Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 74 (18 Sep 2019)
Sequence version 1 (01 Aug 1992)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Rift valley fever virus (strain ZH-548 M12) (RVFV)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes several subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. During replication, makes copies of the genomic or antigenomic RNAs. The new genomes/antigenomes are encapsidated during synthesis by the nucleoprotein, and non capped/polyadenylated.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandNucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L (EC:2.7.7.48)
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRift valley fever virus (strain ZH-548 M12) (RVFV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11589 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesPhenuiviridaePhlebovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002477 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi111D → A: Loss of transcriptional activity but fully active in replication. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002220231 – 2149RNA-directed RNA polymerase LAdd BLAST2149

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P27316

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (PubMed:19812169).

Interacts with Glycoprotein N; this interaction allows efficient polymerase packaging into virus particles (PubMed:21445316).

2 Publications

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini975 – 1166RdRp catalyticPROSITE-ProRule annotationAdd BLAST192

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phlebovirus RNA polymerase family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022531 DUF3770
IPR029124 L_protein_N
IPR007099 RNA-dir_pol_NSvirus
IPR014385 RNA-dir_pol_phlebovirus
IPR007322 RNA_pol_bunyavir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF12603 DUF3770, 1 hit
PF15518 L_protein_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000826 L_PhleboV, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P27316-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSILSKQLV DKTGFVRVPI KHFDCTMLTL ALPTFDVSKM VDRITIDFNL
60 70 80 90 100
DDIQGASEIG STLLPSMSID VEDMANFVHD FTFGHLADKT DRLLMREFPM
110 120 130 140 150
MNDGFDHLSP DMIIKTTSGV YNIVEFTNFR GDERGAFQAA MIKLAKYEVP
160 170 180 190 200
CENRSQGRTV VLYVVSAYRA WCMVYLELER TLKQREMVYR YRLALSVMDE
210 220 230 240 250
LRTLFPELSS TDEELGKTER ELPAMVSSIQ INWSVTESVF PPFSREMFDR
260 270 280 290 300
FRSSPPDSEY ITRIVSRCLI NSQEKLINSS FFAEGNDKAL RFSKNAEECS
310 320 330 340 350
LAVERALNQY RAEDNLRDLN DHKSTIQLPP WLSYHDVDGK DLCPLQGLDV
360 370 380 390 400
RGDHPMCNLW REVVTSANLE EIERMHDDAA AELEFAFGSK GQARERNRYH
410 420 430 440 450
RVHLNMGSDV LVYIAALGVN GKKHKADTLV QQMRDRSKQP FSPDHDVITY
460 470 480 490 500
LNFSLHALVT CGQQMRTCTA LSLVIRDSVG SPEDSSAILV RKGFHEIITE
510 520 530 540 550
HYKFMGSRIG HGCQMVSLIG AELSASVKQH VKPNYFVIKR LLGSGIFLLI
560 570 580 590 600
KPTSSKSHIF VSFALSALAG PLISPLPGFS SPTKMLGILL VTDFVSYKLS
610 620 630 640 650
KLTNLCKCVS LMESSFSFWA EAFGIQAGTL VGDFVPRSSD SAAMDASYMG
660 670 680 690 700
KLSLLTLLED KAATEELQTI ARYIIMEGFV SPPEIPKPHK MTSKFPKVLR
710 720 730 740 750
SELQVYLLNC LCRTIQRIAG EPFILKKKDG SISWGGMFNP FSGRPLLDMQ
760 770 780 790 800
PLISCCYNGY FKNKEEETEP SSLSGMYKKI IELEHLRPQS DAFLGYKDPE
810 820 830 840 850
LPRMHEFSVS YLKEACNHAK LVLRSLYGQN FMEQIDNQII RELSGLTLER
860 870 880 890 900
LATLKATSNF NENWYVYKDV ADKNYTRDKL LVKMSKYASE GKSLAIQKFE
910 920 930 940 950
DCMRQIESQG CMHICLFKKQ QHGGLREIYV MGAEERIVQS VVETIARSIG
960 970 980 990 1000
KFFASDTLCN PPNKVKIPET HGIRARKQCK GPVWTCATSD DARKWNQGHF
1010 1020 1030 1040 1050
VTKFALMLCE FTSPKWWPLI IRGCSMFTKK RMMMNLNYLK ILDGHRELDI
1060 1070 1080 1090 1100
RDDFVMDLFK AYHGEAEVPW AFKGKTYLET TTGMMQGILH YTSSLLHTIH
1110 1120 1130 1140 1150
QEYIRSLSFK IFNLKVAPEM SKSLVCDMMQ GSDDSSMLIS FPADDEKVLT
1160 1170 1180 1190 1200
RCKVAAAICF RMKKELGVYL AIYPSEKSTA NTDFVMEYNS EFYFHTQHVR
1210 1220 1230 1240 1250
PTIRWIAACC SLPEVETLVA RQEEASNLMT SVTEGGGSFS LAAIIQQAQC
1260 1270 1280 1290 1300
TLHYMLMGMG VSELFLEYKK AVLKWNDPGL GFFLLDNPYA CGLGGFRFNL
1310 1320 1330 1340 1350
FKAITRTDLQ KLYAFFMKKV KGSAARDWAD EDVTIPETCS VSPGGALILS
1360 1370 1380 1390 1400
SSLKWGSRKK FQKLRDRLNI PENWIELINE NPEVLYRAPR TGPEILLRIA
1410 1420 1430 1440 1450
EKVHSPGVVS SLSSGNAVCK VMASAVYFLS ATIFEDTGRP EFNFLEDSKY
1460 1470 1480 1490 1500
SLLQKMAAYS GFHGFNDMEP EDILFLFPNI EELESLDSIV YNKGEIDIIP
1510 1520 1530 1540 1550
RVNIRDATQT RVTIFNEQKN LRTSPEKLVS DKWFGTQKSR IGKTTFLAEW
1560 1570 1580 1590 1600
EKLKKIVKWL EDAPEATLAH TPLNNHIQVR NFFARMESKP RTVRITGAPV
1610 1620 1630 1640 1650
KKRSGVSKIA MVIRDHFSRM GHLRGVEDLA GFTRSVSAEI LKHFLFCILQ
1660 1670 1680 1690 1700
GPYSESYKLQ LIYRVLSSVS NVEIKESDGK TKTNLIGILQ RFLDGDHVVP
1710 1720 1730 1740 1750
IIEEMGAGTV GGFIKRQQSK VVQNKVVYYG VGIWRGFMDG YQVHLEIEND
1760 1770 1780 1790 1800
IGQPPRLRNV TTNCQSSPWD LSIPIRQWAE DMGVTNNQDY SSKSSRGARY
1810 1820 1830 1840 1850
WMHSFRMQGP SKPFGCPVYI IKGDMSDVIR LRKEEVEMKV RGSTLNLYTK
1860 1870 1880 1890 1900
HHSHQDLHIL SYTASDNDLS PGIFKSISDE GVAQALQLFE REPSNCWVRC
1910 1920 1930 1940 1950
ESVAPKFISA ILEICEGKRQ IKGINRTRLS EIVRICSESS LRSKVGSMFS
1960 1970 1980 1990 2000
FVANVEEAHD VDYDALMDLM IEDAKNNAFS HVVDCIELDV SGPYEMESFH
2010 2020 2030 2040 2050
GRSTLTCTPS TILIRTYTFY LTLHQTMISV QAFQVILDEG VLLIALVNNY
2060 2070 2080 2090 2100
LRGSKANCWV RCESVAPKFI SAILEICEGK RQIKGINRTR LSEIVEFVLN
2110 2120 2130 2140
LPKIKSRIYV LICRQCHGAN FPPISVRRLM LEDIASVARR LIIVASFGS
Length:2,149
Mass (Da):243,591
Last modified:August 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D5739C6079A88D7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X56464 Genomic RNA Translation: CAA39836.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S18676

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56464 Genomic RNA Translation: CAA39836.1
PIRiS18676

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiP27316

Family and domain databases

InterProiView protein in InterPro
IPR022531 DUF3770
IPR029124 L_protein_N
IPR007099 RNA-dir_pol_NSvirus
IPR014385 RNA-dir_pol_phlebovirus
IPR007322 RNA_pol_bunyavir
PfamiView protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF12603 DUF3770, 1 hit
PF15518 L_protein_N, 1 hit
PIRSFiPIRSF000826 L_PhleboV, 1 hit
PROSITEiView protein in PROSITE
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_RVFVZ
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27316
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 18, 2019
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again