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Entry version 153 (07 Apr 2021)
Sequence version 4 (16 Jun 2009)
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Protein

Surfactin synthase subunit 1

Gene

srfAA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is a multifunctional enzyme able to activate and polymerize the amino acids Leu, Glu, Asp and Val. Activation sites for these AA consist of individual domains.

Caution

The phosphoserine observed at Ser-1006 in PubMed:17218307 undoubtedly results from the secondary neutral loss of pantetheine from the phosphodiester linked cofactor.Curated

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateNote: Binds 3 phosphopantetheines covalently.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: surfactin biosynthesis

This protein is involved in the pathway surfactin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway surfactin biosynthesis and in Antibiotic biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processAntibiotic biosynthesis, Sporulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU03480-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00181

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Surfactin synthase subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:srfAA
Synonyms:srfA, srfA1
Ordered Locus Names:BSU03480
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001930991 – 3587Surfactin synthase subunit 1Add BLAST3587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1006O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1 Publication1
Modified residuei2045O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3073O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P27206

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27206

PRoteomics IDEntifications database

More...
PRIDEi
P27206

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P27206, 4 interactors

Molecular INTeraction database

More...
MINTi
P27206

STRING: functional protein association networks

More...
STRINGi
224308.BSU03480

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27206

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini971 – 1046Carrier 1PROSITE-ProRule annotationAdd BLAST76
Domaini2010 – 2085Carrier 2PROSITE-ProRule annotationAdd BLAST76
Domaini3038 – 3112Carrier 3PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni? – 3114Domain 3 (D-leucine-activating)
Regioni? – 2086Domain 2 (leucine-activating)
Regioni? – 1047Domain 1 (glutamate-activating)

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1020, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27206

Identification of Orthologs from Complete Genome Data

More...
OMAi
NRQHWNQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27206

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.30.559.10, 4 hits
3.40.50.12780, 3 hits
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 3 hits
TIGR01720, NRPS-para261, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P27206-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEITFYPLTD AQKRIWYTEK FYPHTSISNL AGIGKLVSAD AIDYVLVEQA
60 70 80 90 100
IQEFIRRNDA MRLRLRLDEN GEPVQYISEY RPVDIKHTDT TEDPNAIEFI
110 120 130 140 150
SQWSREETKK PLPLYDCDLF RFSLFTIKEN EVWFYANVHH VISDGISMNI
160 170 180 190 200
LGNAIMHIYL ELASGSETKE GISHSFIDHV LSEQEYAQSK RFEKDKAFWN
210 220 230 240 250
KQFESVPELV SLKRNASAGG SLDAERFSKD VPEALHQQIL SFCEANKVSV
260 270 280 290 300
LSVFQSLLAA YLYRVSGQND VVTGTFMGNR TNAKEKQMLG MFVSTVPLRT
310 320 330 340 350
NIDGGQAFSE FVKDRMKDLM KTLRHQKYPY NLLINDLRET KSSLTKLFTV
360 370 380 390 400
SLEYQVMQWQ KEEDLAFLTE PIFSGSGLND VSIHVKDRWD TGKLTIDFDY
410 420 430 440 450
RTDLFSREEI NMICERMITM LENALTHPEH TIDELTLISD AEKEKLLARA
460 470 480 490 500
GGKSVSYRKD MTIPELFQEK AELLSDHPAV VFEDRTLSYR TLHEQSARIA
510 520 530 540 550
NVLKQKGVGP DSPVAVLIER SERMITAIMG ILKAGGAYVP IDPGFPAERI
560 570 580 590 600
QYILEDCGAD FILTESKVAA PEADAELIDL DQAIEEGAEE SLNADVNARN
610 620 630 640 650
LAYIIYTSGT TGRPKGVMIE HRQVHHLVES LQQTIYQSGS QTLRMALLAP
660 670 680 690 700
FHFDASVKQI FASLLLGQTL YIVPKKTVTN GAALTAYYRK NSIEATDGTP
710 720 730 740 750
AHLQMLAAAG DFEGLKLKHM LIGGEGLSSV VADKLLKLFK EAGTAPRLTN
760 770 780 790 800
VYGPTETCVD ASVHPVIPEN AVQSAYVPIG KALGNNRLYI LDQKGRLQPE
810 820 830 840 850
GVAGELYIAG DGVGRGYLHL PELTEEKFLQ DPFVPGDRMY RTGDVVRWLP
860 870 880 890 900
DGTIEYLGRE DDQVKVRGYR IELGEIEAVI QQAPDVAKAV VLARPDEQGN
910 920 930 940 950
LEVCAYVVQK PGSEFAPAGL REHAARQLPD YMVPAYFTEV TEIPLTPSGK
960 970 980 990 1000
VDRRKLFALE VKAVSGTAYT APRNETEKAI AAIWQDVLNV EKAGIFDNFF
1010 1020 1030 1040 1050
ETGGHSLKAM TLLTKIHKET GIEIPLQFLF EHPTITALAE EADHRESKAF
1060 1070 1080 1090 1100
AVIEPAEKQE HYPLSLAQQR TYIVSQFEDA GVGYNMPAAA ILEGPLDIQK
1110 1120 1130 1140 1150
LERAFQGLIR RHESLRTSFV LENSTPRQKI HDSVDFNIEM IERGGRSDEA
1160 1170 1180 1190 1200
IMASFVRTFD LAKAPLFRIG LLGLEENRHM LLFDMHHLIS DGVSIGIMLE
1210 1220 1230 1240 1250
ELARIYKGEQ LPDLRLQYKD YAVWQSRQAA EGYKKDQAYW KEVFAGELPV
1260 1270 1280 1290 1300
LQLLSDYPRP PVQSFEGDRV SIKLDAGVKD RLNRLAEQNG ATLYMVMLSA
1310 1320 1330 1340 1350
YYTLLSKYTG QDDIIVGTPS AGRNHSDTEG IIGMFVNTLA IRSEVKQNET
1360 1370 1380 1390 1400
FTQLISRVRK RVLDAFSHQD YPFEWLVEDL NIPRDVSRHP LFDTMFSLQN
1410 1420 1430 1440 1450
ATEGIPAVGD LSLSVQETNF KIAKFDLTVQ ARETDEGIEI DVDYSTKLFK
1460 1470 1480 1490 1500
QSTADRLLTH FARLLEDAAA DPEKPISEYK LLSEEEAASQ IQQFNPGRTP
1510 1520 1530 1540 1550
YPKDKTIVQL FEEQAANTPD HTALQYEGES LTYRELNERA NRLARGILSL
1560 1570 1580 1590 1600
GAGEGRTAAV LCERSMDMIV SILAVLKSGS AYVPIDPEHP IQRMQHFFRD
1610 1620 1630 1640 1650
SGAKVLLTQR KLKALAEEAE FKGVIVLADE EESYHADARN LALPLDSAAM
1660 1670 1680 1690 1700
ANLTYTSGTT GTPKGNIVTH ANILRTVKET NYLSITEQDT ILGLSNYVFD
1710 1720 1730 1740 1750
AFMFDMFGSL LNGAKLVLIP KETVLDMARL SRVIERENIS ILMITTALFH
1760 1770 1780 1790 1800
LLVDLNPACL STLRKIMFGG ERASVEHVRK ALQTVGKGKL LHMYGPSEST
1810 1820 1830 1840 1850
VFATYHPVDE LEEHTLSVPI GKPVSNTEVY ILDRTGHVQP AGIAGELCVS
1860 1870 1880 1890 1900
GEGLVKGYYN RPELTEEKFV PHPFTSGERM YKTGDLARWL PNGDIEFIGR
1910 1920 1930 1940 1950
IDHQVKIRGQ RIELGEIEHQ LQTHDRVQES VVLAVDQGAG DKLLCAYYVG
1960 1970 1980 1990 2000
EGDISSQEMR EHAAKDLPAY MVPAVFIQMD ELPLTGNGKI DRRALPIPDA
2010 2020 2030 2040 2050
NVSRGVSYVA PRNGTEQKVA DIWAQVLQAE QVGAYDHFFD IGGHSLAGMK
2060 2070 2080 2090 2100
MLALVHQELG VELSLKDLFQ SPTVEGLAQV IASAEKGTAA SISPAEKQDT
2110 2120 2130 2140 2150
YPVSSPQKRM YVLQQLEDAQ TSYNMPAVLR LTGELDVERL NSVMQQLMQR
2160 2170 2180 2190 2200
HEALRTTFEI KDGETVQRIW EEAECEIAYF EAPEEETERI VSEFIKPFKI
2210 2220 2230 2240 2250
DQLPLFRIGL IKHSDTEHVL LFDMHHIISD GASVGVLIEE LSKLYDGETL
2260 2270 2280 2290 2300
EPLRIQYKDY AVWQQQFIQS ELYKKQEEHW LKELDGELPV LTLPTDYSRP
2310 2320 2330 2340 2350
AVQTFEGDRI AFSLEAGKAD ALRRLAKETD STLYMVLLAS YSAFLSKISG
2360 2370 2380 2390 2400
QDDIIVGSPV AGRSQADVSR VIGMFVNTLA LRTYPKGEKT FADYLNEVKE
2410 2420 2430 2440 2450
TALSAFDAQD YPLEDLIGNV QVQRDTSRNP LFDAVFSMQN ANIKDLTMKG
2460 2470 2480 2490 2500
IQLEPHPFER KTAKFDLTLT ADETDGGLTF VLEYNTALFK QETIERWKQY
2510 2520 2530 2540 2550
WMELLDAVTG NPNQPLSSLS LVTETEKQAL LEAWKGKALP VPTDKTVHQL
2560 2570 2580 2590 2600
FEETAQRHKD RPAVTYNGQS WTYGELNAKA NRLARILMDC GISPDDRVGV
2610 2620 2630 2640 2650
LTKPSLEMSA AVLGVLKAGA AFVPIDPDYP DQRIEYILQD SGAKLLLKQE
2660 2670 2680 2690 2700
GISVPDSYTG DVILLDGSRT ILSLPLDEND EENPETAVTA ENLAYMIYTS
2710 2720 2730 2740 2750
GTTGQPKGVM VEHHALVNLC FWHHDAFSMT AEDRSAKYAG FGFDASIWEM
2760 2770 2780 2790 2800
FPTWTIGAEL HVIEEAIRLD IVRLNDYFET NGVTITFLPT QLAEQFMELE
2810 2820 2830 2840 2850
NTSLRVLLTG GDKLKRAVKK PYTLVNNYGP TENTVVATSA EIHPEEGSLS
2860 2870 2880 2890 2900
IGRAIANTRV YILGEGNQVQ PEGVAGELCV AGRGLARGYL NREDETAKRF
2910 2920 2930 2940 2950
VADPFVPGER MYRTGDLVKW TGGGIEYIGR IDQQVKVRGY RIELSEIEVQ
2960 2970 2980 2990 3000
LAQLSEVQDA AVTAVKDKGG NTAIAAYVTP ESADIEALKS ALKETLPDYM
3010 3020 3030 3040 3050
IPAFWVTLNE LPVTANGKVD RKALPEPDIE AGSGEYKAPT TDMEELLAGI
3060 3070 3080 3090 3100
WQDVLGMSEV GVTDNFFSLG GDSIKGIQMA SRLNQHGWKL EMKDLFQHPT
3110 3120 3130 3140 3150
IEELTQYVER AEGKQADQGP VEGEVILTPI QRWFFEKNFT NKHHWNQSVM
3160 3170 3180 3190 3200
LHAKKGFDPE RVEKTLQALI EHHDALRMVY REGQEDVIQY NRGLEAASAQ
3210 3220 3230 3240 3250
LEVIQIEGQA ADYEDRIERE AERLQSSIDL QEGGLLKAGL FQAEDGDHLL
3260 3270 3280 3290 3300
LAIHHLVVDG VSWRILLEDF AAVYTQLEQG NEPVLPQKTH SFAEYAERLQ
3310 3320 3330 3340 3350
DFANSKAFLK EKEYWRQLEE QAVAAKLPKD RESGDQRMKH TKTIEFSLTA
3360 3370 3380 3390 3400
EETEQLTTKV HEAYHTEMND ILLTAFGLAM KEWTGQDRVS VHLEGHGREE
3410 3420 3430 3440 3450
IIEDLTISRT VGWFTSMYPM VLDMKHADDL GYQLKQMKED IRHVPNKGVG
3460 3470 3480 3490 3500
YGILRYLTAP EHKEDVAFSI QPDVSFNYLG QFDEMSDAGL FTRSELPSGQ
3510 3520 3530 3540 3550
SLSPETEKPN ALDVVGYIEN GKLTMSLAYH SLEFHEKTVQ TFSDSFKAHL
3560 3570 3580
LRIIEHCLSQ DGTELTPSDL GDDDLTLDEL DKLMEIF
Length:3,587
Mass (Da):402,146
Last modified:June 16, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CA8D98D71FD0A84
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA08982 differs from that shown. Reason: Frameshift.Curated
The sequence CAA49816 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti146I → M in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti146I → M in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti151L → V in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti151L → V in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti165G → A in BAA02522 (PubMed:8441623).Curated1
Sequence conflicti281T → Q in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti281T → Q in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti460D → T in AAA22815 (PubMed:1847909).Curated1
Sequence conflicti540P → A in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti540P → A in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti562I → Y in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti562I → Y in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti639 – 640GS → PT in CAA49816 (PubMed:8355609).Curated2
Sequence conflicti639 – 640GS → PT in BAA08982 (PubMed:8969502).Curated2
Sequence conflicti644R → P in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti644R → P in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti647 – 649LLA → FLP in CAA49816 (PubMed:8355609).Curated3
Sequence conflicti647 – 649LLA → FLP in BAA08982 (PubMed:8969502).Curated3
Sequence conflicti1026L → Q in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti1026L → Q in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti1132 – 1133DS → VC in CAA49816 (PubMed:8355609).Curated2
Sequence conflicti1132 – 1133DS → VC in BAA08982 (PubMed:8969502).Curated2
Sequence conflicti1164A → R in BAA02522 (PubMed:8441623).Curated1
Sequence conflicti1458L → V in BAA02522 (PubMed:8441623).Curated1
Sequence conflicti1850S → T in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti1850S → T in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti1894D → T in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti1894D → T in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti1911R → A in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti1911R → A in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti1973 – 1980PAVFIQMD → LRCLSKWT in BAA02522 (PubMed:8441623).Curated8
Sequence conflicti2052L → P in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti2052L → P in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti2218H → Q in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti2218H → Q in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti2265 – 2266QQ → HR in CAA49816 (PubMed:8355609).Curated2
Sequence conflicti2265 – 2266QQ → HR in BAA08982 (PubMed:8969502).Curated2
Sequence conflicti2291L → V in BAA02522 (PubMed:8441623).Curated1
Sequence conflicti2349S → C in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti2349S → C in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti2428R → S in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti2428R → S in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti2611 – 2612AV → RC in BAA02522 (PubMed:8441623).Curated2
Sequence conflicti2685E → ENPE in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti2685E → ENPE in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti2755T → S in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti2755T → S in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti2896 – 2897TA → SP in BAA02522 (PubMed:8441623).Curated2
Sequence conflicti3025P → N in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti3025P → N in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti3096F → N in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti3096F → N in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti3271A → S in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti3271A → S in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti3316R → S in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti3316R → S in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti3451Y → S in CAA49816 (PubMed:8355609).Curated1
Sequence conflicti3451Y → S in BAA08982 (PubMed:8969502).Curated1
Sequence conflicti3483 – 3495DEMSD…FTRSE → HQMSHPPFFTTSH in CAA49816 (PubMed:8355609).CuratedAdd BLAST13
Sequence conflicti3483 – 3495DEMSD…FTRSE → HQMSHPPFFTTSH in BAA08982 (PubMed:8969502).CuratedAdd BLAST13
Sequence conflicti3499 – 3500GQ → PH in CAA49816 (PubMed:8355609).Curated2
Sequence conflicti3499 – 3500GQ → PH in BAA08982 (PubMed:8969502).Curated2
Sequence conflicti3507E → R in BAA02522 (PubMed:8441623).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D13262 Genomic DNA Translation: BAA02522.1
X70356 Genomic DNA Translation: CAA49816.1 Frameshift.
D50453 Genomic DNA Translation: BAA08982.1 Frameshift.
AL009126 Genomic DNA Translation: CAB12142.2
M59939 Genomic DNA Translation: AAA22815.1
D30762 Genomic DNA Translation: BAA21034.1
M64702 Genomic DNA Translation: AAA22816.1

Protein sequence database of the Protein Information Resource

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PIRi
I40485

NCBI Reference Sequences

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RefSeqi
NP_388230.2, NC_000964.3
WP_010886402.1, NZ_CP053102.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

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EnsemblBacteriai
CAB12142; CAB12142; BSU_03480

Database of genes from NCBI RefSeq genomes

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GeneIDi
938306

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
bsu:BSU03480

Pathosystems Resource Integration Center (PATRIC)

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PATRICi
fig|224308.179.peg.366

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13262 Genomic DNA Translation: BAA02522.1
X70356 Genomic DNA Translation: CAA49816.1 Frameshift.
D50453 Genomic DNA Translation: BAA08982.1 Frameshift.
AL009126 Genomic DNA Translation: CAB12142.2
M59939 Genomic DNA Translation: AAA22815.1
D30762 Genomic DNA Translation: BAA21034.1
M64702 Genomic DNA Translation: AAA22816.1
PIRiI40485
RefSeqiNP_388230.2, NC_000964.3
WP_010886402.1, NZ_CP053102.1

3D structure databases

SMRiP27206
ModBaseiSearch...

Protein-protein interaction databases

IntActiP27206, 4 interactors
MINTiP27206
STRINGi224308.BSU03480

Proteomic databases

jPOSTiP27206
PaxDbiP27206
PRIDEiP27206

Genome annotation databases

EnsemblBacteriaiCAB12142; CAB12142; BSU_03480
GeneIDi938306
KEGGibsu:BSU03480
PATRICifig|224308.179.peg.366

Phylogenomic databases

eggNOGiCOG1020, Bacteria
InParanoidiP27206
OMAiNRQHWNQ
PhylomeDBiP27206

Enzyme and pathway databases

UniPathwayiUPA00181
BioCyciBSUB:BSU03480-MONOMER

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.559.10, 4 hits
3.40.50.12780, 3 hits
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 3 hits
SUPFAMiSSF47336, SSF47336, 3 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 3 hits
TIGR01720, NRPS-para261, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRFAA_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27206
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: June 16, 2009
Last modified: April 7, 2021
This is version 153 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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