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Entry version 209 (22 Apr 2020)
Sequence version 3 (05 Oct 2010)
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Protein

Serum paraoxonase/arylesterase 1

Gene

PON1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.2 Publications

Miscellaneous

The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+Note: Binds 2 calcium ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi53Calcium 1; catalytic1
Metal bindingi54Calcium 21
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei115Proton acceptorCurated1
Metal bindingi117Calcium 2; via carbonyl oxygen1
Metal bindingi168Calcium 1; catalytic1
Metal bindingi169Calcium 21
Metal bindingi224Calcium 1; catalytic1
Metal bindingi269Calcium 1; catalytic1
Metal bindingi270Calcium 1; catalytic1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.1.2 2681
3.1.1.25 2681
3.1.8.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P27169

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P27169

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.6.2.6 the epithelial na(+) channel (enac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serum paraoxonase/arylesterase 11 Publication (EC:3.1.1.25 Publications, EC:3.1.1.812 Publications, EC:3.1.8.15 Publications)
Short name:
PON 11 Publication
Alternative name(s):
Aromatic esterase 1
Short name:
A-esterase 1
K-45
Serum aryldialkylphosphatase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PON1
Synonyms:PON
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9204 PON1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
168820 gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P27169

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microvascular complications of diabetes 5 (MVCD5)
Disease susceptibility is associated with variations affecting the gene represented in this entry. Homozygosity for the Leu-55 allele is strongly associated with the development of retinal disease in diabetic patients.
Disease descriptionPathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi20 – 21HQ → AA: The signal peptide is cleaved; not associated with HDL. 1 Publication2
Mutagenesisi115H → Q: Reduces activity 10000-fold. 1 Publication1
Mutagenesisi134H → Q: Substantially reduced activity. 1 Publication1
Mutagenesisi284C → A or S: No loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5444

MalaCards human disease database

More...
MalaCardsi
PON1
MIMi168820 gene+phenotype
612633 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000005421

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
803 Amyotrophic lateral sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33529

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P27169 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3167

Drug and drug target database

More...
DrugBanki
DB01327 Cefazolin
DB09130 Copper
DB01395 Drospirenone
DB14600 Edetate disodium anhydrous
DB14596 Loteprednol etabonate
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PON1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153572

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved3 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002232812 – 355Serum paraoxonase/arylesterase 1Add BLAST354
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei2 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 353In form B2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi253N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagine2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.3 Publications
The signal sequence is not cleaved.
Present in two forms, form B contains a disulfide bond, form A does not.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-2233
non-CPTAC-2695

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P27169

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P27169

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P27169

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27169

PeptideAtlas

More...
PeptideAtlasi
P27169

PRoteomics IDEntifications database

More...
PRIDEi
P27169

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
54376

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P27169

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
726

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P27169

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P27169

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005421 Expressed in right lobe of liver and 89 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P27169 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P27169 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000005421 Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterooligomer with phosphate-binding protein (HPBP).

Interacts with CLU.

4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111440, 8 interactors

Protein interaction database and analysis system

More...
IntActi
P27169, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222381

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P27169

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P27169 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1355
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27169

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P27169

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IHDV Eukaryota
ENOG4111QK7 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008932

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_049839_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27169

KEGG Orthology (KO)

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KOi
K01045

Identification of Orthologs from Complete Genome Data

More...
OMAi
TDEDNAM

Database of Orthologous Groups

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OrthoDBi
888266at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P27169

TreeFam database of animal gene trees

More...
TreeFami
TF322436

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.120.10.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008363 Paraoxonase1

The PANTHER Classification System

More...
PANTHERi
PTHR11799:SF16 PTHR11799:SF16, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01731 Arylesterase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01785 PARAOXONASE
PR01786 PARAOXONASE1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P27169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKLIALTLL GMGLALFRNH QSSYQTRLNA LREVQPVELP NCNLVKGIET
60 70 80 90 100
GSEDLEILPN GLAFISSGLK YPGIKSFNPN SPGKILLMDL NEEDPTVLEL
110 120 130 140 150
GITGSKFDVS SFNPHGISTF TDEDNAMYLL VVNHPDAKST VELFKFQEEE
160 170 180 190 200
KSLLHLKTIR HKLLPNLNDI VAVGPEHFYG TNDHYFLDPY LQSWEMYLGL
210 220 230 240 250
AWSYVVYYSP SEVRVVAEGF DFANGINISP DGKYVYIAEL LAHKIHVYEK
260 270 280 290 300
HANWTLTPLK SLDFNTLVDN ISVDPETGDL WVGCHPNGMK IFFYDSENPP
310 320 330 340 350
ASEVLRIQNI LTEEPKVTQV YAENGTVLQG STVASVYKGK LLIGTVFHKA

LYCEL
Length:355
Mass (Da):39,731
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B5895509166167E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WF42F8WF42_HUMAN
Serum paraoxonase/arylesterase 1
PON1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The allelic form of the enzyme with Gln-192 (allozyme A) hydrolyzes paraoxon with a low turnover number and the one with Arg-192 (allozyme B) with a high turnover number.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00604355L → M6 PublicationsCorresponds to variant dbSNP:rs854560EnsemblClinVar.1
Natural variantiVAR_015882102I → V Polymorphism; may be associated with an increased risk for prostate cancer; associated with decreased activity. 1 PublicationCorresponds to variant dbSNP:rs72552787Ensembl.1
Natural variantiVAR_055342160R → G. Corresponds to variant dbSNP:rs13306698Ensembl.1
Natural variantiVAR_006044192Q → R in allozyme B; functional polymorphism; increased arylesterase activity. 7 PublicationsCorresponds to variant dbSNP:rs662EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M63012 mRNA Translation: AAB59538.1
M63013 mRNA Translation: AAA60142.1
M63014 mRNA Translation: AAA60143.1
S56555, S56546, S56548 Genomic DNA Translation: AAB25717.1
S64696 mRNA Translation: AAB27899.1
S64615 mRNA Translation: AAB27714.2
U55885 U55883 Genomic DNA Translation: AAB41835.1
D84371 mRNA Translation: BAA12327.1
U53784 mRNA Translation: AAA97957.1
Z70723 mRNA Translation: CAA94728.1
AK314027 mRNA Translation: BAG36737.1
AF539592 Genomic DNA Translation: AAM97935.1
AC004022 Genomic DNA Translation: AAC35293.1
CH236949 Genomic DNA Translation: EAL24133.1
CH471091 Genomic DNA Translation: EAW76771.1
BC074719 mRNA Translation: AAH74719.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5638.1

Protein sequence database of the Protein Information Resource

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PIRi
A45451

NCBI Reference Sequences

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RefSeqi
NP_000437.3, NM_000446.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000222381; ENSP00000222381; ENSG00000005421

Database of genes from NCBI RefSeq genomes

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GeneIDi
5444

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5444

UCSC genome browser

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UCSCi
uc003uns.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63012 mRNA Translation: AAB59538.1
M63013 mRNA Translation: AAA60142.1
M63014 mRNA Translation: AAA60143.1
S56555, S56546, S56548 Genomic DNA Translation: AAB25717.1
S64696 mRNA Translation: AAB27899.1
S64615 mRNA Translation: AAB27714.2
U55885 U55883 Genomic DNA Translation: AAB41835.1
D84371 mRNA Translation: BAA12327.1
U53784 mRNA Translation: AAA97957.1
Z70723 mRNA Translation: CAA94728.1
AK314027 mRNA Translation: BAG36737.1
AF539592 Genomic DNA Translation: AAM97935.1
AC004022 Genomic DNA Translation: AAC35293.1
CH236949 Genomic DNA Translation: EAL24133.1
CH471091 Genomic DNA Translation: EAW76771.1
BC074719 mRNA Translation: AAH74719.1
CCDSiCCDS5638.1
PIRiA45451
RefSeqiNP_000437.3, NM_000446.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V04X-ray2.20A1-353[»]
1XHRmodel-A40-355[»]
SMRiP27169
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111440, 8 interactors
IntActiP27169, 6 interactors
STRINGi9606.ENSP00000222381

Chemistry databases

BindingDBiP27169
ChEMBLiCHEMBL3167
DrugBankiDB01327 Cefazolin
DB09130 Copper
DB01395 Drospirenone
DB14600 Edetate disodium anhydrous
DB14596 Loteprednol etabonate
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Protein family/group databases

TCDBi1.A.6.2.6 the epithelial na(+) channel (enac) family

PTM databases

GlyConnecti726
iPTMnetiP27169
PhosphoSitePlusiP27169

Polymorphism and mutation databases

BioMutaiPON1
DMDMi308153572

2D gel databases

SWISS-2DPAGEiP27169

Proteomic databases

CPTACiCPTAC-2233
non-CPTAC-2695
jPOSTiP27169
MassIVEiP27169
MaxQBiP27169
PaxDbiP27169
PeptideAtlasiP27169
PRIDEiP27169
ProteomicsDBi54376

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
883 575 antibodies

Genome annotation databases

EnsembliENST00000222381; ENSP00000222381; ENSG00000005421
GeneIDi5444
KEGGihsa:5444
UCSCiuc003uns.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5444
DisGeNETi5444

GeneCards: human genes, protein and diseases

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GeneCardsi
PON1
HGNCiHGNC:9204 PON1
HPAiENSG00000005421 Tissue enriched (liver)
MalaCardsiPON1
MIMi168820 gene+phenotype
612633 phenotype
neXtProtiNX_P27169
OpenTargetsiENSG00000005421
Orphaneti803 Amyotrophic lateral sclerosis
PharmGKBiPA33529

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHDV Eukaryota
ENOG4111QK7 LUCA
GeneTreeiENSGT00390000008932
HOGENOMiCLU_049839_0_1_1
InParanoidiP27169
KOiK01045
OMAiTDEDNAM
OrthoDBi888266at2759
PhylomeDBiP27169
TreeFamiTF322436

Enzyme and pathway databases

BRENDAi3.1.1.2 2681
3.1.1.25 2681
3.1.8.1 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
SABIO-RKiP27169
SIGNORiP27169

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PON1 human
EvolutionaryTraceiP27169

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PON1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5444
PharosiP27169 Tbio

Protein Ontology

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PROi
PR:P27169
RNActiP27169 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000005421 Expressed in right lobe of liver and 89 other tissues
ExpressionAtlasiP27169 baseline and differential
GenevisibleiP27169 HS

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR002640 Arylesterase
IPR008363 Paraoxonase1
PANTHERiPTHR11799:SF16 PTHR11799:SF16, 1 hit
PfamiView protein in Pfam
PF01731 Arylesterase, 1 hit
PRINTSiPR01785 PARAOXONASE
PR01786 PARAOXONASE1

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPON1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27169
Secondary accession number(s): B2RA40
, Q16052, Q6B0J6, Q9UCB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 5, 2010
Last modified: April 22, 2020
This is version 209 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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