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Protein

Heat shock protein 90-1

Gene

HSP90-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a holding molecular chaperone (holdase) which stabilizes unfolding protein intermediates and rapidly releases them in an active form once stress has abated. Functions as a folding molecular chaperone (foldase) that assists the non-covalent folding of proteins in an ATP-dependent manner (PubMed:23827697). Molecular chaperone involved in R gene-mediated disease resistance. Required for full RPS2-mediated resistance through interaction with RAR1. Possesses probably ATPase activity (PubMed:14504384).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34ATPBy similarity1
Binding sitei38ATPBy similarity1
Binding sitei80ATPBy similarity1
Binding sitei85ATPBy similarity1
Binding sitei93ATPBy similarity1
Binding sitei99ATPBy similarity1
Binding sitei172ATPBy similarity1
Binding sitei372ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi100 – 101ATPBy similarity2
Nucleotide bindingi120 – 125ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

  • chaperone-mediated protein folding Source: UniProtKB
  • defense response to bacterium, incompatible interaction Source: UniProtKB

Keywordsi

Molecular functionChaperone
Biological processImmunity, Innate immunity, Plant defense, Stress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-ATH-3371571 HSF1-dependent transactivation
R-ATH-6798695 Neutrophil degranulation
R-ATH-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 90-1Curated
Short name:
AtHSP90.1Curated
Short name:
AtHsp90-11 Publication
Alternative name(s):
Heat shock protein 81-1Curated
Short name:
Hsp81-11 Publication
Heat shock protein 83
Gene namesi
Name:HSP90-11 Publication
Synonyms:HSP81-11 Publication, HSP83
Ordered Locus Names:At5g52640
ORF Names:F6N7.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G52640

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth condition. In case of infection, plants are altered in RPS2-mediated disease resistance.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000629461 – 700Heat shock protein 90-1Add BLAST700

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP27323
PRIDEiP27323

PTM databases

iPTMnetiP27323

Expressioni

Tissue specificityi

Expressed constitutively in roots only. After heat treatment, expressed in most tissues. Levels also increase after heavy metal treatment.

Developmental stagei

Expressed in pollen during pollen development, germination and tube growth. Expressed during embryo development and young seedling growth.1 Publication

Inductioni

By heat shock and infection by avirulent and virulent bacterial pathogens (P.syringae).1 Publication

Gene expression databases

ExpressionAtlasiP27323 baseline and differential
GenevisibleiP27323 AT

Interactioni

Subunit structurei

Homodimer (PubMed:24036116). Interacts with RAR1 (PubMed:14504384, PubMed:17148606). Interacts with OEP61, OEP64 and OM64 (PubMed:24036116). Interacts with POLL (PubMed:26230318).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FKBP62Q389314EBI-1778266,EBI-2409351

GO - Molecular functioni

Protein-protein interaction databases

BioGridi20586, 17 interactors
DIPiDIP-47087N
IntActiP27323, 5 interactors
STRINGi3702.AT5G52640.1

Structurei

3D structure databases

ProteinModelPortaliP27323
SMRiP27323
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi696 – 700TPR repeat-binding5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi247 – 253Poly-Lys7

Domaini

The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.By similarity

Sequence similaritiesi

Belongs to the heat shock protein 90 family.Curated

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
COG0326 LUCA
HOGENOMiHOG000031988
InParanoidiP27323
KOiK04079
OrthoDBiEOG093604DD
PhylomeDBiP27323

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit

Sequencei

Sequence statusi: Complete.

P27323-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES
60 70 80 90 100
LTDKSKLDGQ PELFIRLVPD KSNKTLSIID SGIGMTKADL VNNLGTIARS
110 120 130 140 150
GTKEFMEALQ AGADVSMIGQ FGVGFYSAYL VAEKVVVTTK HNDDEQYVWE
160 170 180 190 200
SQAGGSFTVT RDVDGEPLGR GTKITLFLKD DQLEYLEERR LKDLVKKHSE
210 220 230 240 250
FISYPIYLWT EKTTEKEISD DEDEDEPKKE NEGEVEEVDE EKEKDGKKKK
260 270 280 290 300
KIKEVSHEWE LINKQKPIWL RKPEEITKEE YAAFYKSLTN DWEDHLAVKH
310 320 330 340 350
FSVEGQLEFK AILFVPKRAP FDLFDTRKKL NNIKLYVRRV FIMDNCEELI
360 370 380 390 400
PEYLSFVKGV VDSDDLPLNI SRETLQQNKI LKVIRKNLVK KCIEMFNEIA
410 420 430 440 450
ENKEDYTKFY EAFSKNLKLG IHEDSQNRGK IADLLRYHST KSGDEMTSFK
460 470 480 490 500
DYVTRMKEGQ KDIFYITGES KKAVENSPFL ERLKKRGYEV LYMVDAIDEY
510 520 530 540 550
AVGQLKEYDG KKLVSATKEG LKLEDETEEE KKKREEKKKS FENLCKTIKE
560 570 580 590 600
ILGDKVEKVV VSDRIVDSPC CLVTGEYGWT ANMERIMKAQ ALRDSSMSGY
610 620 630 640 650
MSSKKTMEIN PDNGIMEELR KRAEADKNDK SVKDLVMLLY ETALLTSGFS
660 670 680 690 700
LDEPNTFAAR IHRMLKLGLS IDEDENVEED GDMPELEEDA AEESKMEEVD
Length:700
Mass (Da):80,635
Last modified:December 6, 2002 - v3
Checksum:i5B379E915757EC7B
GO

Sequence cautioni

The sequence AAA32822 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAM91104 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAN46890 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA98082 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA68885 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72S → A in AAA32822 (PubMed:16667903).Curated1
Sequence conflicti72S → P in CAA68885 (PubMed:9426614).Curated1
Sequence conflicti175T → S in AAA32822 (PubMed:16667903).Curated1
Sequence conflicti175T → S in CAA68885 (PubMed:9426614).Curated1
Sequence conflicti210T → I in BAA00615 (PubMed:7697294).Curated1
Sequence conflicti241E → K in CAA68885 (PubMed:9426614).Curated1
Sequence conflicti281Y → S in AAA32822 (PubMed:16667903).Curated1
Sequence conflicti478Missing in CAA68885 (PubMed:9426614).Curated1
Sequence conflicti618E → D in CAA68885 (PubMed:9426614).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62984 mRNA Translation: AAA32822.1 Different initiation.
D00710 Genomic DNA Translation: BAA00615.1
Y07613 Genomic DNA Translation: CAA68885.1 Different initiation.
AB025606 Genomic DNA Translation: BAA98082.1 Different initiation.
CP002688 Genomic DNA Translation: AED96244.2
AY128296 mRNA Translation: AAM91104.1 Different initiation.
BT001091 mRNA Translation: AAN46890.1 Different initiation.
PIRiA45508
RefSeqiNP_200076.2, NM_124642.4
UniGeneiAt.25471

Genome annotation databases

EnsemblPlantsiAT5G52640.1; AT5G52640.1; AT5G52640
GeneIDi835341
GrameneiAT5G52640.1; AT5G52640.1; AT5G52640
KEGGiath:AT5G52640

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62984 mRNA Translation: AAA32822.1 Different initiation.
D00710 Genomic DNA Translation: BAA00615.1
Y07613 Genomic DNA Translation: CAA68885.1 Different initiation.
AB025606 Genomic DNA Translation: BAA98082.1 Different initiation.
CP002688 Genomic DNA Translation: AED96244.2
AY128296 mRNA Translation: AAM91104.1 Different initiation.
BT001091 mRNA Translation: AAN46890.1 Different initiation.
PIRiA45508
RefSeqiNP_200076.2, NM_124642.4
UniGeneiAt.25471

3D structure databases

ProteinModelPortaliP27323
SMRiP27323
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi20586, 17 interactors
DIPiDIP-47087N
IntActiP27323, 5 interactors
STRINGi3702.AT5G52640.1

PTM databases

iPTMnetiP27323

Proteomic databases

PaxDbiP27323
PRIDEiP27323

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G52640.1; AT5G52640.1; AT5G52640
GeneIDi835341
GrameneiAT5G52640.1; AT5G52640.1; AT5G52640
KEGGiath:AT5G52640

Organism-specific databases

AraportiAT5G52640

Phylogenomic databases

eggNOGiKOG0019 Eukaryota
COG0326 LUCA
HOGENOMiHOG000031988
InParanoidiP27323
KOiK04079
OrthoDBiEOG093604DD
PhylomeDBiP27323

Enzyme and pathway databases

ReactomeiR-ATH-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-ATH-3371571 HSF1-dependent transactivation
R-ATH-6798695 Neutrophil degranulation
R-ATH-844456 The NLRP3 inflammasome

Miscellaneous databases

PROiPR:P27323

Gene expression databases

ExpressionAtlasiP27323 baseline and differential
GenevisibleiP27323 AT

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di1.20.120.790, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00505 HSP90, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR019805 Heat_shock_protein_90_CS
IPR037196 HSP90_C
IPR001404 Hsp90_fam
IPR020575 Hsp90_N
IPR020568 Ribosomal_S5_D2-typ_fold
PANTHERiPTHR11528 PTHR11528, 1 hit
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00183 HSP90, 1 hit
PIRSFiPIRSF002583 Hsp90, 1 hit
PRINTSiPR00775 HEATSHOCK90
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SUPFAMiSSF110942 SSF110942, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
PROSITEiView protein in PROSITE
PS00298 HSP90, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHS901_ARATH
AccessioniPrimary (citable) accession number: P27323
Secondary accession number(s): Q03930
, Q8H0Z5, Q96268, Q9LTF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: December 6, 2002
Last modified: May 23, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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