Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Activin receptor type-2B

Gene

Acvr2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity).By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241ATPPROSITE-ProRule annotation1
Active sitei345Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 228ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 3474
ReactomeiR-MMU-1502540 Signaling by Activin
R-MMU-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2B (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIB
Short name:
ACTR-IIB
Gene namesi
Name:Acvr2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:87912 Acvr2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 137ExtracellularSequence analysisAdd BLAST119
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 536CytoplasmicSequence analysisAdd BLAST378

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002440519 – 536Activin receptor type-2BAdd BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 59By similarity
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi49 ↔ 77By similarity
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi84 ↔ 103By similarity
Disulfide bondi90 ↔ 102By similarity
Disulfide bondi104 ↔ 109By similarity

Post-translational modificationi

Phosphorylated. Constitutive phosphorylation is in part catalyzed by its own kinase activity (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP27040
PaxDbiP27040
PRIDEiP27040

PTM databases

PhosphoSitePlusiP27040

Expressioni

Gene expression databases

BgeeiENSMUSG00000061393 Expressed in 276 organ(s), highest expression level in cerebral cortex
CleanExiMM_ACVR2B
GenevisibleiP27040 MM

Interactioni

Subunit structurei

Forms an activin receptor complex with activin type II receptors such as ACVR1B. Interacts with VPS39. Interacts with DYNLT1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ACVR1BP368964EBI-8571194,EBI-1384128From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi197956, 1 interactor
DIPiDIP-5799N
IntActiP27040, 5 interactors
MINTiP27040
STRINGi10090.ENSMUSP00000126108

Structurei

Secondary structure

1536
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP27040
SMRiP27040
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27040

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 504Protein kinasePROSITE-ProRule annotationAdd BLAST291

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni515 – 536Interaction with DYNLT11 PublicationAdd BLAST22

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3653 Eukaryota
ENOG410XS2Z LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000231495
HOVERGENiHBG054502
InParanoidiP27040
KOiK13596
OMAiPAIKDHW
OrthoDBiEOG091G03YO
PhylomeDBiP27040
TreeFamiTF352876

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
PRINTSiPR00653 ACTIVIN2R
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: ActR-IIB1 and ActR-IIB2 have similar but higher affinities for activin A than ActR-II, ActR-IIB3 and ActR-IIB4.
Isoform ActR-IIB1 (identifier: P27040-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE
60 70 80 90 100
GEQDKRLHCY ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY
110 120 130 140 150
FCCCEGNFCN ERFTHLPEPG GPEVTYEPPP TAPTLLTVLA YSLLPIGGLS
160 170 180 190 200
LIVLLAFWMY RHRKPPYGHV DIHEVRQCQR WAGRRDGCAD SFKPLPFQDP
210 220 230 240 250
GPPPPSPLVG LKPLQLLEIK ARGRFGCVWK AQLMNDFVAV KIFPLQDKQS
260 270 280 290 300
WQSEREIFST PGMKHENLLQ FIAAEKRGSN LEVELWLITA FHDKGSLTDY
310 320 330 340 350
LKGNIITWNE LCHVAETMSR GLSYLHEDVP WCRGEGHKPS IAHRDFKSKN
360 370 380 390 400
VLLKSDLTAV LADFGLAVRF EPGKPPGDTH GQVGTRRYMA PEVLEGAINF
410 420 430 440 450
QRDAFLRIDM YAMGLVLWEL VSRCKAADGP VDEYMLPFEE EIGQHPSLEE
460 470 480 490 500
LQEVVVHKKM RPTIKDHWLK HPGLAQLCVT IEECWDHDAE ARLSAGCVEE
510 520 530
RVSLIRRSVN GTTSDCLVSL VTSVTNVDLL PKESSI
Length:536
Mass (Da):60,542
Last modified:August 1, 1992 - v1
Checksum:iBF1C8CAC974BF5E2
GO
Isoform ActR-IIB2 (identifier: P27040-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-198: Missing.

Show »
Length:512
Mass (Da):57,738
Checksum:iF8C53AE6D0825D7A
GO
Isoform ActR-IIB3 (identifier: P27040-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-131: Missing.

Show »
Length:528
Mass (Da):59,657
Checksum:i1559B59DEAF7733B
GO
Isoform ActR-IIB4 (identifier: P27040-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-131: Missing.
     175-198: Missing.

Show »
Length:504
Mass (Da):56,853
Checksum:i42A315009EE8C17A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004951124 – 131Missing in isoform ActR-IIB3 and isoform ActR-IIB4. 1 Publication8
Alternative sequenceiVSP_004952175 – 198Missing in isoform ActR-IIB2 and isoform ActR-IIB4. 2 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84120 mRNA Translation: AAA37172.1
BC106189 mRNA Translation: AAI06190.1
CCDSiCCDS23615.1 [P27040-1]
PIRiA40829
B40829
C40829
D40829
RefSeqiNP_001300686.1, NM_001313757.1 [P27040-2]
NP_031423.1, NM_007397.3 [P27040-1]
XP_006511989.1, XM_006511926.3 [P27040-4]
UniGeneiMm.390239
Mm.8940

Genome annotation databases

EnsembliENSMUST00000035093; ENSMUSP00000035093; ENSMUSG00000061393 [P27040-3]
ENSMUST00000165044; ENSMUSP00000126108; ENSMUSG00000061393 [P27040-1]
ENSMUST00000215746; ENSMUSP00000150566; ENSMUSG00000061393 [P27040-2]
GeneIDi11481
KEGGimmu:11481
UCSCiuc009sax.1 mouse [P27040-1]
uc009say.1 mouse [P27040-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84120 mRNA Translation: AAA37172.1
BC106189 mRNA Translation: AAI06190.1
CCDSiCCDS23615.1 [P27040-1]
PIRiA40829
B40829
C40829
D40829
RefSeqiNP_001300686.1, NM_001313757.1 [P27040-2]
NP_031423.1, NM_007397.3 [P27040-1]
XP_006511989.1, XM_006511926.3 [P27040-4]
UniGeneiMm.390239
Mm.8940

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S4YX-ray2.30A/C23-120[»]
2H64X-ray1.92C19-117[»]
ProteinModelPortaliP27040
SMRiP27040
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197956, 1 interactor
DIPiDIP-5799N
IntActiP27040, 5 interactors
MINTiP27040
STRINGi10090.ENSMUSP00000126108

PTM databases

PhosphoSitePlusiP27040

Proteomic databases

MaxQBiP27040
PaxDbiP27040
PRIDEiP27040

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035093; ENSMUSP00000035093; ENSMUSG00000061393 [P27040-3]
ENSMUST00000165044; ENSMUSP00000126108; ENSMUSG00000061393 [P27040-1]
ENSMUST00000215746; ENSMUSP00000150566; ENSMUSG00000061393 [P27040-2]
GeneIDi11481
KEGGimmu:11481
UCSCiuc009sax.1 mouse [P27040-1]
uc009say.1 mouse [P27040-2]

Organism-specific databases

CTDi93
MGIiMGI:87912 Acvr2b

Phylogenomic databases

eggNOGiKOG3653 Eukaryota
ENOG410XS2Z LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000231495
HOVERGENiHBG054502
InParanoidiP27040
KOiK13596
OMAiPAIKDHW
OrthoDBiEOG091G03YO
PhylomeDBiP27040
TreeFamiTF352876

Enzyme and pathway databases

BRENDAi2.7.10.2 3474
ReactomeiR-MMU-1502540 Signaling by Activin
R-MMU-201451 Signaling by BMP

Miscellaneous databases

EvolutionaryTraceiP27040
PROiPR:P27040
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000061393 Expressed in 276 organ(s), highest expression level in cerebral cortex
CleanExiMM_ACVR2B
GenevisibleiP27040 MM

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF00069 Pkinase, 1 hit
PRINTSiPR00653 ACTIVIN2R
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAVR2B_MOUSE
AccessioniPrimary (citable) accession number: P27040
Secondary accession number(s): Q3KQI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 7, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again