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 40G1 motifPROSITE-ProRule annotation8
Regioni59 – 61G2 motifPROSITE-ProRule annotation3
Regioni131 – 134G3 motifPROSITE-ProRule annotation4
Regioni200 – 203G4 motifPROSITE-ProRule annotation4
Regioni230 – 233G5 motifPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi744 – 827Pro-richAdd BLAST84

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0446, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166903

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27619

KEGG Orthology (KO)

More...
KOi
K01528

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27619

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08771, DLP_1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027741, DNM1
IPR000375, Dynamin_central
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR022812, Dynamin_SF
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR11566, PTHR11566, 1 hit
PTHR11566:SF32, PTHR11566:SF32, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit
PF00169, PH, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00195, DYNAMIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P27619-1) [UniParc]FASTAAdd to basket
Also known as: 4, D, F

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSLITIVNK LQDAFTSLGV HMQLDLPQIA VVGGQSAGKS SVLENFVGKD
60 70 80 90 100
FLPRGSGIVT RRPLILQLIN GVTEYGEFLH IKGKKFSSFD EIRKEIEDET
110 120 130 140 150
DRVTGSNKGI SNIPINLRVY SPHVLNLTLI DLPGLTKVAI GDQPVDIEQQ
160 170 180 190 200
IKQMIFQFIR KETCLILAVT PANTDLANSD ALKLAKEVDP QGVRTIGVIT
210 220 230 240 250
KLDLMDEGTD ARDILENKLL PLRRGYIGVV NRSQKDIEGR KDIHQALAAE
260 270 280 290 300
RKFFLSHPSY RHMADRLGTP YLQRVLNQQL TNHIRDTLPG LRDKLQKQML
310 320 330 340 350
TLEKEVEEFK HFQPGDASIK TKAMLQMIQQ LQSDFERTIE GSGSALVNTN
360 370 380 390 400
ELSGGAKINR IFHERLRFEI VKMACDEKEL RREISFAIRN IHGIRVGLFT
410 420 430 440 450
PDMAFEAIVK RQIALLKEPV IKCVDLVVQE LSVVVRMCTA KMSRYPRLRE
460 470 480 490 500
ETERIITTHV RQREHSCKEQ ILLLIDFELA YMNTNHEDFI GFANAQNKSE
510 520 530 540 550
NANKTGTRQL GNQVIRKGHM VIQNLGIMKG GSRPYWFVLT SESISWYKDE
560 570 580 590 600
DEKEKKFMLP LDGLKLRDIE QGFMSMSRRV TFALFSPDGR NVYKDYKQLE
610 620 630 640 650
LSCETVEDVE SWKASFLRAG VYPEKQETQE NGDESASEES SSDPQLERQV
660 670 680 690 700
ETIRNLVDSY MKIVTKTTRD MVPKAIMMLI INNAKDFING ELLAHLYASG
710 720 730 740 750
DQAQMMEESA ESATRREEML RMYRACKDAL QIIGDVSMAT VSSPLPPPVK
760 770 780 790 800
NDWLPSGLDN PRLSPPSPGG VRGKPGPPAQ SSLGGRNPPL PPSTGRPAPA
810 820 830 840 850
IPNRPGGGAP PLPGGRPGGS LPPPMLPSRV SGAVGGAIVQ QSGANRYVPE
860 870
SMRGQVNQAV GQAAINELSN AFSSRFK
Length:877
Mass (Da):97,809
Last modified:February 28, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B85F96491490B14
GO
Isoform 2 (identifier: P27619-2) [UniParc]FASTAAdd to basket
Also known as: 3, A, B

The sequence of this isoform differs from the canonical sequence as follows:
     830-830: V → R
     831-877: Missing.

Show »
Length:830
Mass (Da):93,031
Checksum:iE7F891A4A849B29D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JJA4E1JJA4_DROME
Dynamin GTPase
shi anon-WO0153538.12, anon-WO0153538.13, anon-WO0153538.14, Ddyn, dDyn
883Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JJA5E1JJA5_DROME
Dynamin GTPase
shi anon-WO0153538.12, anon-WO0153538.13, anon-WO0153538.14, Ddyn, dDyn
836Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4V4I8A4V4I8_DROME
Dynamin GTPase
shi anon-WO0153538.12, anon-WO0153538.13, anon-WO0153538.14, Ddyn, dDyn
877Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PJN9M9PJN9_DROME
Dynamin GTPase
shi anon-WO0153538.12, anon-WO0153538.13, anon-WO0153538.14, Ddyn, dDyn
834Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X2JE15X2JE15_DROME
Dynamin GTPase
shi anon-WO0153538.12, anon-WO0153538.13, anon-WO0153538.14, Ddyn, dDyn
881Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4V4J0A4V4J0_DROME
Dynamin GTPase
shi anon-WO0153538.12, anon-WO0153538.13, anon-WO0153538.14, Ddyn, dDyn
830Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHQ0M9PHQ0_DROME
Dynamin GTPase
shi anon-WO0153538.12, anon-WO0153538.13, anon-WO0153538.14, Ddyn, dDyn
896Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA42061 differs from that shown. Chimeric cDNA. There is a 6 amino acid insertion at position 634 due to a chimera of DNA from chromosome arms X and 3L.Curated
The sequence CAA42067 differs from that shown. Chimeric cDNA. There is a 6 amino acid insertion at position 634 due to a chimera of DNA from chromosome arms X and 3L.Curated
The sequence CAA42068 differs from that shown. Chimeric cDNA. There is a 6 amino acid insertion at position 634 due to a chimera of DNA from chromosome arms X and 3L.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti594K → R in CAA42067 (PubMed:1828536).Curated1
Sequence conflicti594K → R in CAA42068 (PubMed:1828536).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001330830V → R in isoform 2. 2 Publications1
Alternative sequenceiVSP_001331831 – 877Missing in isoform 2. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X59448 mRNA Translation: CAA42067.1 Sequence problems.
X59449 mRNA Translation: CAA42068.1 Sequence problems.
X59435 mRNA Translation: CAA42061.1 Sequence problems.
X59436 mRNA Translation: CAA42062.1
AE014298 Genomic DNA Translation: AAF48536.2
AE014298 Genomic DNA Translation: AAS65368.1
BT010049 mRNA Translation: AAQ22518.1

Protein sequence database of the Protein Information Resource

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PIRi
S15413
S16130
S17974
S17975
S34399

NCBI Reference Sequences

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RefSeqi
NP_001036278.1, NM_001042813.2 [P27619-2]
NP_001036279.1, NM_001042814.2 [P27619-2]
NP_001162766.1, NM_001169295.1 [P27619-1]
NP_001162768.1, NM_001169297.2
NP_524853.2, NM_080114.4 [P27619-2]
NP_727910.1, NM_167470.3 [P27619-1]
NP_727911.1, NM_167471.5 [P27619-2]
NP_996465.1, NM_206742.1 [P27619-1]
NP_996466.1, NM_206743.2 [P27619-1]
NP_996467.1, NM_206744.3 [P27619-2]
NP_996468.1, NM_206745.3 [P27619-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0074118; FBpp0073928; FBgn0003392 [P27619-2]
FBtr0074119; FBpp0073929; FBgn0003392 [P27619-2]
FBtr0074121; FBpp0089278; FBgn0003392 [P27619-2]
FBtr0074122; FBpp0089279; FBgn0003392 [P27619-2]
FBtr0074123; FBpp0089280; FBgn0003392 [P27619-1]
FBtr0074124; FBpp0089277; FBgn0003392 [P27619-1]
FBtr0111036; FBpp0110335; FBgn0003392 [P27619-2]
FBtr0111037; FBpp0110336; FBgn0003392 [P27619-2]
FBtr0301594; FBpp0290809; FBgn0003392 [P27619-1]
FBtr0301595; FBpp0290810; FBgn0003392 [P27619-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
45928

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG18102

UCSC genome browser

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UCSCi
CG18102-RA, d. melanogaster [P27619-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59448 mRNA Translation: CAA42067.1 Sequence problems.
X59449 mRNA Translation: CAA42068.1 Sequence problems.
X59435 mRNA Translation: CAA42061.1 Sequence problems.
X59436 mRNA Translation: CAA42062.1
AE014298 Genomic DNA Translation: AAF48536.2
AE014298 Genomic DNA Translation: AAS65368.1
BT010049 mRNA Translation: AAQ22518.1
PIRiS15413
S16130
S17974
S17975
S34399
RefSeqiNP_001036278.1, NM_001042813.2 [P27619-2]
NP_001036279.1, NM_001042814.2 [P27619-2]
NP_001162766.1, NM_001169295.1 [P27619-1]
NP_001162768.1, NM_001169297.2
NP_524853.2, NM_080114.4 [P27619-2]
NP_727910.1, NM_167470.3 [P27619-1]
NP_727911.1, NM_167471.5 [P27619-2]
NP_996465.1, NM_206742.1 [P27619-1]
NP_996466.1, NM_206743.2 [P27619-1]
NP_996467.1, NM_206744.3 [P27619-2]
NP_996468.1, NM_206745.3 [P27619-2]

3D structure databases

SMRiP27619
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi69991, 54 interactors
DIPiDIP-17621N
IntActiP27619, 4 interactors
STRINGi7227.FBpp0305866

PTM databases

iPTMnetiP27619

Proteomic databases

PaxDbiP27619
PRIDEiP27619

Genome annotation databases

EnsemblMetazoaiFBtr0074118; FBpp0073928; FBgn0003392 [P27619-2]
FBtr0074119; FBpp0073929; FBgn0003392 [P27619-2]
FBtr0074121; FBpp0089278; FBgn0003392 [P27619-2]
FBtr0074122; FBpp0089279; FBgn0003392 [P27619-2]
FBtr0074123; FBpp0089280; FBgn0003392 [P27619-1]
FBtr0074124; FBpp0089277; FBgn0003392 [P27619-1]
FBtr0111036; FBpp0110335; FBgn0003392 [P27619-2]
FBtr0111037; FBpp0110336; FBgn0003392 [P27619-2]
FBtr0301594; FBpp0290809; FBgn0003392 [P27619-1]
FBtr0301595; FBpp0290810; FBgn0003392 [P27619-1]
GeneIDi45928
KEGGidme:Dmel_CG18102
UCSCiCG18102-RA, d. melanogaster [P27619-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
45928
FlyBaseiFBgn0003392, shi

Phylogenomic databases

eggNOGiKOG0446, Eukaryota
GeneTreeiENSGT00940000166903
InParanoidiP27619
KOiK01528
PhylomeDBiP27619

Enzyme and pathway databases

BRENDAi3.6.5.5, 1994
ReactomeiR-DME-1169408, ISG15 antiviral mechanism
R-DME-190873, Gap junction degradation
R-DME-196025, Formation of annular gap junctions
R-DME-432720, Lysosome Vesicle Biogenesis
R-DME-432722, Golgi Associated Vesicle Biogenesis
R-DME-437239, Recycling pathway of L1
R-DME-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
45928, 3 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
shi, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
45928

Protein Ontology

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PROi
PR:P27619

Gene expression databases

BgeeiFBgn0003392, Expressed in head and 45 other tissues
ExpressionAtlasiP27619, baseline and differential
GenevisibleiP27619, DM

Family and domain databases

CDDicd08771, DLP_1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR027741, DNM1
IPR000375, Dynamin_central
IPR001401, Dynamin_GTPase
IPR019762, Dynamin_GTPase_CS
IPR022812, Dynamin_SF
IPR030381, G_DYNAMIN_dom
IPR003130, GED
IPR020850, GED_dom
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR11566, PTHR11566, 1 hit
PTHR11566:SF32, PTHR11566:SF32, 1 hit
PfamiView protein in Pfam
PF01031, Dynamin_M, 1 hit
PF00350, Dynamin_N, 1 hit
PF02212, GED, 1 hit
PF00169, PH, 1 hit
PRINTSiPR00195, DYNAMIN
SMARTiView protein in SMART
SM00053, DYNc, 1 hit
SM00302, GED, 1 hit
SM00233, PH, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410, G_DYNAMIN_1, 1 hit
PS51718, G_DYNAMIN_2, 1 hit
PS51388, GED, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27619
Secondary accession number(s): Q0KHS4, Q9VXM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 28, 2003
Last modified: October 7, 2020
This is version 209 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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