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Protein

Antimicrobial peptide 2

Gene
N/A
Organism
Amaranthus caudatus (Love-lies-bleeding) (Inca-wheat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chitin-binding protein with a defensive function against numerous chitin containing fungal pathogens. It is also a potent inhibitor of Gram-positive bacteria.

Miscellaneous

Its chitin-binding activity is strongly inhibited by divalent cations.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Fungicide
Biological processPlant defense
LigandChitin-binding

Protein family/group databases

CAZyiCBM18 Carbohydrate-Binding Module Family 18
UniLectiniP27275

Names & Taxonomyi

Protein namesi
Recommended name:
Antimicrobial peptide 2
Short name:
AMP2
Cleaved into the following chain:
Antimicrobial peptide 1
Short name:
AMP1
OrganismiAmaranthus caudatus (Love-lies-bleeding) (Inca-wheat)
Taxonomic identifieri3567 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesAmaranthaceaeAmaranthus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
PeptideiPRO_000000527526 – 55Antimicrobial peptide 2Add BLAST30
PeptideiPRO_000000527626 – 54Antimicrobial peptide 1Add BLAST29
PropeptideiPRO_000000527756 – 86Removed in mature formAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 401 Publication
Disulfide bondi34 ↔ 461 Publication
Disulfide bondi39 ↔ 531 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP27275

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

Secondary structure

186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP27275
SMRiP27275
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27275

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 53Chitin-binding type-1Add BLAST25

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.60.10, 1 hit
InterProiView protein in InterPro
IPR013006 Antimicrobial_C6_CS
IPR001002 Chitin-bd_1
IPR018371 Chitin-binding_1_CS
IPR036861 Endochitinase-like_sf
PfamiView protein in Pfam
PF00187 Chitin_bind_1, 1 hit
PRINTSiPR00451 CHITINBINDNG
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000609 Chitin_bd_1, 1 hit
SMARTiView protein in SMART
SM00270 ChtBD1, 1 hit
SUPFAMiSSF57016 SSF57016, 1 hit
PROSITEiView protein in PROSITE
PS00026 CHIT_BIND_I_1, 1 hit
PS60011 PLANT_C6_AMP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27275-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNMKCVALI VIVMMAFMMV DPSMGVGECV RGRCPSGMCC SQFGYCGKGP
60 70 80
KYCGRASTTV DHQADVAATK TAKNPTDAKL AGAGSP
Length:86
Mass (Da):8,912
Last modified:October 1, 1996 - v2
Checksum:iC2C220E7DF373CB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72641 mRNA Translation: CAA51210.1
PIRiS37381

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72641 mRNA Translation: CAA51210.1
PIRiS37381

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MMCNMR-A26-55[»]
1ZNTNMR-A26-55[»]
1ZUVNMR-A26-55[»]
1ZWUNMR-A26-55[»]
ProteinModelPortaliP27275
SMRiP27275
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM18 Carbohydrate-Binding Module Family 18
UniLectiniP27275

Proteomic databases

PRIDEiP27275

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP27275

Family and domain databases

Gene3Di3.30.60.10, 1 hit
InterProiView protein in InterPro
IPR013006 Antimicrobial_C6_CS
IPR001002 Chitin-bd_1
IPR018371 Chitin-binding_1_CS
IPR036861 Endochitinase-like_sf
PfamiView protein in Pfam
PF00187 Chitin_bind_1, 1 hit
PRINTSiPR00451 CHITINBINDNG
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000609 Chitin_bd_1, 1 hit
SMARTiView protein in SMART
SM00270 ChtBD1, 1 hit
SUPFAMiSSF57016 SSF57016, 1 hit
PROSITEiView protein in PROSITE
PS00026 CHIT_BIND_I_1, 1 hit
PS60011 PLANT_C6_AMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAMP_AMACA
AccessioniPrimary (citable) accession number: P27275
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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