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Protein

CD59 glycoprotein

Gene

Cd59

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts at or after the C5b-8 stage of MAC assembly.

GO - Molecular functioni

  • complement binding Source: RGD

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-204005 COPII-mediated vesicle transport
R-RNO-5694530 Cargo concentration in the ER
R-RNO-6798695 Neutrophil degranulation
R-RNO-6807878 COPI-mediated anterograde transport
R-RNO-977606 Regulation of Complement cascade

Names & Taxonomyi

Protein namesi
Recommended name:
CD59 glycoprotein
Alternative name(s):
MAC-inhibitory protein
Short name:
MAC-IP
Membrane attack complex inhibition factor
Short name:
MACIF
Protectin
CD_antigen: CD59
Gene namesi
Name:Cd59
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2311 Cd59

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 222 PublicationsAdd BLAST22
ChainiPRO_000003612423 – 101CD59 glycoproteinAdd BLAST79
PropeptideiPRO_0000036125102 – 126Removed in mature formBy similarityAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 48By similarity
Disulfide bondi28 ↔ 35By similarity
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi41 ↔ 61By similarity
Disulfide bondi67 ↔ 85By similarity
Disulfide bondi86 ↔ 91By similarity
Lipidationi101GPI-anchor amidated asparagineBy similarity1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP27274
PRIDEiP27274

PTM databases

iPTMnetiP27274
PhosphoSitePlusiP27274
SwissPalmiP27274

Expressioni

Gene expression databases

BgeeiENSRNOG00000042821 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiP27274 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP27274, 1 interactor
STRINGi10116.ENSRNOP00000060967

Structurei

3D structure databases

ProteinModelPortaliP27274
SMRiP27274
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 110UPAR/Ly6Add BLAST88

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J39P Eukaryota
ENOG410ZEQP LUCA
GeneTreeiENSGT00390000016309
HOVERGENiHBG005284
InParanoidiP27274
KOiK04008
OMAiNSDLCNS
OrthoDBiEOG091G11NF
PhylomeDBiP27274

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR027101 CD59_glyco
IPR016054 LY6_UPA_recep-like
PANTHERiPTHR10036:SF9 PTHR10036:SF9, 1 hit
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27274-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRARRGFILL LLLAVLCSTG VSLRCYNCLD PVSSCKTNST CSPNLDACLV
60 70 80 90 100
AVSGKQVYQQ CWRFSDCNAK FILSRLEIAN VQYRCCQADL CNKSFEDKPN
110 120
NGAISLLGKT ALLVTSVLAA ILKPCF
Length:126
Mass (Da):13,790
Last modified:November 1, 1997 - v2
Checksum:i54B9C58AB2073005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48255 mRNA Translation: AAA88909.1
BC063176 mRNA Translation: AAH63176.1
PIRiS53340
RefSeqiNP_037057.1, NM_012925.1
UniGeneiRn.1231

Genome annotation databases

EnsembliENSRNOT00000067085; ENSRNOP00000060967; ENSRNOG00000042821
GeneIDi25407
KEGGirno:25407
UCSCiRGD:2311 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48255 mRNA Translation: AAA88909.1
BC063176 mRNA Translation: AAH63176.1
PIRiS53340
RefSeqiNP_037057.1, NM_012925.1
UniGeneiRn.1231

3D structure databases

ProteinModelPortaliP27274
SMRiP27274
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP27274, 1 interactor
STRINGi10116.ENSRNOP00000060967

PTM databases

iPTMnetiP27274
PhosphoSitePlusiP27274
SwissPalmiP27274

Proteomic databases

PaxDbiP27274
PRIDEiP27274

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067085; ENSRNOP00000060967; ENSRNOG00000042821
GeneIDi25407
KEGGirno:25407
UCSCiRGD:2311 rat

Organism-specific databases

CTDi966
RGDi2311 Cd59

Phylogenomic databases

eggNOGiENOG410J39P Eukaryota
ENOG410ZEQP LUCA
GeneTreeiENSGT00390000016309
HOVERGENiHBG005284
InParanoidiP27274
KOiK04008
OMAiNSDLCNS
OrthoDBiEOG091G11NF
PhylomeDBiP27274

Enzyme and pathway databases

ReactomeiR-RNO-204005 COPII-mediated vesicle transport
R-RNO-5694530 Cargo concentration in the ER
R-RNO-6798695 Neutrophil degranulation
R-RNO-6807878 COPI-mediated anterograde transport
R-RNO-977606 Regulation of Complement cascade

Miscellaneous databases

PROiPR:P27274

Gene expression databases

BgeeiENSRNOG00000042821 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiP27274 RN

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR027101 CD59_glyco
IPR016054 LY6_UPA_recep-like
PANTHERiPTHR10036:SF9 PTHR10036:SF9, 1 hit
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD59_RAT
AccessioniPrimary (citable) accession number: P27274
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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