UniProtKB - P27487 (DPP4_HUMAN)
Dipeptidyl peptidase 4
DPP4
Functioni
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:17287217).
Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC (PubMed:10951221, PubMed:10900005, PubMed:11772392, PubMed:14691230).
Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217).
Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion (PubMed:11772392).
In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (PubMed:16651416, PubMed:10593948).
May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation (PubMed:18708048).
When overexpressed, enhanced cell proliferation, a process inhibited by GPC3 (PubMed:17549790).
Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32 (PubMed:16254193, PubMed:10570924).
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (PubMed:10593948).
11 Publications(Microbial infection) Acts as a receptor for human coronavirus MERS-CoV-2.
1 PublicationMiscellaneous
Catalytic activityi
- Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.PROSITE-ProRule annotation1 Publication EC:3.4.14.5
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 630 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 708 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Active sitei | 740 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- aminopeptidase activity Source: UniProtKB-KW
- chemorepellent activity Source: CACAO
- dipeptidyl-peptidase activity Source: UniProtKB
- identical protein binding Source: IntAct
- protease binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- serine-type endopeptidase activity Source: Reactome
- serine-type peptidase activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
- virus receptor activity Source: CACAO
GO - Biological processi
- behavioral fear response Source: Ensembl
- cell adhesion Source: UniProtKB-KW
- endothelial cell migration Source: UniProtKB
- glucagon processing Source: Reactome
- locomotory exploration behavior Source: Ensembl
- membrane fusion Source: ComplexPortal
- negative regulation of extracellular matrix disassembly Source: UniProtKB
- negative regulation of neutrophil chemotaxis Source: CACAO
- peptide hormone processing Source: Reactome
- positive regulation of cell population proliferation Source: UniProtKB
- proteolysis Source: CAFA
- psychomotor behavior Source: Ensembl
- receptor-mediated endocytosis of virus by host cell Source: ComplexPortal
- receptor-mediated virion attachment to host cell Source: ComplexPortal
- regulation of cell-cell adhesion mediated by integrin Source: UniProtKB
- response to hypoxia Source: UniProtKB
- T cell activation Source: UniProtKB
- T cell costimulation Source: UniProtKB
- viral entry into host cell Source: ComplexPortal
Keywordsi
Molecular function | Aminopeptidase, Hydrolase, Protease, Receptor, Serine protease |
Biological process | Cell adhesion |
Enzyme and pathway databases
BRENDAi | 3.4.14.5, 2681 |
PathwayCommonsi | P27487 |
Reactomei | R-HSA-381771, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-400511, Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
SABIO-RKi | P27487 |
SignaLinki | P27487 |
SIGNORi | P27487 |
Protein family/group databases
ESTHERi | human-DPP4, DPP4N_Peptidase_S9 |
MEROPSi | S09.003 |
MoonProti | P27487 |
TCDBi | 8.A.51.1.5, the dipeptidyl-aminopeptidase-like protein 6 beta subunit of kv4 channels (dpp6) family |
Names & Taxonomyi
Protein namesi | Recommended name: Dipeptidyl peptidase 4Curated (EC:3.4.14.51 Publication)Alternative name(s): ADABP Adenosine deaminase complexing protein 2 Short name: ADCP-2 Dipeptidyl peptidase IV Short name: DPP IV T-cell activation antigen CD26 TP103 CD_antigen: CD26 Cleaved into the following 2 chains: Alternative name(s): Dipeptidyl peptidase IV membrane form Alternative name(s): Dipeptidyl peptidase IV soluble form |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3009, DPP4 |
MIMi | 102720, gene |
neXtProti | NX_P27487 |
VEuPathDBi | HostDB:ENSG00000197635 |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Note: Detected in the serum and the seminal fluid.2 Publications
Plasma membrane
- Cell membrane 1 Publication2 Publications; Single-pass type II membrane protein
- Apical cell membrane 1 Publication; Single-pass type II membrane protein
- invadopodium membrane 1 Publication; Single-pass type II membrane protein
- lamellipodium membrane 1 Publication; Single-pass type II membrane protein
Other locations
- Cell junction 1 Publication
- Membrane raft 1 Publication
Note: Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to membrane rafts in T-cell in an interleukin-12-dependent activation (PubMed:12676959). Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005).6 Publications
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- lamellipodium membrane Source: UniProtKB-SubCell
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: UniProtKB
- endocytic vesicle Source: UniProtKB
- focal adhesion Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- intercellular canaliculus Source: Ensembl
- lamellipodium Source: UniProtKB
- membrane Source: UniProtKB
- membrane raft Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 6 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 7 – 28 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 22 | |
Topological domaini | 29 – 766 | ExtracellularSequence analysisAdd BLAST | 738 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 85 | N → A: Does not inhibit dipeptidyl peptidase activity, interaction with ADA and homodimer formation. 1 Publication | 1 | |
Mutagenesisi | 92 | N → A: Does not inhibit dipeptidyl peptidase activity, interaction with ADA and homodimer formation. 1 Publication | 1 | |
Mutagenesisi | 150 | N → A: Does not inhibit dipeptidyl peptidase activity, interaction with ADA and homodimer formation. 1 Publication | 1 | |
Mutagenesisi | 205 | E → K: Inhibits dipeptidyl peptidase activity. 1 Publication | 1 | |
Mutagenesisi | 206 | E → L: Inhibits dipeptidyl peptidase activity. 1 Publication | 1 | |
Mutagenesisi | 219 | N → A: Does not inhibit dipeptidyl peptidase activity, interaction with ADA and homodimer formation. 1 Publication | 1 | |
Mutagenesisi | 229 | N → A: Does not inhibit dipeptidyl peptidase activity, interaction with ADA and homodimer formation. 1 Publication | 1 | |
Mutagenesisi | 281 | N → A: Does not inhibit dipeptidyl peptidase activity, interaction with ADA and homodimer formation. 1 Publication | 1 | |
Mutagenesisi | 321 | N → A: Does not inhibit dipeptidyl peptidase activity, interaction with ADA and homodimer formation. 1 Publication | 1 | |
Mutagenesisi | 520 | N → A: Does not inhibit dipeptidyl peptidase activity, interaction with ADA and homodimer formation. 1 Publication | 1 | |
Mutagenesisi | 685 | N → A: Does not inhibit dipeptidyl peptidase activity, interaction with ADA and homodimer formation. 1 Publication | 1 | |
Mutagenesisi | 750 | H → A: Inhibits weakly homodimerization and dipeptidyl peptidase activity. 2 Publications | 1 | |
Mutagenesisi | 750 | H → E: Inhibits strongly homodimerization, dipeptidyl peptidase activity, interaction with CARD11 and T-cell costimulation activity. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 1803 |
OpenTargetsi | ENSG00000197635 |
PharmGKBi | PA27467 |
Miscellaneous databases
Pharosi | P27487, Tclin |
Chemistry databases
ChEMBLi | CHEMBL284 |
DrugBanki | DB07356, (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE DB06880, (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE DB07072, (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE DB07465, (1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrile DB08051, (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE DB07081, (2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE DB07482, (2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE DB07193, (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine DB03253, (2s)-Pyrrolidin-2-Ylmethylamine DB07092, (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE DB07135, (2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDE DB06994, (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine DB07067, (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE DB06993, (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine DB07154, (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE DB08164, (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE DB07015, (3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine DB07851, (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE DB08445, (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE DB07666, (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE DB07830, (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE DB07021, (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amine DB04578, (S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide DB04577, 1-(1-phenylcyclopentyl)methylamine DB08024, 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE DB07412, 1-biphenyl-2-ylmethanamine DB08588, 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE DB08743, 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE DB01884, 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One DB07181, 4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide DB07271, 4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one DB08672, 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE DB03660, 4-Iodo-L-phenylalanine DB02004, 5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine DB08504, 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM DB07239, 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile DB08530, 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE DB08044, ABT-341 DB06203, Alogliptin DB06011, AMG-222 DB01076, Atorvastatin DB06127, Bisegliptin DB04491, Diisopropylphosphono Group DB11723, Dutogliptin DB01276, Exenatide DB08382, Gosogliptin DB08882, Linagliptin DB06655, Liraglutide DB07328, METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATE DB06939, N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE DB07779, N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE DB08429, N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide DB05001, PSN9301 DB06335, Saxagliptin DB13928, Semaglutide DB01261, Sitagliptin DB04876, Vildagliptin |
DrugCentrali | P27487 |
GuidetoPHARMACOLOGYi | 1612 |
Genetic variation databases
BioMutai | DPP4 |
DMDMi | 1352311 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000027213 | 1 – 766 | Dipeptidyl peptidase 4 membrane formAdd BLAST | 766 | |
ChainiPRO_0000027214 | 39 – 766 | Dipeptidyl peptidase 4 soluble formAdd BLAST | 728 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineCombined sources5 Publications | 1 | |
Glycosylationi | 92 | N-linked (GlcNAc...) asparagineCombined sources3 Publications | 1 | |
Glycosylationi | 150 | N-linked (GlcNAc...) asparagineCombined sources5 Publications | 1 | |
Glycosylationi | 219 | N-linked (GlcNAc...) asparagineCombined sources4 Publications | 1 | |
Glycosylationi | 229 | N-linked (GlcNAc...) asparagineCombined sources5 Publications | 1 | |
Glycosylationi | 281 | N-linked (GlcNAc...) asparagineCombined sources4 Publications | 1 | |
Glycosylationi | 321 | N-linked (GlcNAc...) asparagineCombined sources3 Publications | 1 | |
Disulfide bondi | 328 ↔ 339 | Combined sources1 Publication | ||
Disulfide bondi | 385 ↔ 394 | Combined sources1 Publication | ||
Disulfide bondi | 444 ↔ 447 | Combined sources1 Publication | ||
Disulfide bondi | 454 ↔ 472 | Combined sources1 Publication | ||
Glycosylationi | 520 | N-linked (GlcNAc...) asparagineCombined sources5 Publications | 1 | |
Disulfide bondi | 649 ↔ 762 | Combined sources1 Publication | ||
Glycosylationi | 685 | N-linked (GlcNAc...) asparagine2 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | CPTAC-1292 |
jPOSTi | P27487 |
MassIVEi | P27487 |
MaxQBi | P27487 |
PaxDbi | P27487 |
PeptideAtlasi | P27487 |
PRIDEi | P27487 |
ProteomicsDBi | 54396 |
PTM databases
GlyConnecti | 1177, 20 N-Linked glycans (4 sites) |
GlyGeni | P27487, 12 sites, 21 N-linked glycans (4 sites) |
iPTMneti | P27487 |
PhosphoSitePlusi | P27487 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000197635, Expressed in calcaneal tendon and 193 other tissues |
ExpressionAtlasi | P27487, baseline and differential |
Genevisiblei | P27487, HS |
Organism-specific databases
HPAi | ENSG00000197635, Tissue enhanced (intestine, parathyroid gland, placenta, prostate) |
Interactioni
Subunit structurei
Monomer. Homodimer (PubMed:12832764, PubMed:15448155, PubMed:17287217, PubMed:12646248, PubMed:12483204, PubMed:12906826). Heterodimer with Seprase (FAP) (PubMed:16651416). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation.
Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Associates with collagen (PubMed:8526932).
Interacts with PTPRC; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (PubMed:12676959).
Interacts (via extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity (PubMed:15016824, PubMed:10951221, PubMed:14691230, PubMed:7907293, PubMed:8101391).
Interacts with CAV1 (via the N-terminus); the interaction is direct (PubMed:17287217).
Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11 (PubMed:17287217).
Interacts with IGF2R; the interaction is direct (PubMed:10900005).
Interacts with GPC3 (PubMed:17549790).
Interacts with human coronavirus-EMC spike protein and acts as a receptor for this virus (PubMed:23486063).
17 Publications(Microbial infection) Interacts with MERS coronavirus/MERS-CoV spike protein.
1 PublicationBinary interactionsi
P27487
GO - Molecular functioni
- chemorepellent activity Source: CACAO
- identical protein binding Source: IntAct
- protease binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108137, 437 interactors |
ComplexPortali | CPX-5768, MERS-CoV Spike - human DPP4 receptor complex CPX-5769, MERS-CoV Spike - human DPP4 receptor complex |
CORUMi | P27487 |
DIPi | DIP-351N |
IntActi | P27487, 29 interactors |
MINTi | P27487 |
STRINGi | 9606.ENSP00000353731 |
Chemistry databases
BindingDBi | P27487 |
Miscellaneous databases
RNActi | P27487, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P27487 |
SMRi | P27487 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P27487 |
Family & Domainsi
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2100, Eukaryota |
GeneTreei | ENSGT00940000161291 |
HOGENOMi | CLU_006105_4_3_1 |
InParanoidi | P27487 |
OMAi | AYVWKND |
OrthoDBi | 269253at2759 |
PhylomeDBi | P27487 |
TreeFami | TF313309 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002471, Pept_S9_AS IPR001375, Peptidase_S9 IPR002469, Peptidase_S9B_N |
Pfami | View protein in Pfam PF00930, DPPIV_N, 1 hit PF00326, Peptidase_S9, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00708, PRO_ENDOPEP_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MKTPWKVLLG LLGAAALVTI ITVPVVLLNK GTDDATADSR KTYTLTDYLK
60 70 80 90 100
NTYRLKLYSL RWISDHEYLY KQENNILVFN AEYGNSSVFL ENSTFDEFGH
110 120 130 140 150
SINDYSISPD GQFILLEYNY VKQWRHSYTA SYDIYDLNKR QLITEERIPN
160 170 180 190 200
NTQWVTWSPV GHKLAYVWNN DIYVKIEPNL PSYRITWTGK EDIIYNGITD
210 220 230 240 250
WVYEEEVFSA YSALWWSPNG TFLAYAQFND TEVPLIEYSF YSDESLQYPK
260 270 280 290 300
TVRVPYPKAG AVNPTVKFFV VNTDSLSSVT NATSIQITAP ASMLIGDHYL
310 320 330 340 350
CDVTWATQER ISLQWLRRIQ NYSVMDICDY DESSGRWNCL VARQHIEMST
360 370 380 390 400
TGWVGRFRPS EPHFTLDGNS FYKIISNEEG YRHICYFQID KKDCTFITKG
410 420 430 440 450
TWEVIGIEAL TSDYLYYISN EYKGMPGGRN LYKIQLSDYT KVTCLSCELN
460 470 480 490 500
PERCQYYSVS FSKEAKYYQL RCSGPGLPLY TLHSSVNDKG LRVLEDNSAL
510 520 530 540 550
DKMLQNVQMP SKKLDFIILN ETKFWYQMIL PPHFDKSKKY PLLLDVYAGP
560 570 580 590 600
CSQKADTVFR LNWATYLAST ENIIVASFDG RGSGYQGDKI MHAINRRLGT
610 620 630 640 650
FEVEDQIEAA RQFSKMGFVD NKRIAIWGWS YGGYVTSMVL GSGSGVFKCG
660 670 680 690 700
IAVAPVSRWE YYDSVYTERY MGLPTPEDNL DHYRNSTVMS RAENFKQVEY
710 720 730 740 750
LLIHGTADDN VHFQQSAQIS KALVDVGVDF QAMWYTDEDH GIASSTAHQH
760
IYTHMSHFIK QCFSLP
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WBB6 | F8WBB6_HUMAN | Dipeptidyl-peptidase IV | DPP4 | 118 | Annotation score: | ||
A0A7I2V3F5 | A0A7I2V3F5_HUMAN | Dipeptidyl-peptidase IV | DPP4 | 117 | Annotation score: | ||
A0A7I2V2X8 | A0A7I2V2X8_HUMAN | Dipeptidyl peptidase 4 | DPP4 | 765 | Annotation score: | ||
A0A7I2V2R5 | A0A7I2V2R5_HUMAN | Dipeptidyl peptidase 4 | DPP4 | 734 | Annotation score: | ||
A0A7I2V5R8 | A0A7I2V5R8_HUMAN | Dipeptidyl peptidase 4 | DPP4 hCG_39008 | 474 | Annotation score: | ||
F8WE17 | F8WE17_HUMAN | Dipeptidyl-peptidase IV | DPP4 | 170 | Annotation score: | ||
A0A7I2V2I2 | A0A7I2V2I2_HUMAN | Dipeptidyl-peptidase IV | DPP4 | 296 | Annotation score: | ||
A0A7I2V501 | A0A7I2V501_HUMAN | Dipeptidyl peptidase 4 | DPP4 | 78 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | K → R in AAA52308 (PubMed:1347043).Curated | 1 | |
Sequence conflicti | 7 | V → I in CAA43118 (PubMed:1352704).Curated | 1 | |
Sequence conflicti | 437 | S → I in CAA43118 (PubMed:1352704).Curated | 1 | |
Sequence conflicti | 557 | T → I in AAA52308 (PubMed:1347043).Curated | 1 | |
Sequence conflicti | 663 | D → E in AAA52308 (PubMed:1347043).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_084545 | 266 | V → I1 PublicationCorresponds to variant dbSNP:rs56179129EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60708 mRNA Translation: CAA43118.1 M80536 mRNA Translation: AAA52308.1 M74777 mRNA Translation: AAA51943.1 U13735 , U13710, U13711, U13712, U13713, U13714, U13715, U13716, U13717, U13718, U13719, U13720, U13721, U13722, U13723, U13724, U13725, U13726, U13727, U13728, U13729, U13730, U13731, U13732, U13733, U13734 Genomic DNA Translation: AAB60646.1 AB451339 mRNA Translation: BAG70153.1 AB451488 mRNA Translation: BAG70302.1 AC008063 Genomic DNA Translation: AAX93179.1 CH471058 Genomic DNA Translation: EAX11361.1 BC013329 mRNA Translation: AAH13329.2 BC065265 mRNA Translation: AAH65265.1 S79876 Genomic DNA Translation: AAB35614.1 |
CCDSi | CCDS2216.1 |
PIRi | S24313, CDHU26 |
RefSeqi | NP_001926.2, NM_001935.3 |
Genome annotation databases
Ensembli | ENST00000360534.8; ENSP00000353731.3; ENSG00000197635.11 |
GeneIDi | 1803 |
KEGGi | hsa:1803 |
MANE-Selecti | ENST00000360534.8; ENSP00000353731.3; NM_001935.4; NP_001926.2 |
UCSCi | uc002ubz.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Dipeptidyl peptidase-4 entry |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X60708 mRNA Translation: CAA43118.1 M80536 mRNA Translation: AAA52308.1 M74777 mRNA Translation: AAA51943.1 U13735 , U13710, U13711, U13712, U13713, U13714, U13715, U13716, U13717, U13718, U13719, U13720, U13721, U13722, U13723, U13724, U13725, U13726, U13727, U13728, U13729, U13730, U13731, U13732, U13733, U13734 Genomic DNA Translation: AAB60646.1 AB451339 mRNA Translation: BAG70153.1 AB451488 mRNA Translation: BAG70302.1 AC008063 Genomic DNA Translation: AAX93179.1 CH471058 Genomic DNA Translation: EAX11361.1 BC013329 mRNA Translation: AAH13329.2 BC065265 mRNA Translation: AAH65265.1 S79876 Genomic DNA Translation: AAB35614.1 |
CCDSi | CCDS2216.1 |
PIRi | S24313, CDHU26 |
RefSeqi | NP_001926.2, NM_001935.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1J2E | X-ray | 2.60 | A/B | 33-766 | [»] | |
1N1M | X-ray | 2.50 | A/B | 39-766 | [»] | |
1NU6 | X-ray | 2.10 | A/B | 39-766 | [»] | |
1NU8 | X-ray | 2.50 | A/B | 39-766 | [»] | |
1PFQ | X-ray | 1.90 | A/B | 36-766 | [»] | |
1R9M | X-ray | 2.10 | A/B/C/D | 39-766 | [»] | |
1R9N | X-ray | 2.30 | A/B/C/D | 39-766 | [»] | |
1RWQ | X-ray | 2.20 | A/B | 39-766 | [»] | |
1TK3 | X-ray | 2.00 | A/B | 39-766 | [»] | |
1TKR | X-ray | 2.70 | A/B | 39-766 | [»] | |
1U8E | X-ray | 2.20 | A/B | 39-766 | [»] | |
1W1I | X-ray | 3.03 | A/B/C/D | 39-766 | [»] | |
1WCY | X-ray | 2.20 | A/B | 33-766 | [»] | |
1X70 | X-ray | 2.10 | A/B | 39-766 | [»] | |
2AJL | X-ray | 2.50 | I/J | 39-766 | [»] | |
2BGN | X-ray | 3.15 | A/B/C/D | 39-766 | [»] | |
2BGR | X-ray | 2.00 | A/B | 29-766 | [»] | |
2BUB | X-ray | 2.66 | A/B | 39-766 | [»] | |
2FJP | X-ray | 2.40 | A/B | 39-766 | [»] | |
2G5P | X-ray | 2.40 | A/B | 39-764 | [»] | |
2G5T | X-ray | 2.30 | A/B | 39-764 | [»] | |
2G63 | X-ray | 2.00 | A/B/C/D | 39-764 | [»] | |
2HHA | X-ray | 2.35 | A/B | 40-766 | [»] | |
2I03 | X-ray | 2.40 | A/B/C/D | 39-764 | [»] | |
2I78 | X-ray | 2.50 | A/B/C/D | 39-764 | [»] | |
2IIT | X-ray | 2.35 | A/B | 39-766 | [»] | |
2IIV | X-ray | 2.15 | A/B | 39-766 | [»] | |
2JID | X-ray | 2.80 | A/B | 31-766 | [»] | |
2OAG | X-ray | 2.30 | A/B/C/D | 39-764 | [»] | |
2OGZ | X-ray | 2.10 | A/B | 39-766 | [»] | |
2OLE | X-ray | 2.40 | A/B | 39-766 | [»] | |
2ONC | X-ray | 2.55 | A/B/C/D | 41-766 | [»] | |
2OPH | X-ray | 2.40 | A/B | 39-766 | [»] | |
2OQI | X-ray | 2.80 | A/B/C/D | 39-766 | [»] | |
2OQV | X-ray | 2.80 | A/B | 39-764 | [»] | |
2P8S | X-ray | 2.20 | A/B | 40-766 | [»] | |
2QJR | X-ray | 2.20 | A/B | 31-766 | [»] | |
2QKY | X-ray | 3.10 | A/B/C/D | 40-766 | [»] | |
2QOE | X-ray | 2.30 | A/B | 39-766 | [»] | |
2QT9 | X-ray | 2.10 | A/B | 1-766 | [»] | |
2QTB | X-ray | 2.25 | A/B | 1-766 | [»] | |
2RGU | X-ray | 2.60 | A/B | 39-766 | [»] | |
2RIP | X-ray | 2.90 | A | 38-766 | [»] | |
3BJM | X-ray | 2.35 | A/B | 39-766 | [»] | |
3C43 | X-ray | 2.30 | A/B | 39-766 | [»] | |
3C45 | X-ray | 2.05 | A/B | 39-766 | [»] | |
3CCB | X-ray | 2.49 | A/B/C/D | 39-766 | [»] | |
3CCC | X-ray | 2.71 | A/B/C/D | 39-766 | [»] | |
3D4L | X-ray | 2.00 | A/B | 39-766 | [»] | |
3EIO | X-ray | 2.00 | A/B | 39-766 | [»] | |
3F8S | X-ray | 2.43 | A/B | 31-766 | [»] | |
3G0B | X-ray | 2.25 | A/B/C/D | 39-766 | [»] | |
3G0C | X-ray | 2.69 | A/B/C/D | 39-766 | [»] | |
3G0D | X-ray | 2.39 | A/B/C/D | 39-766 | [»] | |
3G0G | X-ray | 2.45 | A/B/C/D | 39-766 | [»] | |
3H0C | X-ray | 2.66 | A/B | 39-766 | [»] | |
3HAB | X-ray | 2.10 | A/B | 39-766 | [»] | |
3HAC | X-ray | 2.00 | A/B | 39-766 | [»] | |
3KWF | X-ray | 2.40 | A/B | 39-766 | [»] | |
3KWJ | X-ray | 2.80 | A/B | 39-766 | [»] | |
3NOX | X-ray | 2.34 | A/B | 39-766 | [»] | |
3O95 | X-ray | 2.85 | A/B/C/D | 39-766 | [»] | |
3O9V | X-ray | 2.75 | A/B/C/D | 39-766 | [»] | |
3OC0 | X-ray | 2.70 | A/B | 39-766 | [»] | |
3OPM | X-ray | 2.72 | A/B/C/D | 39-766 | [»] | |
3Q0T | X-ray | 2.40 | A/B | 39-766 | [»] | |
3Q8W | X-ray | 3.64 | A/B | 39-764 | [»] | |
3QBJ | X-ray | 2.21 | A/B | 31-766 | [»] | |
3SWW | X-ray | 2.00 | A/B | 39-766 | [»] | |
3SX4 | X-ray | 2.60 | A/B | 39-766 | [»] | |
3VJK | X-ray | 2.49 | A/B | 33-766 | [»] | |
3VJL | X-ray | 2.39 | A/B | 33-766 | [»] | |
3VJM | X-ray | 2.10 | A/B | 33-766 | [»] | |
3W2T | X-ray | 2.36 | A/B | 33-766 | [»] | |
3WQH | X-ray | 2.85 | A/B | 39-766 | [»] | |
4A5S | X-ray | 1.62 | A/B | 39-766 | [»] | |
4DSA | X-ray | 3.25 | A/B | 39-766 | [»] | |
4DSZ | X-ray | 3.20 | A/B | 39-766 | [»] | |
4DTC | X-ray | 3.00 | A/B | 39-766 | [»] | |
4G1F | X-ray | 2.90 | A/B/C/D | 39-766 | [»] | |
4J3J | X-ray | 3.20 | A/B | 39-766 | [»] | |
4JH0 | X-ray | 2.35 | A/B | 39-766 | [»] | |
4KR0 | X-ray | 2.70 | A | 39-766 | [»] | |
4L72 | X-ray | 3.00 | A | 39-766 | [»] | |
4LKO | X-ray | 2.43 | A/B | 39-766 | [»] | |
4N8D | X-ray | 1.65 | A/B | 39-766 | [»] | |
4N8E | X-ray | 2.30 | A/B | 39-766 | [»] | |
4PNZ | X-ray | 1.90 | A/B | 39-766 | [»] | |
4PV7 | X-ray | 3.24 | A/B | 39-766 | [»] | |
4QZV | X-ray | 2.59 | A/C | 39-766 | [»] | |
5I7U | X-ray | 1.95 | A/B | 39-766 | [»] | |
5ISM | X-ray | 2.00 | A/B | 39-766 | [»] | |
5J3J | X-ray | 2.75 | A/B | 40-766 | [»] | |
5KBY | X-ray | 2.24 | A/B/C/D | 39-766 | [»] | |
5T4B | X-ray | 1.76 | A/B | 40-766 | [»] | |
5T4E | X-ray | 1.77 | A/B | 40-766 | [»] | |
5T4F | X-ray | 1.90 | A/B | 40-766 | [»] | |
5T4H | X-ray | 2.61 | A/B | 40-766 | [»] | |
5Y7H | X-ray | 3.00 | A/B | 39-766 | [»] | |
5Y7J | X-ray | 2.52 | A/B/C/D | 39-766 | [»] | |
5Y7K | X-ray | 2.51 | A/B/C/D | 39-766 | [»] | |
5ZID | X-ray | 3.00 | A/B | 40-766 | [»] | |
6B1E | X-ray | 1.77 | A/B | 39-766 | [»] | |
6B1O | X-ray | 1.91 | A/B | 39-766 | [»] | |
AlphaFoldDBi | P27487 | |||||
SMRi | P27487 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108137, 437 interactors |
ComplexPortali | CPX-5768, MERS-CoV Spike - human DPP4 receptor complex CPX-5769, MERS-CoV Spike - human DPP4 receptor complex |
CORUMi | P27487 |
DIPi | DIP-351N |
IntActi | P27487, 29 interactors |
MINTi | P27487 |
STRINGi | 9606.ENSP00000353731 |
Chemistry databases
BindingDBi | P27487 |
ChEMBLi | CHEMBL284 |
DrugBanki | DB07356, (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE DB06880, (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE DB07072, (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE DB07465, (1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrile DB08051, (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE DB07081, (2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE DB07482, (2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE DB07193, (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine DB03253, (2s)-Pyrrolidin-2-Ylmethylamine DB07092, (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE DB07135, (2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDE DB06994, (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine DB07067, (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE DB06993, (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine DB07154, (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE DB08164, (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE DB07015, (3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine DB07851, (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE DB08445, (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE DB07666, (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE DB07830, (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE DB07021, (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amine DB04578, (S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide DB04577, 1-(1-phenylcyclopentyl)methylamine DB08024, 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE DB07412, 1-biphenyl-2-ylmethanamine DB08588, 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE DB08743, 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE DB01884, 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One DB07181, 4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide DB07271, 4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one DB08672, 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE DB03660, 4-Iodo-L-phenylalanine DB02004, 5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine DB08504, 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM DB07239, 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile DB08530, 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE DB08044, ABT-341 DB06203, Alogliptin DB06011, AMG-222 DB01076, Atorvastatin DB06127, Bisegliptin DB04491, Diisopropylphosphono Group DB11723, Dutogliptin DB01276, Exenatide DB08382, Gosogliptin DB08882, Linagliptin DB06655, Liraglutide DB07328, METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATE DB06939, N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE DB07779, N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE DB08429, N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide DB05001, PSN9301 DB06335, Saxagliptin DB13928, Semaglutide DB01261, Sitagliptin DB04876, Vildagliptin |
DrugCentrali | P27487 |
GuidetoPHARMACOLOGYi | 1612 |
Protein family/group databases
ESTHERi | human-DPP4, DPP4N_Peptidase_S9 |
MEROPSi | S09.003 |
MoonProti | P27487 |
TCDBi | 8.A.51.1.5, the dipeptidyl-aminopeptidase-like protein 6 beta subunit of kv4 channels (dpp6) family |
PTM databases
GlyConnecti | 1177, 20 N-Linked glycans (4 sites) |
GlyGeni | P27487, 12 sites, 21 N-linked glycans (4 sites) |
iPTMneti | P27487 |
PhosphoSitePlusi | P27487 |
Genetic variation databases
BioMutai | DPP4 |
DMDMi | 1352311 |
Proteomic databases
CPTACi | CPTAC-1292 |
jPOSTi | P27487 |
MassIVEi | P27487 |
MaxQBi | P27487 |
PaxDbi | P27487 |
PeptideAtlasi | P27487 |
PRIDEi | P27487 |
ProteomicsDBi | 54396 |
Protocols and materials databases
ABCDi | P27487, 15 sequenced antibodies |
Antibodypediai | 19093, 1772 antibodies from 45 providers |
DNASUi | 1803 |
Genome annotation databases
Ensembli | ENST00000360534.8; ENSP00000353731.3; ENSG00000197635.11 |
GeneIDi | 1803 |
KEGGi | hsa:1803 |
MANE-Selecti | ENST00000360534.8; ENSP00000353731.3; NM_001935.4; NP_001926.2 |
UCSCi | uc002ubz.4, human |
Organism-specific databases
CTDi | 1803 |
DisGeNETi | 1803 |
GeneCardsi | DPP4 |
HGNCi | HGNC:3009, DPP4 |
HPAi | ENSG00000197635, Tissue enhanced (intestine, parathyroid gland, placenta, prostate) |
MIMi | 102720, gene |
neXtProti | NX_P27487 |
OpenTargetsi | ENSG00000197635 |
PharmGKBi | PA27467 |
VEuPathDBi | HostDB:ENSG00000197635 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2100, Eukaryota |
GeneTreei | ENSGT00940000161291 |
HOGENOMi | CLU_006105_4_3_1 |
InParanoidi | P27487 |
OMAi | AYVWKND |
OrthoDBi | 269253at2759 |
PhylomeDBi | P27487 |
TreeFami | TF313309 |
Enzyme and pathway databases
BRENDAi | 3.4.14.5, 2681 |
PathwayCommonsi | P27487 |
Reactomei | R-HSA-381771, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-400511, Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
SABIO-RKi | P27487 |
SignaLinki | P27487 |
SIGNORi | P27487 |
Miscellaneous databases
BioGRID-ORCSi | 1803, 17 hits in 1077 CRISPR screens |
ChiTaRSi | DPP4, human |
EvolutionaryTracei | P27487 |
GeneWikii | Dipeptidyl_peptidase-4 |
GenomeRNAii | 1803 |
Pharosi | P27487, Tclin |
PROi | PR:P27487 |
RNActi | P27487, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197635, Expressed in calcaneal tendon and 193 other tissues |
ExpressionAtlasi | P27487, baseline and differential |
Genevisiblei | P27487, HS |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002471, Pept_S9_AS IPR001375, Peptidase_S9 IPR002469, Peptidase_S9B_N |
Pfami | View protein in Pfam PF00930, DPPIV_N, 1 hit PF00326, Peptidase_S9, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00708, PRO_ENDOPEP_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DPP4_HUMAN | |
Accessioni | P27487Primary (citable) accession number: P27487 Secondary accession number(s): Q53TN1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 231 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Peptidase families
Classification of peptidase families and list of entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families