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Protein

Metallothionein A

Gene
N/A
Organism
Colinus virginianus (Northern bobwhite) (Tetrao virginianus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2Divalent metal cation; cluster B1
Metal bindingi6Divalent metal cation; cluster B1
Metal bindingi8Divalent metal cation; cluster B1
Metal bindingi11Divalent metal cation; cluster B1
Metal bindingi13Divalent metal cation; cluster B1
Metal bindingi16Divalent metal cation; cluster B1
Metal bindingi20Divalent metal cation; cluster A1
Metal bindingi21Divalent metal cation; cluster A1
Metal bindingi23Divalent metal cation; cluster A1
Metal bindingi24Divalent metal cation; cluster A1
Metal bindingi28Divalent metal cation; cluster A1
Metal bindingi31Divalent metal cation; cluster A1
Metal bindingi35Divalent metal cation; cluster A1
Metal bindingi37Divalent metal cation; cluster A1

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein A
Short name:
MTA
OrganismiColinus virginianus (Northern bobwhite) (Tetrao virginianus)
Taxonomic identifieri9014 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesOdontophoridaeColinus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000197263‹1 – ›43Metallothionein AAdd BLAST›43

Structurei

3D structure databases

SMRiP27086
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni‹1 – 16BetaAdd BLAST›16
Regioni17 – ›43AlphaAdd BLAST›27

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit

Sequencei

Sequence statusi: Fragment.

P27086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
SCAGSCKCKN CRCRSCRKSC CSCCPAGCNN CAKGCVCKEP ASS
Length:43
Mass (Da):4,401
Last modified:August 1, 1992 - v1
Checksum:i1612EB52656EB875
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62511 mRNA Translation: CAA44370.1
PIRiS33378 S18173

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62511 mRNA Translation: CAA44370.1
PIRiS33378 S18173

3D structure databases

SMRiP27086
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTA_COLVI
AccessioniPrimary (citable) accession number: P27086
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: December 20, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
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Main funding by: National Institutes of Health

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