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Protein

Protein 60A

Gene

gbb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the growth of imaginal tissues and for patterning of the adult wing.1 Publication

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • transforming growth factor beta receptor binding Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor

Enzyme and pathway databases

ReactomeiR-DME-2129379 Molecules associated with elastic fibres
SignaLinkiP27091

Names & Taxonomyi

Protein namesi
Recommended name:
Protein 60A
Alternative name(s):
Protein glass bottom boat
Gene namesi
Name:gbb
Synonyms:60A, gbb-60A, TGFb-60A
ORF Names:CG5562
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0024234 gbb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Flies exhibit transparent larvae, and a reduction of the adult wing size.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
PropeptideiPRO_000003366037 – 335Sequence analysisAdd BLAST299
ChainiPRO_0000033661336 – 455Protein 60AAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 420By similarity
Disulfide bondi383 ↔ 452By similarity
Disulfide bondi387 ↔ 454By similarity
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi419InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP27091
PRIDEiP27091

Expressioni

Tissue specificityi

Expressed in cells of the developing foregut and hindgut during germ band retraction and later embryonic stages. Expressed in the wing disk, mainly in the posterior compartment in the pteropleural and medial regions extending into the progenitors of the scutellum. High levels are found within the posterior and anterior compartments of the wing pouch and low levels in the hinge region. In the eye/antennal disk, expression is highest anterior to the morphogenetic furrow and in the medial regions with lower levels of expression posterior to the morphogenetic furrow. Expressed throughout the posterior compartment of the leg imaginal disks and within the ventral anterior compartment.2 Publications

Developmental stagei

Expressed throughout development with peaks of transcription during early embryogenesis, in pupae, and in adult males.2 Publications

Gene expression databases

BgeeiFBgn0024234 Expressed in 43 organ(s), highest expression level in embryo
ExpressionAtlasiP27091 baseline and differential
GenevisibleiP27091 DM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi63372, 30 interactors
DIPiDIP-19466N
IntActiP27091, 3 interactors
STRINGi7227.FBpp0072036

Structurei

3D structure databases

ProteinModelPortaliP27091
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
InParanoidiP27091
KOiK16621
OMAiIYKDCVV
OrthoDBiEOG091G0C2J
PhylomeDBiP27091

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P27091-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLRNTSEA VAVLASLGLG MVLLMFVATT PPAVEATQSG IYIDNGKDQT
60 70 80 90 100
IMHRVLSEDD KLDVSYEILE FLGIAERPTH LSSHQLSLRK SAPKFLLDVY
110 120 130 140 150
HRITAEEGLS DQDEDDDYER GHRSRRSADL EEDEGEQQKN FITDLDKRAI
160 170 180 190 200
DESDIIMTFL NKRHHNVDEL RHEHGRRLWF DVSNVPNDNY LVMAELRIYQ
210 220 230 240 250
NANEGKWLTA NREFTITVYA IGTGTLGQHT MEPLSSVNTT GDYVGWLELN
260 270 280 290 300
VTEGLHEWLV KSKDNHGIYI GAHAVNRPDR EVKLDDIGLI HRKVDDEFQP
310 320 330 340 350
FMIGFFRGPE LIKATAHSSH HRSKRSASHP RKRKKSVSPN NVPLLEPMES
360 370 380 390 400
TRSCQMQTLY IDFKDLGWHD WIIAPEGYGA FYCSGECNFP LNAHMNATNH
410 420 430 440 450
AIVQTLVHLL EPKKVPKPCC APTRLGALPV LYHLNDENVN LKKYRNMIVK

SCGCH
Length:455
Mass (Da):51,687
Last modified:August 1, 1992 - v1
Checksum:iC8FA795556341F94
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LGA7A0A0B4LGA7_DROME
Glass bottom boat, isoform B
gbb CG5562, Dmel_CG5562
455Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77012 Genomic DNA Translation: AAA28306.1
M84795 mRNA Translation: AAA28307.1
AE013599 Genomic DNA Translation: AAF47075.1
PIRiA43918
RefSeqiNP_001286786.1, NM_001299857.1
NP_477340.1, NM_057992.3
UniGeneiDm.4758

Genome annotation databases

EnsemblMetazoaiFBtr0072127; FBpp0072036; FBgn0024234
FBtr0343274; FBpp0309939; FBgn0024234
GeneIDi37778
KEGGidme:Dmel_CG5562

Similar proteinsi

Entry informationi

Entry namei60A_DROME
AccessioniPrimary (citable) accession number: P27091
Secondary accession number(s): Q9W1I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 12, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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