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Entry version 158 (18 Sep 2019)
Sequence version 3 (12 Jun 2007)
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Protein

Microtubule-associated protein 4

Gene

Map4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 4
Short name:
MAP-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Map4
Synonyms:Mtap4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:97178 Map4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000727522 – 1125Microtubule-associated protein 4Add BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei5PhosphoserineBy similarity1
Modified residuei60PhosphoserineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei254PhosphoserineCombined sources1
Modified residuei260PhosphothreonineCombined sources1
Modified residuei277PhosphothreonineBy similarity1
Modified residuei349PhosphothreonineBy similarity1
Modified residuei381PhosphoserineCombined sources1
Modified residuei410PhosphothreonineBy similarity1
Modified residuei447PhosphothreonineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei494PhosphothreonineBy similarity1
Modified residuei503PhosphothreonineCombined sources1
Modified residuei506PhosphoserineCombined sources1
Modified residuei511PhosphothreonineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei519PhosphoserineBy similarity1
Modified residuei598PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei658PhosphothreonineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei684PhosphoserineBy similarity1
Modified residuei694PhosphoserineBy similarity1
Modified residuei760PhosphoserineCombined sources1
Modified residuei798PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki811Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei826PhosphoserineBy similarity1
Modified residuei901PhosphoserineCombined sources1
Modified residuei914PhosphoserineCombined sources1
Modified residuei915PhosphothreonineBy similarity1
Modified residuei973PhosphoserineBy similarity1
Modified residuei1046PhosphoserineCombined sources1
Modified residuei1118PhosphoserineBy similarity1
Modified residuei1124PhosphoserineBy similarity1
Isoform 4 (identifier: P27546-4)
Modified residuei333PhosphoserineBy similarityCurated1
Modified residuei334Phosphoserine By similarityBy similarityCurated1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-760 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 4 is phosphorylated on Ser-333 and Ser-334 (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P27546

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P27546

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P27546

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27546

PeptideAtlas

More...
PeptideAtlasi
P27546

PRoteomics IDEntifications database

More...
PRIDEi
P27546

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P27546

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P27546

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P27546

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Testis, striated and cardiac muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032479 Expressed in 300 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P27546 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P27546 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SEPTIN2; this interaction impedes tubulin-binding.

Interacts with TRAF3IP1 (PubMed:26487268).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
201586, 6 interactors

Protein interaction database and analysis system

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IntActi
P27546, 15 interactors

Molecular INTeraction database

More...
MINTi
P27546

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035055

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P27546

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati896 – 926Tau/MAP 1Add BLAST31
Repeati965 – 995Tau/MAP 2Add BLAST31
Repeati996 – 1026Tau/MAP 3Add BLAST31
Repeati1027 – 1058Tau/MAP 4Add BLAST32

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG6M Eukaryota
ENOG4111J07 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159742

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27546

KEGG Orthology (KO)

More...
KOi
K10431

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27546

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027324 MAP2/MAP4/Tau
IPR001084 MAP_tubulin-bd_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR11501 PTHR11501, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00418 Tubulin-binding, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00229 TAU_MAP_1, 4 hits
PS51491 TAU_MAP_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P27546-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADLSLVDAL TEPPPEIEGE IKRDFMAALE AEPYDDIVGE TVEKTEFIPL
60 70 80 90 100
LDGDEKTGNS ESKKKPCLDT SQVEGIPSSK PTLLANGDHG MEGNNTAGSP
110 120 130 140 150
TDFLEERVDY PDYQSSQNWP EDASFCFQPQ QVLDTDQAEP FNEHRDDGLA
160 170 180 190 200
DLLFVSSGPT NASAFTERDN PSEDSYGMLP CDSFASTAVV SQEWSVGAPN
210 220 230 240 250
SPCSESCVSP EVTIETLQPA TELSKAAEVE SVKEQLPAKA LETMAEQTTD
260 270 280 290 300
VVHSPSTDTT PGPDTEAALA KDIEEITKPD VILANVTQPS TESDMFLAQD
310 320 330 340 350
MELLTGTEAA HANNIILPTE PDESSTKDVA PPMEEEIVPG NDTTSPKETE
360 370 380 390 400
TTLPIKMDLA PPEDVLLTKE TELAPAKGMV SLSEIEEALA KNDESSAEIP
410 420 430 440 450
VAQETVVSET EVVLATEVVL PSDPITTLTK DVTLPLEAER PLVTDMTPSL
460 470 480 490 500
ETEMTLGKET APPTETNLGM AKDMSPLPES EVTLGKDVVI LPETKVAEFN
510 520 530 540 550
NVTPLSEEEV TSVKDMSPSA ETEAPLAKNA DLHSGTELIV DNSMAPASDL
560 570 580 590 600
ALPLETKVAT VPIKDKGTVQ TEEKPREDSQ LASMQHKGQS TVPPCTASPE
610 620 630 640 650
PVKAAEQMST LPIDAPSPLE NLEQKETPGS QPSEPCSGVS RQEEAKAAVG
660 670 680 690 700
VTGNDITTPP NKEPPPSPEK KAKPLATTQP AKTSTSKAKT QPTSLPKQPA
710 720 730 740 750
PTTSGGLNKK PMSLASGSVP AAPHKRPAAA TATARPSTLP ARDVKPKPIT
760 770 780 790 800
EAKVAEKRTS PSKPSSAPAL KPGPKTTPTV SKATSPSTLV STGPSSRSPA
810 820 830 840 850
TTLPKRPTSI KTEGKPADVK RMTAKSASAD LSRSKTTSAS SVKRNTTPTG
860 870 880 890 900
AAPPAGMTST RVKPMSAPSR SSGALSVDKK PTSTKPSSSA PRVSRLATTV
910 920 930 940 950
SAPDLKSVRS KVGSTENIKH QPGGGRAKVE KKTEAATTAG KPEPNAVTKA
960 970 980 990 1000
AGSIASAQKP PAGKVQIVSK KVSYSHIQSK CGSKDNIKHV PGGGNVQIQN
1010 1020 1030 1040 1050
KKVDISKVSS KCGSKANIKH KPGGGDVKIE SQKLNFKEKA QAKVGSLDNV
1060 1070 1080 1090 1100
GHLPAGGAVK TEGGGSEALP CPGPPAGEEP VIPEAAPDAG APTSASGLSG
1110 1120
HTTLSGGGDQ REPQTLDSQI QETSI
Length:1,125
Mass (Da):117,429
Last modified:June 12, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE948B7F1F5B903E9
GO
Isoform 2 (identifier: P27546-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1124-1125: SI → N

Show »
Length:1,124
Mass (Da):117,343
Checksum:i2947F1F5B903E9EC
GO
Isoform 3 (identifier: P27546-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     927-964: Missing.
     1124-1125: SI → N

Show »
Length:1,086
Mass (Da):113,656
Checksum:i476A250416BBACFD
GO
Isoform 4 (identifier: P27546-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MADLSLVDALTEPPPEIEGEIKRDFM → MSLPEKQPAALT
     30-259: EAEPYDDIVG...DVVHSPSTDT → AAEDEQLSKG...YSVTQSPQAA
     263-419: PDTEAALAKD...TEVVLATEVV → KEKNGLVSSC...KYPELPAREE
     424-531: PITTLTKDVT...TEAPLAKNAD → LLPPTSSPMP...KKELGIAGLY
     535-625: GTELIVDNSM...PSPLENLEQK → KLEQIPEGSH...TQSIPSLLLE
     629-637: GSQPSEPCS → RD
     927-964: Missing.
     965-995: Missing.
     1124-1125: SI → N

Show »
Length:902
Mass (Da):94,517
Checksum:i031215FB486E6845
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PZ43E9PZ43_MOUSE
Microtubule-associated protein
Map4 Mtap4
933Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDN7A0A0G2JDN7_MOUSE
Microtubule-associated protein
Map4
902Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDY5A0A0G2JDY5_MOUSE
Microtubule-associated protein
Map4
220Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFH2A0A0G2JFH2_MOUSE
Microtubule-associated protein
Map4
1,441Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFK3A0A0G2JFK3_MOUSE
Microtubule-associated protein
Map4
207Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFT4A0A0G2JFT4_MOUSE
Microtubule-associated protein
Map4
276Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JG35A0A0G2JG35_MOUSE
Microtubule-associated protein
Map4
290Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JDU1A0A0G2JDU1_MOUSE
Microtubule-associated protein
Map4
116Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8T5A0A140T8T5_MOUSE
Microtubule-associated protein
Map4
414Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JE57A0A0G2JE57_MOUSE
Microtubule-associated protein
Map4
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH42645 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE27434 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti225K → E in AAH55364 (PubMed:15489334).Curated1
Sequence conflicti252V → A in AAH55364 (PubMed:15489334).Curated1
Sequence conflicti394 – 395ES → VR in AAA16372 (PubMed:1718985).Curated2
Sequence conflicti416T → I in AAH55332 (PubMed:15489334).Curated1
Sequence conflicti955A → V in AAH55364 (PubMed:15489334).Curated1
Sequence conflicti982G → V in AAA16372 (PubMed:1718985).Curated1
Sequence conflicti993G → C in AAA16372 (PubMed:1718985).Curated1
Sequence conflicti1053L → F in AAA16372 (PubMed:1718985).Curated1
Sequence conflicti1060K → KV in AAH44654 (PubMed:15489334).Curated1
Sequence conflicti1060K → KV in AAH55364 (PubMed:15489334).Curated1
Sequence conflicti1089A → R in AAA16372 (PubMed:1718985).Curated1
Isoform 4 (identifier: P27546-4)
Sequence conflicti435K → E in BAE23650 (PubMed:16141072).By similarityCurated1
Sequence conflicti435K → E in BAE22377 (PubMed:16141072).By similarityCurated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0260891 – 26MADLS…KRDFM → MSLPEKQPAALT in isoform 4. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_02609030 – 259EAEPY…PSTDT → AAEDEQLSKGNPPECGMDSR KEIGQDGFEWQRTEGKLNEI GLNVSMDGQLKDRLVKNSSF LEQNKLGFFEGKLDKELSIE KPNKAYQETSGHLESGYVIS GTCQPSEGNLVHQKAAEFHP GLTEGKDKAATVQGKVAGKS GLEIKSQPDLNFPGAADTLT QHGEEQETSAWNANFYSVTQ SPQAA in isoform 4. 2 PublicationsAdd BLAST230
Alternative sequenceiVSP_026091263 – 419PDTEA…ATEVV → KEKNGLVSSCSVTGVMSDNS GQLNNKSPLLVAITHPDPTS EHLPTTSPPITMVEFTQENL NAGQDKELEKLRSSEEGPML DQVPQQKKAIRRALSECYHL SVPPAVNLVDKYPELPAREE in isoform 4. 2 PublicationsAdd BLAST157
Alternative sequenceiVSP_026092424 – 531PITTL…AKNAD → LLPPTSSPMPSPMPRKLGVP AMRRSMTVAEDQSASCRLSA GELASLSASQVPTALTFEEP VAKEREEQIHFSNDSNSSGK KELGIAGLY in isoform 4. 2 PublicationsAdd BLAST108
Alternative sequenceiVSP_026093535 – 625GTELI…NLEQK → KLEQIPEGSHKGKGQKNTGE TRVDSCPFICLGGEKQLMAL AGKKEIEVTATQSIPSLLLE in isoform 4. 2 PublicationsAdd BLAST91
Alternative sequenceiVSP_026094629 – 637GSQPSEPCS → RD in isoform 4. 2 Publications9
Alternative sequenceiVSP_026095927 – 964Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_026096965 – 995Missing in isoform 4. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_0260971124 – 1125SI → N in isoform 2, isoform 3 and isoform 4. 2 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M72414 mRNA Translation: AAA16372.1
AK134996 mRNA Translation: BAE22377.1
AK138416 mRNA Translation: BAE23650.1
AK146790 mRNA Translation: BAE27434.1 Different initiation.
BC042645 mRNA Translation: AAH42645.1 Different initiation.
BC044654 mRNA Translation: AAH44654.1
BC050893 mRNA Translation: AAH50893.1
BC055332 mRNA Translation: AAH55332.1
BC055364 mRNA Translation: AAH55364.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS57704.1 [P27546-1]
CCDS81083.1 [P27546-4]

Protein sequence database of the Protein Information Resource

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PIRi
B41206

NCBI Reference Sequences

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RefSeqi
NP_001192259.1, NM_001205330.1 [P27546-1]
NP_001192261.1, NM_001205332.1 [P27546-3]
NP_001298092.1, NM_001311163.1
NP_001298093.1, NM_001311164.1
NP_032659.2, NM_008633.4
XP_017168653.1, XM_017313164.1 [P27546-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035055; ENSMUSP00000035055; ENSMUSG00000032479 [P27546-1]
ENSMUST00000165876; ENSMUSP00000132662; ENSMUSG00000032479 [P27546-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
17758

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17758

UCSC genome browser

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UCSCi
uc009rsz.3 mouse [P27546-2]
uc009rta.3 mouse [P27546-1]
uc009rtb.3 mouse [P27546-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72414 mRNA Translation: AAA16372.1
AK134996 mRNA Translation: BAE22377.1
AK138416 mRNA Translation: BAE23650.1
AK146790 mRNA Translation: BAE27434.1 Different initiation.
BC042645 mRNA Translation: AAH42645.1 Different initiation.
BC044654 mRNA Translation: AAH44654.1
BC050893 mRNA Translation: AAH50893.1
BC055332 mRNA Translation: AAH55332.1
BC055364 mRNA Translation: AAH55364.1
CCDSiCCDS57704.1 [P27546-1]
CCDS81083.1 [P27546-4]
PIRiB41206
RefSeqiNP_001192259.1, NM_001205330.1 [P27546-1]
NP_001192261.1, NM_001205332.1 [P27546-3]
NP_001298092.1, NM_001311163.1
NP_001298093.1, NM_001311164.1
NP_032659.2, NM_008633.4
XP_017168653.1, XM_017313164.1 [P27546-2]

3D structure databases

SMRiP27546
ModBaseiSearch...

Protein-protein interaction databases

BioGridi201586, 6 interactors
IntActiP27546, 15 interactors
MINTiP27546
STRINGi10090.ENSMUSP00000035055

PTM databases

iPTMnetiP27546
PhosphoSitePlusiP27546
SwissPalmiP27546

Proteomic databases

EPDiP27546
jPOSTiP27546
MaxQBiP27546
PaxDbiP27546
PeptideAtlasiP27546
PRIDEiP27546

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035055; ENSMUSP00000035055; ENSMUSG00000032479 [P27546-1]
ENSMUST00000165876; ENSMUSP00000132662; ENSMUSG00000032479 [P27546-2]
GeneIDi17758
KEGGimmu:17758
UCSCiuc009rsz.3 mouse [P27546-2]
uc009rta.3 mouse [P27546-1]
uc009rtb.3 mouse [P27546-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4134
MGIiMGI:97178 Map4

Phylogenomic databases

eggNOGiENOG410IG6M Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00940000159742
InParanoidiP27546
KOiK10431
PhylomeDBiP27546

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Map4 mouse

Protein Ontology

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PROi
PR:P27546

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032479 Expressed in 300 organ(s), highest expression level in cerebellum
ExpressionAtlasiP27546 baseline and differential
GenevisibleiP27546 MM

Family and domain databases

InterProiView protein in InterPro
IPR027324 MAP2/MAP4/Tau
IPR001084 MAP_tubulin-bd_rpt
PANTHERiPTHR11501 PTHR11501, 1 hit
PfamiView protein in Pfam
PF00418 Tubulin-binding, 4 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 4 hits
PS51491 TAU_MAP_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27546
Secondary accession number(s): Q05BJ2
, Q3UIS2, Q3UUH5, Q3UY36, Q7TPC6, Q7TPD4, Q80YQ5, Q8CFP5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: June 12, 2007
Last modified: September 18, 2019
This is version 158 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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