UniProtKB - P27448 (MARK3_HUMAN)
MAP/microtubule affinity-regulating kinase 3
MARK3
Functioni
Serine/threonine-protein kinase (PubMed:23666762).
Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762).
Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613).
Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).
3 PublicationsCatalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 85 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 178 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 62 – 70 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- tau protein binding Source: ARUK-UCL
- tau-protein kinase activity Source: UniProtKB
GO - Biological processi
- intracellular signal transduction Source: GO_Central
- microtubule cytoskeleton organization Source: GO_Central
- negative regulation of hippo signaling Source: UniProtKB
- peptidyl-serine autophosphorylation Source: ARUK-UCL
- peptidyl-serine phosphorylation Source: ARUK-UCL
- positive regulation of protein binding Source: ARUK-UCL
- protein phosphorylation Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P27448 |
Reactomei | R-HSA-5673000, RAF activation R-HSA-5674135, MAP2K and MAPK activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SignaLinki | P27448 |
SIGNORi | P27448 |
Names & Taxonomyi
Protein namesi | Recommended name: MAP/microtubule affinity-regulating kinase 3 (EC:2.7.11.1)Alternative name(s): C-TAK1 Short name: cTAK1 Cdc25C-associated protein kinase 1 ELKL motif kinase 2 Short name: EMK-2 Protein kinase STK10 Ser/Thr protein kinase PAR-1 Short name: Par-1a Serine/threonine-protein kinase p78 |
Gene namesi | Name:MARK3 Synonyms:CTAK1, EMK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6897, MARK3 |
MIMi | 602678, gene |
neXtProti | NX_P27448 |
VEuPathDBi | HostDB:ENSG00000075413 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
Other locations
- dendrite 1 Publication
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Visual impairment and progressive phthisis bulbi (VIPB)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080778 | 570 | R → G in VIPB. 1 PublicationCorresponds to variant dbSNP:rs376395495EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 211 | T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 4140 |
MalaCardsi | MARK3 |
MIMi | 618283, phenotype |
OpenTargetsi | ENSG00000075413 |
PharmGKBi | PA30640 |
Miscellaneous databases
Pharosi | P27448, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5600 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P27448 |
GuidetoPHARMACOLOGYi | 2099 |
Genetic variation databases
BioMutai | MARK3 |
DMDMi | 341941142 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086304 | 1 – 753 | MAP/microtubule affinity-regulating kinase 3Add BLAST | 753 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 42 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 211 | Phosphothreonine; by LKB11 Publication | 1 | ||
Modified residuei | 368 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 374 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 376 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 380 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 383 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 400 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 419 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 469 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 540 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 543 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 549 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 564 | Phosphothreonine; by PKC/PRKCZBy similarity | 1 | ||
Modified residuei | 583 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 598 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 601 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 643 | PhosphoserineCombined sources | 1 | ||
Isoform 5 (identifier: P27448-6) | |||||
Modified residuei | 384 | PhosphoserineCombined sources | 1 | ||
Isoform 6 (identifier: P27448-7) | |||||
Modified residuei | 407 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P27448 |
jPOSTi | P27448 |
MassIVEi | P27448 |
MaxQBi | P27448 |
PaxDbi | P27448 |
PeptideAtlasi | P27448 |
PRIDEi | P27448 |
ProteomicsDBi | 54386 [P27448-5] 54387 [P27448-2] 54388 [P27448-3] 54389 [P27448-4] 54390 [P27448-6] 54391 [P27448-7] 54392 [P27448-8] |
PTM databases
GlyGeni | P27448, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P27448 |
MetOSitei | P27448 |
PhosphoSitePlusi | P27448 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000075413, Expressed in cerebellar hemisphere and 240 other tissues |
ExpressionAtlasi | P27448, baseline and differential |
Genevisiblei | P27448, HS |
Organism-specific databases
HPAi | ENSG00000075413, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
P27448
GO - Molecular functioni
- tau protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 110310, 156 interactors |
DIPi | DIP-34637N |
IntActi | P27448, 76 interactors |
MINTi | P27448 |
STRINGi | 9606.ENSP00000411397 |
Chemistry databases
BindingDBi | P27448 |
Miscellaneous databases
RNActi | P27448, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P27448 |
SMRi | P27448 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P27448 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 307 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 252 | |
Domaini | 326 – 365 | UBAPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 704 – 753 | KA1PROSITE-ProRule annotationAdd BLAST | 50 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 36 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 370 – 600 | DisorderedSequence analysisAdd BLAST | 231 | |
Regioni | 632 – 655 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 28 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 370 – 418 | Polar residuesSequence analysisAdd BLAST | 49 | |
Compositional biasi | 488 – 548 | Polar residuesSequence analysisAdd BLAST | 61 | |
Compositional biasi | 578 – 600 | Polar residuesSequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000154862 |
InParanoidi | P27448 |
OMAi | AKFRQGC |
TreeFami | TF315213 |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR033628, MARK3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
PANTHERi | PTHR24346:SF1, PTHR24346:SF1, 2 hits |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 35 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ
60 70 80 90 100
PHIGNYRLLK TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL
110 120 130 140 150
FREVRIMKIL NHPNIVKLFE VIETEKTLYL IMEYASGGEV FDYLVAHGRM
160 170 180 190 200
KEKEARSKFR QIVSAVQYCH QKRIVHRDLK AENLLLDADM NIKIADFGFS
210 220 230 240 250
NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG VILYTLVSGS
260 270 280 290 300
LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ
310 320 330 340 350
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS
360 370 380 390 400
KMKYDEITAT YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS
410 420 430 440 450
PHHKVQRSVS SSQKQRRYSD HAGPAIPSVV AYPKRSQTST ADSDLKEDGI
460 470 480 490 500
SSRKSSGSAV GGKGIAPASP MLGNASNPNK ADIPERKKSS TVPSSNTASG
510 520 530 540 550
GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS THSISSAATP
560 570 580 590 600
DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG
610 620 630 640 650
STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN
660 670 680 690 700
KEAKPRSLRF TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC
710 720 730 740 750
VHGDGHAENL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE
LKL
Computationally mapped potential isoform sequencesi
There are 35 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YNV4 | H0YNV4_HUMAN | Non-specific serine/threonine prote... | MARK3 | 643 | Annotation score: | ||
J3KNR0 | J3KNR0_HUMAN | Non-specific serine/threonine prote... | MARK3 hCG_25498 | 776 | Annotation score: | ||
A0A7I2YQF7 | A0A7I2YQF7_HUMAN | Non-specific serine/threonine prote... | MARK3 | 738 | Annotation score: | ||
H0YJI9 | H0YJI9_HUMAN | Non-specific serine/threonine prote... | MARK3 | 789 | Annotation score: | ||
A0A7I2V2N8 | A0A7I2V2N8_HUMAN | Non-specific serine/threonine prote... | MARK3 | 726 | Annotation score: | ||
A0A7I2V2U9 | A0A7I2V2U9_HUMAN | Non-specific serine/threonine prote... | MARK3 | 790 | Annotation score: | ||
A0A7I2V3I9 | A0A7I2V3I9_HUMAN | Non-specific serine/threonine prote... | MARK3 | 682 | Annotation score: | ||
A0A7I2V409 | A0A7I2V409_HUMAN | Non-specific serine/threonine prote... | MARK3 | 796 | Annotation score: | ||
A0A7I2V4K8 | A0A7I2V4K8_HUMAN | Non-specific serine/threonine prote... | MARK3 | 781 | Annotation score: | ||
H0YIY6 | H0YIY6_HUMAN | Non-specific serine/threonine prote... | MARK3 | 505 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 125 | E → Q in AAA59991 (Ref. 5) Curated | 1 | |
Sequence conflicti | 139 | E → K in AAL69982 (Ref. 4) Curated | 1 | |
Sequence conflicti | 139 | E → K in AAA59991 (Ref. 5) Curated | 1 | |
Sequence conflicti | 149 | R → K in AAD48007 (Ref. 2) Curated | 1 | |
Sequence conflicti | 425 | A → G in AAA59991 (Ref. 5) Curated | 1 | |
Sequence conflicti | 456 | S → T in AAA59991 (Ref. 5) Curated | 1 | |
Sequence conflicti | 516 | A → D in AAA59991 (Ref. 5) Curated | 1 | |
Sequence conflicti | 603 | N → T in AAA59991 (Ref. 5) Curated | 1 | |
Sequence conflicti | 645 | E → K in AAA59991 (Ref. 5) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080189 | 410 | S → F1 PublicationCorresponds to variant dbSNP:rs10137161Ensembl. | 1 | |
Natural variantiVAR_040765 | 429 | V → A1 Publication | 1 | |
Natural variantiVAR_046763 | 443 | S → G3 PublicationsCorresponds to variant dbSNP:rs56305318Ensembl. | 1 | |
Natural variantiVAR_080778 | 570 | R → G in VIPB. 1 PublicationCorresponds to variant dbSNP:rs376395495EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041582 | 161 | Q → QGCQAGQTIKVQVSFDLLSL MFTF in isoform 2 and isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_043197 | 179 – 257 | Missing in isoform 7. 1 PublicationAdd BLAST | 79 | |
Alternative sequenceiVSP_004943 | 371 – 386 | Missing in isoform 5 and isoform 6. 2 PublicationsAdd BLAST | 16 | |
Alternative sequenceiVSP_004944 | 615 – 638 | Missing in isoform 2, isoform 3 and isoform 5. 4 PublicationsAdd BLAST | 24 | |
Alternative sequenceiVSP_004945 | 615 – 623 | Missing in isoform 4. 1 Publication | 9 | |
Alternative sequenceiVSP_043198 | 624 – 638 | Missing in isoform 7. 1 PublicationAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64205 mRNA Translation: AAC15093.1 AF159295 mRNA Translation: AAD48007.1 AF387637 mRNA Translation: AAK82367.1 AF465413 mRNA Translation: AAL69982.1 M80359 mRNA Translation: AAA59991.1 BX161395 mRNA Translation: CAD61882.1 AL133367 Genomic DNA No translation available. KF456011 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81813.1 CH471061 Genomic DNA Translation: EAW81815.1 CH471061 Genomic DNA Translation: EAW81817.1 BC024773 mRNA Translation: AAH24773.1 AF170723 mRNA Translation: AAD51631.1 |
CCDSi | CCDS41993.1 [P27448-3] CCDS45165.1 [P27448-5] CCDS45166.1 [P27448-4] CCDS45167.1 [P27448-8] CCDS55947.1 [P27448-6] |
PIRi | S27966 |
RefSeqi | NP_001122390.2, NM_001128918.2 [P27448-5] NP_001122391.2, NM_001128919.2 [P27448-4] NP_001122392.2, NM_001128920.2 [P27448-6] NP_001122393.2, NM_001128921.2 [P27448-8] NP_002367.5, NM_002376.6 [P27448-3] |
Genome annotation databases
Ensembli | ENST00000216288; ENSP00000216288; ENSG00000075413 [P27448-6] ENST00000303622; ENSP00000303698; ENSG00000075413 [P27448-3] ENST00000416682; ENSP00000408092; ENSG00000075413 [P27448-2] ENST00000429436; ENSP00000411397; ENSG00000075413 ENST00000440884; ENSP00000402104; ENSG00000075413 [P27448-8] ENST00000553942; ENSP00000450772; ENSG00000075413 [P27448-4] |
GeneIDi | 4140 |
KEGGi | hsa:4140 |
MANE-Selecti | ENST00000429436.7; ENSP00000411397.2; NM_001128918.3; NP_001122390.2 |
UCSCi | uc001ymw.5, human [P27448-5] uc001ymy.5, human uc001ymz.5, human uc001yna.5, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U64205 mRNA Translation: AAC15093.1 AF159295 mRNA Translation: AAD48007.1 AF387637 mRNA Translation: AAK82367.1 AF465413 mRNA Translation: AAL69982.1 M80359 mRNA Translation: AAA59991.1 BX161395 mRNA Translation: CAD61882.1 AL133367 Genomic DNA No translation available. KF456011 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW81813.1 CH471061 Genomic DNA Translation: EAW81815.1 CH471061 Genomic DNA Translation: EAW81817.1 BC024773 mRNA Translation: AAH24773.1 AF170723 mRNA Translation: AAD51631.1 |
CCDSi | CCDS41993.1 [P27448-3] CCDS45165.1 [P27448-5] CCDS45166.1 [P27448-4] CCDS45167.1 [P27448-8] CCDS55947.1 [P27448-6] |
PIRi | S27966 |
RefSeqi | NP_001122390.2, NM_001128918.2 [P27448-5] NP_001122391.2, NM_001128919.2 [P27448-4] NP_001122392.2, NM_001128920.2 [P27448-6] NP_001122393.2, NM_001128921.2 [P27448-8] NP_002367.5, NM_002376.6 [P27448-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2QNJ | X-ray | 2.70 | A/B | 48-370 | [»] | |
3FE3 | X-ray | 1.90 | A/B | 41-367 | [»] | |
7P1L | X-ray | 1.95 | A/B | 48-366 | [»] | |
BMRBi | P27448 | |||||
SMRi | P27448 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110310, 156 interactors |
DIPi | DIP-34637N |
IntActi | P27448, 76 interactors |
MINTi | P27448 |
STRINGi | 9606.ENSP00000411397 |
Chemistry databases
BindingDBi | P27448 |
ChEMBLi | CHEMBL5600 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P27448 |
GuidetoPHARMACOLOGYi | 2099 |
PTM databases
GlyGeni | P27448, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P27448 |
MetOSitei | P27448 |
PhosphoSitePlusi | P27448 |
Genetic variation databases
BioMutai | MARK3 |
DMDMi | 341941142 |
Proteomic databases
EPDi | P27448 |
jPOSTi | P27448 |
MassIVEi | P27448 |
MaxQBi | P27448 |
PaxDbi | P27448 |
PeptideAtlasi | P27448 |
PRIDEi | P27448 |
ProteomicsDBi | 54386 [P27448-5] 54387 [P27448-2] 54388 [P27448-3] 54389 [P27448-4] 54390 [P27448-6] 54391 [P27448-7] 54392 [P27448-8] |
Protocols and materials databases
Antibodypediai | 6515, 472 antibodies from 37 providers |
DNASUi | 4140 |
Genome annotation databases
Ensembli | ENST00000216288; ENSP00000216288; ENSG00000075413 [P27448-6] ENST00000303622; ENSP00000303698; ENSG00000075413 [P27448-3] ENST00000416682; ENSP00000408092; ENSG00000075413 [P27448-2] ENST00000429436; ENSP00000411397; ENSG00000075413 ENST00000440884; ENSP00000402104; ENSG00000075413 [P27448-8] ENST00000553942; ENSP00000450772; ENSG00000075413 [P27448-4] |
GeneIDi | 4140 |
KEGGi | hsa:4140 |
MANE-Selecti | ENST00000429436.7; ENSP00000411397.2; NM_001128918.3; NP_001122390.2 |
UCSCi | uc001ymw.5, human [P27448-5] uc001ymy.5, human uc001ymz.5, human uc001yna.5, human |
Organism-specific databases
CTDi | 4140 |
DisGeNETi | 4140 |
GeneCardsi | MARK3 |
HGNCi | HGNC:6897, MARK3 |
HPAi | ENSG00000075413, Low tissue specificity |
MalaCardsi | MARK3 |
MIMi | 602678, gene 618283, phenotype |
neXtProti | NX_P27448 |
OpenTargetsi | ENSG00000075413 |
PharmGKBi | PA30640 |
VEuPathDBi | HostDB:ENSG00000075413 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000154862 |
InParanoidi | P27448 |
OMAi | AKFRQGC |
TreeFami | TF315213 |
Enzyme and pathway databases
PathwayCommonsi | P27448 |
Reactomei | R-HSA-5673000, RAF activation R-HSA-5674135, MAP2K and MAPK activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SignaLinki | P27448 |
SIGNORi | P27448 |
Miscellaneous databases
BioGRID-ORCSi | 4140, 18 hits in 1086 CRISPR screens |
ChiTaRSi | MARK3, human |
EvolutionaryTracei | P27448 |
GeneWikii | MARK3 |
GenomeRNAii | 4140 |
Pharosi | P27448, Tchem |
PROi | PR:P27448 |
RNActi | P27448, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000075413, Expressed in cerebellar hemisphere and 240 other tissues |
ExpressionAtlasi | P27448, baseline and differential |
Genevisiblei | P27448, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR033628, MARK3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
PANTHERi | PTHR24346:SF1, PTHR24346:SF1, 2 hits |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MARK3_HUMAN | |
Accessioni | P27448Primary (citable) accession number: P27448 Secondary accession number(s): A0A0A0MQR8 Q9UN34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 23, 2022 | |
This is version 212 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families