UniProtKB - P27125 (RHAT_ECOLI)
Protein
L-rhamnose-proton symporter
Gene
rhaT
Organism
Escherichia coli (strain K12)
Status
Functioni
Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-mannose and L-xylose, but at reduced rates.
GO - Molecular functioni
- rhamnose transmembrane transporter activity Source: UniProtKB-UniRule
- symporter activity Source: EcoCyc
GO - Biological processi
- rhamnose transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Sugar transport, Symport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:RHAT-MONOMER MetaCyc:RHAT-MONOMER |
Protein family/group databases
TCDBi | 2.A.7.6.1, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: L-rhamnose-proton symporterAlternative name(s): L-rhamnose-H(+) transport protein |
Gene namesi | Name:rhaT Ordered Locus Names:b3907, JW3878 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 5 | PeriplasmicCurated | 5 | |
Transmembranei | 6 – 26 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 27 – 36 | CytoplasmicCurated | 10 | |
Transmembranei | 37 – 57 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 58 – 61 | PeriplasmicCurated | 4 | |
Transmembranei | 62 – 82 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 83 – 96 | CytoplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 97 – 117 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 118 – 130 | PeriplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 131 – 152 | HelicalCuratedAdd BLAST | 22 | |
Topological domaini | 153 – 174 | CytoplasmicCuratedAdd BLAST | 22 | |
Transmembranei | 175 – 195 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 196 – 208 | PeriplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 209 – 229 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 230 – 254 | CytoplasmicCuratedAdd BLAST | 25 | |
Transmembranei | 255 – 275 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 276 – 289 | PeriplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 290 – 310 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 311 – 321 | CytoplasmicCuratedAdd BLAST | 11 | |
Transmembranei | 322 – 342 | HelicalCuratedAdd BLAST | 21 | |
Topological domaini | 343 – 344 | PeriplasmicCurated | 2 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208272 | 1 – 344 | L-rhamnose-proton symporterAdd BLAST | 344 |
Proteomic databases
PaxDbi | P27125 |
PRIDEi | P27125 |
Expressioni
Inductioni
Induced by L-rhamnose via the RhaR-RhaS regulatory cascade. Also induced by L-mannose or L-xylose.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263535, 4 interactors |
STRINGi | 511145.b3907 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502Z7ID, Bacteria |
HOGENOMi | CLU_066437_0_0_6 |
InParanoidi | P27125 |
PhylomeDBi | P27125 |
Family and domain databases
HAMAPi | MF_01532, RhaT, 1 hit |
InterProi | View protein in InterPro IPR004673, L-rhamnose-proton_sym_RhaT |
Pfami | View protein in Pfam PF06379, RhaT, 1 hit |
i Sequence
Sequence statusi: Complete.
P27125-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNAITMGIF WHLIGAASAA CFYAPFKKVK KWSWETMWSV GGIVSWIILP
60 70 80 90 100
WAISALLLPN FWAYYSSFSL STRLPVFLFG AMWGIGNINY GLTMRYLGMS
110 120 130 140 150
MGIGIAIGIT LIVGTLMTPI INGNFDVLIS TEGGRMTLLG VLVALIGVGI
160 170 180 190 200
VTRAGQLKER KMGIKAEEFN LKKGLVLAVM CGIFSAGMSF AMNAAKPMHE
210 220 230 240 250
AAAALGVDPL YVALPSYVVI MGGGAIINLG FCFIRLAKVK DLSLKADFSL
260 270 280 290 300
AKSLIIHNVL LSTLGGLMWY LQFFFYAWGH ARIPAQYDYI SWMLHMSFYV
310 320 330 340
LCGGIVGLVL KEWNNAGRRP VTVLSLGCVV IIVAANIVGI GMAN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85158 Genomic DNA Translation: AAA24529.1 X60699 Genomic DNA Translation: CAA43109.1 L19201 Genomic DNA Translation: AAB03040.1 U00096 Genomic DNA Translation: AAC76889.1 AP009048 Genomic DNA Translation: BAE77402.1 |
PIRi | B42436 |
RefSeqi | NP_418343.1, NC_000913.3 WP_000063526.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76889; AAC76889; b3907 BAE77402; BAE77402; BAE77402 |
GeneIDi | 948398 |
KEGGi | ecj:JW3878 eco:b3907 |
PATRICi | fig|1411691.4.peg.2798 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85158 Genomic DNA Translation: AAA24529.1 X60699 Genomic DNA Translation: CAA43109.1 L19201 Genomic DNA Translation: AAB03040.1 U00096 Genomic DNA Translation: AAC76889.1 AP009048 Genomic DNA Translation: BAE77402.1 |
PIRi | B42436 |
RefSeqi | NP_418343.1, NC_000913.3 WP_000063526.1, NZ_LN832404.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4263535, 4 interactors |
STRINGi | 511145.b3907 |
Protein family/group databases
TCDBi | 2.A.7.6.1, the drug/metabolite transporter (dmt) superfamily |
Proteomic databases
PaxDbi | P27125 |
PRIDEi | P27125 |
Genome annotation databases
EnsemblBacteriai | AAC76889; AAC76889; b3907 BAE77402; BAE77402; BAE77402 |
GeneIDi | 948398 |
KEGGi | ecj:JW3878 eco:b3907 |
PATRICi | fig|1411691.4.peg.2798 |
Organism-specific databases
EchoBASEi | EB1289 |
Phylogenomic databases
eggNOGi | ENOG502Z7ID, Bacteria |
HOGENOMi | CLU_066437_0_0_6 |
InParanoidi | P27125 |
PhylomeDBi | P27125 |
Enzyme and pathway databases
BioCyci | EcoCyc:RHAT-MONOMER MetaCyc:RHAT-MONOMER |
Miscellaneous databases
PROi | PR:P27125 |
Family and domain databases
HAMAPi | MF_01532, RhaT, 1 hit |
InterProi | View protein in InterPro IPR004673, L-rhamnose-proton_sym_RhaT |
Pfami | View protein in Pfam PF06379, RhaT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHAT_ECOLI | |
Accessioni | P27125Primary (citable) accession number: P27125 Secondary accession number(s): Q2M8K4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families