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Protein

Small nuclear ribonucleoprotein-associated protein B

Gene

Snrpb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (PubMed:19470752).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs
R-MMU-191859 snRNP Assembly
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein-associated protein B
Short name:
snRNP-B
Short name:
snRPB
Alternative name(s):
Sm protein B
Short name:
Sm-B
Short name:
SmB
Gene namesi
Name:Snrpb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98342 Snrpb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255191 – 231Small nuclear ribonucleoprotein-associated protein BAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei108Dimethylated arginine; alternateBy similarity1
Modified residuei108Omega-N-methylarginine; alternateCombined sources1
Modified residuei108Omega-N-methylated arginine; alternateBy similarity1
Modified residuei112Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei112Dimethylated arginine; alternateBy similarity1
Modified residuei112Omega-N-methylarginine; alternateBy similarity1
Modified residuei112Omega-N-methylated arginine; alternateBy similarity1
Modified residuei147Omega-N-methylarginineBy similarity1
Modified residuei172Omega-N-methylarginineBy similarity1

Post-translational modificationi

Methylated. Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine.By similarity

Keywords - PTMi

Methylation

Proteomic databases

EPDiP27048
MaxQBiP27048
PaxDbiP27048
PeptideAtlasiP27048
PRIDEiP27048

PTM databases

iPTMnetiP27048
PhosphoSitePlusiP27048
SwissPalmiP27048

Miscellaneous databases

PMAP-CutDBiP27048

Expressioni

Gene expression databases

BgeeiENSMUSG00000027404 Expressed in 256 organ(s), highest expression level in trachea
CleanExiMM_SNRPB
ExpressionAtlasiP27048 baseline and differential
GenevisibleiP27048 MM

Interactioni

Subunit structurei

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (PubMed:19470752). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (PubMed:19470752). Interacts with TDRD3 and SNUPN (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi203377, 7 interactors
IntActiP27048, 5 interactors
MINTiP27048
STRINGi10090.ENSMUSP00000099488

Structurei

3D structure databases

ProteinModelPortaliP27048
SMRiP27048
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati175 – 1817
Repeati191 – 1966
Repeati216 – 2216
Repeati222 – 2287

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni175 – 228Repeat-rich regionAdd BLAST54

Sequence similaritiesi

Belongs to the snRNP SmB/SmN family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3168 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00670000098029
HOGENOMiHOG000188899
HOVERGENiHBG001019
InParanoidiP27048
KOiK11086
OMAiRGMGMMP
OrthoDBiEOG091G0Y7H
PhylomeDBiP27048
TreeFamiTF314232

Family and domain databases

InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR017131 snRNP-assoc_SmB/SmN
PfamiView protein in Pfam
PF01423 LSM, 1 hit
PIRSFiPIRSF037187 snRNP_SmB/SmN, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P27048-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK
60 70 80 90 100
IKPKNSKQAE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA
110 120 130 140 150
AGGPGIGRAA GRGIPAGVPM PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV
160 170 180 190 200
AAAAAAATAS IAGAPTQYPP GRGGPPPPMG RGAPPPGMMG PPPGMRPPMG
210 220 230
PPMGLPPGRG TPMGMPPPGM RPPPPGMRGL L
Length:231
Mass (Da):23,656
Last modified:August 1, 1992 - v1
Checksum:i5CB0BE7E20B93D4A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGN4A0A0G2JGN4_MOUSE
Small nuclear ribonucleoprotein-ass...
Snrpb
70Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58761 mRNA Translation: AAA40119.1
AK146319 mRNA Translation: BAE27074.1
CCDSiCCDS16735.1
PIRiI53659
RefSeqiNP_033251.1, NM_009225.2
UniGeneiMm.88216

Genome annotation databases

EnsembliENSMUST00000103199; ENSMUSP00000099488; ENSMUSG00000027404
GeneIDi20638
KEGGimmu:20638
UCSCiuc008mij.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58761 mRNA Translation: AAA40119.1
AK146319 mRNA Translation: BAE27074.1
CCDSiCCDS16735.1
PIRiI53659
RefSeqiNP_033251.1, NM_009225.2
UniGeneiMm.88216

3D structure databases

ProteinModelPortaliP27048
SMRiP27048
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203377, 7 interactors
IntActiP27048, 5 interactors
MINTiP27048
STRINGi10090.ENSMUSP00000099488

PTM databases

iPTMnetiP27048
PhosphoSitePlusiP27048
SwissPalmiP27048

Proteomic databases

EPDiP27048
MaxQBiP27048
PaxDbiP27048
PeptideAtlasiP27048
PRIDEiP27048

Protocols and materials databases

DNASUi20638
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103199; ENSMUSP00000099488; ENSMUSG00000027404
GeneIDi20638
KEGGimmu:20638
UCSCiuc008mij.1 mouse

Organism-specific databases

CTDi6628
MGIiMGI:98342 Snrpb

Phylogenomic databases

eggNOGiKOG3168 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00670000098029
HOGENOMiHOG000188899
HOVERGENiHBG001019
InParanoidiP27048
KOiK11086
OMAiRGMGMMP
OrthoDBiEOG091G0Y7H
PhylomeDBiP27048
TreeFamiTF314232

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-111367 SLBP independent Processing of Histone Pre-mRNAs
R-MMU-191859 snRNP Assembly
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway
R-MMU-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Miscellaneous databases

ChiTaRSiSnrpb mouse
PMAP-CutDBiP27048
PROiPR:P27048
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027404 Expressed in 256 organ(s), highest expression level in trachea
CleanExiMM_SNRPB
ExpressionAtlasiP27048 baseline and differential
GenevisibleiP27048 MM

Family and domain databases

InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR017131 snRNP-assoc_SmB/SmN
PfamiView protein in Pfam
PF01423 LSM, 1 hit
PIRSFiPIRSF037187 snRNP_SmB/SmN, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSMB_MOUSE
AccessioniPrimary (citable) accession number: P27048
Secondary accession number(s): Q3UJT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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