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Protein

Erythrocyte band 7 integral membrane protein

Gene

STOM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein homodimerization activity Source: Ensembl
  • RNA polymerase binding Source: AgBase

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.21.1.1 the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Erythrocyte band 7 integral membrane protein
Alternative name(s):
Protein 7.2b
Stomatin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STOM
Synonyms:BND7, EPB72
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148175.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3383 STOM

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
133090 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P27105

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei26 – 54Sequence analysisAdd BLAST29
Topological domaini55 – 288CytoplasmicSequence analysisAdd BLAST234

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi182T → A: No effect on oligomerization. 1 Publication1
Mutagenesisi185W → A: Complete loss of oligomerization. 1 Publication1
Mutagenesisi252Y → A: Complete loss of oligomerization. 1 Publication1
Mutagenesisi263K → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi264N → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi265S → A: Oligomerization reduced to 18%. Reduced lipid raft association. 1
Mutagenesisi266T → A: Complete loss of oligomerization. Reduced lipid raft association. 1
Mutagenesisi267I → A: Complete loss of oligomerization and lipid raft association. 1
Mutagenesisi268V → A: Complete loss of oligomerization and lipid raft association. 1
Mutagenesisi269F → A: Complete loss of oligomerization and lipid raft association. 1
Mutagenesisi270P → A: Complete loss of oligomerization. No effect on lipid raft association. 1
Mutagenesisi271L → A: Complete loss of oligomerization. Reduced lipid raft association. 1
Mutagenesisi272P → A: Oligomerization reduced to 18%. Reduced lipid raft association. 1
Mutagenesisi273I → A: Complete loss of oligomerization. Reduced lipid raft association. 1
Mutagenesisi274D → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi275M → A: Reduced oligomerization and lipid raft association. 1
Mutagenesisi276L → A: Reduced oligomerization and lipid raft association. 1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2040

MalaCards human disease database

More...
MalaCardsi
STOM

Open Targets

More...
OpenTargetsi
ENSG00000148175

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27816

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
114823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000940271 – 288Erythrocyte band 7 integral membrane proteinAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10Phosphoserine; by PKACombined sources1 Publication1
Modified residuei18PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi30S-palmitoyl cysteine1 Publication1
Lipidationi87S-palmitoyl cysteine; partial1 Publication1
Modified residuei161PhosphoserineBy similarity1
Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P27105

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P27105

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P27105

PeptideAtlas

More...
PeptideAtlasi
P27105

PRoteomics IDEntifications database

More...
PRIDEi
P27105

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54374

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P27105

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P27105

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P27105

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in erythrocytes (at protein level). Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148175 Expressed in 237 organ(s), highest expression level in visceral pleura

CleanEx database of gene expression profiles

More...
CleanExi
HS_STOM

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P27105 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P27105 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010961
HPA011419

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and higher order homooligomer. The homodimer is banana-shaped. Interacts with ASIC1, ASIC2 and ASIC3 (By similarity). Interacts with LANCL1. Interacts with SLC2A1 and SLC4A1. Identified in large complexes with SLC40A1, SLC14A1, SLC29A1 and AQP1. Interacts with STOML1; may redistribute STOM from the plasma membrane to late endosomes.By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108354, 145 interactors

Protein interaction database and analysis system

More...
IntActi
P27105, 150 interactors

Molecular INTeraction database

More...
MINTi
P27105

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000286713

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P27105

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P27105

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni265 – 273Required for homooligomerization9
Regioni267 – 269Required for lipid raft association3
Regioni273 – 287Interaction with LANCL11 PublicationAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2621 Eukaryota
COG0330 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153836

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217040

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004815

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P27105

KEGG Orthology (KO)

More...
KOi
K17286

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAVLYFR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0G9K

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P27105

TreeFam database of animal gene trees

More...
TreeFami
TF105750

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR018080 Band_7/stomatin-like_CS
IPR028515 Stomatin
IPR001972 Stomatin_fam

The PANTHER Classification System

More...
PANTHERi
PTHR10264:SF115 PTHR10264:SF115, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01145 Band_7, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00721 STOMATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00244 PHB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117892 SSF117892, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01270 BAND_7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P27105-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEKRHTRDS EAQRLPDSFK DSPSKGLGPC GWILVAFSFL FTVITFPISI
60 70 80 90 100
WMCIKIIKEY ERAIIFRLGR ILQGGAKGPG LFFILPCTDS FIKVDMRTIS
110 120 130 140 150
FDIPPQEILT KDSVTISVDG VVYYRVQNAT LAVANITNAD SATRLLAQTT
160 170 180 190 200
LRNVLGTKNL SQILSDREEI AHNMQSTLDD ATDAWGIKVE RVEIKDVKLP
210 220 230 240 250
VQLQRAMAAE AEASREARAK VIAAEGEMNA SRALKEASMV ITESPAALQL
260 270 280
RYLQTLTTIA AEKNSTIVFP LPIDMLQGII GAKHSHLG
Length:288
Mass (Da):31,731
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FEDA92230D99A24
GO
Isoform 2 (identifier: P27105-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-219: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):13,475
Checksum:i794017BC3ABB59EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VSL7F8VSL7_HUMAN
Erythrocyte band 7 integral membran...
STOM
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6H → D in AAA58432 (PubMed:8825639).Curated1
Sequence conflicti244S → Y in AAH10703 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04466955 – 219Missing in isoform 2. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X60067 mRNA Translation: CAA42671.1
M81635 mRNA Translation: AAA58432.1
X85116, X85117 Genomic DNA Translation: CAA59436.1
U33931
, U33925, U33926, U33927, U33928, U33929, U33930 Genomic DNA Translation: AAC50296.1 Sequence problems.
CR542100 mRNA Translation: CAG46897.1
AL359644 Genomic DNA No translation available.
AL161784 Genomic DNA No translation available.
BC010703 mRNA Translation: AAH10703.1
BI603242 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6830.1 [P27105-1]
CCDS6831.1 [P27105-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S17659

NCBI Reference Sequences

More...
RefSeqi
NP_004090.4, NM_004099.5 [P27105-1]
NP_937837.1, NM_198194.2 [P27105-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.253903

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286713; ENSP00000286713; ENSG00000148175 [P27105-1]
ENST00000347359; ENSP00000339607; ENSG00000148175 [P27105-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2040

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2040

UCSC genome browser

More...
UCSCi
uc004blh.5 human [P27105-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60067 mRNA Translation: CAA42671.1
M81635 mRNA Translation: AAA58432.1
X85116, X85117 Genomic DNA Translation: CAA59436.1
U33931
, U33925, U33926, U33927, U33928, U33929, U33930 Genomic DNA Translation: AAC50296.1 Sequence problems.
CR542100 mRNA Translation: CAG46897.1
AL359644 Genomic DNA No translation available.
AL161784 Genomic DNA No translation available.
BC010703 mRNA Translation: AAH10703.1
BI603242 mRNA No translation available.
CCDSiCCDS6830.1 [P27105-1]
CCDS6831.1 [P27105-2]
PIRiS17659
RefSeqiNP_004090.4, NM_004099.5 [P27105-1]
NP_937837.1, NM_198194.2 [P27105-2]
UniGeneiHs.253903

3D structure databases

ProteinModelPortaliP27105
SMRiP27105
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108354, 145 interactors
IntActiP27105, 150 interactors
MINTiP27105
STRINGi9606.ENSP00000286713

Protein family/group databases

TCDBi8.A.21.1.1 the stomatin/podocin/band 7/nephrosis,2/spfh (stomatin) family

PTM databases

iPTMnetiP27105
PhosphoSitePlusiP27105
SwissPalmiP27105

Polymorphism and mutation databases

DMDMi114823

Proteomic databases

EPDiP27105
MaxQBiP27105
PaxDbiP27105
PeptideAtlasiP27105
PRIDEiP27105
ProteomicsDBi54374

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2040
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286713; ENSP00000286713; ENSG00000148175 [P27105-1]
ENST00000347359; ENSP00000339607; ENSG00000148175 [P27105-2]
GeneIDi2040
KEGGihsa:2040
UCSCiuc004blh.5 human [P27105-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2040
DisGeNETi2040
EuPathDBiHostDB:ENSG00000148175.12

GeneCards: human genes, protein and diseases

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GeneCardsi
STOM
HGNCiHGNC:3383 STOM
HPAiHPA010961
HPA011419
MalaCardsiSTOM
MIMi133090 gene
neXtProtiNX_P27105
OpenTargetsiENSG00000148175
PharmGKBiPA27816

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2621 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00940000153836
HOGENOMiHOG000217040
HOVERGENiHBG004815
InParanoidiP27105
KOiK17286
OMAiNAVLYFR
OrthoDBiEOG091G0G9K
PhylomeDBiP27105
TreeFamiTF105750

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STOM human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Stomatin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2040

Protein Ontology

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PROi
PR:P27105

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000148175 Expressed in 237 organ(s), highest expression level in visceral pleura
CleanExiHS_STOM
ExpressionAtlasiP27105 baseline and differential
GenevisibleiP27105 HS

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR018080 Band_7/stomatin-like_CS
IPR028515 Stomatin
IPR001972 Stomatin_fam
PANTHERiPTHR10264:SF115 PTHR10264:SF115, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
PROSITEiView protein in PROSITE
PS01270 BAND_7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTOM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27105
Secondary accession number(s): B1AM77
, Q14087, Q15609, Q5VX96, Q96FK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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