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Entry version 154 (03 Jul 2019)
Sequence version 2 (01 Feb 1995)
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Protein

Trifunctional NAD biosynthesis/regulator protein NadR

Gene

nadR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The DNA-binding domain binds to the nadB operator sequence in an NAD- and ATP-dependent manner. As NAD levels increase within the cell, the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB increases, repressing the transcription of these genes. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD+. The NMN adenylyltransferase domain also functions as the NAD and ATP sensor.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Feed-back regulated by NAD. A high level of NAD causes NadR to lose enzymatic activity and repress several NAD synthetic genes; conversely, a low NAD level activates the assimilatory enzymatic activities and leads to derepression of biosynthetic genes (By similarity).By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.7 mM for NMN1 Publication
  2. KM=1.7 µM for ATP1 Publication

    pH dependencei

    Optimum pH is 8.6.1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

    This protein regulates the pathway NAD(+) biosynthesis, which is part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

    Pathwayi: NAD(+) biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide.
    Proteins known to be involved in this subpathway in this organism are:
    1. Trifunctional NAD biosynthesis/regulator protein NadR (nadR)
    This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei77NAD 1By similarity1
    Binding sitei104NAD 1By similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi18 – 37H-T-H motifCuratedAdd BLAST20
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi70 – 73NAD 1By similarity4
    Nucleotide bindingi144 – 157NAD 1By similarityAdd BLAST14
    Nucleotide bindingi177 – 179NAD 1By similarity3
    Nucleotide bindingi204 – 206NAD 1By similarity3
    Nucleotide bindingi259 – 261NAD 2By similarity3
    Nucleotide bindingi294 – 297NAD 2By similarity4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionDNA-binding, Kinase, Multifunctional enzyme, Repressor, Transferase
    Biological processPyridine nucleotide biosynthesis, Transcription, Transcription regulation
    LigandATP-binding, NAD, Nucleotide-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    EcoCyc:PD04413
    ECOL316407:JW5800-MONOMER
    MetaCyc:PD04413

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P27278

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00253
    UPA00253;UER00600

    Protein family/group databases

    MoonProt database of moonlighting proteins

    More...
    MoonProti
    P27278

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Trifunctional NAD biosynthesis/regulator protein NadR
    Including the following 3 domains:
    Transcriptional regulator NadR
    Nicotinamide mononucleotide adenylyltransferase (EC:2.7.7.1)
    Short name:
    NMN adenylyltransferase
    Short name:
    NMN-AT
    Short name:
    NMNAT
    Alternative name(s):
    Nicotinamide ribonucleotide adenylyltransferase
    Nicotinamide-nucleotide adenylyltransferase
    Ribosylnicotinamide kinase (EC:2.7.1.22)
    Short name:
    RNK
    Alternative name(s):
    Nicotinamide riboside kinase
    Short name:
    NRK
    Short name:
    NmR-K
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:nadR
    Synonyms:nadI
    Ordered Locus Names:b4390, JW5800
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
    • UP000000625 Componenti: Chromosome

    Organism-specific databases

    Escherichia coli strain K12 genome database

    More...
    EcoGenei
    EG11335 nadR

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    GO - Cellular componenti

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001497281 – 410Trifunctional NAD biosynthesis/regulator protein NadRAdd BLAST410

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P27278

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P27278

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P27278

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer.

    By similarity

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    4260800, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    511145.b4390

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P27278

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 62HTH cro/C1-typePROSITE-ProRule annotationAdd BLAST56

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni63 – 229Nicotinamide mononucleotide adenylyltransferaseAdd BLAST167
    Regioni230 – 410Ribosylnicotinamide kinaseAdd BLAST181

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    In the central section; belongs to the bacterial NMN adenylyltransferase family.Curated
    In the C-terminal section; belongs to the bacterial RNK family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4107VZS Bacteria
    COG1056 LUCA
    COG1396 LUCA
    COG3172 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000127874

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P27278

    KEGG Orthology (KO)

    More...
    KOi
    K06211

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00093 HTH_XRE, 1 hit
    cd02167 NMNAT_NadR, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.620, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001387 Cro/C1-type_HTH
    IPR004821 Cyt_trans-like
    IPR010982 Lambda_DNA-bd_dom_sf
    IPR016429 NAD_NadR
    IPR038727 NadR/Ttd14_AAA_dom
    IPR006417 NadR_NMN_Atrans
    IPR041749 NMNAT_NadR
    IPR027417 P-loop_NTPase
    IPR014729 Rossmann-like_a/b/a_fold

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13521 AAA_28, 1 hit
    PF01381 HTH_3, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF004776 NadR_NMNAT/RNK, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00530 HTH_XRE, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47413 SSF47413, 1 hit
    SSF52540 SSF52540, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00125 cyt_tran_rel, 1 hit
    TIGR01526 nadR_NMN_Atrans, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50943 HTH_CROC1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P27278-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSSFDYLKTA IKQQGCTLQQ VADASGMTKG YLSQLLNAKI KSPSAQKLEA
    60 70 80 90 100
    LHRFLGLEFP RQKKTIGVVF GKFYPLHTGH IYLIQRACSQ VDELHIIMGF
    110 120 130 140 150
    DDTRDRALFE DSAMSQQPTV PDRLRWLLQT FKYQKNIRIH AFNEEGMEPY
    160 170 180 190 200
    PHGWDVWSNG IKKFMAEKGI QPDLIYTSEE ADAPQYMEHL GIETVLVDPK
    210 220 230 240 250
    RTFMSISGAQ IRENPFRYWE YIPTEVKPFF VRTVAILGGE SSGKSTLVNK
    260 270 280 290 300
    LANIFNTTSA WEYGRDYVFS HLGGDEIALQ YSDYDKIALG HAQYIDFAVK
    310 320 330 340 350
    YANKVAFIDT DFVTTQAFCK KYEGREHPFV QALIDEYRFD LVILLENNTP
    360 370 380 390 400
    WVADGLRSLG SSVDRKEFQN LLVEMLEENN IEFVRVEEED YDSRFLRCVE
    410
    LVREMMGEQR
    Length:410
    Mass (Da):47,346
    Last modified:February 1, 1995 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCBC26CD3ABA2F99
    GO

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA97286 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U14003 Genomic DNA Translation: AAA97286.1 Different initiation.
    U00096 Genomic DNA Translation: AAC77343.2
    AP009048 Genomic DNA Translation: BAE78379.1
    X63155 Genomic DNA No translation available.

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S56614

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_418807.4, NC_000913.3
    WP_000093814.1, NZ_LN832404.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    AAC77343; AAC77343; b4390
    BAE78379; BAE78379; BAE78379

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    948911

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ecj:JW5800
    eco:b4390

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|1411691.4.peg.2295

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U14003 Genomic DNA Translation: AAA97286.1 Different initiation.
    U00096 Genomic DNA Translation: AAC77343.2
    AP009048 Genomic DNA Translation: BAE78379.1
    X63155 Genomic DNA No translation available.
    PIRiS56614
    RefSeqiNP_418807.4, NC_000913.3
    WP_000093814.1, NZ_LN832404.1

    3D structure databases

    SMRiP27278
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi4260800, 3 interactors
    STRINGi511145.b4390

    Protein family/group databases

    MoonProtiP27278

    Proteomic databases

    jPOSTiP27278
    PaxDbiP27278
    PRIDEiP27278

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAAC77343; AAC77343; b4390
    BAE78379; BAE78379; BAE78379
    GeneIDi948911
    KEGGiecj:JW5800
    eco:b4390
    PATRICifig|1411691.4.peg.2295

    Organism-specific databases

    EchoBASE - an integrated post-genomic database for E. coli

    More...
    EchoBASEi
    EB1311
    EcoGeneiEG11335 nadR

    Phylogenomic databases

    eggNOGiENOG4107VZS Bacteria
    COG1056 LUCA
    COG1396 LUCA
    COG3172 LUCA
    HOGENOMiHOG000127874
    InParanoidiP27278
    KOiK06211

    Enzyme and pathway databases

    UniPathwayiUPA00253
    UPA00253;UER00600
    BioCyciEcoCyc:PD04413
    ECOL316407:JW5800-MONOMER
    MetaCyc:PD04413
    SABIO-RKiP27278

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P27278

    Family and domain databases

    CDDicd00093 HTH_XRE, 1 hit
    cd02167 NMNAT_NadR, 1 hit
    Gene3Di3.40.50.620, 1 hit
    InterProiView protein in InterPro
    IPR001387 Cro/C1-type_HTH
    IPR004821 Cyt_trans-like
    IPR010982 Lambda_DNA-bd_dom_sf
    IPR016429 NAD_NadR
    IPR038727 NadR/Ttd14_AAA_dom
    IPR006417 NadR_NMN_Atrans
    IPR041749 NMNAT_NadR
    IPR027417 P-loop_NTPase
    IPR014729 Rossmann-like_a/b/a_fold
    PfamiView protein in Pfam
    PF13521 AAA_28, 1 hit
    PF01381 HTH_3, 1 hit
    PIRSFiPIRSF004776 NadR_NMNAT/RNK, 1 hit
    SMARTiView protein in SMART
    SM00530 HTH_XRE, 1 hit
    SUPFAMiSSF47413 SSF47413, 1 hit
    SSF52540 SSF52540, 1 hit
    TIGRFAMsiTIGR00125 cyt_tran_rel, 1 hit
    TIGR01526 nadR_NMN_Atrans, 1 hit
    PROSITEiView protein in PROSITE
    PS50943 HTH_CROC1, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNADR_ECOLI
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27278
    Secondary accession number(s): P76819, Q2M5S7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: February 1, 1995
    Last modified: July 3, 2019
    This is version 154 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
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