Cd40

Functionⁱ

Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.1 Publication

GO - Molecular functionⁱ

antigen binding Source: MGI
enzyme binding Source: MGI
protein domain specific binding Source: MGI
signaling receptor activity Source: InterPro
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell activation
Source: MGI
Inferred from direct assayⁱ
- 14594818
- 16546095
cellular calcium ion homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 21410936
cellular response to erythropoietin Source: Ensembl
cellular response to interleukin-1 Source: Ensembl
cellular response to lipopolysaccharide Source: Ensembl
cellular response to mechanical stimulus Source: Ensembl
cellular response to tumor necrosis factor Source: Ensembl
defense response to protozoan
Source: MGI
Inferred from direct assayⁱ
- 19047410
defense response to virus
Source: MGI
Inferred from direct assayⁱ
- 17277142
immune response-regulating cell surface receptor signaling pathway
Source: MGI
Inferred from direct assayⁱ
- 15240714
inflammatory response Source: MGI
positive regulation of angiogenesis Source: MGI
positive regulation of B cell proliferation
Source: MGI
Inferred from direct assayⁱ
positive regulation of blood vessel endothelial cell migration Source: MGI
positive regulation of endothelial cell apoptotic process Source: MGI
positive regulation of GTPase activity Source: MGI
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
positive regulation of interleukin-12 production
Source: MGI
Inferred from direct assayⁱ
- 15240714
positive regulation of isotype switching to IgG isotypes
Source: MGI
Inferred from direct assayⁱ
- 12882831
positive regulation of MAP kinase activity Source: MGI
positive regulation of NF-kappaB transcription factor activity Source: MGI
positive regulation of protein kinase C signaling Source: MGI
positive regulation of protein phosphorylation Source: MGI
positive regulation of transcription by RNA polymerase II Source: MGI
positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
protein kinase B signaling
Source: MGI
Inferred from direct assayⁱ
- 16546095
regulation of immune response
Source: MGI
Inferred from direct assayⁱ
- 12882831
regulation of immunoglobulin secretion
Source: MGI
Inferred from direct assayⁱ
- 12958312
response to cobalamin Source: Ensembl
response to interferon-gamma Source: Ensembl
response to peptide Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Immunity

Enzyme and pathway databases

Reactomeⁱ	R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-5668541 TNFR2 non-canonical NF-kB pathway R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Reactomeⁱ

R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 5 Alternative name(s): B-cell surface antigen CD40 Bp50 CD40L receptor CD_antigen: CD40
Gene namesⁱ	Name:Cd40 Synonyms:Tnfrsf5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:88336 Cd40

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 193	ExtracellularSequence analysisAdd BLAST	174
Transmembraneⁱ	194 – 215	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	216 – 289	CytoplasmicSequence analysisAdd BLAST	74

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000034560	20 – 289	Tumor necrosis factor receptor superfamily member 5Add BLAST		270

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	26 ↔ 37	PROSITE-ProRule annotation
Disulfide bondⁱ	38 ↔ 51	PROSITE-ProRule annotation
Disulfide bondⁱ	41 ↔ 59	PROSITE-ProRule annotation
Disulfide bondⁱ	62 ↔ 77	PROSITE-ProRule annotation
Disulfide bondⁱ	83 ↔ 103	PROSITE-ProRule annotation
Disulfide bondⁱ	105 ↔ 119	PROSITE-ProRule annotation
Disulfide bondⁱ	111 ↔ 116	PROSITE-ProRule annotation
Disulfide bondⁱ	125 ↔ 143	PROSITE-ProRule annotation
Glycosylationⁱ	153	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P27512
PaxDbⁱ	P27512
PeptideAtlas More...PeptideAtlasⁱ	P27512
PRIDEⁱ	P27512

PTM databases

iPTMnetⁱ	P27512
PhosphoSitePlusⁱ	P27512

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000017652 Expressed in 159 organ(s), highest expression level in spleen
CleanExⁱ	MM_CD40
ExpressionAtlasⁱ	P27512 baseline and differential
Genevisibleⁱ	P27512 MM

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer. Interacts with TRAF1, TRAF2 and TRAF6 (By similarity). Interacts with TRAF3 and TRAF5. Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation.By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Btk	P35991	3	EBI-525742,EBI-625119
Traf2	P39429	3	EBI-525742,EBI-520016
Traf6	P70196	2	EBI-525742,EBI-448028

GO - Molecular functionⁱ

enzyme binding Source: MGI
protein domain specific binding Source: MGI
ubiquitin protein ligase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204251, 18 interactors
CORUMⁱ	P27512
Database of interacting proteins More...DIPⁱ	DIP-33295N
ELMⁱ	P27512
IntActⁱ	P27512, 6 interactors
Molecular INTeraction database More...MINTⁱ	P27512
STRINGⁱ	10090.ENSMUSP00000017799

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P27512
SMRⁱ	P27512
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	25 – 60	TNFR-Cys 1Add BLAST	36
Repeatⁱ	61 – 103	TNFR-Cys 2Add BLAST	43
Repeatⁱ	104 – 144	TNFR-Cys 3Add BLAST	41
Repeatⁱ	145 – 187	TNFR-Cys 4Add BLAST	43

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IY0H Eukaryota ENOG4112DB5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119204
HOVERGENⁱ	HBG005117
InParanoidⁱ	P27512
KEGG Orthology (KO) More...KOⁱ	K03160
OMAⁱ	PGLGVKQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	P27512
TreeFamⁱ	TF331157

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13407 TNFRSF5, 1 hit
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR020435 TNFR_5 IPR034021 TNFRSF5_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01922 TNFACTORR5
SMARTⁱ	View protein in SMART SM00208 TNFR, 4 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 4 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform I (identifier: P27512-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSLPRLCAL WGCLLTAVHL GQCVTCSDKQ YLHDGQCCDL CQPGSRLTSH 
        60         70         80         90        100
CTALEKTQCH PCDSGEFSAQ WNREIRCHQH RHCEPNQGLR VKKEGTAESD 
       110        120        130        140        150
TVCTCKEGQH CTSKDCEACA QHTPCIPGFG VMEMATETTD TVCHPCPVGF 
       160        170        180        190        200
FSNQSSLFEK CYPWTSCEDK NLEVLQKGTS QTNVICGLKS RMRALLVIPV 
       210        220        230        240        250
VMGILITIFG VFLYIKKVVK KPKDNEILPP AARRQDPQEM EDYPGHNTAA 
       260        270        280 
PVQETLHGCQ PVTQEDGKES RISVQERQVT DSIALRPLV

Length:289

Mass (Da):32,093

Last modified:February 26, 2008 - v3

Checksum:ⁱC7970DAD2FEA534A

GO

Isoform II (identifier: P27512-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
166-203: SCEDKNLEVL...ALLVIPVVMG → RFKVPDASPA...YQKGGQETKG
204-289: Missing.

« Hide

        10         20         30         40         50
MVSLPRLCAL WGCLLTAVHL GQCVTCSDKQ YLHDGQCCDL CQPGSRLTSH 
        60         70         80         90        100
CTALEKTQCH PCDSGEFSAQ WNREIRCHQH RHCEPNQGLR VKKEGTAESD 
       110        120        130        140        150
TVCTCKEGQH CTSKDCEACA QHTPCIPGFG VMEMATETTD TVCHPCPVGF 
       160        170        180        190        200
FSNQSSLFEK CYPWTRFKVP DASPAGHSCR DGHPHHHFRG VSLYQKGGQE 

TKG

Show »

Length:203

Mass (Da):22,468

Checksum:ⁱ0C4C94E7CC426202

GO

Isoform III (identifier: P27512-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
216-234: KKVVKKPKDNEILPPAARR → SECSGEEREGGFSPVEPAS
235-289: Missing.

« Hide

        10         20         30         40         50
MVSLPRLCAL WGCLLTAVHL GQCVTCSDKQ YLHDGQCCDL CQPGSRLTSH 
        60         70         80         90        100
CTALEKTQCH PCDSGEFSAQ WNREIRCHQH RHCEPNQGLR VKKEGTAESD 
       110        120        130        140        150
TVCTCKEGQH CTSKDCEACA QHTPCIPGFG VMEMATETTD TVCHPCPVGF 
       160        170        180        190        200
FSNQSSLFEK CYPWTSCEDK NLEVLQKGTS QTNVICGLKS RMRALLVIPV 
       210        220        230 
VMGILITIFG VFLYISECSG EEREGGFSPV EPAS

Show »

Length:234

Mass (Da):25,747

Checksum:ⁱ00DB1DD38347E325

GO

Isoform IV (identifier: P27512-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
216-222: KKVVKKP → SGQETKG
223-289: Missing.

« Hide

        10         20         30         40         50
MVSLPRLCAL WGCLLTAVHL GQCVTCSDKQ YLHDGQCCDL CQPGSRLTSH 
        60         70         80         90        100
CTALEKTQCH PCDSGEFSAQ WNREIRCHQH RHCEPNQGLR VKKEGTAESD 
       110        120        130        140        150
TVCTCKEGQH CTSKDCEACA QHTPCIPGFG VMEMATETTD TVCHPCPVGF 
       160        170        180        190        200
FSNQSSLFEK CYPWTSCEDK NLEVLQKGTS QTNVICGLKS RMRALLVIPV 
       210        220 
VMGILITIFG VFLYISGQET KG

Show »

Length:222

Mass (Da):24,499

Checksum:ⁱEE21E6C76FB42DEF

GO

Isoform V (identifier: P27512-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
187-216: GLKSRMRALLVIPVVMGILITIFGVFLYIK → E

« Hide

        10         20         30         40         50
MVSLPRLCAL WGCLLTAVHL GQCVTCSDKQ YLHDGQCCDL CQPGSRLTSH 
        60         70         80         90        100
CTALEKTQCH PCDSGEFSAQ WNREIRCHQH RHCEPNQGLR VKKEGTAESD 
       110        120        130        140        150
TVCTCKEGQH CTSKDCEACA QHTPCIPGFG VMEMATETTD TVCHPCPVGF 
       160        170        180        190        200
FSNQSSLFEK CYPWTSCEDK NLEVLQKGTS QTNVICEKVV KKPKDNEILP 
       210        220        230        240        250
PAARRQDPQE MEDYPGHNTA APVQETLHGC QPVTQEDGKE SRISVQERQV 
       260
TDSIALRPLV

Show »

Length:260

Mass (Da):28,878

Checksum:ⁱ57A37C0E8CF2F142

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A2A5L7	A2A5L7_MOUSE	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 5	Cd40	121	Annotation score:
S4R2M8	S4R2M8_MOUSE	Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 5	Cd40	44	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	21	G → W in BAE31440 (PubMed:16141072).Curated	1
Sequence conflictⁱ	24	V → L in CAJ18551 (Ref. 6) Curated	1
Sequence conflictⁱ	24	V → L in AAH29254 (PubMed:15489334).Curated	1
Sequence conflictⁱ	92	K → N in BAE36843 (PubMed:16141072).Curated	1
Sequence conflictⁱ	104	T → A in CAJ18551 (Ref. 6) Curated	1
Sequence conflictⁱ	104	T → A in AAH29254 (PubMed:15489334).Curated	1
Sequence conflictⁱ	194	A → T in BAE29991 (PubMed:16141072).Curated	1
Sequence conflictⁱ	221	K → E in BAE31471 (PubMed:16141072).Curated	1
Sequence conflictⁱ	227	I → M in AAB08705 (PubMed:1370315).Curated	1
Sequence conflictⁱ	227	I → M in AAA37404 (PubMed:1281194).Curated	1
Sequence conflictⁱ	227	I → M in CAC29430 (PubMed:11172023).Curated	1
Sequence conflictⁱ	227	I → M in BAC40978 (PubMed:16141072).Curated	1
Sequence conflictⁱ	227	I → M in BAE33789 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_006474	166 – 203	SCEDK…PVVMG → RFKVPDASPAGHSCRDGHPH HHFRGVSLYQKGGQETKG in isoform II. CuratedAdd BLAST	38
Alternative sequenceⁱVSP_006476	187 – 216	GLKSR…FLYIK → E in isoform V. CuratedAdd BLAST	30
Alternative sequenceⁱVSP_006475	204 – 289	Missing in isoform II. CuratedAdd BLAST	86
Alternative sequenceⁱVSP_006477	216 – 234	KKVVK…PAARR → SECSGEEREGGFSPVEPAS in isoform III. CuratedAdd BLAST	19
Alternative sequenceⁱVSP_006479	216 – 222	KKVVKKP → SGQETKG in isoform IV. Curated	7
Alternative sequenceⁱVSP_006480	223 – 289	Missing in isoform IV. CuratedAdd BLAST	67
Alternative sequenceⁱVSP_006478	235 – 289	Missing in isoform III. CuratedAdd BLAST	55

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83312 mRNA Translation: AAB08705.1 M94126 , M94129, M94128, M94127 Genomic DNA Translation: AAA37404.1 AJ401387 mRNA Translation: CAC29427.1 AJ401388 mRNA Translation: CAC29428.1 AJ401389 mRNA Translation: CAC29429.1 AJ401390 mRNA Translation: CAC29430.1 AK089861 mRNA Translation: BAC40978.1 AK150959 mRNA Translation: BAE29991.1 AK152716 mRNA Translation: BAE31440.1 AK152756 mRNA Translation: BAE31471.1 AK152942 mRNA Translation: BAE31613.1 AK156644 mRNA Translation: BAE33789.1 AK161978 mRNA Translation: BAE36663.1 AK162305 mRNA Translation: BAE36843.1 CT010343 mRNA Translation: CAJ18551.1 AL591495, AL591411 Genomic DNA Translation: CAM26470.1 BC029254 mRNA Translation: AAH29254.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS17069.1 [P27512-1] CCDS17070.1 [P27512-5] CCDS17071.1 [P27512-2]
PIRⁱ	A46476
NCBI Reference Sequences More...RefSeqⁱ	NP_035741.2, NM_011611.2 [P27512-1] NP_733803.2, NM_170702.2 [P27512-5] NP_733804.1, NM_170703.2 [P27512-2] NP_733805.1, NM_170704.2 [P27512-4]
UniGeneⁱ	Mm.271833

Genome annotation databases

Ensemblⁱ	ENSMUST00000017799; ENSMUSP00000017799; ENSMUSG00000017652 [P27512-1] ENSMUST00000073707; ENSMUSP00000073386; ENSMUSG00000017652 [P27512-5] ENSMUST00000081310; ENSMUSP00000080059; ENSMUSG00000017652 [P27512-2] ENSMUST00000184221; ENSMUSP00000139193; ENSMUSG00000017652 [P27512-3]
GeneIDⁱ	21939
KEGGⁱ	mmu:21939
UCSC genome browser More...UCSCⁱ	uc008nwx.1 mouse [P27512-5] uc008nwy.1 mouse [P27512-1] uc008nwz.1 mouse [P27512-4] uc008nxb.1 mouse [P27512-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P27512	Isoform III of Tumor necrosis factor receptor superfamily member 5		MOUSE		234	UniRef90_P27512
UPI000A3087A5		MUSPA		289
UPI000A317310		MUSCR		289
UPI0003D6F1BE		MOUSE		158
UPI0007EC7D80		MOUSE		286

Protein	Similar proteins		Species	Score	Length	Source
P27512	Tumor necrosis factor receptor superfamily member 5		CANLF		274	UniRef50_P27512
Tumor necrosis factor receptor superfamily member 5		PIG		278
Tumor necrosis factor receptor superfamily member 5		CALJA		274
Isoform III of Tumor necrosis factor receptor superfamily member 5		MOUSE		234
tumor necrosis factor receptor superfamily member 5		ERIEU		269
+72
P27512-2	Isoform IV of Tumor necrosis factor receptor superfamily member 5		MOUSE		222	UniRef50_P27512-4
tumor necrosis factor receptor superfamily member 5 isoform X3		MESAU		204
UPI000A31B1F7		MUSCR		222
UPI0004E485DC		RAT		223
UPI000B4F721A		MERUN		205
+5
P27512-4	Isoform II of Tumor necrosis factor receptor superfamily member 5		MOUSE		203	UniRef50_P27512-4
tumor necrosis factor receptor superfamily member 5 isoform X3		MESAU		204
UPI000A31B1F7		MUSCR		222
UPI0004E485DC		RAT		223
UPI000B4F721A		MERUN		205
+5
P27512-5	tumor necrosis factor receptor superfamily member 5 isoform X1		MESAU		297	UniRef50_P27512-5
UPI000A315655		MUSCR		260
UPI0003D77FEB		MOUSE		256
UPI0003D0BAB4		RAT		309
UPI00038BD889		MICOH		260
+4

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83312 mRNA Translation: AAB08705.1 M94126 , M94129, M94128, M94127 Genomic DNA Translation: AAA37404.1 AJ401387 mRNA Translation: CAC29427.1 AJ401388 mRNA Translation: CAC29428.1 AJ401389 mRNA Translation: CAC29429.1 AJ401390 mRNA Translation: CAC29430.1 AK089861 mRNA Translation: BAC40978.1 AK150959 mRNA Translation: BAE29991.1 AK152716 mRNA Translation: BAE31440.1 AK152756 mRNA Translation: BAE31471.1 AK152942 mRNA Translation: BAE31613.1 AK156644 mRNA Translation: BAE33789.1 AK161978 mRNA Translation: BAE36663.1 AK162305 mRNA Translation: BAE36843.1 CT010343 mRNA Translation: CAJ18551.1 AL591495, AL591411 Genomic DNA Translation: CAM26470.1 BC029254 mRNA Translation: AAH29254.1
CCDSⁱ	CCDS17069.1 [P27512-1] CCDS17070.1 [P27512-5] CCDS17071.1 [P27512-2]
PIRⁱ	A46476
RefSeqⁱ	NP_035741.2, NM_011611.2 [P27512-1] NP_733803.2, NM_170702.2 [P27512-5] NP_733804.1, NM_170703.2 [P27512-2] NP_733805.1, NM_170704.2 [P27512-4]
UniGeneⁱ	Mm.271833

3D structure databases

ProteinModelPortalⁱ	P27512
SMRⁱ	P27512
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204251, 18 interactors
CORUMⁱ	P27512
DIPⁱ	DIP-33295N
ELMⁱ	P27512
IntActⁱ	P27512, 6 interactors
MINTⁱ	P27512
STRINGⁱ	10090.ENSMUSP00000017799

PTM databases

iPTMnetⁱ	P27512
PhosphoSitePlusⁱ	P27512

Proteomic databases

MaxQBⁱ	P27512
PaxDbⁱ	P27512
PeptideAtlasⁱ	P27512
PRIDEⁱ	P27512

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000017799; ENSMUSP00000017799; ENSMUSG00000017652 [P27512-1] ENSMUST00000073707; ENSMUSP00000073386; ENSMUSG00000017652 [P27512-5] ENSMUST00000081310; ENSMUSP00000080059; ENSMUSG00000017652 [P27512-2] ENSMUST00000184221; ENSMUSP00000139193; ENSMUSG00000017652 [P27512-3]
GeneIDⁱ	21939
KEGGⁱ	mmu:21939
UCSCⁱ	uc008nwx.1 mouse [P27512-5] uc008nwy.1 mouse [P27512-1] uc008nwz.1 mouse [P27512-4] uc008nxb.1 mouse [P27512-2]

Organism-specific databases

CTDⁱ	958
MGIⁱ	MGI:88336 Cd40

Phylogenomic databases

eggNOGⁱ	ENOG410IY0H Eukaryota ENOG4112DB5 LUCA
GeneTreeⁱ	ENSGT00760000119204
HOVERGENⁱ	HBG005117
InParanoidⁱ	P27512
KOⁱ	K03160
OMAⁱ	PGLGVKQ
OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	P27512
TreeFamⁱ	TF331157

Enzyme and pathway databases

Reactomeⁱ	R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-5668541 TNFR2 non-canonical NF-kB pathway R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Reactomeⁱ

R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P27512
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000017652 Expressed in 159 organ(s), highest expression level in spleen
CleanExⁱ	MM_CD40
ExpressionAtlasⁱ	P27512 baseline and differential
Genevisibleⁱ	P27512 MM

Family and domain databases

CDDⁱ	cd13407 TNFRSF5, 1 hit
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR020435 TNFR_5 IPR034021 TNFRSF5_N
Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01922 TNFACTORR5
SMARTⁱ	View protein in SMART SM00208 TNFR, 4 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNR5_MOUSE
Accessionⁱ	P27512Primary (citable) accession number: P27512 Secondary accession number(s): Q3TS33 Q99NE3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	February 26, 2008
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P27512 (TNR5_MOUSE)

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Tumor necrosis factor receptor superfamily member 5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma membrane

Plasma membrane

Plasma membrane

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ