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UniProtKB - P27314 (L_SEOU8)
Protein
RNA-directed RNA polymerase L
Gene
L
Organism
Seoul virus (strain 80-39)
Status
Functioni
Catalytic activityi
- EC:2.7.7.48PROSITE-ProRule annotation
GO - Molecular functioni
- nucleotide binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- cap snatching Source: UniProtKB-KW
- negative stranded viral RNA replication Source: UniProtKB
- RNA-templated viral transcription Source: UniProtKB
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase |
Biological process | Cap snatching, Viral RNA replication |
Ligand | Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-directed RNA polymerase L (EC:2.7.7.48)Short name: Protein L Alternative name(s): Large structural protein Replicase Transcriptase |
Gene namesi | Name:L |
Organismi | Seoul virus (strain 80-39) |
Taxonomic identifieri | 12557 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Polyploviricotina › Ellioviricetes › Bunyavirales › Hantaviridae › Mammantavirinae › Orthohantavirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] Rattus norvegicus (Rat) [TaxID: 10116] Rattus rattus (Black rat) [TaxID: 10117] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000222024 | 1 – 2151 | RNA-directed RNA polymerase LAdd BLAST | 2151 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 956 – 1142 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 187 |
Sequence similaritiesi
Belongs to the hantavirus RNA polymerase family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR016268, RNA-dir_pol_hantavirus IPR024378, RNA-dir_pol_N_hantavirus IPR007099, RNA-dir_pol_NSvirus IPR007322, RNA_pol_bunyavir |
Pfami | View protein in Pfam PF04196, Bunya_RdRp, 1 hit PF12426, DUF3674, 1 hit |
PIRSFi | PIRSF000825, L_HantaV, 1 hit |
PROSITEi | View protein in PROSITE PS50525, RDRP_SSRNA_NEG_SEG, 1 hit |
i Sequence
Sequence statusi: Complete.
P27314-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKYREIHRD LKEFTINSLT AVECMDYLDR LYAVRHDIVD QMIKHEWSDN
60 70 80 90 100
KDSEEPISKV LLFAGIPNNV ITALEKKVIP DHPSGKTLRS FFKMTPDNYR
110 120 130 140 150
ITGSLIEFVE VTVTADVDKG IREKKMKYEL GLKYLEQELM TFFHRGELQN
160 170 180 190 200
PYKITFKVVA VRTDGSNIST QWPSARNDGV VQYMRLVQAE ISYVREHLVK
210 220 230 240 250
TEERAALEAM FNLKFNISSL KTQPYFIPEY KGIDLIRPDI DGLVNYAQSW
260 270 280 290 300
MSKTQEFSFF EVKGSAVFDC FNENEQGHIV KYPMSRHPRN FLLIQCTVLT
310 320 330 340 350
AYKPATILSD QLDSRRACIQ FLNLIPETPA SILAHDMAHR YINLTRDDLL
360 370 380 390 400
AYYAPRIQFN PTQNIKEPGT FKLTSNMMRP ESKIMLDMLS QHEPRENLGK
410 420 430 440 450
SIESLNISSH IVQSDCVSLI TKILSDLELN ISEPSSHEQI TAKHTHVDTV
460 470 480 490 500
LDKFFQNETQ KYLIDILKKT TAWHIGHLVR DITESLIAHS GLRRSKYWSI
510 520 530 540 550
HAYNNGSVIL FILPSKSLEV AGSFVRFMTA FKLGPGLVDK DNLDSILADG
560 570 580 590 600
DILWGVSKIM SLDLNRLLAL NIAFEKALLA TATWFQYYTE DQSQFPLQHS
610 620 630 640 650
IRSVFAYHFL LAICQKMKLC AIFDNLRYLI PAVTSLYSGF PSLVEKLFER
660 670 680 690 700
PFKSALEVYV YYNIKSLLVA LAQNNKARFY SKVKLLGLTV DQSTVGASGI
710 720 730 740 750
YPSFMSRVVY KHYKSLISEV TTCFFLFEKG LHGNVNEEAK IHLETVEWAT
760 770 780 790 800
KFKEKEDKYG EMLVEHGYTI GELVESSELA VQQLYCQDAV ELAANELNRV
810 820 830 840 850
LIAKSQVVAN SILNKYWEEP YFSQTRNISL KGMSGQVQED GHLSSSTTII
860 870 880 890 900
EAIRYLSNSR NNPNVLQLYE ETRHQKAQAR IVRKFQRTEA DRGFFITTLP
910 920 930 940 950
TRCRLEIIED YYDAISKNVA EEYISYGGER KILCIQAALE KALRWASGES
960 970 980 990 1000
FIELSNGKFI RMKRKLMYVS ADATKWSPGD NSAKFRRFTA ALHNGLPDDR
1010 1020 1030 1040 1050
LKNCVIDALR HVYKTDFYMS RKLRHYIDSM DTYEPHVRDF LNFFPDGHHG
1060 1070 1080 1090 1100
EVRGNWLQGN LNKCSSLFGV AMSLLFKEIW TRLFPELDCF FEFAHHSDDA
1110 1120 1130 1140 1150
LFIYGYLEPA DDGTDWFLFV SQQIQAGKLH WFNVNTEMWK SMFNLHEHIL
1160 1170 1180 1190 1200
LLGSIKISPK KTTLSPTNAE FLSTFFEGCA VSIPFIKILL GSLSDLPGLG
1210 1220 1230 1240 1250
YFDDLAAAQT RCVKAMDLGA SPQISQLAVS LSTSKVERLY GTSIGMVNYP
1260 1270 1280 1290 1300
GTYLRTKHSE TPIPLGGSGA MSIMELSTAG IGMSDKNLLK QALIGYMHKH
1310 1320 1330 1340 1350
QKQMSYILGL FKFLMDLSGE TFQHERLGQF SFIGKVQWKI FTPKSEFEFS
1360 1370 1380 1390 1400
DMYSQKFLKV WSEQHPTYDY IIPKGRDNLL IYLVRKLNDP SIITAMTMQS
1410 1420 1430 1440 1450
PLQLRFRMQA KQHMKVCRLD GDWVTFREVL AAANSFAESY EPSQNDIDLF
1460 1470 1480 1490 1500
QTLTSCTFSK EYAWKDFLNN VHCDVIPTKQ VQRAKVARTF TVREKDRIIQ
1510 1520 1530 1540 1550
NSIPAVIGYK FAVTVDEMSD VLDTAKFPDS LAVDLKTMKD GVYRELGLDI
1560 1570 1580 1590 1600
SSPDVMKKVA PMLYKSAKSR VVIVQGNVEG TAEAICAYWL RNMSLIKTIK
1610 1620 1630 1640 1650
VKPHKEVLQA VSIFNRKEDI GQQKDLSALK LCIEVWRWAK ANNAPYRDWF
1660 1670 1680 1690 1700
HALWFEDKTF SEWLDRFIRV GVPPIDPEIQ CAALMIADVK GDRSVLQLQA
1710 1720 1730 1740 1750
NRRAYSGKQY DAYCVQTYNE ETKLYEGDLR VTFNFGLDCA RLEIFWDKKT
1760 1770 1780 1790 1800
YILETSITQK HVLKIMMEEV SKELVRCGMR FNTEQVNGVK HLVLFKTDSG
1810 1820 1830 1840 1850
FEWGKPNIPC IVYKNCALRT GLRTNQAINH KFMITIKDDG LRAIAQYDED
1860 1870 1880 1890 1900
SPRFLLAHAF HTIRDVRYQA VDAVSNVWFT HKGIKLYLNP IISSGLLEYF
1910 1920 1930 1940 1950
MKNIPAAIPP AAYSLIMNRA KISVDLFMFN DLLRLINPGN TLDLSGLEIT
1960 1970 1980 1990 2000
GEGYSTVNSL SSRLWSEEMS LVDDEEEMDD EFTIDLQDVD FENIDIEADV
2010 2020 2030 2040 2050
EHFLQDESAY TGDLLIMSEE TEVKKMRGII KLLEPVKLIK SWVSRGLSIE
2060 2070 2080 2090 2100
KVYNPVNIIL MTRYISKNFN FSGKQVSLLD PYDLTELESI VKGWGESVVD
2110 2120 2130 2140 2150
QFDSLDLEAQ NLVQKQGIVP EDVIPDSLFS FRHTMVLLRR LFGQDSVSTF
Y
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56492 Genomic RNA Translation: CAA39847.1 |
PIRi | S16449 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56492 Genomic RNA Translation: CAA39847.1 |
PIRi | S16449 |
3D structure databases
SMRi | P27314 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR016268, RNA-dir_pol_hantavirus IPR024378, RNA-dir_pol_N_hantavirus IPR007099, RNA-dir_pol_NSvirus IPR007322, RNA_pol_bunyavir |
Pfami | View protein in Pfam PF04196, Bunya_RdRp, 1 hit PF12426, DUF3674, 1 hit |
PIRSFi | PIRSF000825, L_HantaV, 1 hit |
PROSITEi | View protein in PROSITE PS50525, RDRP_SSRNA_NEG_SEG, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | L_SEOU8 | |
Accessioni | P27314Primary (citable) accession number: P27314 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | September 29, 2021 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |