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Entry version 198 (17 Jun 2020)
Sequence version 3 (23 Jan 2007)
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Protein

Erythrocyte band 7 integral membrane protein

Gene

STOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

Transport Classification Database

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TCDBi
8.A.21.1.1 the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Erythrocyte band 7 integral membrane protein
Alternative name(s):
Protein 7.2b
Stomatin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STOM
Synonyms:BND7, EPB72
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148175.12

Human Gene Nomenclature Database

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HGNCi
HGNC:3383 STOM

Online Mendelian Inheritance in Man (OMIM)

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MIMi
133090 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P27105

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei26 – 54Sequence analysisAdd BLAST29
Topological domaini55 – 288CytoplasmicSequence analysisAdd BLAST234

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi182T → A: No effect on oligomerization. 1 Publication1
Mutagenesisi185W → A: Complete loss of oligomerization. 1 Publication1
Mutagenesisi252Y → A: Complete loss of oligomerization. 1 Publication1
Mutagenesisi263K → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi264N → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi265S → A: Oligomerization reduced to 18%. Reduced lipid raft association. 1
Mutagenesisi266T → A: Complete loss of oligomerization. Reduced lipid raft association. 1
Mutagenesisi267I → A: Complete loss of oligomerization and lipid raft association. 1
Mutagenesisi268V → A: Complete loss of oligomerization and lipid raft association. 1
Mutagenesisi269F → A: Complete loss of oligomerization and lipid raft association. 1
Mutagenesisi270P → A: Complete loss of oligomerization. No effect on lipid raft association. 1
Mutagenesisi271L → A: Complete loss of oligomerization. Reduced lipid raft association. 1
Mutagenesisi272P → A: Oligomerization reduced to 18%. Reduced lipid raft association. 1
Mutagenesisi273I → A: Complete loss of oligomerization. Reduced lipid raft association. 1
Mutagenesisi274D → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi275M → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi276L → A: Reduced oligomerization and lipid raft association. 1

Organism-specific databases

DisGeNET

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DisGeNETi
2040

Open Targets

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OpenTargetsi
ENSG00000148175

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27816

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P27105 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
STOM

Domain mapping of disease mutations (DMDM)

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DMDMi
114823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000940271 – 288Erythrocyte band 7 integral membrane proteinAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10Phosphoserine; by PKACombined sources1 Publication1
Modified residuei18PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi30S-palmitoyl cysteine1 Publication1
Lipidationi87S-palmitoyl cysteine; partial1 Publication1
Modified residuei161PhosphoserineBy similarity1
Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-276
CPTAC-277

Encyclopedia of Proteome Dynamics

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EPDi
P27105

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P27105

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P27105

MaxQB - The MaxQuant DataBase

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MaxQBi
P27105

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27105

PeptideAtlas

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PeptideAtlasi
P27105

PRoteomics IDEntifications database

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PRIDEi
P27105

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
3187
54374 [P27105-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P27105

MetOSite database of methionine sulfoxide sites

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MetOSitei
P27105

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P27105

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P27105

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in erythrocytes (at protein level). Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000148175 Expressed in visceral pleura and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P27105 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P27105 HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000148175 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and higher order homooligomer. The homodimer is banana-shaped.

Interacts with ASIC1, ASIC2 and ASIC3 (By similarity).

Interacts with LANCL1.

Interacts with SLC2A1 and SLC4A1. Identified in large complexes with SLC40A1, SLC14A1, SLC29A1 and AQP1.

Interacts with STOML1; may redistribute STOM from the plasma membrane to late endosomes.

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P27105
With#Exp.IntAct
AIG1 - isoform 2 [Q9NVV5-2]3EBI-1211440,EBI-11957045
APOA2 [P02652]3EBI-1211440,EBI-1171525
ATP1B3 [P54709]3EBI-1211440,EBI-1054481
ATP6V0B [Q99437]3EBI-1211440,EBI-3904417
ATP6V0C [P27449]3EBI-1211440,EBI-721179
BCL2L2 [Q92843]3EBI-1211440,EBI-707714
BNIP1 [Q12981]3EBI-1211440,EBI-4402847
C2 [P06681]3EBI-1211440,EBI-2835920
CFHR5 [Q9BXR6]3EBI-1211440,EBI-11579371
CHST1 [O43916]3EBI-1211440,EBI-748017
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-1211440,EBI-12256978
CLRN2 [A0PK11]3EBI-1211440,EBI-12813623
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-1211440,EBI-11522780
CNIH3 [Q8TBE1]3EBI-1211440,EBI-12208021
CTXN3 [Q4LDR2]3EBI-1211440,EBI-12019274
CYB5B [O43169]3EBI-1211440,EBI-1058710
CYB5R3 [P00387]3EBI-1211440,EBI-1046040
DAGLA [Q9Y4D2]3EBI-1211440,EBI-12808806
DVL3 [Q92997]3EBI-1211440,EBI-739789
EMP1 [P54849]3EBI-1211440,EBI-4319440
ERG28 [Q9UKR5]3EBI-1211440,EBI-711490
FAXDC2 [Q96IV6]3EBI-1211440,EBI-12142299
FUNDC2 [Q9BWH2]3EBI-1211440,EBI-714482
GIMAP1 [Q8WWP7]3EBI-1211440,EBI-11991950
GIMAP5 [Q96F15]3EBI-1211440,EBI-6166686
GPR25 [O00155]3EBI-1211440,EBI-10178951
GPR37L1 [O60883]3EBI-1211440,EBI-2927498
GRM2 [Q14416]3EBI-1211440,EBI-10232876
HMOX2 [P30519]3EBI-1211440,EBI-712096
KCNK1 [O00180]3EBI-1211440,EBI-3914675
KTN1 - isoform 3 [Q86UP2-3]3EBI-1211440,EBI-12007212
LNPEP - isoform 2 [Q9UIQ6-2]3EBI-1211440,EBI-12133176
MGLL [A0A0C4DFN3]3EBI-1211440,EBI-12866138
MMP14 [P50281]3EBI-1211440,EBI-992788
NKG7 [Q16617]5EBI-1211440,EBI-3919611
ORMDL1 [Q9P0S3]3EBI-1211440,EBI-1054848
PEMT - isoform 2 [Q9UBM1-2]3EBI-1211440,EBI-17513590
PGA4 [P0DJD7]3EBI-1211440,EBI-12957629
PMP22 [Q01453]3EBI-1211440,EBI-2845982
PTCH1 - isoform M [Q13635-3]3EBI-1211440,EBI-14199621
RPRM [Q9NS64]3EBI-1211440,EBI-1052363
RTP2 [Q5QGT7]3EBI-1211440,EBI-10244780
SCD [O00767]3EBI-1211440,EBI-2684237
SELENOK [Q9Y6D0]3EBI-1211440,EBI-9679163
SERP2 [Q8N6R1]3EBI-1211440,EBI-749270
SFT2D1 [Q8WV19]3EBI-1211440,EBI-2854842
SFT2D2 [O95562]3EBI-1211440,EBI-4402330
SFXN1 [Q9H9B4]3EBI-1211440,EBI-355861
SFXN5 [Q8TD22]3EBI-1211440,EBI-17274136
SLC35B4 [Q969S0]3EBI-1211440,EBI-10281213
SLC4A1 [P02730]14EBI-1211440,EBI-7576138
SMCO4 [Q9NRQ5]3EBI-1211440,EBI-8640191
itself3EBI-1211440,EBI-1211440
STOML1 [Q9UBI4]4EBI-1211440,EBI-2681162
STX6 [O43752]3EBI-1211440,EBI-2695795
TECR [Q9NZ01]3EBI-1211440,EBI-2877718
THSD7B [C9JKN6]3EBI-1211440,EBI-17192156
TMEM109 [Q9BVC6]3EBI-1211440,EBI-1057733
TMEM120B [A0PK00]3EBI-1211440,EBI-10171534
TMEM140 [Q9NV12]3EBI-1211440,EBI-2844246
TMEM14B [Q9NUH8]3EBI-1211440,EBI-8638294
TMEM189-UBE2V1 [I3L0A0]3EBI-1211440,EBI-12213001
TMEM203 [Q969S6]3EBI-1211440,EBI-12274070
TMEM208 [Q9BTX3]3EBI-1211440,EBI-12876824
TMEM254 [Q8TBM7]3EBI-1211440,EBI-11956809
TMEM60 [Q9H2L4]3EBI-1211440,EBI-2852148
TMEM86B [Q8N661]3EBI-1211440,EBI-2548832
TMEM98 [Q9Y2Y6]3EBI-1211440,EBI-7333781
TMPO [P42167]3EBI-1211440,EBI-455283
TNF [P01375]3EBI-1211440,EBI-359977
TNFRSF10C [O14798]3EBI-1211440,EBI-717441
TSPO2 [Q5TGU0]3EBI-1211440,EBI-12195249
TTMP [Q5BVD1]3EBI-1211440,EBI-10243654
VAMP4 [O75379]3EBI-1211440,EBI-744953
WFDC2 [Q14508]3EBI-1211440,EBI-723529
YIPF6 [Q96EC8]3EBI-1211440,EBI-751210
RNA-directed RNA polymerase (PRO_0000037552) from Hepatitis C virus genotype 1b (isolate Con1).3EBI-1211440,EBI-9005440

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
108354, 162 interactors

Protein interaction database and analysis system

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IntActi
P27105, 168 interactors

Molecular INTeraction database

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MINTi
P27105

STRING: functional protein association networks

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STRINGi
9606.ENSP00000286713

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P27105 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P27105

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni265 – 273Required for homooligomerization9
Regioni267 – 269Required for lipid raft association3
Regioni273 – 287Interaction with LANCL11 PublicationAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2621 Eukaryota
COG0330 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182769

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024949_3_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P27105

KEGG Orthology (KO)

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KOi
K17286

Identification of Orthologs from Complete Genome Data

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OMAi
NTHAHSQ

Database for complete collections of gene phylogenies

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PhylomeDBi
P27105

TreeFam database of animal gene trees

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TreeFami
TF105750

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR043202 Band-7_stomatin-like
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR018080 Band_7/stomatin-like_CS
IPR028515 Stomatin
IPR001972 Stomatin_HflK_HflKC_fam

The PANTHER Classification System

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PANTHERi
PTHR10264 PTHR10264, 1 hit
PTHR10264:SF115 PTHR10264:SF115, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01145 Band_7, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00721 STOMATIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00244 PHB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF117892 SSF117892, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS01270 BAND_7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P27105-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MAEKRHTRDS EAQRLPDSFK DSPSKGLGPC GWILVAFSFL FTVITFPISI
60 70 80 90 100
WMCIKIIKEY ERAIIFRLGR ILQGGAKGPG LFFILPCTDS FIKVDMRTIS
110 120 130 140 150
FDIPPQEILT KDSVTISVDG VVYYRVQNAT LAVANITNAD SATRLLAQTT
160 170 180 190 200
LRNVLGTKNL SQILSDREEI AHNMQSTLDD ATDAWGIKVE RVEIKDVKLP
210 220 230 240 250
VQLQRAMAAE AEASREARAK VIAAEGEMNA SRALKEASMV ITESPAALQL
260 270 280
RYLQTLTTIA AEKNSTIVFP LPIDMLQGII GAKHSHLG
Length:288
Mass (Da):31,731
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FEDA92230D99A24
GO
Isoform 2 (identifier: P27105-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-219: Missing.

Show »
Length:123
Mass (Da):13,475
Checksum:i794017BC3ABB59EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VSL7F8VSL7_HUMAN
Erythrocyte band 7 integral membran...
STOM
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6H → D in AAA58432 (PubMed:8825639).Curated1
Sequence conflicti244S → Y in AAH10703 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04466955 – 219Missing in isoform 2. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X60067 mRNA Translation: CAA42671.1
M81635 mRNA Translation: AAA58432.1
X85116, X85117 Genomic DNA Translation: CAA59436.1
U33931 U33930 Genomic DNA Translation: AAC50296.1 Sequence problems.
CR542100 mRNA Translation: CAG46897.1
AL359644 Genomic DNA No translation available.
AL161784 Genomic DNA No translation available.
BC010703 mRNA Translation: AAH10703.1
BI603242 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS6830.1 [P27105-1]
CCDS6831.1 [P27105-2]

Protein sequence database of the Protein Information Resource

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PIRi
S17659

NCBI Reference Sequences

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RefSeqi
NP_004090.4, NM_004099.5 [P27105-1]
NP_937837.1, NM_198194.2 [P27105-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000286713; ENSP00000286713; ENSG00000148175 [P27105-1]
ENST00000347359; ENSP00000339607; ENSG00000148175 [P27105-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2040

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2040

UCSC genome browser

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UCSCi
uc004blh.5 human [P27105-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60067 mRNA Translation: CAA42671.1
M81635 mRNA Translation: AAA58432.1
X85116, X85117 Genomic DNA Translation: CAA59436.1
U33931 U33930 Genomic DNA Translation: AAC50296.1 Sequence problems.
CR542100 mRNA Translation: CAG46897.1
AL359644 Genomic DNA No translation available.
AL161784 Genomic DNA No translation available.
BC010703 mRNA Translation: AAH10703.1
BI603242 mRNA No translation available.
CCDSiCCDS6830.1 [P27105-1]
CCDS6831.1 [P27105-2]
PIRiS17659
RefSeqiNP_004090.4, NM_004099.5 [P27105-1]
NP_937837.1, NM_198194.2 [P27105-2]

3D structure databases

SMRiP27105
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi108354, 162 interactors
IntActiP27105, 168 interactors
MINTiP27105
STRINGi9606.ENSP00000286713

Protein family/group databases

TCDBi8.A.21.1.1 the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family

PTM databases

iPTMnetiP27105
MetOSiteiP27105
PhosphoSitePlusiP27105
SwissPalmiP27105

Polymorphism and mutation databases

BioMutaiSTOM
DMDMi114823

Proteomic databases

CPTACiCPTAC-276
CPTAC-277
EPDiP27105
jPOSTiP27105
MassIVEiP27105
MaxQBiP27105
PaxDbiP27105
PeptideAtlasiP27105
PRIDEiP27105
ProteomicsDBi3187
54374 [P27105-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2509 254 antibodies

The DNASU plasmid repository

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DNASUi
2040

Genome annotation databases

EnsembliENST00000286713; ENSP00000286713; ENSG00000148175 [P27105-1]
ENST00000347359; ENSP00000339607; ENSG00000148175 [P27105-2]
GeneIDi2040
KEGGihsa:2040
UCSCiuc004blh.5 human [P27105-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2040
DisGeNETi2040
EuPathDBiHostDB:ENSG00000148175.12

GeneCards: human genes, protein and diseases

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GeneCardsi
STOM
HGNCiHGNC:3383 STOM
HPAiENSG00000148175 Low tissue specificity
MIMi133090 gene
neXtProtiNX_P27105
OpenTargetsiENSG00000148175
PharmGKBiPA27816

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2621 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00950000182769
HOGENOMiCLU_024949_3_0_1
InParanoidiP27105
KOiK17286
OMAiNTHAHSQ
PhylomeDBiP27105
TreeFamiTF105750

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
2040 0 hits in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
STOM human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Stomatin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2040
PharosiP27105 Tbio

Protein Ontology

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PROi
PR:P27105
RNActiP27105 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148175 Expressed in visceral pleura and 236 other tissues
ExpressionAtlasiP27105 baseline and differential
GenevisibleiP27105 HS

Family and domain databases

InterProiView protein in InterPro
IPR043202 Band-7_stomatin-like
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR018080 Band_7/stomatin-like_CS
IPR028515 Stomatin
IPR001972 Stomatin_HflK_HflKC_fam
PANTHERiPTHR10264 PTHR10264, 1 hit
PTHR10264:SF115 PTHR10264:SF115, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
PROSITEiView protein in PROSITE
PS01270 BAND_7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTOM_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27105
Secondary accession number(s): B1AM77
, Q14087, Q15609, Q5VX96, Q96FK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: June 17, 2020
This is version 198 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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