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Protein

Adenylate kinase 4, mitochondrial

Gene

AK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.UniRule annotation3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5.3 µM for AMP with ATP as phosphate donor1 Publication
  2. KM=1.4 µM for AMP with GTP as phosphate donor1 Publication
  3. KM=507 µM for dAMP with ATP as phosphate donor1 Publication
  1. Vmax=90 pmol/min/µg enzyme with AMP as substrate and ATP as phosphate donor1 Publication
  2. Vmax=80 pmol/min/µg enzyme with AMP as substrate and GTP as phosphate donor1 Publication
  3. Vmax=88 pmol/min/µg enzyme with dAMP as substrate and ATP as phosphate donor1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei36AMPUniRule annotation1 Publication1
Binding sitei41AMPUniRule annotation1
Binding sitei96AMPUniRule annotation1
Binding sitei126NTPUniRule annotation1 Publication1
Binding sitei170AMPUniRule annotation1 Publication1
Binding sitei199NTP; via carbonyl oxygenUniRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi15 – 20NTPUniRule annotation1 Publication6
Nucleotide bindingi62 – 64AMPUniRule annotation1 Publication3
Nucleotide bindingi89 – 92AMPUniRule annotation1 Publication4
Nucleotide bindingi135 – 136NTPUniRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.4.3 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-499943 Interconversion of nucleotide di- and triphosphates

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adenylate kinase 4, mitochondrialUniRule annotation (EC:2.7.4.10UniRule annotation, EC:2.7.4.6UniRule annotation)
Short name:
AK 4UniRule annotation
Alternative name(s):
Adenylate kinase 3-likeUniRule annotation
GTP:AMP phosphotransferase AK4UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AK4UniRule annotation
Synonyms:AK3, AK3L1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162433.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:363 AK4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
103030 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P27144

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi4K → G: Abolishes mitochondrial import; when associated with G-7. 1 Publication1
Mutagenesisi7R → G: Abolishes mitochondrial import; when associated with G-4. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
205

Open Targets

More...
OpenTargetsi
ENSG00000162433

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165750325

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4926

Drug and drug target database

More...
DrugBanki
DB00718 Adefovir Dipivoxil
DB00300 Tenofovir

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AK4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
125157

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001589261 – 223Adenylate kinase 4, mitochondrialAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60N6-succinyllysineBy similarity1
Modified residuei175N6-acetyllysineBy similarity1
Modified residuei179N6-acetyllysine; alternateBy similarity1
Modified residuei179N6-succinyllysine; alternateBy similarity1
Modified residuei186N6-acetyllysine; alternateBy similarity1
Modified residuei186N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P27144

MaxQB - The MaxQuant DataBase

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MaxQBi
P27144

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27144

PeptideAtlas

More...
PeptideAtlasi
P27144

PRoteomics IDEntifications database

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PRIDEi
P27144

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54375

Consortium for Top Down Proteomics

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TopDownProteomicsi
P27144

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P27144

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P27144

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P27144

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in kidney, moderately expressed in heart and liver and weakly expressed in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162433 Expressed in 224 organ(s), highest expression level in cortex of kidney

CleanEx database of gene expression profiles

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CleanExi
HS_AK3
HS_AK3L1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P27144 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P27144 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042753
HPA049461

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.UniRule annotation1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106708, 18 interactors

Protein interaction database and analysis system

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IntActi
P27144, 9 interactors

Molecular INTeraction database

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MINTi
P27144

STRING: functional protein association networks

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STRINGi
9606.ENSP00000322175

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P27144

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P27144

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P27144

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P27144

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 64NMPbindUniRule annotation1 PublicationAdd BLAST30
Regioni125 – 162LIDUniRule annotation1 PublicationAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.UniRule annotation1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylate kinase family. AK3 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3078 Eukaryota
COG0563 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154568

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000238772

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000458

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P27144

KEGG Orthology (KO)

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KOi
K00939

Identification of Orthologs from Complete Genome Data

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OMAi
MARLRHY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G06BH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27144

TreeFam database of animal gene trees

More...
TreeFami
TF312916

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01428 ADK, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00235 Adenylate_kinase_Adk, 1 hit
MF_03169 Adenylate_kinase_AK3, 1 hit
MF_03170 Adenylate_kinase_AK4, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006259 Adenyl_kin_sub
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR007862 Adenylate_kinase_lid-dom
IPR036193 ADK_active_lid_dom_sf
IPR028586 AK3/Ak4_mitochondrial
IPR028585 AK4_mitochondrial
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR23359 PTHR23359, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05191 ADK_lid, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00094 ADENYLTKNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF57774 SSF57774, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01351 adk, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P27144-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV
60 70 80 90 100
GEMAKQYIEK SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL
110 120 130 140 150
DKICEVDLVI SLNIPFETLK DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD
160 170 180 190 200
VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP VIELYKSRGV LHQFSGTETN
210 220
KIWPYVYTLF SNKITPIQSK EAY
Length:223
Mass (Da):25,268
Last modified:August 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i653341A8EB3BC723
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3DQ64D3DQ64_HUMAN
Adenylate kinase 4, mitochondrial
AK4 hCG_2031840
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22C → S in AAH40224 (PubMed:15489334).Curated1
Sequence conflicti22C → S in AAI46654 (PubMed:15489334).Curated1
Sequence conflicti23Q → R in AAH66944 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X60673 mRNA Translation: CAA43088.1
CR456830 mRNA Translation: CAG33111.1
AK313611 mRNA Translation: BAG36374.1
AC099680 Genomic DNA No translation available.
AL356212 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06538.1
CH471059 Genomic DNA Translation: EAX06540.1
CH471059 Genomic DNA Translation: EAX06544.1
BC016180 mRNA Translation: AAH16180.1
BC040224 mRNA Translation: AAH40224.1
BC066944 mRNA Translation: AAH66944.1
BC136886 mRNA Translation: AAI36887.1
BC136887 mRNA Translation: AAI36888.1
BC148270 mRNA Translation: AAI48271.1
BC146653 mRNA Translation: AAI46654.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS629.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A42820 KIHUA3

NCBI Reference Sequences

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RefSeqi
NP_001005353.1, NM_001005353.2
NP_037542.1, NM_013410.3
NP_982289.1, NM_203464.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.10862

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327299; ENSP00000322175; ENSG00000162433
ENST00000395334; ENSP00000378743; ENSG00000162433
ENST00000545314; ENSP00000445912; ENSG00000162433

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
205

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:205

UCSC genome browser

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UCSCi
uc001dby.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60673 mRNA Translation: CAA43088.1
CR456830 mRNA Translation: CAG33111.1
AK313611 mRNA Translation: BAG36374.1
AC099680 Genomic DNA No translation available.
AL356212 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06538.1
CH471059 Genomic DNA Translation: EAX06540.1
CH471059 Genomic DNA Translation: EAX06544.1
BC016180 mRNA Translation: AAH16180.1
BC040224 mRNA Translation: AAH40224.1
BC066944 mRNA Translation: AAH66944.1
BC136886 mRNA Translation: AAI36887.1
BC136887 mRNA Translation: AAI36888.1
BC148270 mRNA Translation: AAI48271.1
BC146653 mRNA Translation: AAI46654.1
CCDSiCCDS629.1
PIRiA42820 KIHUA3
RefSeqiNP_001005353.1, NM_001005353.2
NP_037542.1, NM_013410.3
NP_982289.1, NM_203464.2
UniGeneiHs.10862

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AR7X-ray2.15A/B1-223[»]
2BBWX-ray2.05A/B1-223[»]
3NDPX-ray2.30A/B1-223[»]
ProteinModelPortaliP27144
SMRiP27144
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106708, 18 interactors
IntActiP27144, 9 interactors
MINTiP27144
STRINGi9606.ENSP00000322175

Chemistry databases

BindingDBiP27144
ChEMBLiCHEMBL4926
DrugBankiDB00718 Adefovir Dipivoxil
DB00300 Tenofovir

PTM databases

iPTMnetiP27144
PhosphoSitePlusiP27144

Polymorphism and mutation databases

BioMutaiAK4
DMDMi125157

2D gel databases

UCD-2DPAGEiP27144

Proteomic databases

EPDiP27144
MaxQBiP27144
PaxDbiP27144
PeptideAtlasiP27144
PRIDEiP27144
ProteomicsDBi54375
TopDownProteomicsiP27144

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
205
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327299; ENSP00000322175; ENSG00000162433
ENST00000395334; ENSP00000378743; ENSG00000162433
ENST00000545314; ENSP00000445912; ENSG00000162433
GeneIDi205
KEGGihsa:205
UCSCiuc001dby.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
205
DisGeNETi205
EuPathDBiHostDB:ENSG00000162433.14

GeneCards: human genes, protein and diseases

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GeneCardsi
AK4
HGNCiHGNC:363 AK4
HPAiHPA042753
HPA049461
MIMi103030 gene
neXtProtiNX_P27144
OpenTargetsiENSG00000162433
PharmGKBiPA165750325

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3078 Eukaryota
COG0563 LUCA
GeneTreeiENSGT00940000154568
HOGENOMiHOG000238772
HOVERGENiHBG000458
InParanoidiP27144
KOiK00939
OMAiMARLRHY
OrthoDBiEOG091G06BH
PhylomeDBiP27144
TreeFamiTF312916

Enzyme and pathway databases

BRENDAi2.7.4.3 2681
ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AK4 human
EvolutionaryTraceiP27144

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AK3L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
205

Protein Ontology

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PROi
PR:P27144

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162433 Expressed in 224 organ(s), highest expression level in cortex of kidney
CleanExiHS_AK3
HS_AK3L1
ExpressionAtlasiP27144 baseline and differential
GenevisibleiP27144 HS

Family and domain databases

CDDicd01428 ADK, 1 hit
HAMAPiMF_00235 Adenylate_kinase_Adk, 1 hit
MF_03169 Adenylate_kinase_AK3, 1 hit
MF_03170 Adenylate_kinase_AK4, 1 hit
InterProiView protein in InterPro
IPR006259 Adenyl_kin_sub
IPR000850 Adenylat/UMP-CMP_kin
IPR033690 Adenylat_kinase_CS
IPR007862 Adenylate_kinase_lid-dom
IPR036193 ADK_active_lid_dom_sf
IPR028586 AK3/Ak4_mitochondrial
IPR028585 AK4_mitochondrial
IPR027417 P-loop_NTPase
PANTHERiPTHR23359 PTHR23359, 1 hit
PfamiView protein in Pfam
PF05191 ADK_lid, 1 hit
PRINTSiPR00094 ADENYLTKNASE
SUPFAMiSSF52540 SSF52540, 1 hit
SSF57774 SSF57774, 1 hit
TIGRFAMsiTIGR01351 adk, 1 hit
PROSITEiView protein in PROSITE
PS00113 ADENYLATE_KINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAD4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27144
Secondary accession number(s): B2R927
, D3DQ62, Q6IBH4, Q6NXQ5, Q8IUU9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: December 5, 2018
This is version 186 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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