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Protein

Erythrocyte band 7 integral membrane protein

Gene

STOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.

GO - Molecular functioni

  • protein homodimerization activity Source: Ensembl
  • RNA polymerase binding Source: AgBase

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

TCDBi8.A.21.1.1 the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Erythrocyte band 7 integral membrane protein
Alternative name(s):
Protein 7.2b
Stomatin
Gene namesi
Name:STOM
Synonyms:BND7, EPB72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148175.12
HGNCiHGNC:3383 STOM
MIMi133090 gene
neXtProtiNX_P27105

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Intramembranei26 – 54Sequence analysisAdd BLAST29
Topological domaini55 – 288CytoplasmicSequence analysisAdd BLAST234

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi182T → A: No effect on oligomerization. 1 Publication1
Mutagenesisi185W → A: Complete loss of oligomerization. 1 Publication1
Mutagenesisi252Y → A: Complete loss of oligomerization. 1 Publication1
Mutagenesisi263K → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi264N → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi265S → A: Oligomerization reduced to 18%. Reduced lipid raft association. 1
Mutagenesisi266T → A: Complete loss of oligomerization. Reduced lipid raft association. 1
Mutagenesisi267I → A: Complete loss of oligomerization and lipid raft association. 1
Mutagenesisi268V → A: Complete loss of oligomerization and lipid raft association. 1
Mutagenesisi269F → A: Complete loss of oligomerization and lipid raft association. 1
Mutagenesisi270P → A: Complete loss of oligomerization. No effect on lipid raft association. 1
Mutagenesisi271L → A: Complete loss of oligomerization. Reduced lipid raft association. 1
Mutagenesisi272P → A: Oligomerization reduced to 18%. Reduced lipid raft association. 1
Mutagenesisi273I → A: Complete loss of oligomerization. Reduced lipid raft association. 1
Mutagenesisi274D → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi275M → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi276L → A: Reduced oligomerization and lipid raft association. 1

Organism-specific databases

DisGeNETi2040
MalaCardsiSTOM
OpenTargetsiENSG00000148175
PharmGKBiPA27816

Polymorphism and mutation databases

DMDMi114823

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000940271 – 288Erythrocyte band 7 integral membrane proteinAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphoserine; by PKACombined sources1 Publication1
Modified residuei18PhosphoserineCombined sources1
Lipidationi30S-palmitoyl cysteine1 Publication1
Lipidationi87S-palmitoyl cysteine; partial1 Publication1
Modified residuei161PhosphoserineBy similarity1
Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP27105
MaxQBiP27105
PaxDbiP27105
PeptideAtlasiP27105
PRIDEiP27105
ProteomicsDBi54374

PTM databases

iPTMnetiP27105
PhosphoSitePlusiP27105
SwissPalmiP27105

Expressioni

Tissue specificityi

Detected in erythrocytes (at protein level). Widely expressed.2 Publications

Gene expression databases

BgeeiENSG00000148175 Expressed in 237 organ(s), highest expression level in visceral pleura
CleanExiHS_STOM
ExpressionAtlasiP27105 baseline and differential
GenevisibleiP27105 HS

Organism-specific databases

HPAiHPA010961
HPA011419

Interactioni

Subunit structurei

Homodimer and higher order homooligomer. The homodimer is banana-shaped. Interacts with ASIC1, ASIC2 and ASIC3 (By similarity). Interacts with LANCL1. Interacts with SLC2A1 and SLC4A1. Identified in large complexes with SLC40A1, SLC14A1, SLC29A1 and AQP1. Interacts with STOML1; may redistribute STOM from the plasma membrane to late endosomes.By similarity4 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108354, 145 interactors
IntActiP27105, 150 interactors
MINTiP27105
STRINGi9606.ENSP00000286713

Structurei

3D structure databases

ProteinModelPortaliP27105
SMRiP27105
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 273Required for homooligomerization9
Regioni267 – 269Required for lipid raft association3
Regioni273 – 287Interaction with LANCL11 PublicationAdd BLAST15

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Phylogenomic databases

eggNOGiKOG2621 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000074454
HOGENOMiHOG000217040
HOVERGENiHBG004815
InParanoidiP27105
KOiK17286
OMAiNAVLYFR
OrthoDBiEOG091G0G9K
PhylomeDBiP27105
TreeFamiTF105750

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR018080 Band_7/stomatin-like_CS
IPR028515 Stomatin
IPR001972 Stomatin_fam
PANTHERiPTHR10264:SF115 PTHR10264:SF115, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
PROSITEiView protein in PROSITE
PS01270 BAND_7, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P27105-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEKRHTRDS EAQRLPDSFK DSPSKGLGPC GWILVAFSFL FTVITFPISI
60 70 80 90 100
WMCIKIIKEY ERAIIFRLGR ILQGGAKGPG LFFILPCTDS FIKVDMRTIS
110 120 130 140 150
FDIPPQEILT KDSVTISVDG VVYYRVQNAT LAVANITNAD SATRLLAQTT
160 170 180 190 200
LRNVLGTKNL SQILSDREEI AHNMQSTLDD ATDAWGIKVE RVEIKDVKLP
210 220 230 240 250
VQLQRAMAAE AEASREARAK VIAAEGEMNA SRALKEASMV ITESPAALQL
260 270 280
RYLQTLTTIA AEKNSTIVFP LPIDMLQGII GAKHSHLG
Length:288
Mass (Da):31,731
Last modified:January 23, 2007 - v3
Checksum:i5FEDA92230D99A24
GO
Isoform 2 (identifier: P27105-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-219: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,475
Checksum:i794017BC3ABB59EF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VSL7F8VSL7_HUMAN
Erythrocyte band 7 integral membran...
STOM
168Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6H → D in AAA58432 (PubMed:8825639).Curated1
Sequence conflicti244S → Y in AAH10703 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04466955 – 219Missing in isoform 2. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60067 mRNA Translation: CAA42671.1
M81635 mRNA Translation: AAA58432.1
X85116, X85117 Genomic DNA Translation: CAA59436.1
U33931
, U33925, U33926, U33927, U33928, U33929, U33930 Genomic DNA Translation: AAC50296.1 Sequence problems.
CR542100 mRNA Translation: CAG46897.1
AL359644 Genomic DNA No translation available.
AL161784 Genomic DNA No translation available.
BC010703 mRNA Translation: AAH10703.1
BI603242 mRNA No translation available.
CCDSiCCDS6830.1 [P27105-1]
CCDS6831.1 [P27105-2]
PIRiS17659
RefSeqiNP_004090.4, NM_004099.5 [P27105-1]
NP_937837.1, NM_198194.2 [P27105-2]
UniGeneiHs.253903

Genome annotation databases

EnsembliENST00000286713; ENSP00000286713; ENSG00000148175 [P27105-1]
ENST00000347359; ENSP00000339607; ENSG00000148175 [P27105-2]
GeneIDi2040
KEGGihsa:2040
UCSCiuc004blh.5 human [P27105-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60067 mRNA Translation: CAA42671.1
M81635 mRNA Translation: AAA58432.1
X85116, X85117 Genomic DNA Translation: CAA59436.1
U33931
, U33925, U33926, U33927, U33928, U33929, U33930 Genomic DNA Translation: AAC50296.1 Sequence problems.
CR542100 mRNA Translation: CAG46897.1
AL359644 Genomic DNA No translation available.
AL161784 Genomic DNA No translation available.
BC010703 mRNA Translation: AAH10703.1
BI603242 mRNA No translation available.
CCDSiCCDS6830.1 [P27105-1]
CCDS6831.1 [P27105-2]
PIRiS17659
RefSeqiNP_004090.4, NM_004099.5 [P27105-1]
NP_937837.1, NM_198194.2 [P27105-2]
UniGeneiHs.253903

3D structure databases

ProteinModelPortaliP27105
SMRiP27105
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108354, 145 interactors
IntActiP27105, 150 interactors
MINTiP27105
STRINGi9606.ENSP00000286713

Protein family/group databases

TCDBi8.A.21.1.1 the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family

PTM databases

iPTMnetiP27105
PhosphoSitePlusiP27105
SwissPalmiP27105

Polymorphism and mutation databases

DMDMi114823

Proteomic databases

EPDiP27105
MaxQBiP27105
PaxDbiP27105
PeptideAtlasiP27105
PRIDEiP27105
ProteomicsDBi54374

Protocols and materials databases

DNASUi2040
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286713; ENSP00000286713; ENSG00000148175 [P27105-1]
ENST00000347359; ENSP00000339607; ENSG00000148175 [P27105-2]
GeneIDi2040
KEGGihsa:2040
UCSCiuc004blh.5 human [P27105-1]

Organism-specific databases

CTDi2040
DisGeNETi2040
EuPathDBiHostDB:ENSG00000148175.12
GeneCardsiSTOM
HGNCiHGNC:3383 STOM
HPAiHPA010961
HPA011419
MalaCardsiSTOM
MIMi133090 gene
neXtProtiNX_P27105
OpenTargetsiENSG00000148175
PharmGKBiPA27816
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2621 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000074454
HOGENOMiHOG000217040
HOVERGENiHBG004815
InParanoidiP27105
KOiK17286
OMAiNAVLYFR
OrthoDBiEOG091G0G9K
PhylomeDBiP27105
TreeFamiTF105750

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiSTOM human
GeneWikiiStomatin
GenomeRNAii2040
PROiPR:P27105
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148175 Expressed in 237 organ(s), highest expression level in visceral pleura
CleanExiHS_STOM
ExpressionAtlasiP27105 baseline and differential
GenevisibleiP27105 HS

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR018080 Band_7/stomatin-like_CS
IPR028515 Stomatin
IPR001972 Stomatin_fam
PANTHERiPTHR10264:SF115 PTHR10264:SF115, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
PROSITEiView protein in PROSITE
PS01270 BAND_7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTOM_HUMAN
AccessioniPrimary (citable) accession number: P27105
Secondary accession number(s): B1AM77
, Q14087, Q15609, Q5VX96, Q96FK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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