UniProtKB - P27512 (TNR5_MOUSE)
Tumor necrosis factor receptor superfamily member 5
Cd40
Functioni
GO - Molecular functioni
- antigen binding Source: MGI
- enzyme binding Source: MGI
- protein domain specific binding Source: MGI
- signaling receptor activity Source: InterPro
- ubiquitin protein ligase binding Source: MGI
GO - Biological processi
- B cell activation Source: MGI
- CD40 signaling pathway Source: MGI
- cellular calcium ion homeostasis Source: BHF-UCL
- cellular response to erythropoietin Source: Ensembl
- cellular response to interleukin-1 Source: GO_Central
- cellular response to lipopolysaccharide Source: Ensembl
- cellular response to mechanical stimulus Source: Ensembl
- cellular response to tumor necrosis factor Source: GO_Central
- defense response to protozoan Source: MGI
- defense response to virus Source: MGI
- immune response-regulating cell surface receptor signaling pathway Source: MGI
- inflammatory response Source: MGI
- positive regulation of angiogenesis Source: MGI
- positive regulation of B cell proliferation Source: MGI
- positive regulation of blood vessel endothelial cell migration Source: MGI
- positive regulation of endothelial cell apoptotic process Source: MGI
- positive regulation of GTPase activity Source: MGI
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- positive regulation of interleukin-12 production Source: MGI
- positive regulation of isotype switching to IgG isotypes Source: MGI
- positive regulation of MAP kinase activity Source: MGI
- positive regulation of NF-kappaB transcription factor activity Source: MGI
- positive regulation of protein kinase C signaling Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
- protein kinase B signaling Source: MGI
- regulation of immune response Source: MGI
- regulation of immunoglobulin secretion Source: MGI
- response to cobalamin Source: Ensembl
- response to interferon-gamma Source: GO_Central
- response to peptide Source: Ensembl
- TRIF-dependent toll-like receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Receptor |
Biological process | Immunity |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 5Alternative name(s): B-cell surface antigen CD40 Bp50 CD40L receptor CD_antigen: CD40 |
Gene namesi | Name:Cd40 Synonyms:Tnfrsf5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88336, Cd40 |
Subcellular locationi
Plasma membrane
Plasma membrane
Plasma membrane
Plasma membrane
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Plasma Membrane
- CD40 receptor complex Source: BHF-UCL
- external side of plasma membrane Source: MGI
- plasma membrane Source: BHF-UCL
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
- neuronal cell body Source: MGI
- varicosity Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 193 | ExtracellularSequence analysisAdd BLAST | 174 | |
Transmembranei | 194 – 215 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 216 – 289 | CytoplasmicSequence analysisAdd BLAST | 74 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000034560 | 20 – 289 | Tumor necrosis factor receptor superfamily member 5Add BLAST | 270 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 26 ↔ 37 | PROSITE-ProRule annotation | ||
Disulfide bondi | 38 ↔ 51 | PROSITE-ProRule annotation | ||
Disulfide bondi | 41 ↔ 59 | PROSITE-ProRule annotation | ||
Disulfide bondi | 62 ↔ 77 | PROSITE-ProRule annotation | ||
Disulfide bondi | 83 ↔ 103 | PROSITE-ProRule annotation | ||
Disulfide bondi | 105 ↔ 119 | PROSITE-ProRule annotation | ||
Disulfide bondi | 111 ↔ 116 | PROSITE-ProRule annotation | ||
Disulfide bondi | 125 ↔ 143 | PROSITE-ProRule annotation | ||
Glycosylationi | 153 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P27512 |
MaxQBi | P27512 |
PaxDbi | P27512 |
PeptideAtlasi | P27512 |
PRIDEi | P27512 |
PTM databases
GlyGeni | P27512, 1 site |
iPTMneti | P27512 |
PhosphoSitePlusi | P27512 |
SwissPalmi | P27512 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000017652, Expressed in spleen and 186 other tissues |
ExpressionAtlasi | P27512, baseline and differential |
Genevisiblei | P27512, MM |
Interactioni
Subunit structurei
Monomer and homodimer.
Interacts with TRAF1, TRAF2 and TRAF6 (By similarity).
Interacts with TRAF3 and TRAF5.
Interacts with TRAF6 and MAP3K8; the interaction is required for ERK activation.
By similarity3 PublicationsBinary interactionsi
Hide detailsP27512
With | #Exp. | IntAct |
---|---|---|
Btk [P35991] | 3 | EBI-525742,EBI-625119 |
Traf2 [P39429] | 3 | EBI-525742,EBI-520016 |
Traf6 [P70196] | 2 | EBI-525742,EBI-448028 |
GO - Molecular functioni
- enzyme binding Source: MGI
- protein domain specific binding Source: MGI
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204251, 18 interactors |
CORUMi | P27512 |
DIPi | DIP-33295N |
ELMi | P27512 |
IntActi | P27512, 6 interactors |
MINTi | P27512 |
STRINGi | 10090.ENSMUSP00000017799 |
Miscellaneous databases
RNActi | P27512, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 25 – 60 | TNFR-Cys 1Add BLAST | 36 | |
Repeati | 61 – 103 | TNFR-Cys 2Add BLAST | 43 | |
Repeati | 104 – 144 | TNFR-Cys 3Add BLAST | 41 | |
Repeati | 145 – 187 | TNFR-Cys 4Add BLAST | 43 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S5TQ, Eukaryota |
GeneTreei | ENSGT00940000161464 |
HOGENOMi | CLU_052667_4_0_1 |
InParanoidi | P27512 |
OMAi | DAVCGFQ |
OrthoDBi | 1038336at2759 |
PhylomeDBi | P27512 |
TreeFami | TF331157 |
Family and domain databases
CDDi | cd13407, TNFRSF5, 1 hit |
InterProi | View protein in InterPro IPR001368, TNFR/NGFR_Cys_rich_reg IPR020435, TNFR_5 IPR034021, TNFRSF5_N |
Pfami | View protein in Pfam PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01922, TNFACTORR5 |
SMARTi | View protein in SMART SM00208, TNFR, 4 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 1 hit PS50050, TNFR_NGFR_2, 4 hits |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVSLPRLCAL WGCLLTAVHL GQCVTCSDKQ YLHDGQCCDL CQPGSRLTSH
60 70 80 90 100
CTALEKTQCH PCDSGEFSAQ WNREIRCHQH RHCEPNQGLR VKKEGTAESD
110 120 130 140 150
TVCTCKEGQH CTSKDCEACA QHTPCIPGFG VMEMATETTD TVCHPCPVGF
160 170 180 190 200
FSNQSSLFEK CYPWTSCEDK NLEVLQKGTS QTNVICGLKS RMRALLVIPV
210 220 230 240 250
VMGILITIFG VFLYIKKVVK KPKDNEILPP AARRQDPQEM EDYPGHNTAA
260 270 280
PVQETLHGCQ PVTQEDGKES RISVQERQVT DSIALRPLV
The sequence of this isoform differs from the canonical sequence as follows:
166-203: SCEDKNLEVL...ALLVIPVVMG → RFKVPDASPA...YQKGGQETKG
204-289: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
216-234: KKVVKKPKDNEILPPAARR → SECSGEEREGGFSPVEPAS
235-289: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
216-222: KKVVKKP → SGQETKG
223-289: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2A5L7 | A2A5L7_MOUSE | Tumor necrosis factor receptor supe... | Cd40 | 121 | Annotation score: | ||
S4R2M8 | S4R2M8_MOUSE | Tumor necrosis factor receptor supe... | Cd40 | 44 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | G → W in BAE31440 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 24 | V → L in CAJ18551 (Ref. 6) Curated | 1 | |
Sequence conflicti | 24 | V → L in AAH29254 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 92 | K → N in BAE36843 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 104 | T → A in CAJ18551 (Ref. 6) Curated | 1 | |
Sequence conflicti | 104 | T → A in AAH29254 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 194 | A → T in BAE29991 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 221 | K → E in BAE31471 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 227 | I → M in AAB08705 (PubMed:1370315).Curated | 1 | |
Sequence conflicti | 227 | I → M in AAA37404 (PubMed:1281194).Curated | 1 | |
Sequence conflicti | 227 | I → M in CAC29430 (PubMed:11172023).Curated | 1 | |
Sequence conflicti | 227 | I → M in BAC40978 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 227 | I → M in BAE33789 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006474 | 166 – 203 | SCEDK…PVVMG → RFKVPDASPAGHSCRDGHPH HHFRGVSLYQKGGQETKG in isoform II. CuratedAdd BLAST | 38 | |
Alternative sequenceiVSP_006476 | 187 – 216 | GLKSR…FLYIK → E in isoform V. CuratedAdd BLAST | 30 | |
Alternative sequenceiVSP_006475 | 204 – 289 | Missing in isoform II. CuratedAdd BLAST | 86 | |
Alternative sequenceiVSP_006477 | 216 – 234 | KKVVK…PAARR → SECSGEEREGGFSPVEPAS in isoform III. CuratedAdd BLAST | 19 | |
Alternative sequenceiVSP_006479 | 216 – 222 | KKVVKKP → SGQETKG in isoform IV. Curated | 7 | |
Alternative sequenceiVSP_006480 | 223 – 289 | Missing in isoform IV. CuratedAdd BLAST | 67 | |
Alternative sequenceiVSP_006478 | 235 – 289 | Missing in isoform III. CuratedAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83312 mRNA Translation: AAB08705.1 M94126 , M94129, M94128, M94127 Genomic DNA Translation: AAA37404.1 AJ401387 mRNA Translation: CAC29427.1 AJ401388 mRNA Translation: CAC29428.1 AJ401389 mRNA Translation: CAC29429.1 AJ401390 mRNA Translation: CAC29430.1 AK089861 mRNA Translation: BAC40978.1 AK150959 mRNA Translation: BAE29991.1 AK152716 mRNA Translation: BAE31440.1 AK152756 mRNA Translation: BAE31471.1 AK152942 mRNA Translation: BAE31613.1 AK156644 mRNA Translation: BAE33789.1 AK161978 mRNA Translation: BAE36663.1 AK162305 mRNA Translation: BAE36843.1 CT010343 mRNA Translation: CAJ18551.1 AL591411 Genomic DNA No translation available. AL591495 Genomic DNA No translation available. BC029254 mRNA Translation: AAH29254.1 |
CCDSi | CCDS17069.1 [P27512-1] CCDS17070.1 [P27512-5] CCDS17071.1 [P27512-2] |
PIRi | A46476 |
RefSeqi | NP_035741.2, NM_011611.2 [P27512-1] NP_733803.2, NM_170702.2 [P27512-5] NP_733804.1, NM_170703.2 [P27512-2] NP_733805.1, NM_170704.2 [P27512-4] |
Genome annotation databases
Ensembli | ENSMUST00000017799; ENSMUSP00000017799; ENSMUSG00000017652 [P27512-1] ENSMUST00000073707; ENSMUSP00000073386; ENSMUSG00000017652 [P27512-5] ENSMUST00000081310; ENSMUSP00000080059; ENSMUSG00000017652 [P27512-2] ENSMUST00000184221; ENSMUSP00000139193; ENSMUSG00000017652 [P27512-3] |
GeneIDi | 21939 |
KEGGi | mmu:21939 |
UCSCi | uc008nwx.1, mouse [P27512-5] uc008nwy.1, mouse [P27512-1] uc008nwz.1, mouse [P27512-4] uc008nxb.1, mouse [P27512-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83312 mRNA Translation: AAB08705.1 M94126 , M94129, M94128, M94127 Genomic DNA Translation: AAA37404.1 AJ401387 mRNA Translation: CAC29427.1 AJ401388 mRNA Translation: CAC29428.1 AJ401389 mRNA Translation: CAC29429.1 AJ401390 mRNA Translation: CAC29430.1 AK089861 mRNA Translation: BAC40978.1 AK150959 mRNA Translation: BAE29991.1 AK152716 mRNA Translation: BAE31440.1 AK152756 mRNA Translation: BAE31471.1 AK152942 mRNA Translation: BAE31613.1 AK156644 mRNA Translation: BAE33789.1 AK161978 mRNA Translation: BAE36663.1 AK162305 mRNA Translation: BAE36843.1 CT010343 mRNA Translation: CAJ18551.1 AL591411 Genomic DNA No translation available. AL591495 Genomic DNA No translation available. BC029254 mRNA Translation: AAH29254.1 |
CCDSi | CCDS17069.1 [P27512-1] CCDS17070.1 [P27512-5] CCDS17071.1 [P27512-2] |
PIRi | A46476 |
RefSeqi | NP_035741.2, NM_011611.2 [P27512-1] NP_733803.2, NM_170702.2 [P27512-5] NP_733804.1, NM_170703.2 [P27512-2] NP_733805.1, NM_170704.2 [P27512-4] |
3D structure databases
SMRi | P27512 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204251, 18 interactors |
CORUMi | P27512 |
DIPi | DIP-33295N |
ELMi | P27512 |
IntActi | P27512, 6 interactors |
MINTi | P27512 |
STRINGi | 10090.ENSMUSP00000017799 |
PTM databases
GlyGeni | P27512, 1 site |
iPTMneti | P27512 |
PhosphoSitePlusi | P27512 |
SwissPalmi | P27512 |
Proteomic databases
EPDi | P27512 |
MaxQBi | P27512 |
PaxDbi | P27512 |
PeptideAtlasi | P27512 |
PRIDEi | P27512 |
Protocols and materials databases
Antibodypediai | 3736, 2792 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000017799; ENSMUSP00000017799; ENSMUSG00000017652 [P27512-1] ENSMUST00000073707; ENSMUSP00000073386; ENSMUSG00000017652 [P27512-5] ENSMUST00000081310; ENSMUSP00000080059; ENSMUSG00000017652 [P27512-2] ENSMUST00000184221; ENSMUSP00000139193; ENSMUSG00000017652 [P27512-3] |
GeneIDi | 21939 |
KEGGi | mmu:21939 |
UCSCi | uc008nwx.1, mouse [P27512-5] uc008nwy.1, mouse [P27512-1] uc008nwz.1, mouse [P27512-4] uc008nxb.1, mouse [P27512-2] |
Organism-specific databases
CTDi | 958 |
MGIi | MGI:88336, Cd40 |
Phylogenomic databases
eggNOGi | ENOG502S5TQ, Eukaryota |
GeneTreei | ENSGT00940000161464 |
HOGENOMi | CLU_052667_4_0_1 |
InParanoidi | P27512 |
OMAi | DAVCGFQ |
OrthoDBi | 1038336at2759 |
PhylomeDBi | P27512 |
TreeFami | TF331157 |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-5676594, TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
Miscellaneous databases
BioGRID-ORCSi | 21939, 0 hits in 19 CRISPR screens |
PROi | PR:P27512 |
RNActi | P27512, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000017652, Expressed in spleen and 186 other tissues |
ExpressionAtlasi | P27512, baseline and differential |
Genevisiblei | P27512, MM |
Family and domain databases
CDDi | cd13407, TNFRSF5, 1 hit |
InterProi | View protein in InterPro IPR001368, TNFR/NGFR_Cys_rich_reg IPR020435, TNFR_5 IPR034021, TNFRSF5_N |
Pfami | View protein in Pfam PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01922, TNFACTORR5 |
SMARTi | View protein in SMART SM00208, TNFR, 4 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 1 hit PS50050, TNFR_NGFR_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR5_MOUSE | |
Accessioni | P27512Primary (citable) accession number: P27512 Secondary accession number(s): Q3TS33 Q99NE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | February 26, 2008 | |
Last modified: | February 10, 2021 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot