UniProtKB - P27038 (AVR2A_MOUSE)
Activin receptor type-2A
Acvr2a
Functioni
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).
1 PublicationCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 219 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 322 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 198 – 206 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- activin-activated receptor activity Source: GO_Central
- activin binding Source: MGI
- ATP binding Source: UniProtKB-KW
- BMP receptor activity Source: UniProtKB
- coreceptor activity Source: MGI
- growth factor binding Source: MGI
- inhibin binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- PDZ domain binding Source: UniProtKB
- protein self-association Source: MGI
- protein serine/threonine kinase activity Source: MGI
GO - Biological processi
- activin receptor signaling pathway Source: MGI
- anterior/posterior pattern specification Source: MGI
- BMP signaling pathway Source: UniProtKB
- cellular response to BMP stimulus Source: MGI
- cellular response to growth factor stimulus Source: GO_Central
- determination of left/right symmetry Source: MGI
- embryonic skeletal system development Source: MGI
- gastrulation with mouth forming second Source: MGI
- male gonad development Source: MGI
- mesoderm development Source: MGI
- odontogenesis of dentin-containing tooth Source: MGI
- penile erection Source: MGI
- positive regulation of activin receptor signaling pathway Source: MGI
- positive regulation of bone mineralization Source: MGI
- positive regulation of erythrocyte differentiation Source: MGI
- positive regulation of follicle-stimulating hormone secretion Source: MGI
- positive regulation of osteoblast differentiation Source: MGI
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein phosphorylation Source: GO_Central
- regulation of nitric-oxide synthase activity Source: MGI
- regulation of signal transduction Source: MGI
- Sertoli cell proliferation Source: MGI
- spermatogenesis Source: MGI
- sperm ejaculation Source: MGI
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 3474 |
Reactomei | R-MMU-1502540, Signaling by Activin R-MMU-201451, Signaling by BMP |
Names & Taxonomyi
Protein namesi | Recommended name: Activin receptor type-2A (EC:2.7.11.30)Alternative name(s): Activin receptor type IIA Short name: ACTR-IIA |
Gene namesi | Name:Acvr2a Synonyms:Acvr2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102806, Acvr2a |
VEuPathDBi | HostDB:ENSMUSG00000052155 |
Subcellular locationi
Other locations
Plasma Membrane
- activin receptor complex Source: GO_Central
- inhibin-betaglycan-ActRII complex Source: MGI
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: UniProtKB
- cytoplasm Source: MGI
- receptor complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 135 | ExtracellularSequence analysisAdd BLAST | 116 | |
Transmembranei | 136 – 161 | HelicalSequence analysisAdd BLAST | 26 | |
Topological domaini | 162 – 513 | CytoplasmicSequence analysisAdd BLAST | 352 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000024399 | 20 – 513 | Activin receptor type-2AAdd BLAST | 494 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 60 | 1 Publication | ||
Glycosylationi | 43 | N-linked (GlcNAc...) asparagine | 1 | |
Disulfide bondi | 50 ↔ 78 | 1 Publication | ||
Glycosylationi | 66 | N-linked (GlcNAc...) asparagine | 1 | |
Disulfide bondi | 85 ↔ 104 | 1 Publication | ||
Disulfide bondi | 91 ↔ 103 | 1 Publication | ||
Disulfide bondi | 105 ↔ 110 | 1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | P27038 |
PaxDbi | P27038 |
PRIDEi | P27038 |
ProteomicsDBi | 273507 |
PTM databases
GlyGeni | P27038, 2 sites |
iPTMneti | P27038 |
PhosphoSitePlusi | P27038 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000052155, Expressed in pituitary gland and 325 other tissues |
ExpressionAtlasi | P27038, baseline and differential |
Genevisiblei | P27038, MM |
Interactioni
Subunit structurei
Interacts with AIP1.
Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:10681527).
Interacts with type I receptor ACVR1 (By similarity).
Interacts with BMP7 (By similarity).
By similarity1 PublicationBinary interactionsi
P27038
With | #Exp. | IntAct |
---|---|---|
BMP2 [P12643] from Homo sapiens. | 2 | EBI-1036102,EBI-1029262 |
GO - Molecular functioni
- growth factor binding Source: MGI
- inhibin binding Source: BHF-UCL
- PDZ domain binding Source: UniProtKB
- protein self-association Source: MGI
Protein-protein interaction databases
BioGRIDi | 197955, 9 interactors |
CORUMi | P27038 |
DIPi | DIP-5825N |
IntActi | P27038, 3 interactors |
STRINGi | 10090.ENSMUSP00000067305 |
Miscellaneous databases
RNActi | P27038, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P27038 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P27038 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 192 – 485 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 294 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3653, Eukaryota |
GeneTreei | ENSGT00940000157233 |
HOGENOMi | CLU_000288_8_4_1 |
InParanoidi | P27038 |
OMAi | SRCTVQD |
OrthoDBi | 390511at2759 |
PhylomeDBi | P27038 |
TreeFami | TF352876 |
Family and domain databases
Gene3Di | 2.10.60.10, 1 hit |
InterProi | View protein in InterPro IPR000472, Activin_recp IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR045860, Snake_toxin-like_sf IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57302, SSF57302, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC
60 70 80 90 100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV
110 120 130 140 150
YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI
160 170 180 190 200
AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR
210 220 230 240 250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI
260 270 280 290 300
GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
310 320 330 340 350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG
360 370 380 390 400
KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR
410 420 430 440 450
CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG
460 470 480 490 500
MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM
510
VTNVDFPPKE SSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65287 mRNA Translation: AAA37171.1 |
CCDSi | CCDS16021.1 |
PIRi | A39896 |
RefSeqi | NP_031422.3, NM_007396.4 |
Genome annotation databases
Ensembli | ENSMUST00000063886; ENSMUSP00000067305; ENSMUSG00000052155 |
GeneIDi | 11480 |
KEGGi | mmu:11480 |
UCSCi | uc008jpn.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M65287 mRNA Translation: AAA37171.1 |
CCDSi | CCDS16021.1 |
PIRi | A39896 |
RefSeqi | NP_031422.3, NM_007396.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BTE | X-ray | 1.50 | A/B | 25-121 | [»] | |
1LX5 | X-ray | 3.30 | B | 20-121 | [»] | |
2GOO | X-ray | 2.20 | C/F | 20-121 | [»] | |
SMRi | P27038 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 197955, 9 interactors |
CORUMi | P27038 |
DIPi | DIP-5825N |
IntActi | P27038, 3 interactors |
STRINGi | 10090.ENSMUSP00000067305 |
PTM databases
GlyGeni | P27038, 2 sites |
iPTMneti | P27038 |
PhosphoSitePlusi | P27038 |
Proteomic databases
MaxQBi | P27038 |
PaxDbi | P27038 |
PRIDEi | P27038 |
ProteomicsDBi | 273507 |
Protocols and materials databases
Antibodypediai | 18817, 490 antibodies from 37 providers |
DNASUi | 11480 |
Genome annotation databases
Ensembli | ENSMUST00000063886; ENSMUSP00000067305; ENSMUSG00000052155 |
GeneIDi | 11480 |
KEGGi | mmu:11480 |
UCSCi | uc008jpn.2, mouse |
Organism-specific databases
CTDi | 92 |
MGIi | MGI:102806, Acvr2a |
VEuPathDBi | HostDB:ENSMUSG00000052155 |
Phylogenomic databases
eggNOGi | KOG3653, Eukaryota |
GeneTreei | ENSGT00940000157233 |
HOGENOMi | CLU_000288_8_4_1 |
InParanoidi | P27038 |
OMAi | SRCTVQD |
OrthoDBi | 390511at2759 |
PhylomeDBi | P27038 |
TreeFami | TF352876 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 3474 |
Reactomei | R-MMU-1502540, Signaling by Activin R-MMU-201451, Signaling by BMP |
Miscellaneous databases
BioGRID-ORCSi | 11480, 1 hit in 65 CRISPR screens |
ChiTaRSi | Acvr2a, mouse |
EvolutionaryTracei | P27038 |
PROi | PR:P27038 |
RNActi | P27038, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000052155, Expressed in pituitary gland and 325 other tissues |
ExpressionAtlasi | P27038, baseline and differential |
Genevisiblei | P27038, MM |
Family and domain databases
Gene3Di | 2.10.60.10, 1 hit |
InterProi | View protein in InterPro IPR000472, Activin_recp IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR045860, Snake_toxin-like_sf IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57302, SSF57302, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AVR2A_MOUSE | |
Accessioni | P27038Primary (citable) accession number: P27038 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families