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Protein

Amine oxidase [flavin-containing] B

Gene

MAOB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei156Important for catalytic activity1
Sitei365Important for catalytic activity1
Sitei382Important for catalytic activity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS00966-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.4.3.4 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P27338

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P27338

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amine oxidase [flavin-containing] B (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type B
Short name:
MAO-B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAOB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000069535.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6834 MAOB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
309860 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P27338

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 489CytoplasmicAdd BLAST488
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei490 – 516Helical; Anchor for type IV membrane proteinAdd BLAST27
Topological domaini517 – 520Mitochondrial intermembrane4

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi5C → S: No loss of activity. 1 Publication1
Mutagenesisi156C → S: Complete loss of activity. 1 Publication1
Mutagenesisi158T → A: Dramatic loss of activity. 1 Publication1
Mutagenesisi172C → S: No loss of activity. 1 Publication1
Mutagenesisi192C → S: No loss of activity. 1 Publication1
Mutagenesisi199I → F: Alters specificity towards synthetic inhibitors. 1
Mutagenesisi297C → S: No loss of activity. 1 Publication1
Mutagenesisi312C → S: No loss of activity. 1 Publication1
Mutagenesisi365C → S: Complete loss of activity. 1 Publication1
Mutagenesisi382H → R: Significant loss of activity. 1 Publication1
Mutagenesisi386K → M: No loss of activity. 1 Publication1
Mutagenesisi389C → A: Complete loss of activity. 2 Publications1
Mutagenesisi389C → S: No loss of activity. 2 Publications1
Mutagenesisi394S → A: No loss of activity. 1 Publication1
Mutagenesisi397C → S: Complete loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
4129

Open Targets

More...
OpenTargetsi
ENSG00000069535

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA237

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2039

Drug and drug target database

More...
DrugBanki
DB08176 (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE
DB08516 (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]
DB08480 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN
DB01472 4-Methoxyamphetamine
DB04307 5-Hydroxy-N-Propargyl-1(R)-Aminoindan
DB07512 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE
DB07513 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE
DB00915 Amantadine
DB00182 Amphetamine
DB04889 Bicifadine
DB01445 Bufotenine
DB00988 Dopamine
DB01363 Ephedra
DB02509 Farnesol
DB03147 Flavin adenine dinucleotide
DB00614 Furazolidone
DB04818 Iproniazid
DB02095 Isatin
DB01247 Isocarboxazid
DB04147 Lauryl Dimethylamine-N-Oxide
DB00601 Linezolid
DB01577 Methamphetamine
DB01442 MMDA
DB01171 Moclobemide
DB08082 N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE
DB04677 N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE
DB02211 N-Methyl-N-Propargyl-1(R)-Aminoindan
DB03894 N-Propargyl-1(S)-Aminoindan
DB08804 Nandrolone decanoate
DB04820 Nialamide
DB00184 Nicotine
DB04821 Nomifensine
DB01626 Pargyline
DB00780 Phenelzine
DB00191 Phentermine
DB00721 Procaine
DB01168 Procarbazine
DB01367 Rasagiline
DB06654 Safinamide
DB01037 Selegiline
DB01104 Sertraline
DB00752 Tranylcypromine
DB04832 Zimelidine
DB00909 Zonisamide

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2490

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MAOB

Domain mapping of disease mutations (DMDM)

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DMDMi
113980

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000998592 – 520Amine oxidase [flavin-containing] BAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserine1 Publication1
Modified residuei52N6-acetyllysineBy similarity1
Modified residuei397S-8alpha-FAD cysteine1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P27338

MaxQB - The MaxQuant DataBase

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MaxQBi
P27338

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P27338

PeptideAtlas

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PeptideAtlasi
P27338

PRoteomics IDEntifications database

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PRIDEi
P27338

ProteomicsDB human proteome resource

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ProteomicsDBi
54379

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P27338

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P27338

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P27338

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000069535 Expressed in 215 organ(s), highest expression level in cauda epididymis

CleanEx database of gene expression profiles

More...
CleanExi
HS_MAOB

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P27338 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037200
HPA002328

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110302, 5 interactors

Protein interaction database and analysis system

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IntActi
P27338, 6 interactors

Molecular INTeraction database

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MINTi
P27338

STRING: functional protein association networks

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STRINGi
9606.ENSP00000367309

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P27338

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1520
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P27338

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P27338

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P27338

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi36 – 52Arg/Lys-rich (basic)Add BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0029 Eukaryota
ENOG410XSNC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161545

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000221615

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004255

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P27338

KEGG Orthology (KO)

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KOi
K00274

Identification of Orthologs from Complete Genome Data

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OMAi
VYEAKYV

Database of Orthologous Groups

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OrthoDBi
EOG091G0G7P

Database for complete collections of gene phylogenies

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PhylomeDBi
P27338

TreeFam database of animal gene trees

More...
TreeFami
TF313314

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.50.50.60, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01593 Amino_oxidase, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00757 AMINEOXDASEF

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51905 SSF51905, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P27338-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSNKCDVVVV GGGISGMAAA KLLHDSGLNV VVLEARDRVG GRTYTLRNQK
60 70 80 90 100
VKYVDLGGSY VGPTQNRILR LAKELGLETY KVNEVERLIH HVKGKSYPFR
110 120 130 140 150
GPFPPVWNPI TYLDHNNFWR TMDDMGREIP SDAPWKAPLA EEWDNMTMKE
160 170 180 190 200
LLDKLCWTES AKQLATLFVN LCVTAETHEV SALWFLWYVK QCGGTTRIIS
210 220 230 240 250
TTNGGQERKF VGGSGQVSER IMDLLGDRVK LERPVIYIDQ TRENVLVETL
260 270 280 290 300
NHEMYEAKYV ISAIPPTLGM KIHFNPPLPM MRNQMITRVP LGSVIKCIVY
310 320 330 340 350
YKEPFWRKKD YCGTMIIDGE EAPVAYTLDD TKPEGNYAAI MGFILAHKAR
360 370 380 390 400
KLARLTKEER LKKLCELYAK VLGSLEALEP VHYEEKNWCE EQYSGGCYTT
410 420 430 440 450
YFPPGILTQY GRVLRQPVDR IYFAGTETAT HWSGYMEGAV EAGERAAREI
460 470 480 490 500
LHAMGKIPED EIWQSEPESV DVPAQPITTT FLERHLPSVP GLLRLIGLTT
510 520
IFSATALGFL AHKRGLLVRV
Length:520
Mass (Da):58,763
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i358D1025F5BCA604
GO
Isoform 2 (identifier: P27338-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.
     380-427: PVHYEEKNWC...VDRIYFAGTE → GSTPASGQDL...PACHGEDSRG
     428-520: Missing.

Note: No experimental confirmation available.
Show »
Length:411
Mass (Da):46,539
Checksum:iCDF2F7AD6D7EC66F
GO

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 59474±14.0 Da from positions 2 - 520. Determined by ESI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0570471 – 16Missing in isoform 2. Add BLAST16
Alternative sequenceiVSP_057048380 – 427PVHYE…FAGTE → GSTPASGQDLLCRHRDCHTL ERLHGGGCRGRGESSPRDPA CHGEDSRG in isoform 2. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_057049428 – 520Missing in isoform 2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S62734 mRNA Translation: AAB27229.1
M69135 Genomic DNA Translation: AAA59551.1
AK298942 mRNA Translation: BAH12909.1
AK312679 mRNA Translation: BAG35560.1
M69177 mRNA Translation: AAA59550.1
M89637 Genomic DNA Translation: AAB46386.1
AL008709 Genomic DNA No translation available.
AL020990 Genomic DNA No translation available.
BX537148 Genomic DNA No translation available.
Z95125 Genomic DNA No translation available.
CH471141 Genomic DNA Translation: EAW59378.1
CH471141 Genomic DNA Translation: EAW59380.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14261.1 [P27338-1]

Protein sequence database of the Protein Information Resource

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PIRi
JH0817

NCBI Reference Sequences

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RefSeqi
NP_000889.3, NM_000898.4 [P27338-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.654473

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000378069; ENSP00000367309; ENSG00000069535 [P27338-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4129

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4129

UCSC genome browser

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UCSCi
uc004dfz.5 human [P27338-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Monoamine oxidase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62734 mRNA Translation: AAB27229.1
M69135 Genomic DNA Translation: AAA59551.1
AK298942 mRNA Translation: BAH12909.1
AK312679 mRNA Translation: BAG35560.1
M69177 mRNA Translation: AAA59550.1
M89637 Genomic DNA Translation: AAB46386.1
AL008709 Genomic DNA No translation available.
AL020990 Genomic DNA No translation available.
BX537148 Genomic DNA No translation available.
Z95125 Genomic DNA No translation available.
CH471141 Genomic DNA Translation: EAW59378.1
CH471141 Genomic DNA Translation: EAW59380.1
CCDSiCCDS14261.1 [P27338-1]
PIRiJH0817
RefSeqiNP_000889.3, NM_000898.4 [P27338-1]
UniGeneiHs.654473

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GOSX-ray3.00A/B2-520[»]
1H8Rmodel-A5-459[»]
1OJ9X-ray2.30A/B2-520[»]
1OJAX-ray1.70A/B2-520[»]
1OJCX-ray2.40A/B2-520[»]
1OJDX-ray3.10A/B/C/D/E/F/G/H/I/L2-520[»]
1S2QX-ray2.07A/B1-520[»]
1S2YX-ray2.12A/B1-520[»]
1S3BX-ray1.65A/B1-520[»]
1S3EX-ray1.60A/B1-520[»]
2BK3X-ray1.80A/B2-520[»]
2BK4X-ray1.90A/B2-520[»]
2BK5X-ray1.83A/B1-520[»]
2BYBX-ray2.20A/B2-520[»]
2C64X-ray2.20A/B2-520[»]
2C65X-ray1.70A/B2-520[»]
2C66X-ray2.50A/B2-520[»]
2C67X-ray1.70A/B2-520[»]
2C70X-ray2.06A/B2-520[»]
2C72X-ray2.00A/B2-520[»]
2C73X-ray2.20A/B2-520[»]
2C75X-ray1.70A/B2-520[»]
2C76X-ray1.70A/B2-520[»]
2V5ZX-ray1.60A/B2-520[»]
2V60X-ray2.00A/B2-520[»]
2V61X-ray1.70A/B2-520[»]
2VRLX-ray2.40A/B1-520[»]
2VRMX-ray2.30A/B1-520[»]
2VZ2X-ray2.30A/B1-520[»]
2XCGX-ray1.90A/B1-520[»]
2XFNX-ray1.60A/B1-520[»]
2XFOX-ray2.10A/B1-520[»]
2XFPX-ray1.66A/B1-520[»]
2XFQX-ray2.20A/B1-520[»]
2XFUX-ray2.20A/B2-520[»]
3PO7X-ray1.80A/B1-520[»]
3ZYXX-ray2.20A/B2-520[»]
4A79X-ray1.89A/B1-520[»]
4A7AX-ray1.70A/B1-520[»]
4CRTX-ray1.80A/B1-520[»]
5MRLX-ray2.42A/B1-520[»]
6FVZX-ray1.80A/B1-520[»]
6FW0X-ray1.60A/B1-520[»]
6FWCX-ray1.70A/B1-520[»]
ProteinModelPortaliP27338
SMRiP27338
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110302, 5 interactors
IntActiP27338, 6 interactors
MINTiP27338
STRINGi9606.ENSP00000367309

Chemistry databases

BindingDBiP27338
ChEMBLiCHEMBL2039
DrugBankiDB08176 (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE
DB08516 (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]
DB08480 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN
DB01472 4-Methoxyamphetamine
DB04307 5-Hydroxy-N-Propargyl-1(R)-Aminoindan
DB07512 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE
DB07513 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE
DB00915 Amantadine
DB00182 Amphetamine
DB04889 Bicifadine
DB01445 Bufotenine
DB00988 Dopamine
DB01363 Ephedra
DB02509 Farnesol
DB03147 Flavin adenine dinucleotide
DB00614 Furazolidone
DB04818 Iproniazid
DB02095 Isatin
DB01247 Isocarboxazid
DB04147 Lauryl Dimethylamine-N-Oxide
DB00601 Linezolid
DB01577 Methamphetamine
DB01442 MMDA
DB01171 Moclobemide
DB08082 N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE
DB04677 N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE
DB02211 N-Methyl-N-Propargyl-1(R)-Aminoindan
DB03894 N-Propargyl-1(S)-Aminoindan
DB08804 Nandrolone decanoate
DB04820 Nialamide
DB00184 Nicotine
DB04821 Nomifensine
DB01626 Pargyline
DB00780 Phenelzine
DB00191 Phentermine
DB00721 Procaine
DB01168 Procarbazine
DB01367 Rasagiline
DB06654 Safinamide
DB01037 Selegiline
DB01104 Sertraline
DB00752 Tranylcypromine
DB04832 Zimelidine
DB00909 Zonisamide
GuidetoPHARMACOLOGYi2490

PTM databases

CarbonylDBiP27338
iPTMnetiP27338
PhosphoSitePlusiP27338

Polymorphism and mutation databases

BioMutaiMAOB
DMDMi113980

Proteomic databases

EPDiP27338
MaxQBiP27338
PaxDbiP27338
PeptideAtlasiP27338
PRIDEiP27338
ProteomicsDBi54379

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4129
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378069; ENSP00000367309; ENSG00000069535 [P27338-1]
GeneIDi4129
KEGGihsa:4129
UCSCiuc004dfz.5 human [P27338-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4129
DisGeNETi4129
EuPathDBiHostDB:ENSG00000069535.13

GeneCards: human genes, protein and diseases

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GeneCardsi
MAOB
HGNCiHGNC:6834 MAOB
HPAiCAB037200
HPA002328
MIMi309860 gene
neXtProtiNX_P27338
OpenTargetsiENSG00000069535
PharmGKBiPA237

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
GeneTreeiENSGT00940000161545
HOGENOMiHOG000221615
HOVERGENiHBG004255
InParanoidiP27338
KOiK00274
OMAiVYEAKYV
OrthoDBiEOG091G0G7P
PhylomeDBiP27338
TreeFamiTF313314

Enzyme and pathway databases

BioCyciMetaCyc:HS00966-MONOMER
BRENDAi1.4.3.4 2681
ReactomeiR-HSA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
SABIO-RKiP27338
SIGNORiP27338

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAOB human
EvolutionaryTraceiP27338

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Monoamine_oxidase_B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4129

Protein Ontology

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PROi
PR:P27338

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000069535 Expressed in 215 organ(s), highest expression level in cauda epididymis
CleanExiHS_MAOB
GenevisibleiP27338 HS

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAOFB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27338
Secondary accession number(s): B2R6R3
, B7Z5H3, D3DWC3, Q7Z6S2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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