Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 180 (05 Jun 2019)
Sequence version 2 (25 Oct 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Calpain-D

Gene

sol

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in eye development.1 Publication
Calcium-regulated non-lysosomal thiol-protease.By similarity

Miscellaneous

Although homology to other calpains is high within the protease domain, the lack of calcium-binding sites suggests that this protein is a protease that may not be activated by calcium ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1079By similarity1
Active sitei1245By similarity1
Active sitei1265By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1 – 35RanBP2-type 1PROSITE-ProRule annotationAdd BLAST35
Zinc fingeri135 – 164RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri643 – 673RanBP2-type 3PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri704 – 733RanBP2-type 4PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri744 – 774RanBP2-type 5PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri927 – 956RanBP2-type 6PROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Hydrolase, Protease, Thiol protease
Biological processSensory transduction, Vision
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.B35 1994

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C02.010

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpain-D (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase D
Short name:
CANP D
Small optic lobes protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sol
Synonyms:CalpD
ORF Names:CG1391
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003464 sol

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants cause specific cells to degenerate in the developing optic lobes, resulting in the absence of certain classes of columnar neurons.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002077331 – 1594Calpain-DAdd BLAST1594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei250Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27398

PRoteomics IDEntifications database

More...
PRIDEi
P27398

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P27398

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Present throughout development, with expression levels lower in larvae than other life stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003464 Expressed in 31 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P27398 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P27398 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
68777, 74 interactors

Protein interaction database and analysis system

More...
IntActi
P27398, 13 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0088620

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27398

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1014 – 1321Calpain catalyticPROSITE-ProRule annotationAdd BLAST308

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi421 – 460Ser-richAdd BLAST40
Compositional biasi470 – 509Ala-richAdd BLAST40
Compositional biasi607 – 629Ala-richAdd BLAST23
Compositional biasi673 – 699Gln-richAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 35RanBP2-type 1PROSITE-ProRule annotationAdd BLAST35
Zinc fingeri135 – 164RanBP2-type 2PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri643 – 673RanBP2-type 3PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri704 – 733RanBP2-type 4PROSITE-ProRule annotationAdd BLAST30
Zinc fingeri744 – 774RanBP2-type 5PROSITE-ProRule annotationAdd BLAST31
Zinc fingeri927 – 956RanBP2-type 6PROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158312

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27398

KEGG Orthology (KO)

More...
KOi
K08582

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSKKWQC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27398

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00044 CysPc, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR038765 Papain-like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00648 Peptidase_C2, 1 hit
PF00641 zf-RanBP, 6 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704 CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230 CysPc, 1 hit
SM00547 ZnF_RBZ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit
SSF90209 SSF90209, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS01358 ZF_RANBP2_1, 5 hits
PS50199 ZF_RANBP2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform BImported (identifier: P27398-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTISSVLQW SCTKCNTINP TESLKCFNCG TVRKVFPQQQ QQQHRSSSIT
60 70 80 90 100
ASWTADDALE QEQAEKGQER DKEKGRAAVA RSEYKHVYKS LLRGCLKRPQ
110 120 130 140 150
RNSQNLPANC VDCEDTRKYI KSSIELYRHF SNPALNRRWV CHACGTDNSS
160 170 180 190 200
VTWHCLICDT VSYLAPIYKD AIAADRGQDL AGSLGNRGEL LAADHSHPHH
210 220 230 240 250
HHHYLHQELE EQHQHQLHSQ HLHKRHLKGR SASGSGSGPG SGSGLRRTQS
260 270 280 290 300
LSTAIDKSAS GRSCHICYAN NQSKDIFNLP QIKPAPQLTG IPPVAACSNS
310 320 330 340 350
RFAIANDTFC RRKQNNNNKN QNHKVVRESG AKRKYNFTIT TLSRSAAKDA
360 370 380 390 400
GHGQMKPLRQ VVNLNLNLQQ EPQQKSPANP QQLQRKTQRE PAAVSMNPTQ
410 420 430 440 450
FTIPRNGVFI AVNEWSEPMA SSSSVSSSSN HHHHHHSNSN SNSSGNSNII
460 470 480 490 500
NNNSSSSSGS NKLYENECVA LAQQQLRAAA AQAAQAAATA VAIASSPSAK
510 520 530 540 550
AMAEPAPTAT MPIYAQVNKQ HKLKKKQQIA SESQTNNNTG SGEIADAVSE
560 570 580 590 600
SLTAGLGTST DGSGEASESE SQVEEHSIYA KVWKGPRKAT ESKIMHDPGS
610 620 630 640 650
SSRLSGAASA AAGTASAGAI AAAVGAAAAS RHDNKTQLGN GSRSKMWICI
660 670 680 690 700
KCSYAYNRLW LQTCEMCEAK AEQQQQQLQL QQQQQQQQQH HHHHLQQQQA
710 720 730 740 750
EAPRDEPWTC KKCTLVNYST AMACVVCGGS KLKSISSIED MTLRKGEFWT
760 770 780 790 800
CSHCTLKNSL HSPVCSACKS HRQPQLSMAM EAVRERPDGQ SYEEQDAAAV
810 820 830 840 850
GGGGGSAHQS GANEVKAPTA LNLPLTSVAL PMPMLQLPTS TAAGLRGSRS
860 870 880 890 900
PSPRMQLLPS LQQQRNSSSS GAIPKRHSTG GSIVPRNISI AGLANYNLQQ
910 920 930 940 950
GQGVGSASVV SASGAGSGAG AVGASTSTKK WQCPACTYDN CAASVVCDIC
960 970 980 990 1000
SSPRGLASAV LGEALGRKSV RVALTPADIR QESKLMENLR QLEETEALTK
1010 1020 1030 1040 1050
WQNIIQYCRD NSELFVDDSF PPAPKSLYYN PASGAGEGNP VVQWRRPHEI
1060 1070 1080 1090 1100
NCDGGAYPPW AVFRTPLPSD ICQGVLGNCW LLSALAVLAE REDLVKEVLV
1110 1120 1130 1140 1150
TKEICGQGAY QVRLCKDGKW TTVLVDDLLP CDKRGHLVYS QAKRKQLWVP
1160 1170 1180 1190 1200
LIEKAVAKIH GCYEALVSGR AIEGLATLTG APCESIPLQA SSLPMPSEDE
1210 1220 1230 1240 1250
LDKDLIWAQL LSSRCVRFLM GASCGGGNMK VDEEEYQQKG LRPRHAYSVL
1260 1270 1280 1290 1300
DVKDIQGHRL LKLRNPWGHY SWRGDWSDDS SLWTDDLRDA LMPHGASEGV
1310 1320 1330 1340 1350
FWISFEDVLN YFDCIDICKV RSGWNEVRLQ GTLQPLCSIS CVLLTVLEPT
1360 1370 1380 1390 1400
EAEFTLFQEG QRNSEKSQRS QLDLCVVIFR TRSPAAPEIG RLVEHSKRQV
1410 1420 1430 1440 1450
RGFVGCHKML ERDIYLLVCL AFNHWHTGIE DPHQYPQCIL AIHSSKRLLV
1460 1470 1480 1490 1500
EQISPSPHLL ADAIISLTLT KGQRHEGREG MTAYYLTKGW AGLVVMVENR
1510 1520 1530 1540 1550
HENKWIHVKC DCQESYNVVS TRGELKTVDS VPPLQRQVII VLTQLEGSGG
1560 1570 1580 1590
FSIAHRLTHR LANSRGLHDW GPPGATHCPP IENVHGLHAP RLIT
Length:1,594
Mass (Da):174,313
Last modified:October 25, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1CDDE8090B5DA198
GO
Isoform AImported (identifier: P27398-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     394-395: VS → YA
     396-1594: Missing.

Show »
Length:395
Mass (Da):44,202
Checksum:i2740C711A619780A
GO
Isoform EImported (identifier: P27398-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     701-701: Missing.

Show »
Length:1,593
Mass (Da):174,184
Checksum:i2B989757525814BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JJ98E1JJ98_DROME
FI20257p1
sol CalpD, Dmel\CG1391, DmSol, nofE, PC79
1,593Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAS65411 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti384Q → H in AAB95431 (PubMed:1714593).Curated1
Sequence conflicti623A → G in AAB95431 (PubMed:1714593).Curated1
Sequence conflicti679Q → H in AAB95431 (PubMed:1714593).Curated1
Sequence conflicti694H → HHHH in AAB95431 (PubMed:1714593).Curated1
Sequence conflicti694H → HHHH in AAC28409 (PubMed:9144213).Curated1
Sequence conflicti836Q → R in AAM75061 (PubMed:12537569).Curated1
Sequence conflicti915A → G in AAC28409 (PubMed:9144213).Curated1
Sequence conflicti928T → S in AAB95431 (PubMed:1714593).Curated1
Sequence conflicti928T → S in AAC28409 (PubMed:9144213).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011791394 – 395VS → YA in isoform A. 1 Publication2
Alternative sequenceiVSP_005246396 – 1594Missing in isoform A. 1 PublicationAdd BLAST1199
Alternative sequenceiVSP_058143701Missing in isoform E. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M64084 mRNA Translation: AAB95431.1
AF017777 Genomic DNA Translation: AAC28409.1
AE014298 Genomic DNA Translation: AAF50826.4
AE014298 Genomic DNA Translation: AAF50827.3
AE014298 Genomic DNA Translation: AAS65411.2 Sequence problems.
AY128468 mRNA Translation: AAM75061.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A41146 BVFFSL
T08428

NCBI Reference Sequences

More...
RefSeqi
NP_476737.3, NM_057389.6 [P27398-2]
NP_476738.3, NM_057390.6 [P27398-1]
NP_996524.2, NM_206801.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089678; FBpp0088620; FBgn0003464 [P27398-1]
FBtr0089679; FBpp0088621; FBgn0003464 [P27398-2]
FBtr0301583; FBpp0290798; FBgn0003464 [P27398-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44014

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1391

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64084 mRNA Translation: AAB95431.1
AF017777 Genomic DNA Translation: AAC28409.1
AE014298 Genomic DNA Translation: AAF50826.4
AE014298 Genomic DNA Translation: AAF50827.3
AE014298 Genomic DNA Translation: AAS65411.2 Sequence problems.
AY128468 mRNA Translation: AAM75061.1
PIRiA41146 BVFFSL
T08428
RefSeqiNP_476737.3, NM_057389.6 [P27398-2]
NP_476738.3, NM_057390.6 [P27398-1]
NP_996524.2, NM_206801.3

3D structure databases

SMRiP27398
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68777, 74 interactors
IntActiP27398, 13 interactors
STRINGi7227.FBpp0088620

Protein family/group databases

MEROPSiC02.010

PTM databases

iPTMnetiP27398

Proteomic databases

PaxDbiP27398
PRIDEiP27398

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089678; FBpp0088620; FBgn0003464 [P27398-1]
FBtr0089679; FBpp0088621; FBgn0003464 [P27398-2]
FBtr0301583; FBpp0290798; FBgn0003464 [P27398-5]
GeneIDi44014
KEGGidme:Dmel_CG1391

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
44014
FlyBaseiFBgn0003464 sol

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00940000158312
InParanoidiP27398
KOiK08582
OMAiSSKKWQC
PhylomeDBiP27398

Enzyme and pathway databases

BRENDAi3.4.22.B35 1994

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
44014

Protein Ontology

More...
PROi
PR:P27398

Gene expression databases

BgeeiFBgn0003464 Expressed in 31 organ(s), highest expression level in female gonad
ExpressionAtlasiP27398 baseline and differential
GenevisibleiP27398 DM

Family and domain databases

CDDicd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR038765 Papain-like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PfamiView protein in Pfam
PF00648 Peptidase_C2, 1 hit
PF00641 zf-RanBP, 6 hits
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SM00547 ZnF_RBZ, 6 hits
SUPFAMiSSF54001 SSF54001, 1 hit
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS01358 ZF_RANBP2_1, 5 hits
PS50199 ZF_RANBP2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAND_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27398
Secondary accession number(s): O61346
, Q7KU57, Q7KU58, Q8MQP3, Q9VRH3, Q9VRH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 25, 2004
Last modified: June 5, 2019
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again