Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myelin protein P0

Gene

Mpz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin protein P0
Alternative name(s):
Myelin peripheral protein
Short name:
MPP
Myelin protein zero
Gene namesi
Name:Mpz
Synonyms:P0
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103177 Mpz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 153ExtracellularBy similarityAdd BLAST124
Transmembranei154 – 179HelicalBy similarityAdd BLAST26
Topological domaini180 – 248CytoplasmicBy similarityAdd BLAST69

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000001930130 – 248Myelin protein P0Add BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 127PROSITE-ProRule annotation
Glycosylationi122N-linked (GlcNAc...) (complex) asparagineSequence analysis1
Modified residuei210Phosphoserine; by PKCBy similarity1
Modified residuei226Phosphoserine1 Publication1
Modified residuei228Phosphoserine1 Publication1
Modified residuei233Phosphoserine; by PKCBy similarity1
Modified residuei237Phosphoserine1 Publication1
Modified residuei243Phosphoserine1 Publication1

Post-translational modificationi

N-glycosylated; contains sulfate-substituted glycan.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP27573
PaxDbiP27573
PRIDEiP27573

PTM databases

iPTMnetiP27573
PhosphoSitePlusiP27573

Expressioni

Tissue specificityi

Found only in peripheral nervous system Schwann cells.

Gene expression databases

CleanExiMM_MPZ

Interactioni

Subunit structurei

Homodimer and homotetramer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084604EBI-1634589,EBI-1633915

Protein-protein interaction databases

BioGridi201482, 1 interactor
DIPiDIP-51664N
IntActiP27573, 2 interactors
STRINGi10090.ENSMUSP00000066701

Structurei

3D structure databases

ProteinModelPortaliP27573
SMRiP27573
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 143Ig-like V-typeAdd BLAST114

Sequence similaritiesi

Belongs to the myelin P0 protein family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJG4 Eukaryota
ENOG4111R0Y LUCA
HOGENOMiHOG000232144
HOVERGENiHBG096384
InParanoidiP27573
KOiK06770
PhylomeDBiP27573

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR019566 Myelin-PO_C
IPR000920 Myelin_P0-rel
IPR019738 Myelin_P0_CS
IPR029869 P0
PANTHERiPTHR13869 PTHR13869, 1 hit
PTHR13869:SF7 PTHR13869:SF7, 1 hit
PfamiView protein in Pfam
PF10570 Myelin-PO_C, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR00213 MYELINP0
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00568 MYELIN_P0, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P27573-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPGAPSSSP SPILAALLFS SLVLSPALAI VVYTDREIYG AVGSQVTLHC
60 70 80 90 100
SFWSSEWVSD DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGAFKERIQ
110 120 130 140 150
WVGDPRWKDG SIVIHNLDYS DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV
160 170 180 190 200
PTRYGVVLGA VIGGILGVVL LLLLLFYLIR YCWLRRQAAL QRRLSAMEKG
210 220 230 240
RFHKSSKDSS KRGRQTPVLY AMLDHSRSTK AASEKKSKGL GESRKDKK
Length:248
Mass (Da):27,622
Last modified:August 1, 1992 - v1
Checksum:i936D66684300CAC9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QK82E9QK82_MOUSE
Myelin protein P0
Mpz
248Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62860
, M62857, M62858, M62859 Genomic DNA Translation: AAA39867.1
AK089180 mRNA Translation: BAC40781.1
AK157960 mRNA Translation: BAE34285.1
CH466520 Genomic DNA Translation: EDL39129.1
CH466520 Genomic DNA Translation: EDL39131.1
BC139139 mRNA Translation: AAI39140.1
BC141226 mRNA Translation: AAI41227.1
CCDSiCCDS15479.1
PIRiA54662
RefSeqiNP_001302428.1, NM_001315499.1
NP_001302429.1, NM_001315500.1
NP_032649.2, NM_008623.5
UniGeneiMm.9986

Genome annotation databases

GeneIDi17528
KEGGimmu:17528

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62860
, M62857, M62858, M62859 Genomic DNA Translation: AAA39867.1
AK089180 mRNA Translation: BAC40781.1
AK157960 mRNA Translation: BAE34285.1
CH466520 Genomic DNA Translation: EDL39129.1
CH466520 Genomic DNA Translation: EDL39131.1
BC139139 mRNA Translation: AAI39140.1
BC141226 mRNA Translation: AAI41227.1
CCDSiCCDS15479.1
PIRiA54662
RefSeqiNP_001302428.1, NM_001315499.1
NP_001302429.1, NM_001315500.1
NP_032649.2, NM_008623.5
UniGeneiMm.9986

3D structure databases

ProteinModelPortaliP27573
SMRiP27573
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201482, 1 interactor
DIPiDIP-51664N
IntActiP27573, 2 interactors
STRINGi10090.ENSMUSP00000066701

PTM databases

iPTMnetiP27573
PhosphoSitePlusiP27573

Proteomic databases

MaxQBiP27573
PaxDbiP27573
PRIDEiP27573

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17528
KEGGimmu:17528

Organism-specific databases

CTDi4359
MGIiMGI:103177 Mpz

Phylogenomic databases

eggNOGiENOG410IJG4 Eukaryota
ENOG4111R0Y LUCA
HOGENOMiHOG000232144
HOVERGENiHBG096384
InParanoidiP27573
KOiK06770
PhylomeDBiP27573

Miscellaneous databases

PROiPR:P27573
SOURCEiSearch...

Gene expression databases

CleanExiMM_MPZ

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR019566 Myelin-PO_C
IPR000920 Myelin_P0-rel
IPR019738 Myelin_P0_CS
IPR029869 P0
PANTHERiPTHR13869 PTHR13869, 1 hit
PTHR13869:SF7 PTHR13869:SF7, 1 hit
PfamiView protein in Pfam
PF10570 Myelin-PO_C, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR00213 MYELINP0
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00568 MYELIN_P0, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYP0_MOUSE
AccessioniPrimary (citable) accession number: P27573
Secondary accession number(s): Q542C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again