UniProtKB - P27037 (AVR2A_HUMAN)
Activin receptor type-2A
ACVR2A
Functioni
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401).
Mediates induction of adipogenesis by GDF6 (By similarity).
By similarity2 PublicationsCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 219 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 322 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 198 – 206 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- activin binding Source: Ensembl
- ATP binding Source: UniProtKB-KW
- BMP receptor activity Source: UniProtKB
- coreceptor activity Source: BHF-UCL
- growth factor binding Source: Ensembl
- inhibin binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- PDZ domain binding Source: Ensembl
- protein self-association Source: Ensembl
- protein serine/threonine kinase activity Source: Reactome
- transmembrane receptor protein serine/threonine kinase activity Source: ProtInc
GO - Biological processi
- activin receptor signaling pathway Source: BHF-UCL
- anterior/posterior pattern specification Source: Ensembl
- BMP signaling pathway Source: BHF-UCL
- cellular response to BMP stimulus Source: BHF-UCL
- cellular response to growth factor stimulus Source: GO_Central
- determination of left/right symmetry Source: Ensembl
- embryonic skeletal system development Source: Ensembl
- gastrulation with mouth forming second Source: Ensembl
- mesoderm development Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- penile erection Source: Ensembl
- positive regulation of activin receptor signaling pathway Source: HGNC-UCL
- positive regulation of bone mineralization Source: BHF-UCL
- positive regulation of erythrocyte differentiation Source: HGNC-UCL
- positive regulation of osteoblast differentiation Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- protein phosphorylation Source: GO_Central
- regulation of nitric-oxide synthase activity Source: Ensembl
- Sertoli cell proliferation Source: Ensembl
- spermatogenesis Source: Ensembl
- sperm ejaculation Source: Ensembl
- transmembrane receptor protein serine/threonine kinase signaling pathway Source: ProtInc
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P27037 |
Reactomei | R-HSA-1181150, Signaling by NODAL R-HSA-1433617, Regulation of signaling by NODAL R-HSA-1502540, Signaling by Activin R-HSA-201451, Signaling by BMP |
SignaLinki | P27037 |
SIGNORi | P27037 |
Names & Taxonomyi
Protein namesi | Recommended name: Activin receptor type-2A (EC:2.7.11.30)Alternative name(s): Activin receptor type IIA Short name: ACTR-IIA Short name: ACTRIIA |
Gene namesi | Name:ACVR2A Synonyms:ACVR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:173, ACVR2A |
MIMi | 102581, gene |
neXtProti | NX_P27037 |
VEuPathDBi | HostDB:ENSG00000121989 |
Subcellular locationi
Other locations
Plasma Membrane
- activin receptor complex Source: GO_Central
- inhibin-betaglycan-ActRII complex Source: BHF-UCL
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: Ensembl
- cytoplasm Source: HGNC-UCL
- receptor complex Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 135 | ExtracellularSequence analysisAdd BLAST | 116 | |
Transmembranei | 136 – 161 | HelicalSequence analysisAdd BLAST | 26 | |
Topological domaini | 162 – 513 | CytoplasmicSequence analysisAdd BLAST | 352 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 92 |
MalaCardsi | ACVR2A |
OpenTargetsi | ENSG00000121989 |
PharmGKBi | PA24494 |
Miscellaneous databases
Pharosi | P27037, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5616 |
DrugBanki | DB12118, Sotatercept |
DrugCentrali | P27037 |
GuidetoPHARMACOLOGYi | 1791 |
Genetic variation databases
BioMutai | ACVR2A |
DMDMi | 114722 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000024398 | 20 – 513 | Activin receptor type-2AAdd BLAST | 494 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 60 | By similarity | ||
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 50 ↔ 78 | By similarity | ||
Glycosylationi | 66 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 85 ↔ 104 | By similarity | ||
Disulfide bondi | 91 ↔ 103 | By similarity | ||
Disulfide bondi | 105 ↔ 110 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P27037 |
jPOSTi | P27037 |
MassIVEi | P27037 |
MaxQBi | P27037 |
PaxDbi | P27037 |
PeptideAtlasi | P27037 |
PRIDEi | P27037 |
ProteomicsDBi | 5369 54373 [P27037-1] |
PTM databases
GlyGeni | P27037, 2 sites |
iPTMneti | P27037 |
PhosphoSitePlusi | P27037 |
Expressioni
Gene expression databases
Bgeei | ENSG00000121989, Expressed in amniotic fluid and 241 other tissues |
Genevisiblei | P27037, HS |
Organism-specific databases
HPAi | ENSG00000121989, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- growth factor binding Source: Ensembl
- inhibin binding Source: Ensembl
- PDZ domain binding Source: Ensembl
- protein self-association Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 106607, 86 interactors |
DIPi | DIP-520N |
IntActi | P27037, 17 interactors |
MINTi | P27037 |
STRINGi | 9606.ENSP00000241416 |
Chemistry databases
BindingDBi | P27037 |
Miscellaneous databases
RNActi | P27037, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P27037 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P27037 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 192 – 485 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 294 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3653, Eukaryota |
GeneTreei | ENSGT00940000157233 |
HOGENOMi | CLU_000288_8_4_1 |
InParanoidi | P27037 |
OMAi | SRCTVQD |
OrthoDBi | 390511at2759 |
PhylomeDBi | P27037 |
TreeFami | TF352876 |
Family and domain databases
Gene3Di | 2.10.60.10, 1 hit |
InterProi | View protein in InterPro IPR000472, Activin_recp IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR045860, Snake_toxin-like_sf IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57302, SSF57302, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWEKD RTNQTGVEPC
60 70 80 90 100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CVEKKDSPEV
110 120 130 140 150
YFCCCEGNMC NEKFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI
160 170 180 190 200
AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR
210 220 230 240 250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI
260 270 280 290 300
GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
310 320 330 340 350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG
360 370 380 390 400
KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR
410 420 430 440 450
CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG
460 470 480 490 500
MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM
510
VTNVDFPPKE SSL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | L → V in BAA06548 (Ref. 4) Curated | 1 | |
Sequence conflicti | 204 – 206 | GCV → PSL in BAA06548 (Ref. 4) Curated | 3 | |
Sequence conflicti | 348 | E → V in BAA06548 (Ref. 4) Curated | 1 | |
Sequence conflicti | 507 | P → L in AAH67417 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032809 | 258 | S → R1 PublicationCorresponds to variant dbSNP:rs34917571Ensembl. | 1 | |
Natural variantiVAR_032810 | 306 | D → N in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764255410Ensembl. | 1 | |
Natural variantiVAR_064692 | 367 | A → T Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054689 | 1 – 108 | Missing in isoform 2. 1 PublicationAdd BLAST | 108 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63128 mRNA Translation: CAA44839.1 M93415 mRNA Translation: AAA35504.1 X62381 mRNA Translation: CAA44245.1 D31770 mRNA Translation: BAA06548.1 AK301629 mRNA Translation: BAG63114.1 AK314124 mRNA Translation: BAG36815.1 AC009480 Genomic DNA Translation: AAX93050.1 CH471058 Genomic DNA Translation: EAX11561.1 CH471058 Genomic DNA Translation: EAX11562.1 BC067418 mRNA Translation: AAH67418.1 BC067417 mRNA Translation: AAH67417.1 BC069707 mRNA Translation: AAH69707.1 |
CCDSi | CCDS33301.1 [P27037-1] CCDS63030.1 [P27037-2] |
PIRi | JQ1486 |
RefSeqi | NP_001265508.1, NM_001278579.1 [P27037-1] NP_001265509.1, NM_001278580.1 [P27037-2] NP_001607.1, NM_001616.4 [P27037-1] |
Genome annotation databases
Ensembli | ENST00000241416; ENSP00000241416; ENSG00000121989 ENST00000404590; ENSP00000384338; ENSG00000121989 ENST00000535787; ENSP00000439988; ENSG00000121989 [P27037-2] |
GeneIDi | 92 |
KEGGi | hsa:92 |
MANE-Selecti | ENST00000241416.12; ENSP00000241416.7; NM_001616.5; NP_001607.1 |
UCSCi | uc002twg.5, human [P27037-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63128 mRNA Translation: CAA44839.1 M93415 mRNA Translation: AAA35504.1 X62381 mRNA Translation: CAA44245.1 D31770 mRNA Translation: BAA06548.1 AK301629 mRNA Translation: BAG63114.1 AK314124 mRNA Translation: BAG36815.1 AC009480 Genomic DNA Translation: AAX93050.1 CH471058 Genomic DNA Translation: EAX11561.1 CH471058 Genomic DNA Translation: EAX11562.1 BC067418 mRNA Translation: AAH67418.1 BC067417 mRNA Translation: AAH67417.1 BC069707 mRNA Translation: AAH69707.1 |
CCDSi | CCDS33301.1 [P27037-1] CCDS63030.1 [P27037-2] |
PIRi | JQ1486 |
RefSeqi | NP_001265508.1, NM_001278579.1 [P27037-1] NP_001265509.1, NM_001278580.1 [P27037-2] NP_001607.1, NM_001616.4 [P27037-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3Q4T | X-ray | 1.96 | A/B | 191-488 | [»] | |
3SOC | X-ray | 1.95 | A/B | 191-488 | [»] | |
4ASX | X-ray | 2.05 | A/B | 191-488 | [»] | |
5NH3 | X-ray | 2.35 | A/B | 20-135 | [»] | |
SMRi | P27037 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106607, 86 interactors |
DIPi | DIP-520N |
IntActi | P27037, 17 interactors |
MINTi | P27037 |
STRINGi | 9606.ENSP00000241416 |
Chemistry databases
BindingDBi | P27037 |
ChEMBLi | CHEMBL5616 |
DrugBanki | DB12118, Sotatercept |
DrugCentrali | P27037 |
GuidetoPHARMACOLOGYi | 1791 |
PTM databases
GlyGeni | P27037, 2 sites |
iPTMneti | P27037 |
PhosphoSitePlusi | P27037 |
Genetic variation databases
BioMutai | ACVR2A |
DMDMi | 114722 |
Proteomic databases
EPDi | P27037 |
jPOSTi | P27037 |
MassIVEi | P27037 |
MaxQBi | P27037 |
PaxDbi | P27037 |
PeptideAtlasi | P27037 |
PRIDEi | P27037 |
ProteomicsDBi | 5369 54373 [P27037-1] |
Protocols and materials databases
ABCDi | P27037, 1 sequenced antibody |
Antibodypediai | 18817, 490 antibodies from 37 providers |
DNASUi | 92 |
Genome annotation databases
Ensembli | ENST00000241416; ENSP00000241416; ENSG00000121989 ENST00000404590; ENSP00000384338; ENSG00000121989 ENST00000535787; ENSP00000439988; ENSG00000121989 [P27037-2] |
GeneIDi | 92 |
KEGGi | hsa:92 |
MANE-Selecti | ENST00000241416.12; ENSP00000241416.7; NM_001616.5; NP_001607.1 |
UCSCi | uc002twg.5, human [P27037-1] |
Organism-specific databases
CTDi | 92 |
DisGeNETi | 92 |
GeneCardsi | ACVR2A |
HGNCi | HGNC:173, ACVR2A |
HPAi | ENSG00000121989, Low tissue specificity |
MalaCardsi | ACVR2A |
MIMi | 102581, gene |
neXtProti | NX_P27037 |
OpenTargetsi | ENSG00000121989 |
PharmGKBi | PA24494 |
VEuPathDBi | HostDB:ENSG00000121989 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3653, Eukaryota |
GeneTreei | ENSGT00940000157233 |
HOGENOMi | CLU_000288_8_4_1 |
InParanoidi | P27037 |
OMAi | SRCTVQD |
OrthoDBi | 390511at2759 |
PhylomeDBi | P27037 |
TreeFami | TF352876 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P27037 |
Reactomei | R-HSA-1181150, Signaling by NODAL R-HSA-1433617, Regulation of signaling by NODAL R-HSA-1502540, Signaling by Activin R-HSA-201451, Signaling by BMP |
SignaLinki | P27037 |
SIGNORi | P27037 |
Miscellaneous databases
BioGRID-ORCSi | 92, 36 hits in 1065 CRISPR screens |
ChiTaRSi | ACVR2A, human |
EvolutionaryTracei | P27037 |
GeneWikii | ACVR2A |
GenomeRNAii | 92 |
Pharosi | P27037, Tchem |
PROi | PR:P27037 |
RNActi | P27037, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121989, Expressed in amniotic fluid and 241 other tissues |
Genevisiblei | P27037, HS |
Family and domain databases
Gene3Di | 2.10.60.10, 1 hit |
InterProi | View protein in InterPro IPR000472, Activin_recp IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR008271, Ser/Thr_kinase_AS IPR045860, Snake_toxin-like_sf IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit PF00069, Pkinase, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57302, SSF57302, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AVR2A_HUMAN | |
Accessioni | P27037Primary (citable) accession number: P27037 Secondary accession number(s): B2RAB8 Q92474 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 217 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families