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Entry version 126 (26 Feb 2020)
Sequence version 2 (15 Mar 2005)
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Protein

Quinoprotein glucose dehydrogenase

Gene

gdh

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

The P1 form can oxidize only D-glucose, while the P2 form can also oxidize maltose. The sequence of P1 form is shown here.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyrroloquinoline quinone

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei470Proton acceptorSequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandPQQ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Quinoprotein glucose dehydrogenase (EC:1.1.5.2)
Alternative name(s):
Glucose dehydrogenase [pyrroloquinoline-quinone]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gdh
Ordered Locus Names:GOX0265
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri290633 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006375 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 54HelicalSequence analysisAdd BLAST20
Transmembranei59 – 76HelicalSequence analysisAdd BLAST18
Transmembranei94 – 108HelicalSequence analysisAdd BLAST15
Transmembranei123 – 138HelicalSequence analysisAdd BLAST16

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002555834 – 808Quinoprotein glucose dehydrogenaseAdd BLAST775

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
290633.GOX0265

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bacterial PQQ dehydrogenase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DZG Bacteria
COG4993 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018478_1_0_5

KEGG Orthology (KO)

More...
KOi
K00117

Identification of Orthologs from Complete Genome Data

More...
OMAi
YQHMTCR

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10280 PQQ_mGDH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018391 PQQ_beta_propeller_repeat
IPR017511 PQQ_mDH
IPR002372 PQQ_repeat
IPR011047 Quinoprotein_ADH-like_supfam
IPR001479 Quinoprotein_DH_CS

The PANTHER Classification System

More...
PANTHERi
PTHR32303:SF4 PTHR32303:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01011 PQQ, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00564 PQQ, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998 SSF50998, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03074 PQQ_membr_DH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00363 BACTERIAL_PQQ_1, 1 hit
PS00364 BACTERIAL_PQQ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P27175-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTSRPGLW ALITAAVFAL CGAILTVGGA WVAAIGGPLY YVILGLALLA
60 70 80 90 100
TAFLSFRRNP AALYLFAVVV FGTVIWELTV VGLDIWALIP RSDIVIILGI
110 120 130 140 150
WLLLPFVSRQ IGGTRTTVLP LAGAVGVAVL ALFASLFTDP HDISGDLPTQ
160 170 180 190 200
IANASPADPD NVPASEWHAY GRTQAGDRWS PLNQINASNV SNLKVAWHIH
210 220 230 240 250
TKDMMNSNDP GEATNEATPI EFNNTLYMCS LHQKLFAVDG ATGNVKWVYD
260 270 280 290 300
PKLQINPGFQ HLTCRGVSFH ETPANATDSD GNPAPTDCAK RIILPVNDGR
310 320 330 340 350
LVEVDADTGK TCSGFGNNGE IDLRVPNQPY TTPGQYEPTS PPVITDKLII
360 370 380 390 400
ANSAITDNGS VKQASGATQA FDVYTGKRVW VFDASNPDPN QLPDDSHPVF
410 420 430 440 450
HPNSPNSWIV SSYDRNLNLV YIPMGVGTPD QWGGDRTKDS ERFAPGIVAL
460 470 480 490 500
NADTGKLAWF YQTVHHDLWD MDVPSQPSLV DVTQKDGTLV PAIYAPTKTG
510 520 530 540 550
DIFVLDRRTG KEIVPAPETP VPQGAAPGDH TSPTQPMSQL TLRPKNPLND
560 570 580 590 600
SDIWGGTIFD QMFCSIYFHT LRYEGPFTPP SLKGSLIFPG DLGMFEWGGL
610 620 630 640 650
AVDPQRQVAF ANPISLPFVS QLVPRGPGNP LWPEKDAKGT GGETGLQHNY
660 670 680 690 700
GIPYAVNLHP FLDPVLLPFG IKMPCRTPPW GYVAGIDLKT NKVVWQHRNG
710 720 730 740 750
TLRDSMYGSS LPIPLPPIKI GVPSLGGPLS TAGNLGFLTA SMDYYIRAYN
760 770 780 790 800
LTTGKVLWQD RLPAGAQATP ITYAINGKQY IVTYAGGHNS FPTRMGDDII

AYALPDQK
Length:808
Mass (Da):87,335
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FFF304215A63D29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4T → I in CAA44594 (PubMed:1833618).Curated1
Sequence conflicti8G → R in CAA44594 (PubMed:1833618).Curated1
Sequence conflicti110 – 123QIGGT…LPLAG → ARSVARGRPSCRSP (PubMed:1833618).CuratedAdd BLAST14
Sequence conflicti146D → E in CAA44594 (PubMed:1833618).Curated1
Sequence conflicti188S → T in CAA44594 (PubMed:1833618).Curated1
Sequence conflicti213A → Q (PubMed:1833618).Curated1
Sequence conflicti277T → M in CAA44594 (PubMed:1833618).Curated1
Sequence conflicti291 – 292RI → DS in CAA44594 (PubMed:1833618).Curated2
Sequence conflicti395D → E in CAA44594 (PubMed:1833618).Curated1
Sequence conflicti415R → A in CAA44594 (PubMed:1833618).Curated1
Sequence conflicti472 – 473DV → EL in CAA44594 (PubMed:1833618).Curated2
Sequence conflicti635 – 636KD → EN in CAA44594 (PubMed:1833618).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti788H → N in P2 form. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X62710 Genomic DNA Translation: CAA44594.1 Sequence problems.
CP000009 Genomic DNA Translation: AAW60048.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S17716 QPKEX

NCBI Reference Sequences

More...
RefSeqi
WP_011251851.1, NZ_LT900338.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAW60048; AAW60048; GOX0265

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29627144

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gox:GOX0265

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62710 Genomic DNA Translation: CAA44594.1 Sequence problems.
CP000009 Genomic DNA Translation: AAW60048.1
PIRiS17716 QPKEX
RefSeqiWP_011251851.1, NZ_LT900338.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi290633.GOX0265

Genome annotation databases

EnsemblBacteriaiAAW60048; AAW60048; GOX0265
GeneIDi29627144
KEGGigox:GOX0265

Phylogenomic databases

eggNOGiENOG4105DZG Bacteria
COG4993 LUCA
HOGENOMiCLU_018478_1_0_5
KOiK00117
OMAiYQHMTCR

Family and domain databases

CDDicd10280 PQQ_mGDH, 1 hit
InterProiView protein in InterPro
IPR018391 PQQ_beta_propeller_repeat
IPR017511 PQQ_mDH
IPR002372 PQQ_repeat
IPR011047 Quinoprotein_ADH-like_supfam
IPR001479 Quinoprotein_DH_CS
PANTHERiPTHR32303:SF4 PTHR32303:SF4, 1 hit
PfamiView protein in Pfam
PF01011 PQQ, 5 hits
SMARTiView protein in SMART
SM00564 PQQ, 3 hits
SUPFAMiSSF50998 SSF50998, 1 hit
TIGRFAMsiTIGR03074 PQQ_membr_DH, 1 hit
PROSITEiView protein in PROSITE
PS00363 BACTERIAL_PQQ_1, 1 hit
PS00364 BACTERIAL_PQQ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHG_GLUOX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27175
Secondary accession number(s): Q5FU98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: March 15, 2005
Last modified: February 26, 2020
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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