ACVR2A

Functionⁱ

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).By similarity1 Publication

Catalytic activityⁱ

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactorⁱ

Mg²⁺By similarity, Mn²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	219	ATPPROSITE-ProRule annotation		1
Active siteⁱ	322	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	198 – 206	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

activin binding Source: Ensembl
ATP binding Source: UniProtKB-KW
BMP receptor activity Source: UniProtKB
coreceptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10746731
growth factor binding Source: Ensembl
inhibin binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
PDZ domain binding Source: Ensembl
protein self-association Source: Ensembl
protein serine/threonine kinase activity
Source: Reactome
Inferred from experimentⁱ
- 8622651
- 8721982
transmembrane receptor protein serine/threonine kinase activity
Source: ProtInc
Traceable author statementⁱ
- 1314589

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activin receptor signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12665502
- 18326817
anterior/posterior pattern specification Source: Ensembl
BMP signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 18436533
cellular response to BMP stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18326817
- 19366699
determination of left/right symmetry Source: Ensembl
embryonic skeletal system development Source: Ensembl
gastrulation with mouth forming second Source: Ensembl
mesoderm development Source: Ensembl
penile erection Source: Ensembl
positive regulation of activin receptor signaling pathway
Source: HGNC
Inferred from direct assayⁱ
- 12665502
positive regulation of bone mineralization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18436533
positive regulation of erythrocyte differentiation
Source: HGNC
Inferred from direct assayⁱ
- 9032295
positive regulation of osteoblast differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18436533
positive regulation of pathway-restricted SMAD protein phosphorylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19366699
positive regulation of protein phosphorylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17472960
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18326817
regulation of BMP signaling pathway Source: Ensembl
regulation of nitric-oxide synthase activity Source: Ensembl
Sertoli cell proliferation Source: Ensembl
spermatogenesis Source: Ensembl
sperm ejaculation Source: Ensembl
transmembrane receptor protein serine/threonine kinase signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 1314589

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Receptor, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-1181150 Signaling by NODAL R-HSA-1433617 Regulation of signaling by NODAL R-HSA-1502540 Signaling by Activin R-HSA-201451 Signaling by BMP
SignaLinkⁱ	P27037
SIGNORⁱ	P27037

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Activin receptor type-2A (EC:2.7.11.30) Alternative name(s): Activin receptor type IIA Short name: ACTR-IIA Short name: ACTRIIA
Gene namesⁱ	Name:ACVR2A Synonyms:ACVR2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000121989.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:173 ACVR2A
MIMⁱ	102581 gene
neXtProtⁱ	NX_P27037

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 135	ExtracellularSequence analysisAdd BLAST	116
Transmembraneⁱ	136 – 161	HelicalSequence analysisAdd BLAST	26
Topological domainⁱ	162 – 513	CytoplasmicSequence analysisAdd BLAST	352

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	92
MalaCards human disease database More...MalaCardsⁱ	ACVR2A
Open Targets More...OpenTargetsⁱ	ENSG00000121989
PharmGKBⁱ	PA24494

Chemistry databases

ChEMBLⁱ	CHEMBL5616
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1791

Polymorphism and mutation databases

DMDMⁱ	114722

DMDMⁱ

114722

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000024398	20 – 513	Activin receptor type-2AAdd BLAST		494

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	30 ↔ 60	By similarity
Glycosylationⁱ	43	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	50 ↔ 78	By similarity
Glycosylationⁱ	66	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	85 ↔ 104	By similarity
Disulfide bondⁱ	91 ↔ 103	By similarity
Disulfide bondⁱ	105 ↔ 110	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P27037
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P27037
PaxDbⁱ	P27037
PeptideAtlas More...PeptideAtlasⁱ	P27037
PRIDEⁱ	P27037
ProteomicsDBⁱ	54373

PTM databases

iPTMnetⁱ	P27037
PhosphoSitePlusⁱ	P27037

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000121989 Expressed in 224 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_ACVR2A
Genevisibleⁱ	P27037 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046997

HPAⁱ

HPA046997

Interactionⁱ

Subunit structureⁱ

Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).By similarity

GO - Molecular functionⁱ

growth factor binding Source: Ensembl
inhibin binding Source: Ensembl
PDZ domain binding Source: Ensembl
protein self-association Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106607, 37 interactors
Database of interacting proteins More...DIPⁱ	DIP-520N
IntActⁱ	P27037, 3 interactors
Molecular INTeraction database More...MINTⁱ	P27037
STRINGⁱ	9606.ENSP00000241416

Chemistry databases

BindingDBⁱ

P27037

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	28 – 34	Combined sources	7
Helixⁱ	37 – 40	Combined sources	4
Beta strandⁱ	44 – 49	Combined sources	6
Beta strandⁱ	58 – 67	Combined sources	10
Beta strandⁱ	70 – 80	Combined sources	11
Beta strandⁱ	95 – 97	Combined sources	3
Beta strandⁱ	99 – 105	Combined sources	7
Helixⁱ	110 – 112	Combined sources	3
Beta strandⁱ	191 – 199	Combined sources	9
Beta strandⁱ	205 – 211	Combined sources	7
Beta strandⁱ	214 – 221	Combined sources	8
Helixⁱ	223 – 225	Combined sources	3
Helixⁱ	226 – 236	Combined sources	11
Beta strandⁱ	249 – 256	Combined sources	8
Beta strandⁱ	258 – 268	Combined sources	11
Helixⁱ	275 – 281	Combined sources	7
Helixⁱ	286 – 303	Combined sources	18
Beta strandⁱ	307 – 310	Combined sources	4
Beta strandⁱ	313 – 315	Combined sources	3
Beta strandⁱ	317 – 319	Combined sources	3
Beta strandⁱ	327 – 330	Combined sources	4
Beta strandⁱ	336 – 338	Combined sources	3
Beta strandⁱ	345 – 347	Combined sources	3
Helixⁱ	363 – 365	Combined sources	3
Helixⁱ	368 – 371	Combined sources	4
Helixⁱ	379 – 398	Combined sources	20
Beta strandⁱ	404 – 406	Combined sources	3
Helixⁱ	416 – 419	Combined sources	4
Helixⁱ	425 – 432	Combined sources	8
Helixⁱ	443 – 446	Combined sources	4
Helixⁱ	449 – 461	Combined sources	13
Helixⁱ	466 – 468	Combined sources	3
Helixⁱ	472 – 485	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	P27037
SMRⁱ	P27037
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P27037

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	192 – 485	Protein kinasePROSITE-ProRule annotationAdd BLAST		294

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3653 Eukaryota ENOG410XS2Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000231495
HOVERGENⁱ	HBG054502
InParanoidⁱ	P27037
KEGG Orthology (KO) More...KOⁱ	K04670
OMAⁱ	RIIQMQR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03YO
PhylomeDBⁱ	P27037
TreeFamⁱ	TF352876

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF00069 Pkinase, 1 hit
PRINTSⁱ	PR00653 ACTIVIN2R
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P27037-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC 
        60         70         80         90        100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV 
       110        120        130        140        150
YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI 
       160        170        180        190        200
AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR 
       210        220        230        240        250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI 
       260        270        280        290        300
GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 
       310        320        330        340        350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG 
       360        370        380        390        400
KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR 
       410        420        430        440        450
CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG 
       460        470        480        490        500
MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM 
       510 
VTNVDFPPKE SSL

Length:513

Mass (Da):57,848

Last modified:August 1, 1992 - v1

Checksum:ⁱA89822E880979618

GO

Isoform 2 (identifier: P27037-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-108: Missing.

« Hide

        10         20         30         40         50
MCNEKFSYFP EMEVTQPTSN PVTPKPPYYN ILLYSLVPLM LIAGIVICAF 
        60         70         80         90        100
WVYRHHKMAY PPVLVPTQDP GPPPPSPLLG LKPLQLLEVK ARGRFGCVWK 
       110        120        130        140        150
AQLLNEYVAV KIFPIQDKQS WQNEYEVYSL PGMKHENILQ FIGAEKRGTS 
       160        170        180        190        200
VDVDLWLITA FHEKGSLSDF LKANVVSWNE LCHIAETMAR GLAYLHEDIP 
       210        220        230        240        250
GLKDGHKPAI SHRDIKSKNV LLKNNLTACI ADFGLALKFE AGKSAGDTHG 
       260        270        280        290        300
QVGTRRYMAP EVLEGAINFQ RDAFLRIDMY AMGLVLWELA SRCTAADGPV 
       310        320        330        340        350
DEYMLPFEEE IGQHPSLEDM QEVVVHKKKR PVLRDYWQKH AGMAMLCETI 
       360        370        380        390        400
EECWDHDAEA RLSAGCVGER ITQMQRLTNI ITTEDIVTVV TMVTNVDFPP 

KESSL

Note: No experimental confirmation available.

Show »

Length:405

Mass (Da):45,713

Checksum:ⁱF0D4F7B18BD200AB

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	13	L → V in BAA06548 (Ref. 4) Curated	1
Sequence conflictⁱ	204 – 206	GCV → PSL in BAA06548 (Ref. 4) Curated	3
Sequence conflictⁱ	348	E → V in BAA06548 (Ref. 4) Curated	1
Sequence conflictⁱ	507	P → L in AAH67417 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032809	258	S → R1 PublicationCorresponds to variant dbSNP:rs34917571Ensembl.	1
Natural variantⁱVAR_032810	306	D → N in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764255410Ensembl.	1
Natural variantⁱVAR_064692	367	A → T Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054689	1 – 108	Missing in isoform 2. 1 PublicationAdd BLAST		108

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63128 mRNA Translation: CAA44839.1 M93415 mRNA Translation: AAA35504.1 X62381 mRNA Translation: CAA44245.1 D31770 mRNA Translation: BAA06548.1 AK301629 mRNA Translation: BAG63114.1 AK314124 mRNA Translation: BAG36815.1 AC009480 Genomic DNA Translation: AAX93050.1 CH471058 Genomic DNA Translation: EAX11561.1 CH471058 Genomic DNA Translation: EAX11562.1 BC067418 mRNA Translation: AAH67418.1 BC067417 mRNA Translation: AAH67417.1 BC069707 mRNA Translation: AAH69707.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33301.1 [P27037-1] CCDS63030.1 [P27037-2]
PIRⁱ	JQ1486
NCBI Reference Sequences More...RefSeqⁱ	NP_001265508.1, NM_001278579.1 [P27037-1] NP_001265509.1, NM_001278580.1 [P27037-2] NP_001607.1, NM_001616.4 [P27037-1]
UniGeneⁱ	Hs.470174

Genome annotation databases

Ensemblⁱ	ENST00000241416; ENSP00000241416; ENSG00000121989 [P27037-1] ENST00000404590; ENSP00000384338; ENSG00000121989 [P27037-1] ENST00000535787; ENSP00000439988; ENSG00000121989 [P27037-2]
GeneIDⁱ	92
KEGGⁱ	hsa:92
UCSC genome browser More...UCSCⁱ	uc002twg.5 human [P27037-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P27037	Serine/threonine-protein kinase receptor		MACMU		513	UniRef100_P27037
Serine/threonine-protein kinase receptor		PANTR		513
Serine/threonine-protein kinase receptor		MACFA		513
Serine/threonine-protein kinase receptor		PONAB		513
Serine/threonine-protein kinase receptor		SAIBB		513
+8
P27037-2	Activin receptor type-2A	)	MOUSE		513	UniRef100_P27038
Serine/threonine-protein kinase receptor		RABIT		543
Serine/threonine-protein kinase receptor		CRIGR		513
Serine/threonine-protein kinase receptor		RAT		513
Activin receptor (Fragment)		Rattus sp.		175
+3

Protein	Similar proteins		Species	Score	Length	Source
P27037	Activin receptor type-2A	)	MOUSE		513	UniRef90_P27038
Activin receptor type-2A		SHEEP		513
Activin receptor type-2A	)	RAT		513
Serine/threonine-protein kinase receptor		RABIT		543
Serine/threonine-protein kinase receptor		CRIGR		513
+103

Protein	Similar proteins		Species	Score	Length	Source
P27037	Activin receptor type-2A	)	MOUSE		513	UniRef50_P27038
Activin receptor type-2A		SHEEP		513
Activin receptor type-2A	)	RAT		513
Activin receptor type-2A		CHICK		513
Activin receptor type-2A		BOVIN		513
+813

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63128 mRNA Translation: CAA44839.1 M93415 mRNA Translation: AAA35504.1 X62381 mRNA Translation: CAA44245.1 D31770 mRNA Translation: BAA06548.1 AK301629 mRNA Translation: BAG63114.1 AK314124 mRNA Translation: BAG36815.1 AC009480 Genomic DNA Translation: AAX93050.1 CH471058 Genomic DNA Translation: EAX11561.1 CH471058 Genomic DNA Translation: EAX11562.1 BC067418 mRNA Translation: AAH67418.1 BC067417 mRNA Translation: AAH67417.1 BC069707 mRNA Translation: AAH69707.1
CCDSⁱ	CCDS33301.1 [P27037-1] CCDS63030.1 [P27037-2]
PIRⁱ	JQ1486
RefSeqⁱ	NP_001265508.1, NM_001278579.1 [P27037-1] NP_001265509.1, NM_001278580.1 [P27037-2] NP_001607.1, NM_001616.4 [P27037-1]
UniGeneⁱ	Hs.470174

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3Q4T	X-ray	1.96	A/B	191-488	[»]
	3SOC	X-ray	1.95	A/B	191-488	[»]
	4ASX	X-ray	2.05	A/B	191-488	[»]
	5NH3	X-ray	2.35	A/B	20-135	[»]
ProteinModelPortalⁱ	P27037
SMRⁱ	P27037
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106607, 37 interactors
DIPⁱ	DIP-520N
IntActⁱ	P27037, 3 interactors
MINTⁱ	P27037
STRINGⁱ	9606.ENSP00000241416

Chemistry databases

BindingDBⁱ	P27037
ChEMBLⁱ	CHEMBL5616
GuidetoPHARMACOLOGYⁱ	1791

PTM databases

iPTMnetⁱ	P27037
PhosphoSitePlusⁱ	P27037

Polymorphism and mutation databases

DMDMⁱ	114722

DMDMⁱ

114722

Proteomic databases

EPDⁱ	P27037
MaxQBⁱ	P27037
PaxDbⁱ	P27037
PeptideAtlasⁱ	P27037
PRIDEⁱ	P27037
ProteomicsDBⁱ	54373

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	92
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000241416; ENSP00000241416; ENSG00000121989 [P27037-1] ENST00000404590; ENSP00000384338; ENSG00000121989 [P27037-1] ENST00000535787; ENSP00000439988; ENSG00000121989 [P27037-2]
GeneIDⁱ	92
KEGGⁱ	hsa:92
UCSCⁱ	uc002twg.5 human [P27037-1]

Organism-specific databases

CTDⁱ	92
DisGeNETⁱ	92
EuPathDBⁱ	HostDB:ENSG00000121989.14
GeneCardsⁱ	ACVR2A
HGNCⁱ	HGNC:173 ACVR2A
HPAⁱ	HPA046997
MalaCardsⁱ	ACVR2A
MIMⁱ	102581 gene
neXtProtⁱ	NX_P27037
OpenTargetsⁱ	ENSG00000121989
PharmGKBⁱ	PA24494
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3653 Eukaryota ENOG410XS2Z LUCA
GeneTreeⁱ	ENSGT00760000118876
HOGENOMⁱ	HOG000231495
HOVERGENⁱ	HBG054502
InParanoidⁱ	P27037
KOⁱ	K04670
OMAⁱ	RIIQMQR
OrthoDBⁱ	EOG091G03YO
PhylomeDBⁱ	P27037
TreeFamⁱ	TF352876

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-1181150 Signaling by NODAL R-HSA-1433617 Regulation of signaling by NODAL R-HSA-1502540 Signaling by Activin R-HSA-201451 Signaling by BMP
SignaLinkⁱ	P27037
SIGNORⁱ	P27037

Miscellaneous databases

EvolutionaryTraceⁱ	P27037
GeneWikiⁱ	ACVR2A
GenomeRNAiⁱ	92
Protein Ontology More...PROⁱ	PR:P27037
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000121989 Expressed in 224 organ(s), highest expression level in amniotic fluid
CleanExⁱ	HS_ACVR2A
Genevisibleⁱ	P27037 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000472 Activin_recp IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR008271 Ser/Thr_kinase_AS IPR000333 TGFB_receptor
PANTHERⁱ	PTHR23255 PTHR23255, 1 hit
Pfamⁱ	View protein in Pfam PF01064 Activin_recp, 1 hit PF00069 Pkinase, 1 hit
PRINTSⁱ	PR00653 ACTIVIN2R
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AVR2A_HUMAN
Accessionⁱ	P27037Primary (citable) accession number: P27037 Secondary accession number(s): B2RAB8 , B4DWQ2, D3DP85, Q53TH4, Q6NWV2, Q92474
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	August 1, 1992
	Last modified:	October 10, 2018
	This is version 195 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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Supporting data

UniProtKB - P27037 (AVR2A_HUMAN)

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Activin receptor type-2A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ