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Protein

Aryl hydrocarbon receptor nuclear translocator

Gene

ARNT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-HSA-1989781 PPARA activates gene expression
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211976 Endogenous sterols
R-HSA-211981 Xenobiotics
R-HSA-8937144 Aryl hydrocarbon receptor signalling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P27540

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P27540

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P27540 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator
Short name:
ARNT protein
Alternative name(s):
Class E basic helix-loop-helix protein 2
Short name:
bHLHe2
Dioxin receptor, nuclear translocator
Hypoxia-inducible factor 1-beta
Short name:
HIF-1-beta
Short name:
HIF1-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARNT
Synonyms:BHLHE2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143437.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:700 ARNT

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
126110 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P27540

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi91R → A: Diminishes DNA interaction. 1 Publication1
Mutagenesisi93N → A: Diminishes DNA interaction. 1 Publication1
Mutagenesisi94H → A: Severely diminishes DNA interaction. 1 Publication1
Mutagenesisi98E → A: Severely diminishes DNA interaction. 1 Publication1
Mutagenesisi99R → A: Diminishes DNA interaction. 1 Publication1
Mutagenesisi101R → A: Severely diminishes DNA interaction. 1 Publication1
Mutagenesisi102R → A: Severely diminishes DNA interaction. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
405

Open Targets

More...
OpenTargetsi
ENSG00000143437

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24994

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5618

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARNT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
114163

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001271182 – 789Aryl hydrocarbon receptor nuclear translocatorAdd BLAST788

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei77PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P27540

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P27540

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27540

PeptideAtlas

More...
PeptideAtlasi
P27540

PRoteomics IDEntifications database

More...
PRIDEi
P27540

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54398
54399 [P27540-2]
54400 [P27540-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P27540

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P27540

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143437 Expressed in 221 organ(s), highest expression level in endocervix

CleanEx database of gene expression profiles

More...
CleanExi
HS_ARNT

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P27540 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P27540 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004318
HPA001759

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homodimer only upon binding to a DNA (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Interacts with TACC3 (By similarity). Interacts with HIF1A, EPAS1, NPAS1 and NPAS3; forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:20699359, PubMed:16181639) (By similarity). Forms a heterodimer with AHRR, as well as with other bHLH proteins (Probable). Interacts with NOCA7 (PubMed:10395741). Interacts with TACC3 (By similarity). Interacts with AHR; the heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409). Interacts with SIM1 and NPAS4 (By similarity).By similarity1 Publication4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106898, 111 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P27540

Database of interacting proteins

More...
DIPi
DIP-30886N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P27540

Protein interaction database and analysis system

More...
IntActi
P27540, 28 interactors

Molecular INTeraction database

More...
MINTi
P27540

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351407

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1789
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P27540

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27540

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P27540

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 142bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini161 – 235PAS 1PROSITE-ProRule annotationAdd BLAST75
Domaini349 – 419PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini424 – 467PACAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni88 – 128DNA-binding1 PublicationAdd BLAST41
Regioni112 – 264Required for heterodimer formation with EPAS1By similarityAdd BLAST153
Regioni112 – 168Required for heterodimer formation with HIF1ABy similarityAdd BLAST57
Regioni167 – 171Mediates the transcription activity and dimerization of the AHR:ARNT complexBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi99 – 102Poly-Arg4
Compositional biasi503 – 507Poly-Gln5
Compositional biasi710 – 769Gln-richAdd BLAST60
Compositional biasi738 – 741Poly-Ser4

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQ5T Eukaryota
ENOG410XVHF LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157585

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234380

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000164

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27540

KEGG Orthology (KO)

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KOi
K09097

Identification of Orthologs from Complete Genome Data

More...
OMAi
PNDKERF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03AI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27540

TreeFam database of animal gene trees

More...
TreeFami
TF319983

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit
cd00130 PAS, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00785 NCTRNSLOCATR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00229 sensory_box, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P27540-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRA IKRRPGLDFD
60 70 80 90 100
DDGEGNSKFL RCDDDQMSND KERFARSDDE QSSADKERLA RENHSEIERR
110 120 130 140 150
RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST
160 170 180 190 200
DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP
210 220 230 240 250
QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ
260 270 280 290 300
SSMRMCMGSR RSFICRMRCG SSSVDPVSVN RLSFVRNRCR NGLGSVKDGE
310 320 330 340 350
PHFVVVHCTG YIKAWPPAGV SLPDDDPEAG QGSKFCLVAI GRLQVTSSPN
360 370 380 390 400
CTDMSNVCQP TEFISRHNIE GIFTFVDHRC VATVGYQPQE LLGKNIVEFC
410 420 430 440 450
HPEDQQLLRD SFQQVVKLKG QVLSVMFRFR SKNQEWLWMR TSSFTFQNPY
460 470 480 490 500
SDEIEYIICT NTNVKNSSQE PRPTLSNTIQ RPQLGPTANL PLEMGSGQLA
510 520 530 540 550
PRQQQQQTEL DMVPGRDGLA SYNHSQVVQP VTTTGPEHSK PLEKSDGLFA
560 570 580 590 600
QDRDPRFSEI YHNINADQSK GISSSTVPAT QQLFSQGNTF PPTPRPAENF
610 620 630 640 650
RNSGLAPPVT IVQPSASAGQ MLAQISRHSN PTQGATPTWT PTTRSGFSAQ
660 670 680 690 700
QVATQATAKT RTSQFGVGSF QTPSSFSSMS LPGAPTASPG AAAYPSLTNR
710 720 730 740 750
GSNFAPETGQ TAGQFQTRTA EGVGVWPQWQ GQQPHHRSSS SEQHVQQPPA
760 770 780
QQPGQPEVFQ EMLSMLGDQS NSYNNEEFPD LTMFPPFSE
Length:789
Mass (Da):86,636
Last modified:August 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E278F8E62BFBF6D
GO
Isoform 2 (identifier: P27540-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     77-91: Missing.

Show »
Length:774
Mass (Da):84,948
Checksum:i0653070528296044
GO
Isoform 3 (identifier: P27540-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     319-323: Missing.

Note: No experimental confirmation available.
Show »
Length:775
Mass (Da):85,296
Checksum:i74839AACC350CB6B
GO
Isoform 4 (identifier: P27540-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     601-602: Missing.

Show »
Length:787
Mass (Da):86,366
Checksum:i956940ABFFF1E71A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NGV6A6NGV6_HUMAN
Aryl hydrocarbon receptor nuclear t...
ARNT
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDB3D6RDB3_HUMAN
Aryl hydrocarbon receptor nuclear t...
ARNT
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD93114 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAD38953 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti627R → H in BAG36518 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024280430R → Q. Corresponds to variant dbSNP:rs2229175Ensembl.1
Natural variantiVAR_014819511D → N. Corresponds to variant dbSNP:rs1805133Ensembl.1
Natural variantiVAR_018906517D → E1 PublicationCorresponds to variant dbSNP:rs10305741Ensembl.1
Natural variantiVAR_020189706P → L. Corresponds to variant dbSNP:rs2275237Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0365321 – 9Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_00209277 – 91Missing in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_036533319 – 323Missing in isoform 3. 1 Publication5
Alternative sequenceiVSP_055030601 – 602Missing in isoform 4. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M69238 mRNA Translation: AAA51777.1
Y18859
, AJ251863, AJ404851, AJ404852, AJ404853, AJ404854 Genomic DNA Translation: CAC21446.1
AK290177 mRNA Translation: BAF82866.1
AK293027 mRNA Translation: BAF85716.1
AK313780 mRNA Translation: BAG36518.1
AB209877 mRNA Translation: BAD93114.1 Different initiation.
AL834279 mRNA Translation: CAD38953.1 Different initiation.
AY430083 Genomic DNA Translation: AAQ96598.1
AL355860 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53510.1
CH471121 Genomic DNA Translation: EAW53513.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS65641.1 [P27540-3]
CCDS65642.1 [P27540-4]
CCDS970.1 [P27540-1]
CCDS971.1 [P27540-2]

Protein sequence database of the Protein Information Resource

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PIRi
I59550

NCBI Reference Sequences

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RefSeqi
NP_001184254.1, NM_001197325.1
NP_001272964.1, NM_001286035.1 [P27540-3]
NP_001272965.1, NM_001286036.1 [P27540-4]
NP_001659.1, NM_001668.3 [P27540-1]
NP_848514.1, NM_178427.2 [P27540-2]
XP_016856778.1, XM_017001289.1 [P27540-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.632446

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354396; ENSP00000346372; ENSG00000143437 [P27540-4]
ENST00000358595; ENSP00000351407; ENSG00000143437 [P27540-1]
ENST00000505755; ENSP00000427571; ENSG00000143437 [P27540-2]
ENST00000515192; ENSP00000423851; ENSG00000143437 [P27540-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
405

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:405

UCSC genome browser

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UCSCi
uc001evr.2 human [P27540-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69238 mRNA Translation: AAA51777.1
Y18859
, AJ251863, AJ404851, AJ404852, AJ404853, AJ404854 Genomic DNA Translation: CAC21446.1
AK290177 mRNA Translation: BAF82866.1
AK293027 mRNA Translation: BAF85716.1
AK313780 mRNA Translation: BAG36518.1
AB209877 mRNA Translation: BAD93114.1 Different initiation.
AL834279 mRNA Translation: CAD38953.1 Different initiation.
AY430083 Genomic DNA Translation: AAQ96598.1
AL355860 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53510.1
CH471121 Genomic DNA Translation: EAW53513.1
CCDSiCCDS65641.1 [P27540-3]
CCDS65642.1 [P27540-4]
CCDS970.1 [P27540-1]
CCDS971.1 [P27540-2]
PIRiI59550
RefSeqiNP_001184254.1, NM_001197325.1
NP_001272964.1, NM_001286035.1 [P27540-3]
NP_001272965.1, NM_001286036.1 [P27540-4]
NP_001659.1, NM_001668.3 [P27540-1]
NP_848514.1, NM_178427.2 [P27540-2]
XP_016856778.1, XM_017001289.1 [P27540-3]
UniGeneiHs.632446

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D7Gmodel-C87-145[»]
1X0ONMR-A356-470[»]
2A24NMR-B358-465[»]
2ARNmodel-A335-462[»]
2B02X-ray1.50A354-470[»]
2HV1NMR-A/B356-470[»]
2K7SNMR-A356-470[»]
3F1NX-ray1.48B356-470[»]
3F1OX-ray1.60B356-470[»]
3F1PX-ray1.17B356-470[»]
3H7WX-ray1.65B356-470[»]
3H82X-ray1.50B356-470[»]
4EQ1X-ray1.60A/B357-464[»]
4GHIX-ray1.50B356-470[»]
4GS9X-ray1.72B356-470[»]
4H6JX-ray1.52B357-470[»]
4LPZX-ray3.15A/B356-470[»]
4PKYX-ray3.20A/D356-470[»]
4XT2X-ray1.70B/D356-470[»]
5TBMX-ray1.85B356-467[»]
5UFPX-ray1.90B356-467[»]
5V0LX-ray4.00A70-346[»]
ProteinModelPortaliP27540
SMRiP27540
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106898, 111 interactors
CORUMiP27540
DIPiDIP-30886N
ELMiP27540
IntActiP27540, 28 interactors
MINTiP27540
STRINGi9606.ENSP00000351407

Chemistry databases

ChEMBLiCHEMBL5618

Protein family/group databases

MoonDBiP27540 Predicted

PTM databases

iPTMnetiP27540
PhosphoSitePlusiP27540

Polymorphism and mutation databases

BioMutaiARNT
DMDMi114163

Proteomic databases

EPDiP27540
MaxQBiP27540
PaxDbiP27540
PeptideAtlasiP27540
PRIDEiP27540
ProteomicsDBi54398
54399 [P27540-2]
54400 [P27540-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
405
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354396; ENSP00000346372; ENSG00000143437 [P27540-4]
ENST00000358595; ENSP00000351407; ENSG00000143437 [P27540-1]
ENST00000505755; ENSP00000427571; ENSG00000143437 [P27540-2]
ENST00000515192; ENSP00000423851; ENSG00000143437 [P27540-3]
GeneIDi405
KEGGihsa:405
UCSCiuc001evr.2 human [P27540-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
405
DisGeNETi405
EuPathDBiHostDB:ENSG00000143437.20

GeneCards: human genes, protein and diseases

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GeneCardsi
ARNT
HGNCiHGNC:700 ARNT
HPAiCAB004318
HPA001759
MIMi126110 gene
neXtProtiNX_P27540
OpenTargetsiENSG00000143437
PharmGKBiPA24994

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQ5T Eukaryota
ENOG410XVHF LUCA
GeneTreeiENSGT00940000157585
HOGENOMiHOG000234380
HOVERGENiHBG000164
InParanoidiP27540
KOiK09097
OMAiPNDKERF
OrthoDBiEOG091G03AI
PhylomeDBiP27540
TreeFamiTF319983

Enzyme and pathway databases

ReactomeiR-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor
R-HSA-1989781 PPARA activates gene expression
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211976 Endogenous sterols
R-HSA-211981 Xenobiotics
R-HSA-8937144 Aryl hydrocarbon receptor signalling
SignaLinkiP27540
SIGNORiP27540

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARNT human
EvolutionaryTraceiP27540

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Aryl_hydrocarbon_receptor_nuclear_translocator

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
405

Protein Ontology

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PROi
PR:P27540

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143437 Expressed in 221 organ(s), highest expression level in endocervix
CleanExiHS_ARNT
ExpressionAtlasiP27540 baseline and differential
GenevisibleiP27540 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARNT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27540
Secondary accession number(s): B2R9H1
, C4AMA1, F8WAP6, Q59ED4, Q5QP39, Q8NDC7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: December 5, 2018
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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