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Protein

HTH-type transcriptional regulator CynR

Gene

cynR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 37H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00291

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CynR
Alternative name(s):
Cyn operon transcriptional activator
Gene namesi
Name:cynR
Ordered Locus Names:b0338, JW5894
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11421 cynR

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056121 – 299HTH-type transcriptional regulator CynRAdd BLAST299

Proteomic databases

PaxDbiP27111
PRIDEiP27111

Expressioni

Inductioni

Negatively autoregulated.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259814, 4 interactors
DIPiDIP-9364N
STRINGi316407.85674480

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi93 – 97Combined sources5
Helixi99 – 102Combined sources4
Turni103 – 105Combined sources3
Helixi106 – 116Combined sources11
Beta strandi122 – 126Combined sources5
Helixi129 – 137Combined sources9
Beta strandi142 – 149Combined sources8
Beta strandi155 – 170Combined sources16
Helixi174 – 177Combined sources4
Beta strandi179 – 181Combined sources3
Helixi183 – 188Combined sources6
Beta strandi190 – 194Combined sources5
Helixi199 – 210Combined sources12
Beta strandi216 – 222Combined sources7
Helixi224 – 233Combined sources10
Beta strandi237 – 241Combined sources5
Helixi243 – 247Combined sources5
Beta strandi251 – 258Combined sources8
Beta strandi262 – 270Combined sources9
Helixi277 – 290Combined sources14

3D structure databases

ProteinModelPortaliP27111
SMRiP27111
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27111

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105DND Bacteria
ENOG410YUCG LUCA
HOGENOMiHOG000233514
InParanoidiP27111
KOiK11921
OMAiYFPPILM
PhylomeDBiP27111

Family and domain databases

CDDicd08425 PBP2_CynR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037403 CynR_PBP2
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P27111-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRHINYFL AVAEHGSFTR AASALHVSQP ALSQQIRQLE ESLGVPLFDR
60 70 80 90 100
SGRTIRLTDA GEVWRQYASR ALQELGAGKR AIHDVADLTR GSLRIAVTPT
110 120 130 140 150
FTSYFIGPLM ADFYARYPSI TLQLQEMSQE KIEDMLCRDE LDVGIAFAPV
160 170 180 190 200
HSPELEAIPL LTESLALVVA QHHPLAVHEQ VALSRLHDEK LVLLSAEFAT
210 220 230 240 250
REQIDHYCEK AGLHPQVVIE ANSISAVLEL IRRTSLSTLL PAAIATQHDG
260 270 280 290
LKAISLAPPL LERTAVLLRR KNSWQTAAAK AFLHMALDKC AVVGGNESR
Length:299
Mass (Da):32,961
Last modified:November 13, 2007 - v5
Checksum:i5649F6FF2437624A
GO

Sequence cautioni

The sequence AAB18062 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93053 Genomic DNA Translation: AAA23628.1
U73857 Genomic DNA Translation: AAB18062.1 Different initiation.
U00096 Genomic DNA Translation: AAC73441.3
AP009048 Genomic DNA Translation: BAE76120.1
PIRiA41900
RefSeqiNP_414872.3, NC_000913.3
WP_000952503.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73441; AAC73441; b0338
BAE76120; BAE76120; BAE76120
GeneIDi945001
KEGGiecj:JW5894
eco:b0338
PATRICifig|511145.12.peg.346

Entry informationi

Entry nameiCYNR_ECOLI
AccessioniPrimary (citable) accession number: P27111
Secondary accession number(s): Q2MC86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 140 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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