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Entry version 78 (02 Dec 2020)
Sequence version 2 (01 Apr 1993)
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Protein

Envelope glycoprotein B

Gene

gB

Organism
Murid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Envelope glycoprotein BUniRule annotation
Short name:
gBUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gBUniRule annotation
ORF Names:UL55
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMurid herpesvirus 1 (strain Smith) (MuHV-1) (Mouse cytomegalovirus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10367 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiMus musculus (Mouse) [TaxID: 10090]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008774 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini38 – 783Virion surfaceUniRule annotationAdd BLAST746
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei784 – 804HelicalUniRule annotationAdd BLAST21
Topological domaini805 – 928IntravirionUniRule annotationAdd BLAST124

Keywords - Cellular componenti

Host cell membrane, Host endosome, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37UniRule annotationAdd BLAST37
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003819538 – 928Envelope glycoprotein BUniRule annotationAdd BLAST891

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi93N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi111 ↔ 581UniRule annotation
Disulfide bondi127 ↔ 537UniRule annotation
Disulfide bondi200 ↔ 265UniRule annotation
Glycosylationi223N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi315N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi354N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi357 ↔ 411UniRule annotation
Glycosylationi398N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi429N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi470N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi487N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Disulfide bondi606 ↔ 643UniRule annotation
Glycosylationi618N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi667N-linked (GlcNAc...) asparagine; by hostUniRule annotation1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei497 – 498Cleavage; by host furinSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; disulfide-linked. Binds to heparan sulfate proteoglycans.

Interacts with gH/gL heterodimer.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27171

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni167 – 173Involved in fusion and/or binding to host membraneUniRule annotation7
Regioni252 – 259Involved in fusion and/or binding to host membraneUniRule annotation8
Regioni729 – 781Hydrophobic membrane proximal regionUniRule annotationAdd BLAST53
Regioni740 – 780Hydrophobic membrane proximal regionAdd BLAST41

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi916 – 919Internalization motifUniRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi266 – 269Poly-Val4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae glycoprotein B family.UniRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.100, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_04032, HSV_GB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035377, Glycoprot_B_PH1
IPR035381, Glycoprot_B_PH2
IPR038631, Glycoprot_B_PH2_sf
IPR000234, Herpes_Glycoprot_B

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17416, Glycoprot_B_PH1, 1 hit
PF17417, Glycoprot_B_PH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P27171-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRRNERGCR SSSWYAMSTA LAVTIWCLLA CTSEVIAAAS TPGTTPKAKT
60 70 80 90 100
DTSSETASAE TETATSGAAT GKKEATPTQA SKITGTTIVP FVNETEDMVS
110 120 130 140 150
VDIDKYPYRV CMAVSTDLVR FGKSIDCINH TPKTPVQEGI MVVYKENIVA
160 170 180 190 200
YTFEVITYHK DAIFQRSYAD TTTNYFLGTS VTKMAFPIWE LDEVNRNNRC
210 220 230 240 250
YSAASRILNG EVYVAYHEDS YRNYTMVLVE DDYRSKNSKR YVTTKSRYHK
260 270 280 290 300
GAWTWRYTES CNMNCVVVVT KARSNTPYEF FVLSSGEVVE ISPFYNGENS
310 320 330 340 350
EPFEEDTRNF WIRKNYTMKT YFGELAAPKK VVPLMAFLER EDMTIGWEIF
360 370 380 390 400
PKQNVTCDWK KWQTVSRAIR TDTNTGYHFV SKGLTATFVA SKRKIDYNTT
410 420 430 440 450
TEGKNYNTFR CVYDEFVEEV NRVFEDEYNE THVKDGELEM YRTTGGLIVL
460 470 480 490 500
WQGLKAKSLH NLEKFAALNN VSVATASPPV TTAATENGTT VRSRRKRSFD
510 520 530 540 550
NLDDVVTDIS YAQLQFTYDV LKDYINDALR NIMDAWCRDQ KRTAEMLKEL
560 570 580 590 600
SKINPSNILS AIYERPVTAK LAGDVIAMSE CVKVDQSSVK VLKDMRIFQD
610 620 630 640 650
GKVVNCYSRP LVVFQFINST KLESGQLGEN NEIMLGTFRT ENCDTNSRKI
660 670 680 690 700
FVVGTVGYEY RDYRFRNVTS LEHIDLVDTL IGLDIEPLEN TDFKVLELYS
710 720 730 740 750
KGELRASNVF SLDEIMREYN SQKQHIRTLS AKVNDNTPSY LLGLDTFMQG
760 770 780 790 800
LGVAGKGIGV AIGAVGGAVS SVVNAVTGFL TNPFGGFTTI LLVIGVLAVV
810 820 830 840 850
YLIFTRPVEY FFPYATQTAV QYAPPGGAHG GLESGPPGAP GLHRRVNAGG
860 870 880 890 900
SDDSGKAWTS DKKGLERTYT EQDALLILRA LKQLDDSQRN EKAQQKATRL
910 920
PTGILDRLKG NDTSGYQRLP AEDSDFEY
Length:928
Mass (Da):104,109
Last modified:April 1, 1993 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EDBF3FE7A43810D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti522K → R in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti527D → E in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti556S → T in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti562I → V in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti583K → Q in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti587S → K in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti617I → V in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti672E → D in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti675D → Q in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti806R → RQRSAAAR in AAA45939 (PubMed:1718083).Curated1
Sequence conflicti890N → T in AAA45939 (PubMed:1718083).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M86302 Genomic DNA Translation: AAA45936.1
X67021 Genomic DNA Translation: CAA47416.1
U68299 Genomic DNA No translation available.
M73549 Genomic DNA Translation: AAA45939.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A41992, VGBEMC

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86302 Genomic DNA Translation: AAA45936.1
X67021 Genomic DNA Translation: CAA47416.1
U68299 Genomic DNA No translation available.
M73549 Genomic DNA Translation: AAA45939.1
PIRiA41992, VGBEMC

3D structure databases

SMRiP27171
ModBaseiSearch...

Family and domain databases

Gene3Di2.30.29.100, 1 hit
HAMAPiMF_04032, HSV_GB, 1 hit
InterProiView protein in InterPro
IPR035377, Glycoprot_B_PH1
IPR035381, Glycoprot_B_PH2
IPR038631, Glycoprot_B_PH2_sf
IPR000234, Herpes_Glycoprot_B
PfamiView protein in Pfam
PF17416, Glycoprot_B_PH1, 1 hit
PF17417, Glycoprot_B_PH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGB_MUHVS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27171
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: April 1, 1993
Last modified: December 2, 2020
This is version 78 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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