Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 139 (12 Aug 2020)
Sequence version 3 (24 Jul 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Calpastatin

Gene

Cast

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1474228, Degradation of the extracellular matrix

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I27.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calpastatin
Alternative name(s):
Calpain inhibitor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cast
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
2278, Cast

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi613G → A: 2.9-fold increase in the IC(50). 1 Publication1
Mutagenesisi613G → FG: Turns CAST from an inhibitor into a substrate. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001476351 – 713CalpastatinAdd BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei86N6-acetyllysineBy similarity1
Modified residuei122PhosphoserineCombined sources1
Modified residuei171PhosphoserineCombined sources1
Modified residuei173PhosphothreonineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei281PhosphoserineBy similarity1
Modified residuei401PhosphoserineBy similarity1
Modified residuei403PhosphoserineBy similarity1
Modified residuei410PhosphoserineBy similarity1
Modified residuei445PhosphoserineBy similarity1
Modified residuei521PhosphoserineBy similarity1
Modified residuei532PhosphoserineBy similarity1
Modified residuei580PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P27321

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27321

PeptideAtlas

More...
PeptideAtlasi
P27321

PRoteomics IDEntifications database

More...
PRIDEi
P27321

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P27321

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P27321

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-44338N

Protein interaction database and analysis system

More...
IntActi
P27321, 1 interactor

Molecular INTeraction database

More...
MINTi
P27321

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000058759

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1713
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27321

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P27321

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati208 – 260Inhibitory domain 1Add BLAST53
Repeati341 – 393Inhibitory domain 2Add BLAST53
Repeati451 – 504Inhibitory domain 3Add BLAST54
Repeati588 – 641Inhibitory domain 4Add BLAST54

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four flexible inhibitory domains can inhibit one calcium-bound calpain molecule by occupying both sides of the active site.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RHIZ, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27321

KEGG Orthology (KO)

More...
KOi
K04281

Database of Orthologous Groups

More...
OrthoDBi
203890at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27321

Family and domain databases

Database of protein disorder

More...
DisProti
DP01994

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026998, Calpastatin
IPR001259, Prot_inh_calpain

The PANTHER Classification System

More...
PANTHERi
PTHR10077, PTHR10077, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00748, Calpain_inhib, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P27321-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRPGPKPAA SSRPRRGAAA SHTQEHVNEK NIGSSSKPAE KKGSDEVTAS
60 70 80 90 100
SAATGTSPRM STTGAKAVKI ESEKSQSSEP PVIHEKKPKG KPKEGSEPQT
110 120 130 140 150
LPKHASDTGS KHAHKEKALS RSNEQIVSEK SSESKTKFQD APSADGESVA
160 170 180 190 200
GGVTVATASD KVVVKKKEKK SLTPTLPMES TLNKLSDKSG VNAALDDLID
210 220 230 240 250
TLGECEDTNK DDPPYTGPVV LDPMDSTYLE ALGIKEGTIP PEYRKLLEKN
260 270 280 290 300
EAITGPLPDS PKPMGIDHAI DALSSDFTCS SPTGKQTEKE KSTGESSKAQ
310 320 330 340 350
SAGVTRSAVP PQEKKRKVEE EVMNDQALQA LSDSLGTRQP DPQSHLRQAK
360 370 380 390 400
QVKEAKAKEE RQEKCGEDED TVPAEYRLKP AKDKDGKPLL PEPEETSKCL
410 420 430 440 450
SESELIGELS ADFVQPTYQE KPSMPAAKIK KGVVPDDAVE TLARSLGTRK
460 470 480 490 500
EDPEDEKSLV DKVKEKAKEE DHEKLGEKEE TIPPDYRLEI VKDKDGKPLL
510 520 530 540 550
PKEAEEQLPP LSDDFLLDAL SQDFSSPANI LSLGFEDAKL SAAVSETVSQ
560 570 580 590 600
VPAPSNHTAA PPPGTERRDK ELDDALDELS DSLGQRQPDP DENKPLDDKV
610 620 630 640 650
KEKIKAEHSE KLGERDDTIP PEYRHLLDND GKDKPEKPLT KNTEKLGQDQ
660 670 680 690 700
DPIDALSEDL DSCPPTTETS QNTTKEKGKK TSSSKASKNE EKTKDSSKKT
710
EEVPKPKVDE DAT
Length:713
Mass (Da):77,313
Last modified:July 24, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55505300F59A8DE3
GO
Isoform 2 (identifier: P27321-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     98-135: Missing.

Show »
Length:675
Mass (Da):73,172
Checksum:iD3514B481F47F5A1
GO
Isoform 3 (identifier: P27321-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     166-188: Missing.

Show »
Length:690
Mass (Da):74,714
Checksum:i5FB95F6D6FAE3487
GO
Isoform 4 (identifier: P27321-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-79: Missing.
     98-135: Missing.

Show »
Length:662
Mass (Da):71,769
Checksum:i184C191B609C0CD3
GO
Isoform 5 (identifier: P27321-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-135: Missing.
     166-188: Missing.

Show »
Length:652
Mass (Da):70,573
Checksum:i26A465A95B697D11
GO
Isoform 6 (identifier: P27321-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-79: Missing.
     98-135: Missing.
     166-188: Missing.

Show »
Length:639
Mass (Da):69,170
Checksum:i777B3D8554E57AE7
GO
Isoform 7 (identifier: P27321-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-177: Missing.

Show »
Length:536
Mass (Da):58,859
Checksum:iD9BA9EB299CA6BCB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LPH1F1LPH1_RAT
Calpain inhibitor
Cast
713Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3ZL24D3ZL24_RAT
Calpain inhibitor
Cast
652Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JSY2A0A0G2JSY2_RAT
Calpain inhibitor
Cast
675Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D4A129D4A129_RAT
Calpain inhibitor
Cast
176Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
O55154O55154_RAT
Calpastatin
Cast CAST
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK29411 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAK29412 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA40053 differs from that shown. Reason: Frameshift.Curated
The sequence CAA40053 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA73915 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA73916 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA73917 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti161K → E in CAA40053 (PubMed:17570336).Curated1
Sequence conflicti161K → E in AAK29411 (Ref. 5) Curated1
Sequence conflicti209N → S in CAA73917 (PubMed:9475181).Curated1
Sequence conflicti314K → E in AAK29412 (Ref. 5) Curated1
Sequence conflicti463V → G in ABA86879 (PubMed:17570336).Curated1
Sequence conflicti463V → G in ABA86880 (PubMed:17570336).Curated1
Sequence conflicti463V → G in ABA86881 (PubMed:17570336).Curated1
Sequence conflicti463V → G in ABA86882 (PubMed:17570336).Curated1
Sequence conflicti463V → G in ABA86883 (PubMed:17570336).Curated1
Sequence conflicti463V → G in ABA86884 (PubMed:17570336).Curated1
Sequence conflicti463V → G in ABB90254 (PubMed:17570336).Curated1
Sequence conflicti463V → G in CAA73916 (PubMed:9475181).Curated1
Sequence conflicti481T → A in CAA73917 (PubMed:9475181).Curated1
Sequence conflicti518D → G in CAA73917 (PubMed:9475181).Curated1
Sequence conflicti611K → R in CAA73915 (PubMed:9475181).Curated1
Sequence conflicti646L → P in AAH91239 (PubMed:15489334).Curated1
Sequence conflicti646L → P in CAA73915 (PubMed:9475181).Curated1
Sequence conflicti646L → P in CAA73917 (PubMed:9475181).Curated1
Sequence conflicti646L → P in AAK29411 (Ref. 5) Curated1
Sequence conflicti646L → P in AAK29412 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0269711 – 177Missing in isoform 7. 1 PublicationAdd BLAST177
Alternative sequenceiVSP_00075367 – 79Missing in isoform 4 and isoform 6. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_00075498 – 135Missing in isoform 2, isoform 4, isoform 5 and isoform 6. 5 PublicationsAdd BLAST38
Alternative sequenceiVSP_026972166 – 188Missing in isoform 3, isoform 5 and isoform 6. 3 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ186624 mRNA Translation: ABA86879.1
DQ186625 mRNA Translation: ABA86880.1
DQ186626 mRNA Translation: ABA86881.1
DQ186627 mRNA Translation: ABA86882.1
DQ186628 mRNA Translation: ABA86883.1
DQ186629 mRNA Translation: ABA86884.1
DQ287975 mRNA Translation: ABB90254.1
BC091239 mRNA Translation: AAH91239.1
X56729 mRNA Translation: CAA40053.1 Sequence problems.
Y13587 mRNA Translation: CAA73915.1 Different initiation.
Y13588 mRNA Translation: CAA73916.1 Different initiation.
Y13589 mRNA Translation: CAA73917.1 Different initiation.
AF346597 mRNA Translation: AAK29411.1 Different initiation.
AF346598 mRNA Translation: AAK29412.1 Different initiation.
X62520 mRNA Translation: CAA44386.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S15074
S20611

NCBI Reference Sequences

More...
RefSeqi
NP_001028887.1, NM_001033715.1
NP_001028888.1, NM_001033716.1
NP_445747.2, NM_053295.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25403

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25403

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ186624 mRNA Translation: ABA86879.1
DQ186625 mRNA Translation: ABA86880.1
DQ186626 mRNA Translation: ABA86881.1
DQ186627 mRNA Translation: ABA86882.1
DQ186628 mRNA Translation: ABA86883.1
DQ186629 mRNA Translation: ABA86884.1
DQ287975 mRNA Translation: ABB90254.1
BC091239 mRNA Translation: AAH91239.1
X56729 mRNA Translation: CAA40053.1 Sequence problems.
Y13587 mRNA Translation: CAA73915.1 Different initiation.
Y13588 mRNA Translation: CAA73916.1 Different initiation.
Y13589 mRNA Translation: CAA73917.1 Different initiation.
AF346597 mRNA Translation: AAK29411.1 Different initiation.
AF346598 mRNA Translation: AAK29412.1 Different initiation.
X62520 mRNA Translation: CAA44386.1
PIRiS15074
S20611
RefSeqiNP_001028887.1, NM_001033715.1
NP_001028888.1, NM_001033716.1
NP_445747.2, NM_053295.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BOWX-ray2.40C571-664[»]
3DF0X-ray2.95C193-278[»]
SMRiP27321
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-44338N
IntActiP27321, 1 interactor
MINTiP27321
STRINGi10116.ENSRNOP00000058759

Protein family/group databases

MEROPSiI27.001

PTM databases

iPTMnetiP27321
PhosphoSitePlusiP27321

Proteomic databases

jPOSTiP27321
PaxDbiP27321
PeptideAtlasiP27321
PRIDEiP27321

Genome annotation databases

GeneIDi25403
KEGGirno:25403

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
831
RGDi2278, Cast

Phylogenomic databases

eggNOGiENOG502RHIZ, Eukaryota
InParanoidiP27321
KOiK04281
OrthoDBi203890at2759
PhylomeDBiP27321

Enzyme and pathway databases

ReactomeiR-RNO-1474228, Degradation of the extracellular matrix

Miscellaneous databases

EvolutionaryTraceiP27321

Protein Ontology

More...
PROi
PR:P27321

Family and domain databases

DisProtiDP01994
InterProiView protein in InterPro
IPR026998, Calpastatin
IPR001259, Prot_inh_calpain
PANTHERiPTHR10077, PTHR10077, 2 hits
PfamiView protein in Pfam
PF00748, Calpain_inhib, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICAL_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27321
Secondary accession number(s): A5GXY4
, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, Q5BK19, Q99MG1, Q99MG2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 24, 2007
Last modified: August 12, 2020
This is version 139 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again