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Entry version 94 (12 Aug 2020)
Sequence version 1 (01 Aug 1992)
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Protein

Cell surface glycoprotein

Gene

slgA

Organism
Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of the cell.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MFER523846:G1GOR-235-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell surface glycoprotein
Alternative name(s):
S-layer protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:slgA
Ordered Locus Names:Mfer_0225
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMethanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri523846 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002315 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • S-layer
  • Note: This archaea is covered by an S-layer with hexagonal symmetry.

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, S-layer, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003261823 – 593Cell surface glycoproteinAdd BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GalNAc...) asparagine1 Publication1
Glycosylationi58N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi122N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi145N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi500N-linked (GalNAc...) asparagineSequence analysis1
Glycosylationi516N-linked (GalNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated; contains glycans composed of methyl-Man, Man and GalNAc residues in a molar ratio of 2:3:1.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P27373

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P27373

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_459779_0_0_2

KEGG Orthology (KO)

More...
KOi
K07218

Database of Orthologous Groups

More...
OrthoDBi
82089at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006633, Carb-bd_sugar_hydrolysis-dom
IPR007742, NosD_dom
IPR022441, Para_beta_helix_rpt-2
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05048, NosD, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00722, CASH, 2 hits
SM00710, PbH1, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51126, SSF51126, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03804, para_beta_helix, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P27373-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKFTLLMLL LIVISMSGIA GAAEVKNLNT SKTFTKIQEA IDDPSTTDGN
60 70 80 90 100
IIIVGPGNYT ENILVNKSLT LKSNGSAIIN AVSSEKSTIT IKANNVWIEG
110 120 130 140 150
FIIIGGKNGI YMENVTGCTI TNNTIQNAFV SGWEYYGGNG ICLVNSTNNT
160 170 180 190 200
ITNNIIRNNT WNGINVCESK GNIIKNNTIM YSGGIGIYVW GFNKFEGNNI
210 220 230 240 250
IENNRIINAT YGGIYLFRPS NNKICRNYIA NVSSGGGGMS GAICIDVSDY
260 270 280 290 300
NIVKDNIGIN CDGGLFTDGM IGNEITNNIF KNCKVAVSES TYGPASRNNK
310 320 330 340 350
IYGNYFINYE TAISDPKGEL VDNIWNTTEG GNYWSNYTGN NTGDGTGNIP
360 370 380 390 400
YYYDNKPLVV DLAIEDIAAK PSGIEVRVKN LGKADIKKID PLTKLKIKIS
410 420 430 440 450
CDNDVYETFI DPLSAGESQI VRWDKIVPEG NHTIKAEIPY SAEGYLIGTN
460 470 480 490 500
IRDADISNNV FSKIVQGFVQ NKTFTITLTN LGKSTITIKY YISIYTNPVN
510 520 530 540 550
GTKVSYRELT ITLKPNETKT IELGKYPFKY AVSGTMIVKN PSRYRIPLNL
560 570 580 590
RIKYEIEGLN PQMREISKYI APRGEFRYIA RYTGKEEGYA DVW
Length:593
Mass (Da):65,481
Last modified:August 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE064669967B7611C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X58297 Genomic DNA Translation: CAA41230.1
CP002278 Genomic DNA Translation: ADP77028.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S16225

NCBI Reference Sequences

More...
RefSeqi
WP_013413306.1, NC_014658.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ADP77028; ADP77028; Mfer_0225

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9961940

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mfv:Mfer_0225

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58297 Genomic DNA Translation: CAA41230.1
CP002278 Genomic DNA Translation: ADP77028.1
PIRiS16225
RefSeqiWP_013413306.1, NC_014658.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiP27373

Proteomic databases

PRIDEiP27373

Genome annotation databases

EnsemblBacteriaiADP77028; ADP77028; Mfer_0225
GeneIDi9961940
KEGGimfv:Mfer_0225

Phylogenomic databases

HOGENOMiCLU_459779_0_0_2
KOiK07218
OrthoDBi82089at2157

Enzyme and pathway databases

BioCyciMFER523846:G1GOR-235-MONOMER

Family and domain databases

Gene3Di2.160.20.10, 1 hit
InterProiView protein in InterPro
IPR006633, Carb-bd_sugar_hydrolysis-dom
IPR007742, NosD_dom
IPR022441, Para_beta_helix_rpt-2
IPR006626, PbH1
IPR012334, Pectin_lyas_fold
IPR011050, Pectin_lyase_fold/virulence
PfamiView protein in Pfam
PF05048, NosD, 2 hits
SMARTiView protein in SMART
SM00722, CASH, 2 hits
SM00710, PbH1, 8 hits
SUPFAMiSSF51126, SSF51126, 1 hit
TIGRFAMsiTIGR03804, para_beta_helix, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSG_METFV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27373
Secondary accession number(s): E3GXJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: August 12, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome
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