Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 164 (29 Sep 2021)
Sequence version 2 (01 Feb 1995)
Previous versions | rss
Add a publicationFeedback
Protein

Trifunctional NAD biosynthesis/regulator protein NadR

Gene

nadR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD+. The NMN adenylyltransferase domain also functions as the NAD and ATP sensor.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Feed-back regulated by NAD. A high level of NAD causes NadR to lose enzymatic activity and repress several NAD synthetic genes; conversely, a low NAD level activates the assimilatory enzymatic activities and leads to derepression of biosynthetic genes (By similarity).By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.7 mM for NMN1 Publication
  2. KM=1.7 µM for ATP1 Publication

pH dependencei

Optimum pH is 8.6.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

This protein regulates the pathway NAD(+) biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide. This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei77NAD 1By similarity1
Binding sitei104NAD 1By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi18 – 37H-T-H motifCuratedAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi70 – 73NAD 1By similarity4
Nucleotide bindingi144 – 157NAD 1By similarityAdd BLAST14
Nucleotide bindingi177 – 179NAD 1By similarity3
Nucleotide bindingi204 – 206NAD 1By similarity3
Nucleotide bindingi259 – 261NAD 2By similarity3
Nucleotide bindingi294 – 297NAD 2By similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Kinase, Multifunctional enzyme, Repressor, Transferase
Biological processPyridine nucleotide biosynthesis, Transcription, Transcription regulation
LigandATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:PD04413
MetaCyc:PD04413

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P27278

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00253
UPA00253;UER00600

Protein family/group databases

MoonProt database of moonlighting proteins

More...
MoonProti
P27278

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trifunctional NAD biosynthesis/regulator protein NadR
Including the following 3 domains:
Transcriptional regulator NadR
Nicotinamide mononucleotide adenylyltransferase (EC:2.7.7.1)
Short name:
NMN adenylyltransferase
Short name:
NMN-AT
Short name:
NMNAT
Alternative name(s):
Nicotinamide ribonucleotide adenylyltransferase
Nicotinamide-nucleotide adenylyltransferase
Ribosylnicotinamide kinase (EC:2.7.1.22)
Short name:
RNK
Alternative name(s):
Nicotinamide riboside kinase
Short name:
NRK
Short name:
NmR-K
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nadR
Synonyms:nadI
Ordered Locus Names:b4390, JW5800
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001497281 – 410Trifunctional NAD biosynthesis/regulator protein NadRAdd BLAST410

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P27278

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27278

PRoteomics IDEntifications database

More...
PRIDEi
P27278

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4260800, 3 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b4390

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27278

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 62HTH cro/C1-typePROSITE-ProRule annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 229Nicotinamide mononucleotide adenylyltransferaseAdd BLAST167
Regioni230 – 410Ribosylnicotinamide kinaseAdd BLAST181

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the central section; belongs to the bacterial NMN adenylyltransferase family.Curated
In the C-terminal section; belongs to the bacterial RNK family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1056, Bacteria
COG3172, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_052648_0_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27278

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27278

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00093, HTH_XRE, 1 hit
cd02167, NMNAT_NadR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.260.40, 1 hit
3.40.50.300, 1 hit
3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001387, Cro/C1-type_HTH
IPR004821, Cyt_trans-like
IPR010982, Lambda_DNA-bd_dom_sf
IPR016429, NAD_NadR
IPR038727, NadR/Ttd14_AAA_dom
IPR006417, NadR_NMN_Atrans
IPR041749, NMNAT_NadR
IPR027417, P-loop_NTPase
IPR014729, Rossmann-like_a/b/a_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13521, AAA_28, 1 hit
PF01381, HTH_3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004776, NadR_NMNAT/RNK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00530, HTH_XRE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47413, SSF47413, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00125, cyt_tran_rel, 1 hit
TIGR01526, nadR_NMN_Atrans, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50943, HTH_CROC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P27278-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSFDYLKTA IKQQGCTLQQ VADASGMTKG YLSQLLNAKI KSPSAQKLEA
60 70 80 90 100
LHRFLGLEFP RQKKTIGVVF GKFYPLHTGH IYLIQRACSQ VDELHIIMGF
110 120 130 140 150
DDTRDRALFE DSAMSQQPTV PDRLRWLLQT FKYQKNIRIH AFNEEGMEPY
160 170 180 190 200
PHGWDVWSNG IKKFMAEKGI QPDLIYTSEE ADAPQYMEHL GIETVLVDPK
210 220 230 240 250
RTFMSISGAQ IRENPFRYWE YIPTEVKPFF VRTVAILGGE SSGKSTLVNK
260 270 280 290 300
LANIFNTTSA WEYGRDYVFS HLGGDEIALQ YSDYDKIALG HAQYIDFAVK
310 320 330 340 350
YANKVAFIDT DFVTTQAFCK KYEGREHPFV QALIDEYRFD LVILLENNTP
360 370 380 390 400
WVADGLRSLG SSVDRKEFQN LLVEMLEENN IEFVRVEEED YDSRFLRCVE
410
LVREMMGEQR
Length:410
Mass (Da):47,346
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCBC26CD3ABA2F99
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA97286 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97286.1 Different initiation.
U00096 Genomic DNA Translation: AAC77343.2
AP009048 Genomic DNA Translation: BAE78379.1
X63155 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
S56614

NCBI Reference Sequences

More...
RefSeqi
NP_418807.4, NC_000913.3
WP_000093814.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC77343; AAC77343; b4390
BAE78379; BAE78379; BAE78379

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948911

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5800
eco:b4390

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2295

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14003 Genomic DNA Translation: AAA97286.1 Different initiation.
U00096 Genomic DNA Translation: AAC77343.2
AP009048 Genomic DNA Translation: BAE78379.1
X63155 Genomic DNA No translation available.
PIRiS56614
RefSeqiNP_418807.4, NC_000913.3
WP_000093814.1, NZ_LN832404.1

3D structure databases

SMRiP27278
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4260800, 3 interactors
STRINGi511145.b4390

Protein family/group databases

MoonProtiP27278

Proteomic databases

jPOSTiP27278
PaxDbiP27278
PRIDEiP27278

Genome annotation databases

EnsemblBacteriaiAAC77343; AAC77343; b4390
BAE78379; BAE78379; BAE78379
GeneIDi948911
KEGGiecj:JW5800
eco:b4390
PATRICifig|1411691.4.peg.2295

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB1311

Phylogenomic databases

eggNOGiCOG1056, Bacteria
COG3172, Bacteria
HOGENOMiCLU_052648_0_1_6
InParanoidiP27278
PhylomeDBiP27278

Enzyme and pathway databases

UniPathwayiUPA00253
UPA00253;UER00600
BioCyciEcoCyc:PD04413
MetaCyc:PD04413
SABIO-RKiP27278

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P27278

Family and domain databases

CDDicd00093, HTH_XRE, 1 hit
cd02167, NMNAT_NadR, 1 hit
Gene3Di1.10.260.40, 1 hit
3.40.50.300, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001387, Cro/C1-type_HTH
IPR004821, Cyt_trans-like
IPR010982, Lambda_DNA-bd_dom_sf
IPR016429, NAD_NadR
IPR038727, NadR/Ttd14_AAA_dom
IPR006417, NadR_NMN_Atrans
IPR041749, NMNAT_NadR
IPR027417, P-loop_NTPase
IPR014729, Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF13521, AAA_28, 1 hit
PF01381, HTH_3, 1 hit
PIRSFiPIRSF004776, NadR_NMNAT/RNK, 1 hit
SMARTiView protein in SMART
SM00530, HTH_XRE, 1 hit
SUPFAMiSSF47413, SSF47413, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00125, cyt_tran_rel, 1 hit
TIGR01526, nadR_NMN_Atrans, 1 hit
PROSITEiView protein in PROSITE
PS50943, HTH_CROC1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNADR_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27278
Secondary accession number(s): P76819, Q2M5S7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1995
Last modified: September 29, 2021
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again