Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calmodulin-like protein 3

Gene

CALML3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.2 Publications

Miscellaneous

Binds four calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
  • enzyme regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 3
Alternative name(s):
CaM-like protein
Short name:
CLP
Calmodulin-related protein NB-1
Gene namesi
Name:CALML3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000178363.4
HGNCiHGNC:1452 CALML3
MIMi114184 gene
neXtProtiNX_P27482

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi810
OpenTargetsiENSG00000178363
PharmGKBiPA26044

Polymorphism and mutation databases

BioMutaiCALML3
DMDMi115502

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735471 – 149Calmodulin-like protein 3Add BLAST149

Proteomic databases

EPDiP27482
MaxQBiP27482
PaxDbiP27482
PeptideAtlasiP27482
PRIDEiP27482
ProteomicsDBi54395
TopDownProteomicsiP27482

PTM databases

iPTMnetiP27482
PhosphoSitePlusiP27482

Expressioni

Tissue specificityi

Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells.1 Publication

Inductioni

By TGFB1.1 Publication

Gene expression databases

BgeeiENSG00000178363 Expressed in 110 organ(s), highest expression level in mammalian vulva
CleanExiHS_CALML3
GenevisibleiP27482 HS

Organism-specific databases

HPAiCAB010070
HPA044999

Interactioni

Subunit structurei

Interacts with MYO10, the interaction is calcium-dependent and essential for MYO10 function in filopodial extension.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi107261, 139 interactors
IntActiP27482, 20 interactors
MINTiP27482
STRINGi9606.ENSP00000315299

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP27482
SMRiP27482
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27482

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP27482
KOiK02183
OMAiCITTQEL
OrthoDBiEOG091G0V73
PhylomeDBiP27482
TreeFamiTF300912

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

P27482-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADQLTEEQV TEFKEAFSLF DKDGDGCITT RELGTVMRSL GQNPTEAELR
60 70 80 90 100
DMMSEIDRDG NGTVDFPEFL GMMARKMKDT DNEEEIREAF RVFDKDGNGF
110 120 130 140
VSAAELRHVM TRLGEKLSDE EVDEMIRAAD TDGDGQVNYE EFVRVLVSK
Length:149
Mass (Da):16,891
Last modified:January 23, 2007 - v2
Checksum:i1AB883E8ED4D263D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58026 mRNA Translation: AAA36356.1
X13461 Genomic DNA Translation: CAA31809.1
AL732437 Genomic DNA No translation available.
AK313934 mRNA Translation: BAG36653.1
CH471072 Genomic DNA Translation: EAW86443.1
BC031889 mRNA Translation: AAH31889.1
CCDSiCCDS7069.1
PIRiA38278 MCHUNB
RefSeqiNP_005176.1, NM_005185.3
UniGeneiHs.239600

Genome annotation databases

EnsembliENST00000315238; ENSP00000315299; ENSG00000178363
GeneIDi810
KEGGihsa:810
UCSCiuc001iie.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58026 mRNA Translation: AAA36356.1
X13461 Genomic DNA Translation: CAA31809.1
AL732437 Genomic DNA No translation available.
AK313934 mRNA Translation: BAG36653.1
CH471072 Genomic DNA Translation: EAW86443.1
BC031889 mRNA Translation: AAH31889.1
CCDSiCCDS7069.1
PIRiA38278 MCHUNB
RefSeqiNP_005176.1, NM_005185.3
UniGeneiHs.239600

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GGZX-ray1.50A2-149[»]
ProteinModelPortaliP27482
SMRiP27482
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107261, 139 interactors
IntActiP27482, 20 interactors
MINTiP27482
STRINGi9606.ENSP00000315299

PTM databases

iPTMnetiP27482
PhosphoSitePlusiP27482

Polymorphism and mutation databases

BioMutaiCALML3
DMDMi115502

Proteomic databases

EPDiP27482
MaxQBiP27482
PaxDbiP27482
PeptideAtlasiP27482
PRIDEiP27482
ProteomicsDBi54395
TopDownProteomicsiP27482

Protocols and materials databases

DNASUi810
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315238; ENSP00000315299; ENSG00000178363
GeneIDi810
KEGGihsa:810
UCSCiuc001iie.2 human

Organism-specific databases

CTDi810
DisGeNETi810
EuPathDBiHostDB:ENSG00000178363.4
GeneCardsiCALML3
HGNCiHGNC:1452 CALML3
HPAiCAB010070
HPA044999
MIMi114184 gene
neXtProtiNX_P27482
OpenTargetsiENSG00000178363
PharmGKBiPA26044
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP27482
KOiK02183
OMAiCITTQEL
OrthoDBiEOG091G0V73
PhylomeDBiP27482
TreeFamiTF300912

Miscellaneous databases

ChiTaRSiCALML3 human
EvolutionaryTraceiP27482
GeneWikiiCALML3
GenomeRNAii810
PROiPR:P27482
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178363 Expressed in 110 organ(s), highest expression level in mammalian vulva
CleanExiHS_CALML3
GenevisibleiP27482 HS

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCALL3_HUMAN
AccessioniPrimary (citable) accession number: P27482
Secondary accession number(s): B2R9V6, Q5SQI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again