UniProtKB - P27150 (RL1_THETH)
Protein
50S ribosomal protein L1
Gene
rplA
Organism
Thermus thermophilus
Status
Functioni
The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.By similarity
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.UniRule annotation
GO - Molecular functioni
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: InterPro
- tRNA binding Source: UniProtKB-KW
GO - Biological processi
- regulation of translation Source: UniProtKB-KW
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Repressor, Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding, tRNA-binding |
Biological process | Translation regulation |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L1UniRule annotation |
Gene namesi | Name:rplAUniRule annotation Synonyms:rpl1UniRule annotation |
Organismi | Thermus thermophilus |
Taxonomic identifieri | 274 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000125765 | 2 – 229 | 50S ribosomal protein L1Add BLAST | 228 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit.
UniRule annotation1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P27150 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P27150 |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL1 family.UniRule annotation
Family and domain databases
CDDi | cd00403, Ribosomal_L1, 1 hit |
Gene3Di | 3.40.50.790, 1 hit |
HAMAPi | MF_01318_B, Ribosomal_L1_B, 1 hit |
InterProi | View protein in InterPro IPR005878, Ribosom_L1_bac-type IPR002143, Ribosomal_L1 IPR023674, Ribosomal_L1-like IPR028364, Ribosomal_L1/biogenesis IPR016095, Ribosomal_L1_3-a/b-sand IPR023673, Ribosomal_L1_CS |
Pfami | View protein in Pfam PF00687, Ribosomal_L1, 1 hit |
PIRSFi | PIRSF002155, Ribosomal_L1, 1 hit |
SUPFAMi | SSF56808, SSF56808, 1 hit |
TIGRFAMsi | TIGR01169, rplA_bact, 1 hit |
PROSITEi | View protein in PROSITE PS01199, RIBOSOMAL_L1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P27150-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKHGKRYRA LLEKVDPNKI YTIDEAAHLV KELATAKFDE TVEVHAKLGI
60 70 80 90 100
DPRRSDQNVR GTVSLPHGLG KQVRVLAIAK GEKIKEAEEA GADYVGGEEI
110 120 130 140 150
IQKILDGWMD FDAVVATPDV MGAVGSKLGR ILGPRGLLPN PKAGTVGFNI
160 170 180 190 200
GEIIREIKAG RIEFRNDKTG AIHAPVGKAS FPPEKLADNI RAFIRALEAH
210 220
KPEGAKGTFL RSVYVTTTMG PSVRINPHS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | P → V AA sequence (PubMed:1637860).Curated | 1 | |
Sequence conflicti | 4 – 5 | HG → TN AA sequence (PubMed:1637860).Curated | 2 | |
Sequence conflicti | 14 | K → F AA sequence (PubMed:1637860).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81375 Genomic DNA Translation: CAA57139.1 |
PIRi | S66577 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81375 Genomic DNA Translation: CAA57139.1 |
PIRi | S66577 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AD2 | X-ray | 1.90 | A | 2-229 | [»] | |
1ZHO | X-ray | 2.60 | A/C/E/G | 2-229 | [»] | |
2HW8 | X-ray | 2.10 | A | 2-229 | [»] | |
2OUM | X-ray | 2.55 | A | 2-229 | [»] | |
2OV7 | X-ray | 2.30 | A/B/C | 2-229 | [»] | |
2VPL | X-ray | 2.30 | A/C | 2-229 | [»] | |
3U4M | X-ray | 2.00 | A | 1-229 | [»] | |
3U56 | X-ray | 2.10 | A | 1-229 | [»] | |
3UMY | X-ray | 1.90 | A | 2-229 | [»] | |
4F9T | X-ray | 1.46 | A | 1-229 | [»] | |
4QG3 | X-ray | 2.00 | A | 2-229 | [»] | |
4QGB | X-ray | 2.60 | A/B | 14-229 | [»] | |
4QVI | X-ray | 1.90 | A | 1-229 | [»] | |
4REO | X-ray | 1.35 | A | 1-229 | [»] | |
5IB7 | X-ray | 2.99 | 71 | 1-229 | [»] | |
5IB8 | X-ray | 3.13 | 71 | 1-229 | [»] | |
5IBB | X-ray | 2.96 | 71/79 | 1-229 | [»] | |
5IMQ | electron microscopy | 3.80 | Z | 1-229 | [»] | |
5IMR | electron microscopy | - | Z | 1-229 | [»] | |
5J8B | X-ray | 2.60 | C | 2-229 | [»] | |
SMRi | P27150 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P27150 |
Family and domain databases
CDDi | cd00403, Ribosomal_L1, 1 hit |
Gene3Di | 3.40.50.790, 1 hit |
HAMAPi | MF_01318_B, Ribosomal_L1_B, 1 hit |
InterProi | View protein in InterPro IPR005878, Ribosom_L1_bac-type IPR002143, Ribosomal_L1 IPR023674, Ribosomal_L1-like IPR028364, Ribosomal_L1/biogenesis IPR016095, Ribosomal_L1_3-a/b-sand IPR023673, Ribosomal_L1_CS |
Pfami | View protein in Pfam PF00687, Ribosomal_L1, 1 hit |
PIRSFi | PIRSF002155, Ribosomal_L1, 1 hit |
SUPFAMi | SSF56808, SSF56808, 1 hit |
TIGRFAMsi | TIGR01169, rplA_bact, 1 hit |
PROSITEi | View protein in PROSITE PS01199, RIBOSOMAL_L1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL1_THETH | |
Accessioni | P27150Primary (citable) accession number: P27150 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | January 23, 2007 | |
Last modified: | August 12, 2020 | |
This is version 118 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Ribosomal proteins
Ribosomal proteins families and list of entries