UniProtKB - P27090 (TGFB2_MOUSE)
Transforming growth factor beta-2 proprotein
Tgfb2
Functioni
GO - Molecular functioni
- amyloid-beta binding Source: UniProtKB
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB
- identical protein binding Source: MGI
- protein-containing complex binding Source: MGI
- protein homodimerization activity Source: UniProtKB
- protein N-terminus binding Source: MGI
- signaling receptor binding Source: UniProtKB
- transforming growth factor beta receptor binding Source: UniProtKB
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: UniProtKB
GO - Biological processi
- activation of protein kinase activity Source: UniProtKB
- ascending aorta morphogenesis Source: BHF-UCL
- atrial septum morphogenesis Source: BHF-UCL
- atrial septum primum morphogenesis Source: BHF-UCL
- atrioventricular valve morphogenesis Source: BHF-UCL
- axon guidance Source: MGI
- blood vessel development Source: MGI
- blood vessel remodeling Source: MGI
- BMP signaling pathway Source: GO_Central
- cardiac epithelial to mesenchymal transition Source: UniProtKB
- cardiac left ventricle morphogenesis Source: DFLAT
- cardiac muscle cell proliferation Source: UniProtKB
- cardiac right ventricle morphogenesis Source: BHF-UCL
- cardioblast differentiation Source: UniProtKB
- cartilage condensation Source: MGI
- cell-cell junction organization Source: UniProtKB
- cell cycle arrest Source: UniProtKB
- cell death Source: UniProtKB
- cell migration Source: UniProtKB
- cell morphogenesis Source: UniProtKB
- collagen fibril organization Source: UniProtKB
- cranial skeletal system development Source: BHF-UCL
- dopamine biosynthetic process Source: UniProtKB
- embryonic digestive tract development Source: AgBase
- embryonic limb morphogenesis Source: BHF-UCL
- embryonic neurocranium morphogenesis Source: MGI
- endocardial cushion fusion Source: BHF-UCL
- endocardial cushion morphogenesis Source: BHF-UCL
- epithelial to mesenchymal transition Source: UniProtKB
- extracellular matrix organization Source: MGI
- extrinsic apoptotic signaling pathway Source: BHF-UCL
- eye development Source: UniProtKB
- face morphogenesis Source: UniProtKB
- glial cell migration Source: UniProtKB
- hair follicle development Source: UniProtKB
- hair follicle morphogenesis Source: UniProtKB
- heart development Source: MGI
- heart morphogenesis Source: UniProtKB
- heart valve morphogenesis Source: BHF-UCL
- hemopoiesis Source: UniProtKB
- inner ear development Source: BHF-UCL
- kidney development Source: BHF-UCL
- male gonad development Source: BHF-UCL
- membranous septum morphogenesis Source: BHF-UCL
- negative regulation of alkaline phosphatase activity Source: UniProtKB
- negative regulation of angiogenesis Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cartilage development Source: MGI
- negative regulation of cell growth Source: AgBase
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of epithelial cell proliferation Source: UniProtKB
- negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
- negative regulation of gene expression Source: UniProtKB
- negative regulation of immune response Source: MGI
- negative regulation of keratinocyte differentiation Source: UniProtKB
- negative regulation of macrophage cytokine production Source: UniProtKB
- negative regulation of Ras protein signal transduction Source: BHF-UCL
- negative regulation of release of sequestered calcium ion into cytosol Source: MGI
- neural retina development Source: BHF-UCL
- neural tube closure Source: BHF-UCL
- neuron development Source: UniProtKB
- neuron fate commitment Source: MGI
- neutrophil chemotaxis Source: UniProtKB
- outflow tract morphogenesis Source: DFLAT
- outflow tract septum morphogenesis Source: BHF-UCL
- pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- pharyngeal arch artery morphogenesis Source: BHF-UCL
- positive regulation of activation-induced cell death of T cells Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of cardioblast differentiation Source: UniProtKB
- positive regulation of cell adhesion mediated by integrin Source: UniProtKB
- positive regulation of cell cycle Source: UniProtKB
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell migration Source: MGI
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of epithelial cell migration Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
- positive regulation of extracellular matrix disassembly Source: UniProtKB
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
- positive regulation of gene expression Source: UniProtKB
- positive regulation of GTP binding Source: UniProtKB
- positive regulation of heart contraction Source: UniProtKB
- positive regulation of immune response Source: UniProtKB
- positive regulation of integrin biosynthetic process Source: UniProtKB
- positive regulation of neuron apoptotic process Source: UniProtKB
- positive regulation of Notch signaling pathway Source: MGI
- positive regulation of ossification Source: AgBase
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
- positive regulation of protein localization to nucleus Source: UniProtKB
- positive regulation of protein secretion Source: UniProtKB
- positive regulation of stress-activated MAPK cascade Source: UniProtKB
- positive regulation of timing of catagen Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- pulmonary valve morphogenesis Source: BHF-UCL
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of apoptotic process Source: MGI
- regulation of apoptotic process involved in outflow tract morphogenesis Source: BHF-UCL
- regulation of cell population proliferation Source: GO_Central
- regulation of extracellular matrix organization Source: MGI
- regulation of timing of catagen Source: UniProtKB
- regulation of transforming growth factor beta2 production Source: UniProtKB
- response to drug Source: UniProtKB
- response to estrogen Source: MGI
- response to hypoxia Source: UniProtKB
- response to progesterone Source: UniProtKB
- response to wounding Source: AgBase
- salivary gland morphogenesis Source: AgBase
- secondary palate development Source: BHF-UCL
- skeletal system development Source: BHF-UCL
- SMAD protein signal transduction Source: BHF-UCL
- somatic stem cell division Source: UniProtKB
- substantia propria of cornea development Source: BHF-UCL
- transforming growth factor beta receptor signaling pathway Source: UniProtKB
- uterus development Source: BHF-UCL
- ventricular septum morphogenesis Source: BHF-UCL
- ventricular trabecula myocardium morphogenesis Source: BHF-UCL
- wound healing Source: UniProtKB
Keywordsi
Molecular function | Growth factor, Mitogen |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation R-MMU-2129379, Molecules associated with elastic fibres |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-2 proproteinCleaved into the following 2 chains: |
Gene namesi | Name:Tgfb2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98726, Tgfb2 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Endosome
- endosome Source: UniProtKB
Extracellular region or secreted
- basement membrane Source: MGI
- collagen-containing extracellular matrix Source: MGI
- extracellular matrix Source: UniProtKB
- extracellular region Source: UniProtKB
- extracellular space Source: MGI
Golgi apparatus
- trans-Golgi network Source: MGI
Other locations
- axon Source: UniProtKB
- cell surface Source: MGI
- cytoplasm Source: MGI
- neuronal cell body Source: UniProtKB
- secretory granule Source: MGI
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000033786 | 21 – 302 | Latency-associated peptideBy similarityAdd BLAST | 282 | |
ChainiPRO_0000033787 | 303 – 414 | Transforming growth factor beta-2By similarityAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 140 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 309 ↔ 318 | By similarity | ||
Disulfide bondi | 317 ↔ 380 | By similarity | ||
Disulfide bondi | 346 ↔ 411 | By similarity | ||
Disulfide bondi | 350 ↔ 413 | By similarity | ||
Disulfide bondi | 379 | InterchainBy similarity |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
MaxQBi | P27090 |
PaxDbi | P27090 |
PeptideAtlasi | P27090 |
PRIDEi | P27090 |
PTM databases
GlyConnecti | 2777, 1 N-Linked glycan (1 site) |
GlyGeni | P27090, 3 sites |
iPTMneti | P27090 |
PhosphoSitePlusi | P27090 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000039239, Expressed in uterus and 394 other tissues |
Genevisiblei | P27090, MM |
Interactioni
Subunit structurei
Interacts with the serine proteases, HTRA1 and HTRA3 (PubMed:15206957, PubMed:14973287).
Interacts with ASPN (By similarity).
Interacts with MFAP5 (PubMed:23963447). Latency-associated peptide:
Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity). Latency-associated peptide:
Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-2 (By similarity). Latency-associated peptide:
Interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (PubMed:14985127). Transforming growth factor beta-2: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-2:
Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
By similarity4 PublicationsGO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB
- identical protein binding Source: MGI
- protein homodimerization activity Source: UniProtKB
- protein N-terminus binding Source: MGI
- signaling receptor binding Source: UniProtKB
- transforming growth factor beta receptor binding Source: UniProtKB
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 204160, 2 interactors |
ComplexPortali | CPX-827, TGF-beta-2 complex CPX-836, TGF-beta-2-TGFR complex |
IntActi | P27090, 1 interactor |
MINTi | P27090 |
STRINGi | 10090.ENSMUSP00000043849 |
Miscellaneous databases
RNActi | P27090, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P27090 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157390 |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | P27090 |
OMAi | QPFYPEN |
TreeFami | TF318514 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MHYCVLSTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL
60 70 80 90 100
TSPPEDYPEP DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA
110 120 130 140 150
KEVYKIDMPS HLPSENAIPP TFYRPYFRIV RFDVSTMEKN ASNLVKAEFR
160 170 180 190 200
VFRLQNPKAR VAEQRIELYQ ILKSKDLTSP TQRYIDSKVV KTRAEGEWLS
210 220 230 240 250
FDVTDAVQEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP NKSEELEARF
260 270 280 290 300
AGIDGTSTYA SGDQKTIKST RKKTSGKTPH LLLMLLPSYR LESQQSSRRK
310 320 330 340 350
KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC
360 370 380 390 400
PYLWSSDTQH TKVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGNTPKI
410
EQLSNMIVKS CKCS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YXU9 | A0A0A6YXU9_MOUSE | Transforming growth factor beta | Tgfb2 | 442 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 95 – 96 | DE → EQ in CAA40672 (PubMed:2797004).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57413 mRNA Translation: CAA40672.1 BC011170 mRNA Translation: AAH11170.1 |
CCDSi | CCDS15601.1 |
PIRi | A40148, WFMSB2 |
RefSeqi | NP_033393.2, NM_009367.4 |
Genome annotation databases
Ensembli | ENSMUST00000045288; ENSMUSP00000043849; ENSMUSG00000039239 |
GeneIDi | 21808 |
KEGGi | mmu:21808 |
UCSCi | uc007dzo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X57413 mRNA Translation: CAA40672.1 BC011170 mRNA Translation: AAH11170.1 |
CCDSi | CCDS15601.1 |
PIRi | A40148, WFMSB2 |
RefSeqi | NP_033393.2, NM_009367.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5TX2 | X-ray | 1.82 | A/B | 303-414 | [»] | |
5TX6 | X-ray | 2.75 | A/B/C | 303-414 | [»] | |
SMRi | P27090 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204160, 2 interactors |
ComplexPortali | CPX-827, TGF-beta-2 complex CPX-836, TGF-beta-2-TGFR complex |
IntActi | P27090, 1 interactor |
MINTi | P27090 |
STRINGi | 10090.ENSMUSP00000043849 |
PTM databases
GlyConnecti | 2777, 1 N-Linked glycan (1 site) |
GlyGeni | P27090, 3 sites |
iPTMneti | P27090 |
PhosphoSitePlusi | P27090 |
Proteomic databases
MaxQBi | P27090 |
PaxDbi | P27090 |
PeptideAtlasi | P27090 |
PRIDEi | P27090 |
Protocols and materials databases
Antibodypediai | 20732, 561 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000045288; ENSMUSP00000043849; ENSMUSG00000039239 |
GeneIDi | 21808 |
KEGGi | mmu:21808 |
UCSCi | uc007dzo.2, mouse |
Organism-specific databases
CTDi | 7042 |
MGIi | MGI:98726, Tgfb2 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157390 |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | P27090 |
OMAi | QPFYPEN |
TreeFami | TF318514 |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation R-MMU-2129379, Molecules associated with elastic fibres |
Miscellaneous databases
BioGRID-ORCSi | 21808, 0 hits in 19 CRISPR screens |
ChiTaRSi | Tgfb2, mouse |
PROi | PR:P27090 |
RNActi | P27090, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039239, Expressed in uterus and 394 other tissues |
Genevisiblei | P27090, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB2_MOUSE | |
Accessioni | P27090Primary (citable) accession number: P27090 Secondary accession number(s): Q91VP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families